Space flight

A theme that has come to the fore in advanced planning for long-range space exploration is the concept of "propellantless propulsion" or "field propulsion." One version of this concept involves the projected possibility that empty space itself (the quantum vacuum, or space-time metric) might be manipulated so as to provide energy/thrust for future space vehicles. Although such a proposal has a certain science-fiction quality about it, modern theory describes the vacuum as a polarizable medium that sustains energetic quantum fluctuations. Thus the possibility that matter/vacuum interactions might be engineered for space-flight applications is not a priori ruled out, although certain constraints need to be acknowledged. The structure and implications of such a far-reaching hypothesis are considered herein. Comment: Paper withdrawn. Author Ibison does not subscribe to some of the speculations in this document

Going to Mars The Mars Science Laboratory spacecraft containing the Curiosity rover, was launched from Earth in November 2011 and arrived at Gale crater on Mars in August 2012. Zeitlin et al. (p. 1080 ) report measurements of the energetic particle radiation environment inside the spacecraft during its cruise to Mars, confirming the hazard likely to be posed by this radiation to astronauts on a future potential trip to Mars. Williams et al. (p. 1068 , see the Perspective by Jerolmack ) report the detection of sedimentary conglomerates (pebbles mixed with sand and turned to rock) at Gale crater. The rounding of the rocks suggests abrasion of the pebbles as they were transported by flowing water several kilometers or more from their source.

Decreased bone mineral density (BMD) in astronauts returning from long-duration spaceflight missions has been well documented, but the altered mechanical loading environment experienced by the musculoskeletal system, which may contribute to these changes, has not been well characterized. The current study describes the loading environment of the lower extremity (LE) during typical days on the International Space Station (ISS) compared to similar data for the same individuals living on Earth. Data from in-shoe force measurements are also used as input to the enhanced daily load stimulus (EDLS) model to determine the mechanical ''dose'' experienced by the musculoskeletal system and to associate this dose with changes in BMD.

MELiSSA is a bioregenerative life support system designed by the European Space Agency (ESA) for the complete recycling of gas, liquid and solid wastes during long distance space exploration. The system uses the combined activity of different living organisms: microbial cultures in bioreactors, a plant compartment and a human crew. In this minireview, the development of a short-cut ecological system for the biotransformation of organic waste is discussed from a microorganism’s perspective. The artificial ecological model—still in full development—that is inspired by Earth’s own geomicrobiological ecosystem serves as an ideal study object on microbial ecology and will become an indispensable travel
companion in manned space exploration.

We have measured charged nuclear fragments produced by 1 GeV/nucleon 56 Fe ions interacting with aluminium, polyethylene and lead. These materials are relevant for assessment of radiation risk for manned space flight. The data will be presented in a form suitable for comparison with models of nuclear fragmentation and transport, including linear energy transfer (LET) spectrum, fluence for iron and fragments, event-tack-and event-dose-averaged LET, total dose and iron contribution to dose. Ó 2005 Published by Elsevier Ltd on behalf of COSPAR.

With 5-7 month long duration missions at 51.6°inclination in Low Earth Orbit, the ionizing radiation levels to which International Space Station (ISS) crewmembers are exposed will be the highest planned occupational exposures in the world. Even with the expectation that regulatory dose limits will not be exceeded during a single tour of duty aboard the ISS, the ''as low as reasonably achievable'' (ALARA) precept requires that radiological risks be minimized when possible through a dose optimization process. Judicious placement of efficient shielding materials in locations where crewmembers sleep, rest, or work is an important means for implementing ALARA for spaceflight. Polyethylene (C n H n ) is a relatively inexpensive, stable, and, with a low atomic number, an effective shielding material that has been certified for use aboard the ISS. Several designs for placement of slabs or walls of polyethylene have been evaluated for radiation exposure reduction in the Crew Quarters (CQ) of the Zvezda (Star) Service Module. Optimization of shield designs relies on accurate characterization of the expected primary and secondary particle environment and modeling of the predicted radiobiological responses of critical organs and tissues. Results of the studies shown herein indicate that 20% or more reduction in equivalent dose to the CQ occupant is achievable. These results suggest that shielding design and risk analysis are necessary measures for reducing long-term radiological risks to ISS inhabitants and for meeting legal ALARA requirements. Verification of shield concepts requires results from specific designs to be compared with onboard dosimetry.

