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Advances in Surface Chemistry: Design and Functionalization of Nanostructured Materials for Biomedical Applications

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Special Issue Editor

Dr. Álvaro De Jesús Ruíz-Baltazar

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Guest Editor

CONACYT-Centro de Física Aplicada y Tecnología Avanzada, Universidad Nacional Autónoma de México, Boulevard Juriquilla 3001, Juriquilla, Querétaro C.P. 76230, QRO, Mexico
Interests: nanostructured materials; biomedical applications; biocompatible nanomaterials; surface modification strategies; synthesis methodology; nanoscale biointerfaces

Special Issue Information

Dear Colleagues,

This Special Issue, entitled “Advances in Surface Chemistry: Design and Functionalization of Nanostructured Materials for Biomedical Applications,” compiles significant progress in the design and synthesis of nanostructured materials for biomedical applications. The primary aim is to highlight design and synthesis methodologies that provide a high degree of functionality for use in the biomedical field.

The Special Issue explores innovative characteristics of nanostructured materials and surface functionalization techniques to maximize their utility in biomedicine. It delves into the types of biomedical applications these materials can be used for, including, but not limited to, the following:

Drug Delivery: Nanostructured materials can be designed and functionalized to deliver drugs to specific areas of the body, improving the efficacy of treatment and reducing side effects.
Biosensors: The unique properties of nanostructured materials can be harnessed to create highly sensitive and specific biosensors for disease detection and monitoring.
Therapy: Nanostructured materials can be used in various therapeutic applications, such as targeted cancer therapy, gene therapy, and regenerative medicine.

Topics of interest for this Special Issue include surface chemistry, nanostructured materials, biomedical applications, material design, synthesis methodologies, functionalization techniques, innovative biomaterials, biomedical advancements, surface modification, materials for biomedical applications, and other related topics.

This Special Issue aims to inspire further research and development in the field of nanostructured materials for biomedical applications. It serves as a comprehensive resource for researchers, providing insights into the latest advancements and future directions in this exciting field.

Dr. Álvaro De Jesús Ruíz-Baltazar
Guest Editor

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17 pages, 3450 KiB

Open AccessArticle

Evaluation of Superparamagnetic Fe₃O₄-Ag Decorated Nanoparticles: Cytotoxicity Studies in Human Fibroblasts (HFF-1) and Breast Cancer Cells (MCF-7)

by Álvaro de Jesús Ruíz-Baltazar, Simón Yobanny Reyes-López, Néstor Méndez-Lozano and Karla Juárez-Moreno

Appl. Sci. 2024, 14(15), 6750; https://doi.org/10.3390/app14156750 - 2 Aug 2024

Viewed by 1185

Abstract

This study investigates the cytotoxicity profile of superparamagnetic Fe₃O₄-Ag decorated nanoparticles against human fibroblasts (HFF-1) and breast cancer cells (MCF-7). The nanoparticles underwent comprehensive characterization employing scanning electron microscopy (SEM), X-ray diffraction (XRD) analysis, X-ray photoelectron spectroscopy (XPS), and magnetic assays including hysteresis curves and zero-field-cooled (ZFC) plots. The nanoparticles exhibited superparamagnetic behavior as evidenced by magnetic studies. Cytotoxicity assays demonstrated that both HFF-1 and MCF-7 cells maintained nearly 100% viability upon nanoparticle exposure, underscoring the outstanding biocompatibility of Fe₃O₄/Ag decorated nanoparticles and suggesting their potential utility in biomedical applications such as drug delivery and magnetic targeting. Furthermore, the study analyzed the cytotoxic effects of Fe₃O₄ and Fe₃O₄-Ag decorated nanoparticles to evaluate their biocompatibility for further therapeutic efficacy. Results showed that neither type of nanoparticle significantly reduced cell viability in HFF-1 fibroblasts, indicating non-cytotoxicity at the tested concentrations. Similarly, MCF-7 breast cancer cells did not exhibit a significant change in viability when exposed to different nanoparticle concentrations, highlighting the compatibility of these nanoparticles with both healthy and cancerous cells. Additionally, the production of reactive oxygen species (ROS) by cells exposed to the nanoparticles was examined to guarantee their biosafety for further therapeutic potential. Higher concentrations (50–100 μg/mL) of Fe₃O₄-Ag nanoparticles decreased ROS production in both HFF-1 and MCF-7 cells, while Fe₃O₄ nanoparticles were more effective in generating ROS. This differential response suggests that Fe₃O₄-Ag nanoparticles might modulate oxidative stress more effectively, thus beneficial for future anticancer strategies due to cancer cells’ susceptibility to ROS-induced damage. These findings contribute to understanding nanoparticle interactions with cellular oxidative mechanisms, which are crucial for developing safe and effective nanoparticle-based therapies. This investigation advances our understanding of nanostructured materials in biological settings and highlights their promising prospects in biomedicine. Full article

(This article belongs to the Special Issue Advances in Surface Chemistry: Design and Functionalization of Nanostructured Materials for Biomedical Applications)

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