Triple Negative Breast Cancer
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Recent papers in Triple Negative Breast Cancer
Systemic therapy for triple negative breast cancer (TNBC) is mostly based upon chemotherapy. Epithelial Growth Factor Receptor (EGFR) is overexpressed in around 50% of TNBC and may play a role in its pathogenesis. Consequently, we... more
The aim of the study was to compare dosimetric parameters of planning target volume (PTV) and organs at risk (lungs) between 3D-conformal radiation therapy (3D CRT) and intensity-modulated radiation therapy (IMRT) in breast cancer, also... more
Triple negative breast cancer (TNBC) is a subtype of breast tumor which comprises 24% of newly diagnosed tumors that lacks hormone receptor expression and HER2 gene amplification. This study illustrated the pathological features of triple... more
Breast cancer stem cells (BCSCs) represent a heterogeneous subpopulation of rare cells within breast cancer tumors, displaying an enhanced tumor initiating capability and underlying disease progression and therapy resistance. Unraveling... more
The search for cytotoxic agents from marine natural products ultimately led to the production of eribulin, which is a synthetic macrocyclic ketone analog of halichondrin B. Eribulin binds to tubulin to induce mitotic arrest and gained... more
Triple-negative breast cancer is a type of aggressive breast cancer without the immunohistochemical expression of estrogen receptors, progesterone receptors and human epidermal growth factor receptor-2; with poor prognosis, greater... more
Citation: Hong Xiao, et al. (2016) Survival Analysis of Women with Triple Negative Breast Cancer Using EMR-Linked Cancer Registry Data in Florida. J Womens Health Gyn 1: 1-10. Abstract Background: Triple negative breast cancer (TNBC) is... more
Matrix-producing carcinoma (MPC) is an uncommon variant of metaplas-tic carcinoma. It was first described by Wargotz and Norris in 1989 as inva-sive breast carcinoma with direct transition to cartilaginous stroma without intervening... more
Context: Piper cubeba L. (family Piperaceae) is used traditionally for the treatment of many diseases, including cancer. Aims: To determine the anticancer activity of P. cubeba crude extracts on cancer cells and identify chemical... more
Metabolic syndrome and type 2 diabetes are associated with increased risk of breast cancer development and progression. Methylglyoxal (MG), a glycolysis by-product, is generated through a non-enzymatic reaction from triose-phosphate... more
Observations on the role of ovarian hormones in breast cancer growth, as well as interest in contraception, stimulated research into the biology of estrogens. The identification of the classical receptors ERα and ERβ and the... more
"A breast cancer is a malignant tumor that starts from cells of the breast. A malignant tumor is a group of cancer cells that may grow into (invade) surrounding tissues or spread (metastasize) to distant areas of the body. Breast... more
Objective: The fermented wheat germ extract, which is the active ingredient of nutraceuticals widely used by cancer patients in Europe, Korea and the United States, possesses cytotoxic and anti-metastatic effects in various human... more
Dear Sir/Madam We are currently hosting the Oncologist & Diagnostics Conference which is going to be organized during August 28-30, 2017 Brussels, Belgium. With great pride and honour, we would like to invite you to participate in... more
Neural stem cells maintain their tumor tropism after internalizing gold nanorods. When exposed to a laser, the loaded cells heat up, destroying surrounding tumor cells.