The CCU and Incubator are habitats under development by SSBRP for gravitational biology research on ISS. They will accommodate multiple specimen types and reside in either Habitat Holding Racks, or the Centrifuge Rotor, which provides selectable gravity levels of up to 2 g. The CCU can support multiple Cell Specimen Chambers, CSCs (18, 9 or 6 CSCs; 3, 10 or 30 mL in volume, respectively). CSCs are temperature controlled from 4-39 degrees C, with heat shock to 45 degrees C. CCU provides automated nutrient supply, magnetic stirring, pH/O2 monitoring, gas supply, specimen lighting, and video microscopy. Sixty sample containers holding up to 2 mL each, stored at 4-39 degrees C, are available for automated cell sampling, subculture, and injection of additives and fixatives. CSCs, sample containers, and fresh/spent media bags are crew-replaceable for long-term experiments. The Incubator provides a 4-45 degrees C controlled environment for life science experiments or storage of experimenta...

We have studied the application and the feasibility of confocal scanning laser microscopy (CSLM) in microgravity research. Its superior spatial resolution and 3D imaging capabilities and its use of light as a probe, render this instrument ideally suited for the study of living biological material on a (sub-)cellular level. In this paper a number of pertinent biological microgravity experiments is listed, concentrating on the direct observation of developing cells and cellular structures under microgravity condition. A conceptual instrument design is also presented, aimed at sounding rocket application followed by Biorack/Biolab application at a later stage.

Purpose: Prolonged exposure to microgravity during spaceflight causes metabolic changes that increase the risk of renal stone formation. Studies during the Gemini, Apollo, Skylab and Shuttle missions demonstrated alterations in renal function, fluid homeostasis and bone resorption that result in increased urinary supersaturation of calcium oxalate, brushite, sodium urate and uric acid. Developing countermeasures to increased urinary supersaturation is an important priority as the duration of space missions increases. Materials and Methods: A total of 11 sets of identical twins remained on 6-degree head down, tilt bed rest for 30 days to simulate prolonged microgravity. One twin per pair was randomly selected to exercise while supine in a lower body negative pressure chamber 6 days weekly for 40 minutes, followed by 5 minutes of resting lower body negative pressure at 50 mm Hg. The other twin served as a nonexercise control. Pressure in the exercise lower body negative pressure chamber (52 to 63 mm Hg) was adjusted to produce footward forces equivalent to those for upright running on Earth at 1.0 to 1.2 ϫ body weight. Pre-bed rest urinary stone risk profiles were done elsewhere after 5 days of a standardized diet, consisting of 170 mEq sodium, 1,000 mg calcium, 0.8 gm/kg animal protein and 2,500 kcal, and then throughout the bed rest and recovery phases of the protocol. Results: A significant increase in urinary calcium after just 1 week of bed rest was noted in the nonexercise control group (p ϭ 0.001). However, no such increase was noted in the exercise group. Brushite supersaturation increased significantly from bed rest in each group, although the increase was significantly higher in the nonexercise control group than in the exercise group (p ϭ 0.006). Calcium oxalate supersaturation increased during bed rest in the exercise group (p ϭ 0.004). It trended toward a higher level in the nonexercise control group, although this did not achieve significance (p ϭ 0.055) Mean urine volume Ϯ SD was significantly higher in the nonexercise control group than in the exercise group at bed rest week 2 and at week 3 (2.01 Ϯ 0.21 vs 1.63 0.18 l and 2.03 Ϯ 0.22 vs 1.81 Ϯ 0.20, respectively). Urinary pH was significantly higher in the nonexercise control group than in the exercise group at week 1 and week 3 (6.62 Ϯ 0.7 vs 6.49 Ϯ 0.5 and 6.58 Ϯ 0.6 vs 6.49 Ϯ 0.8, respectively, p ϭ 0.01). Conclusions: Bed rest significantly alters the urinary environment to favor calculous formation. Lower body negative pressure chamber treadmill exercise offers some protection against increases in stone risk during simulated microgravity, particularly with regard to the risks of hypercalciuria and brushite stone formation. The use of lower body negative pressure to augment aerobic exercise in space may decrease the risk of stone formation in astronauts. Adjunct measures, including aggressive hydration and alkalinization therapy, should be considered.

