Yeast Genetics
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Recent papers in Yeast Genetics
The meiotic developmental pathway in yeast enables both differentiation of vegetative cells into haploid spores that ensure long-term survival, and recombination of the parental DNA to create genetic diversity. Despite the importance of... more
In the last 40 years, several scientific and technological advances in microbiology of the fermentation have greatly contributed to evolution of the ethanol industry in Brazil. These contributions have increased our view and comprehension... more
Industrial processes of ethanol production in Brazil are characterized by large-volume fermenters, short fermentation times, recycling of yeast cells and stressful conditions that can affect yeast cell viability and fermentation yields of... more
In Saccharomyces cerevisiae, the spindle position checkpoint ensures that cells do not exit mitosis until the mitotic spindle moves into the mother/bud neck and thus guarantees that each cell receives one nucleus [1-6]. Mitotic exit is... more
More than 30 years ago Dan Koshland published an inspirational essay presenting the bacterium as a model neuron (Koshland, Trends Neurosci 6:133–137, 1983). In the article he argued that there are several similarities between neurons and... more
Volatile phenols are aromatic compounds produced by some yeasts of the genus Brettanomyces as defense against the toxicity of hydroxycinnamic acids (p-coumaric acid, ferulic acid and caffeic acid). The origin of these compounds in... more
Aging is one of the chief biomedical problems of the 21st century. After decades of basic research on biogerontology (the science of aging), the aging process still remains an enigma. Although hundreds of "theories" on aging have been... more
The Saccharomyces cerevisiae BNI1 gene product (Bni1p) is a member of the formin family of proteins, which participate in cell polarization, cytokinesis, and vertebrate limb formation. During mating pheromone response, bni1 mutants showed... more
The cell cycle is composed of bistable molecular switches that govern the transitions between gap phases (G1 and G2) and the phases in which DNA is replicated (S) and partitioned between daughter cells (M). Many molecular details of the... more
Imperatively Hidden Objects/Factors (IHO/F) refers to relevant items, which we cannot perceive and measure yet. Nevertheless, they have an impact on our predicted outcome. We have created model that allows for the integration and... more
We previously isolated 18 Saccharomyces cerevisiae strains from coconut toddy in Sri Lanka. All the 18 strains (SLY-1 to SLY-18) could grow aerobically up to 18 mmol L−1 vanillin in yeast extract–peptone–dextrose (YPD) medium, and the... more
Please click here http://singledrug.com/media/Temporal_Analysis_of_Aging_description.pdf to see it. I plan to add the following: I found Osh6 at a very high rank of lifespan extending genes. That is why I want to take all the... more
Ribosomal DNA (rDNA) recombination in budding yeast is regulated by multiple converging processes, including posttranslational modifications such as SUMOylation. In this study, we report that the absence of a SUMO E3 ligase, Siz2, results... more
Aging is one of the chief biomedical problems of the 21st century. After decades of basic research on biogerontology (the science of aging), the aging process still remains an enigma. Although hundreds of "theories" on aging have been... more
Over the past 15 years, the seismic shifts caused by the convergence of biomolecular, chemical, physical, mathematical and computational sciences alongside cutting-edge developments in information technology and engineering have erupted... more
Pre-mRNA splicing, the removal of noncoding intron sequences from the pre-mRNA, is a critical reaction in eukaryotic gene expression. Pre-mRNA splicing is carried out by a remarkable macromolecular machine, the spliceosome, which... more
In Saccharomyces cerevisiae, the spindle position checkpoint ensures that cells do not exit mitosis until the mitotic spindle moves into the mother/bud neck and thus guarantees that each cell receives one nucleus [1-6]. Mitotic exit is... more
Both the delivery of secretory vesicles and asymmetric distribution of mRNA to the bud are dependent upon the actin cytoskeleton in yeast. Here we examined whether components of the exocytic apparatus play a role in mRNA transport. By... more
Heavy metals and metalloids such as cadmium [Cd(II)] and arsenic [As(III)] are widespread environmental toxicants responsible for multiple adverse health effects in humans. However, the molecular mechanisms underlying metal-induced... more
During mitosis in budding yeast the nucleus first moves to the mother-bud neck and then into the neck. Both movements depend on interactions of cytoplasmic microtubules with the cortex. We investigated the mechanism of these movements in... more