Breast cancer (BC) is the most frequent cancer among women in the world and it remains a leading cause of cancer death in women globally. Among BCs, triple negative breast cancer (TNBC) is the most aggressive, and for its histochemical... more
Triple negative breast cancer TNBC is the type of breast cancer that does not have Estrogen receptor, Progesterone receptor and human epidermal growth factor receptors 2 (HER2) when stained with the Immunohistochemistry stains. As it's... more
The purpose of this review article is to discuss the potential of T-type voltage gated calcium channels (VGCCs) as drug targets in breast cancer. Breast cancer, attributable to the different molecular subtypes, has a crucial need for... more
Activating protein-1 (AP-1) family members, especially Fra-1 and c-Jun, are highly expressed in invasive cancers and can mediate enhanced migration and proliferation. The aim of this study was to explore the significance of elevated... more
receptor-2 (HER2), which is suggested to be a reflection of absence of extensive glandular component. This cancer is considered as a subgroup of basal like breast cancers when classified by gene expression and carry a poor prognosis due... more
Training health workers in clinical breast examination for early detection of breast cancer in low-and middle-income countries. Training health workers in clinical breast examination for early detection of breast cancer in low-and... more
Invitation Conference Series LLC welcomes you to attend the 2nd Cancer Diagnostics Conference & Expo during May 08-10, 2017 Barcelona, Spain. We cordially invite all the participants who are interested in sharing their knowledge and... more
To explain a bimodal pattern of hazard of relapse among early stage breast cancer patients identified in multiple databases, we proposed that late relapses result from steady stochastic progressions from single dormant malignant cells to... more
Wnt/beta-catenin signaling has been suggested to be active in basal-like breast cancer. However, in highly aggressive metastatic triple-negative breast cancers (TNBC) the role of beta-catenin and the underlying mechanism(s) for the... more
Cancer immunotherapy has evolved enormously in the recent years with better understanding of immune reactions, immune mi-croenvironment and immunosurveillance. Breast cancer is characterized by large heterogeneity, a fact which rather... more
Calculation of breast cancer area by an image analysis on mammography using thresholding method has been done.The mammography images ware taken from three sides of projection which include oblique (mlo), lateral (ml) and cranial caudal... more
Dear Sir/Madam We are currently hosting the Oncologist & Diagnostics Conference which is going to be organized during August 28-30, 2017 Brussels, Belgium. With great pride and honour, we would like to invite you to participate in... more
Background: Breast cancer (BC) among Nigerians is characterised by high grade, triple negative, basal-like phenotype tumours with high proliferation indices and poor prognosis. The loss of Dicer expression has been speculated to play a... more
Introduction: In locally and locally advanced triple-negative breast cancer (TNBC), neoadjuvant chemotherapy (NAC) only induces a pCR in 30-35% of patients. Clinical and pathological factors are not enough to distinguish the patients who... more
Triple negative breast cancer (TNBC) is a heterogeneous group of clinically aggressive breast cancers. TNBC patients have a high risk of recurrence and metastasis, and current treatment options remain limited. There is strong evidence... more
Triple-negative breast cancer (TNBC) is a highly heterogeneous disease with multiple, distinct molecular subtypes that exhibit unique transcriptional programs and clinical progression trajectories. Despite knowledge of the molecular... more
INTRODUCTION : The breast cancer markers that are most important in determining therapy are estrogen receptor, progesterone receptor, and HER-2/neu. Clinicians evaluate clinical and pathologic staging and the expression of estrogen... more
Triple negative breast carcinomas (TNBCs) are a group of primary breast tumors with aggressive clinical behavior that have no targeted therapy at present. Comparative studies for subtypes of triple negative group of invasive breast... more
Nowadays internet is becoming a platform where different user can post there ideas and opinions. The social networking sites and blogs offer a wide variety of such informative text which can be used to establish or determine a mindset for... more
586Background: The goal of this Phase I/II trial is to assess the safety and efficacy of concurrent administration of durvalumab with weekly nab-paclitaxel (100 mg/m2) x 12 followed by dd AC x 4 as...
Purpose: As monotherapies, eribulin (chemotherapy) and pembrolizumab (immunotherapy) have shown promise for patients with metastatic triple-negative breast cancer (mTNBC). This phase Ib/II study examined eribulin plus pembrolizumab as a... more
Fcγ RIIA (CD32A) and their ligands, including the immunoglobulin Fc fragment and pentraxins, are key players in a variety of innate immune responses. Still unclear is whether additional ligands of CD32A do exist. The objective of this... more
Trastuzumab emtansine (T-DM1) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugated to the microtubule-targeting agent emtansine (DM1). T-DM1 is an effective agent in the treatment of patients with... more
Although greater than 90% of breast cancer-related mortality can be attributed to metastases, the molecular mechanisms underpinning the dissemination of primary breast tumor cells and their ability to establish malignant lesions in... more
Wnt/b-catenin signalling has been suggested to be active in basal-like breast cancer. However, in highly aggressive metastatic triple-negative breast cancers (TNBC) the role of b-catenin and the underlying mechanism(s) for the... more