Harry T. Whelan, MD1a,2,3, John M Houle, BS1a, Noel T. Whelan1a,3, Deborah L. Donohoe, AS, LATG1a, Joan Cwiklinski, MSN, CPNP1a, Meic H. Schmidt, MD1c, Lisa Gould, MD, PhD.1b, David Larson, MD1b, Glenn A. Meyer, MD1a, Vita Cevenini3, Helen ...

In January 2004, President George W. Bush unveiled plans to send astronauts to the Moon in 2015 and shortly thereafter to Mars. With the prospect of manned exploration of the planets drawing ever closer, the new discipline of Space Medicine is destined to come to the fore. Moreover, investigations of how human beings function under space conditions could provide important new insights into fundamental questions of human physiology and disease. We draw attention here to one such instance of a disease process that can be provoked by extended periods of exposure to low gravity.

FLUKA is an integrated particle transport code that has enhanced multigroup low-energy neutron transport capability similar to the well-known MORSE transport code. Gammas are produced in groups but many important individual lines are speciÿcally included, and subsequently transported by the main FLUKA routines which use a modiÿed version of EGS4 for electromagnetic (EM) transport. Recoil protons are also transported by the primary FLUKA transport simulation. The neutron cross-section libraries employed within FLUKA were supplied by Giancarlo Panini (ENEA, Italy) based upon the most recent data from JEF-1, JEF-2.2, ENDF=B-VI, JENDL-3, etc. More than 60 di erent materials are included in the FLUKA databases with temperature ranges including down to cryogenic temperatures. This code has been used extensively to model the neutron environments near high-energy physics experiment shielding. A simulation of the Space Shuttle based upon a spherical aluminum equivalent shielding distribution has been performed with reasonable results. There are good prospects for extending this calculation to a more realistic 3-D geometrical representation of the Shuttle including an accurate representation of its composition, which is an essential ingredient for the improvement of the predictions. A proposed project to develop a combined analysis and simulation package based upon FLUKA and the analysis infrastructure provided by the ROOT software is under active consideration. The code to be developed for this project will be of direct application to the problem of simulating the neutron environment in space, including the albedo e ects.

The mechanism of the loss of skeletal muscle mass that occurs during spaceflight is not well understood. Myostatin has been proposed as a negative modulator of muscle mass, and IGF-I and IGF-II are known positive regulators of muscle differentiation and growth. We investigated whether muscle loss associated with spaceflight is accompanied by increased levels of myostatin and a reduction in IGF-I and -II levels in the muscle, and whether these changes correlate with an increase in muscle proteolysis and apoptosis. Twelve male adult rats sent on the 17-day NASA STS-90 NeuroLab space flight were divided upon return to earth into two groups, and killed either 1 day later (R1) or after 13 days of acclimatization (R13). Ground-based control rats were maintained for the same periods in either vivarium (R3 and R15, respectively), or flight-simulated cages (R5 and R17, respectively). RNA and protein were isolated from the tibialis anterior, biceps femoris, quadriceps, and gastrocnemius muscles. Myostatin, IGF-I, IGF-II and proteasome 2c mRNA concentrations were determined by reverse transcription/PCR; myostatin and ubiquitin mRNA were also measured by Northern blot analysis; myostatin protein was estimated by immunohistochemistry; the apoptotic index and the release of 3-methylhistidine were determined respectively by the TUNEL assay and by HPLC. Muscle weights were 19-24% lower in the R1 rats compared with the control R3 and R5 rats, but were not significantly different after the recovery period. The myostatin/ -actin mRNA ratios (means ...) were higher in the muscles of the R1 rats compared with the control R5 rats: 5·0-fold in tibialis (5·35 1·85 vs 1·07 0·26), 3·0-fold in biceps (2·46 0·70 vs 0·81 0·04), 1·9-fold in quadriceps (7·84 1·73 vs 4·08 0·52), and 2·2-fold in gastrocnemius (0·99 0·35 vs 0·44 0·17). These values also normalized upon acclimatization. Our antibody against a myostatin peptide was validated by detection of the recombinant human myostatin protein on Western blots, which also showed that myostatin immunostaining was increased in muscle sections from R1 rats, compared with control R3 rats, and normalized upon acclimatization. In contrast, IGF-II mRNA concentrations in the muscles from R1 rats were 64-89% lower than those in R3 animals. With the exception of the gastrocnemius, IGF-II was also decreased in R5 animals maintained in flight-simulated cages, and normalized upon acclimatization. The intramuscular IGF-I mRNA levels were not significantly different between the spaceflight rats and the controls. No increase was found in the proteolysis markers 3-methyl histidine, ubiquitin mRNA, and proteasome 2C mRNA. In conclusion, the loss of skeletal muscle mass that occurs during spaceflight is associated with increased myostatin mRNA and protein levels in the skeletal muscle, and a decrease in IGF-II mRNA levels. These alterations are normalized upon restoration of normal gravity and caging conditions. These data suggest that reciprocal changes in the expression of myostatin and IGF-II may contribute to the multifactorial pathophysiology of muscle atrophy that occurs during spaceflight.

