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  • RESEARCH BRIEFINGS

Built-up sleep pressure drives the loss of neuronal connections during slumber

Imaging of all synaptic connections of individual neurons in larval zebrafish across several days and nights indicates that sleep is necessary, but not sufficient, for the sleep-associated loss of synapses. Both the need to sleep accumulated during wake — known as sleep pressure — and the sleep state itself are required for synapse removal.

This is a summary of: Suppermpool, A. et al. Sleep pressure modulates single-neuron synapse number in zebrafish. Nature 629, 639–645 (2024).

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doi: https://doi.org/10.1038/d41586-024-01559-7

‘Expert opinion’ and the figure are published under a CC BY 4.0 licence.

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