The Mars Science Laboratory spacecraft, containing the Curiosity rover, was launched to Mars on 26 November 2011, and for most of the 253-day, 560-million-kilometer cruise to Mars, the Radiation Assessment Detector made detailed measurements of the energetic particle radiation environment inside the spacecraft. These data provide insights into the radiation hazards that would be associated with a human mission to Mars. We report measurements of the radiation dose, dose equivalent, and linear energy transfer spectra. The dose equivalent for even the shortest round-trip with current propulsion systems and comparable shielding is found to be 0.66 ± 0.12 sievert.

Background: Arabidopsis plants were grown on the International Space Station within specialized hardware that combined a plant growth habitat with a camera system that can capture images at regular intervals of growth. The Imaging hardware delivers telemetric data from the ISS, specifically images received in real-time from experiments on orbit, providing science without sample return. Comparable Ground Controls were grown in a sister unit that is maintained in the Orbital Environment Simulator at Kennedy Space Center. One of many types of biological data that can be analyzed in this fashion is root morphology. Arabidopsis seeds were geminated on orbit on nutrient gel Petri plates in a configuration that encouraged growth along the surface of the gel. Photos were taken every six hours for the 15 days of the experiment.

Objective: First popularized as neurasthenia in the late 1800s by American George Beard, asthenia has been viewed by Russian psychologists and flight surgeons as a major problem that affects cosmonauts participating in longduration space missions. However, there is some controversy about whether this syndrome exists in space; this controversy is attributable in part to the fact that it is not recognized in the current American psychiatric diagnostic system. Methods: To address this issue empirically, we retrospectively examined the data from our 4 1/2-year, NASA-funded study of crew member and mission control interactions during the Shuttle/Mir space program. Three of the authors identified eight items of stage 1 asthenia from one of our measures, the Profile of Mood States (POMS). Scores on these items from 13 Russian and American crew members were compared with scores derived from the opinions of six Russian space experts. Results: Crew members' scores in space were significantly lower than the experts' scores on seven of the eight items, and they generally were in the "not at all" to "a little" range of the item scales. There were no differences in mean scores before and after launch or across the four quarters of the missions. There were no differences in response between Russian and American crew members. Conclusions: We could not demonstrate the presence of asthenia in space as operationally defined using the POMS. However, the POMS addresses only emotional and not physiological aspects of the syndrome, and the subject responses in our study generally were skewed toward the positive end of the scales. Further research on this syndrome needs to be done and should include physiological measures and measures that are specific to asthenia.

Radiation assessment and protection in space is the Wrst step in planning future missions to the Moon and Mars, where mission and number of space travelers will increase and the protection of the geomagnetic shielding against the cosmic radiation will be absent. In this framework, the shielding eVectiveness of two Xexible materials, Kevlar and Nextel, were tested, which are largely used in the construction of spacecrafts. Accelerator-based tests clearly demonstrated that Kevlar is an excellent shield for heavy ions, close to polyethylene, whereas Nextel shows poor shielding characteristics. Measurements on Xight performed onboard of the International Space Station and of the Foton-M3 capsule have been carried out with special attention to the neutron component; shielded and unshielded detectors (thermoluminescence dosemeters, bubble detectors) were exposed to a real radiation environment to test the shielding properties of the materials under study. The results indicate no signiWcant eVects of shielding, suggesting that thin shields in low-Earth Orbit have little eVect on absorbed dose. This manuscript is based on a contribution given at the Heavy Ions in Therapy and Space Symposium

In vertebrates (including humans) altered gravitational environments such as weightlessness can induce malfunction of the inner ears due to a mismatch between canal and statolith afferents. This leads to an illusionary tilt because the inputs from the inner ear are not confirmed by the other sensory organs, which then results in intersensory conflict. Vertebrates in orbit therefore face severe orientation problems. In humans the intersensory conflict may additionally lead to a malaise commonly referred to as space motion sickness (SMS). After the initial days of weightlessness the orientation problems (and SMS) disappear as the brain develops a new interpretation of the available sensory data. The present contribution reviews the neurobiological responses, particularly those of fish, observed under altered gravitational states concerning behavior and neuroplastic reactivities. Investigations employing microgravity (spaceflight, parabolic aircraft flights, clinostat) and hypergravity (laboratory centrifuges as ground-based research tools) provide insights for understanding the basic phenomena, many of which remain only incompletely explained

Objective: Selection of an appropriate diet for rodent spaceflight experiments is critical and may have significant effects on mission results. The National Aeronautics and Space Administration (NASA) rodent food bar (RFB) was reformulated and designated as the nutrient-upgraded RFB (NuRFB). The objectives of this study were to determine whether the NuRFB nutrient formulation meets the 1995 National Research Council (NRC) nutrient recommendations and whether the NuRFB can be used for short-term (45-d) and long-term (90-d) spaceflight experiments. Methods: Nutrient and moisture analyses of the NuRFB were performed. Young (age 13-14 wk) male Sprague-Dawley rats (n ¼ 16/group) were individually caged and fed a diet treatment consisting of 1) NuRFB, 2) RFB, or 3) modified AIN-93 G containing 4% instead of the 7% fat for 45-or 90-d. At the end of the study, organs were weighted, and serum clinical chemistry indicators of organ function and hematologic measurements were determined. Results: Chemical analysis of the diet ingredients showed that the NuRFB met the 1995 NRC nutrient recommendations for rats. Subsequent animal feeding studies showed that NuRFB was comparable to RFB and modified AIN-93 G for supporting rat growth and body weight maintenance. In addition, the safety of the NuRFB for use as a spaceflight diet was indicated by the absence of changes in organ weight or function. Conclusion: Based on the study results, the NuRFB performed similarly to the RFB and met the criteria necessary for short-term and long-term rodent spaceflight experiments.

A number of interpersonal issues relevant to manned space missions have been identified from the literature. These include crew tension, cohesion, leadership, language and cultural factors, and displacement. Ground-based studies by others and us have clarified some of the parameters of these issues and have indicated ways in which they could be studied during actual space missions. In this paper, we summarize some of our findings related to social and cultural issues from a NASA-funded study conducted during several Shuttle/Mir space missions. We used standardized mood and group climate measures that were completed on a weekly basis by American and Russian crew and mission control subjects who participated in these missions. Our results indicated that American subjects reported more dissatisfaction with their interpersonal environment than their Russian counterparts, especially American astronauts. Mission control personnel were more dysphoric than crewmembers, but both groups were ...

Since the very early manned missions in space, a state of anemia associated with reduced erythropoietin levels and reduced plasma volume was disclosed. The reduction in red blood cell mass is driven by a process of selective hemolysis, which has been named neocytolysis. This phenomenon also occurs in people living at a high altitude who descend rapidly to sea level. The origin of the signal leading to destruction of newly produced red blood cells probably is located in central circulation, but the operating mechanism is unknown. The importance of plasma cell volume reduction in the genesis of a lower red cell mass also is supported by the inverse correlation seen at moderate altitude. People arriving at moderate altitude have increased erythropoietin concentration that decreases after a few days and is in inverse correlation with central venous pressure. Studies under simulated microgravity conditions in human beings (bed rest, head-down tilt at ؊6°, water immersion) and in rats provide further insight in unraveling the mechanism of astronauts' anemia, a problem difficult to study in space because of the limited availability of spaceflights. Semin Nephrol 25:379-387

It has always been a desire of mankind to conquest Space. A major step in realizing this dream was the completion of the International Space Station (ISS). Living there for several months confirmed early observations of short-term spaceflights that a loss of gravity affects the health of astronauts. Space medicine tries to understand the mechanism of microgravity-induced health problems and to conceive potent countermeasures. There are four different aspects which make space medicine appealing: i) finding better strategies for adapting astronauts to weightlessness; ii) identification of microgravity-induced diseases (e.g. osteoporosis, muscle atrophy, cardiac problems and others); iii) defining new therapies to conquer these diseases which will benefit astronauts as well as people on Earth in the end; and iv) on top of that, unveiling the mechanisms of weightlessness-dependent molecular and cellular changes is a requirement for improving space medicine. In mammalian cells, microgravity induces apoptosis and alters the cytoskeleton and affects signal transduction pathways, cell differentiation, growth, proliferation, migration and adhesion.

Bed rest studies of the past 20 years are reviewed. Head-down bed rest (HDBR) has proved its usefulness as a reliable simulation model for the most physiological effects of spaceflight. As well as continuing to search for better understanding of the physiological changes induced, these studies focused mostly on identifying effective countermeasures with encouraging but limited success. HDBR is characterised by immobilization, inactivity, confinement and elimination of Gz gravitational stimuli, such as posture change and direction, which affect body sensors and responses. These induce upward fluid shift, unloading the body's upright weight, absence of work against gravity, reduced energy requirements and reduction in overall sensory stimulation. The upward fluid shift by acting on central volume receptors induces a 10-15% reduction in plasma volume which leads to a now welldocumented set of cardiovascular changes including changes in cardiac performance and baroreflex sensitivity that are identical to those in space. Calcium excretion is increased from the beginning of bed rest leading to a sustained negative calcium balance. Calcium absorption is reduced. Body weight, muscle mass, muscle strength is reduced, as is the resistance of muscle to insulin. Bone density, stiffness of bones of the lower limbs and spinal cord and bone architecture are altered. Circadian rhythms may shift and are dampened. Ways to improve the process of evaluating countermeasures-exercise (aerobic, resistive, vibration), nutritional and pharmacological-are proposed. Artificial gravity requires systematic evaluation. This review points to clinical applications of BR research revealing the crucial role of gravity to health.

This experiment was conducted as part of a risk mitigation BIOTUBE Precursor hardware demonstration payload aboard the Space Shuttle Atlantis on STS-101. The objectives were to provide a demonstration and test of the newly developed BIOTUBE water delivery subsystem, and to determine the optimal water volume and germination paper combination for the automated imbibition and germination of flax (Linum usitatissimum)

This correspondence presents a prototype of a powered hand exoskeleton that is designed to fit over the gloved hand of an astronaut and offset the stiffness of the pressurized space suit. This will keep the productive time spent in extravehicular activity from being constrained by hand fatigue. The exoskeleton has a three-finger design, the third and fourth fingers being combined to lighten and simplify the assembly. The motions of the hand are monitored by an array of pressure sensors mounted between the exoskeleton and the hand. Controller commands are determined by a state-of-the-art programmable microcontroller using pressure sensor input. These commands are applied to a PWM driven dc motor array which provides the motive power to move the exoskeleton fingers. The resultant motion of the exoskeleton allows the astronaut to perform both precision grasping tasks with the thumb and forefinger, as well as a power grasp with the entire hand.

A theme that has come to the fore in advanced planning for long-range space exploration is the concept of "propellantless propulsion" or "field propulsion." One version of this concept involves the projected possibility that empty space itself (the quantum vacuum, or space-time metric) might be manipulated so as to provide energy/thrust for future space vehicles. Although such a proposal has a certain science-fiction quality about it, modern theory describes the vacuum as a polarizable medium that sustains energetic quantum fluctuations. Thus the possibility that matter/vacuum interactions might be engineered for space-flight applications is not a priori ruled out, although certain constraints need to be acknowledged. The structure and implications of such a far-reaching hypothesis are considered herein.

In space we find an extreem vacuum. Human beings need an atmosphere to survive. This makes inflatables most apt for use in human space flight. Savings in weight and packaging volume are perfect for getting them off ground. With the development of TransHab, NASA made a big step forward in proofing the technology-readiness of using inflatables for human space habitat. Protection of micro-meteorites and radiation proofed to be even better than in the aluminium ISS Module. The shape of TransHab was based on a toroid. The sphere is the natural shape of a flexible skin with an inside pressure and naturally combining maximum volume with minimum surface (insulation/protection etc). It is astonishing why this very efficient shape has not been used more often for space applications. This paper will investigate on a concept level the possibilities of a sphere for use in microgravity and planetary habitats. Possibilities for habitats for 1-2 person, 6 persons and up to sixty and more, all using...

This paper examines the role of the Morton Thiokol engineers in the decisions surrounding the launch of the Challenger, particularly with reference to an analysis of this event by Edward Tufte. The engineers at Morton Thiokol recommended against the launch of Challenger because the projected launch temperature between 26°F to 29°F was far outside their field database of successful launches. The engineers had asked for, but not received, data necessary to determine the cause of massive blow-by on the launch the previous January, and they had informed their managers and NASA that continuing flights could be catastrophic if the cause of the problems with the launches was not discovered. The authors conclude that the engineers thus did what they were ethically as well as professionally obligated to do.

In a previous work, we proposed a new test of general relativity ͑GR͒ based on a general deflection formula which applies to all values of asymptotic speed V ϱ (0рV ϱ р1). The formula simplifies to Einstein's light deflection result when V ϱ ϭ1. At low velocity, the general deflection equation reduces to the classical Newtonian contribution along with additional terms which contain the GR effect. A spacecraft, such as the proposed interstellar mission which involves a close pass of the Sun, can be used to exaggerate the GR effect so that it can be accurately measured. In this paper we provide a detailed derivation of the general deflection equation, expressed in terms of the parametrized post-Newtonian constants ␤ and ␥. The resulting formula demonstrates that by measuring spacecraft trajectories we can determine ␤ and ␥ independently. We show via a detailed covariance analysis that ␤ and ␥ may be determined to a precision of ϳ4ϫ10 Ϫ5 and ϳ8ϫ10 Ϫ6 , respectively, using foreseeable improvements in spacecraft tracking.

Single event burnout was seen in power MOSFETs exposed to high energy neutrons. Devices with rated voltage 2 400 volts exhibited burnout at substantially less than the rated voltage. Tests with high energy protons gave similar results. Burnout was also seen in limited tests with lower energy protons and neutrons. Correlations with heavy-ion data are discussed. Accelerator proton data gave favorable comparisons with burnout rates .measured on the APEX spacecraft. Implications for burnout at lower altitudes are also discussed.

As countermeasure to heavy workloads or monotony, astronauts have drawn on leisure activities imported from Earth or invented in situ. Aside from consumption of media, physical exercise, Earth observation, communication with ground or crew and the practising of instruments, also games play an important role. With a few exceptions, the emphasis, however, lies on virtual games and software applications. A review of play activities in orbit and their benefits to date suggests a need for additional recreational opportunities. In response, an interactive strategy game for use in microgravity is presented that relies on interlocking sphere-shaped game pieces in order to make the most of the kinetic and sensory potential of reduced gravity conditions. Aside from the play value and aesthetics of this reconfigurable modular game structure, the activity may help maintain and enhance manual dexterity, mental alertness and sociability amongst the crew. The design solution and prototype are presented and needs for further research and development are outlined. She specialises in habitability design strategies for extended space flight and other capsule environments.

A plant nutrient delivery system that uses a microporous, hydrophilic tube was developed with potential application for crop production in the microgravity of space. The tube contains a nutrient solution and delivers it to the roots. Pumps attached to the tubing create a very small suction that holds the solution within the tube. This system was used to grow wheat (Triticum aestivum cv. Yecora Rojo) for 107 days in a controlled environment at suctions of 0.40, 1.48, or 2.58 kPa. The water absorbed through the pores of the tube by baby diaper sections decreased as suction increased. Correspondingly, final plant biomass, seed number, and spikelet number also tended to decrease as suction increased. The reduced yield at higher suction suggests that the plants experienced water stress, although all suctions were below those typical of soils at field capacity.

The effect of spaceflight on starch development in soybean (Glycine maxL., BRIC-03) and potato (Solanum tuberosum, Astroculture-05) was compared with ground controls by biophysical and biochemical measurements. Starch grains from plants from both flights were on average 20-50% smaller in diameter than ground controls. The ratio A×/Ap (A×difference of magnetic susceptibilities, A p -difference of densities between starch and water) of starch grains was ca. 15% and 4% higher for space-grown soybean cotyledons and potato tubers, respectively, than in corresponding ground controls. Since the densities of particles were similar for all samples (1.36 to 1.38 g/cm3), the observed difference in A~Ap was due to different magnetic susceptibilities and indicates modified composition of starch grains. In starch preparations from soybean cotyledons (BRIC-03) subjected to controlled enzymatic degradation with c~-amylase for 24 hours, 77±6% of the starch from the flight cotyledons was degraded compared to 58+ 12% in ground controls. The amylose content in starch was also higher in space-grown tissues. The good correlation between the amylose content and A~A p suggests, that the magnetic susceptibility of starch grains is related to their amylose content. Since the seedlings from the BRIC-03 experiment showed elevated post-flight ethylene levels, material from another flight experiment (GENEX) which had normal levels of ethylene was examined and showed no difference to ground controls in size distribution, density, A×/Ao and amylose content. Therefore the role of ethylene appears to be more important for changes in starch metabolism than microgravity.

As the duration of space flights increases and crews become more heterogeneous, psychosocial factors are likely to play an increasingly important role in determining mission success. The operations of the International Space Station and planning of interplanetary missions represent important future challenges for how to select, train and monitor crews. So far, empirical evidence about psychological factors in space is based on simulations and personnel in analog environments (i.e. polar expeditions, submarines). It is apparent that attempts to transfer from these environments to space requires a thorough analysis of the human behavior specific to the fields. Recommendations for research include the effects of multi-nationality on crew interaction, development of tension within crews and between Mission Control, and prediction of critical phases in adaptation over time. Selection of interpersonally compatible crews, pre-mission team training and implementation of tools for self-monitoring of psychological parameters ensure that changes in mission requirements maximize crew performance. ___________________________________________________

Thanks to their photosynthetic and nutritive properties, cyanobacteria of the Arthrospira genus are of interest as food supplements, as efficient oxygen producing life support system organisms for manned space flight, and for the production of biofuels. Despite these potential valuable applications, full genome sequences and genetic information in general on Arthrospira remain scarce. This is mainly due to the difficulty to extract sufficient high molecular weight nucleic acids from these filamentous cyanobacteria. In this article, an efficient and reproducible DNA extraction procedure for cyanobacteria of the genus Arthrospira was developed. The method is based on the combination of a soft mechanical lysis with enzymatic disruption of the cell wall. The comparison with other extraction protocols clearly indicates that this optimised method allows the recovery of a larger amount of DNA. Furthermore, the extracted DNA presents a high molecular weight, a reduced degradation and an excellent overall quality. It can be directly used for molecular biology purposes such as PCR, and clone library construction.

Mars is a compelling astrobiological target, and a human mission would provide an opportunity to collect immense amounts of scientific data. Exploration alone, however, cannot justify the increased risk. Instead, three factors drive a human mission: economics, education, and exploration. A human mission has a unique potential to inspire the next generation of young people to enter critically needed science and engineering disciplines. A mission is economically feasible, and the research and development program put in place for a human mission would propel growth in related high-technology industries. The main hurdles are human physiological responses to 1-2 years of radiation and microgravity exposure. However, enabling technologies are sufficiently mature in these areas that they can be developed within a few decade timescale. Hence, the decision of whether or not to undertake a human mission to Mars is a political decision, and thus, educational and economic benefits are the crucial factors.

The Orbital Express (OE) mission performed the first autonomous rendezvous and docking in the history of the United States on May 5–6, 2007 with the Advanced Video Guidance Sensor (AVGS) acting as one of the primary docking sensors. Since that event, the OE ...