Leishmania major alters host copper dynamics. Macrophages utilize copper via ATP7A to stress the pathogen, countered by Leishmania that reduces ATP7A and the copper importer CTR1. Infection elevates mouse systemic copper that aids in its defense.

Male humpback whales respond to seismic air gun activity by increasing singing and breeding activity.

Phenotypic profiling using fluorescent probes combined with cell sorting and single-cell derived growth analysis detects differential cultivability and antimicrobial susceptibility in isogenic, but phenotypically heterogenous bacterial populations.

Multi-dimensional analysis of gene expression, myofiber types and metabolic activity in whole skeletal muscle reveals specific regionalization of gene expression and metabolites related to the glycolytic and oxidative potential of myofibers

Longitudinal snRNA-seq 5’ in a Mecp2e1 mutant mouse model reveals sex-specific gene expression differences in specific cell types, with mutant females showing early and dynamic transcriptional changes linked to disease progression, enhancing our understanding of RTT.

An expanded PRS (EPRS) approach combining polygenic risk scores and rare variant clustering enhances cancer risk stratification for breast and prostate cancers. High-PRS groups with rare high-impact gene variants have up to 15- and 22-fold higher risk for breast and prostate cancers, respectively, compared to intermediate-PRS groups without rare variants.

Acute manipulations of neuronal activity of cortical projection neurons using DREADDs affects synaptic connectivity and leads to rapid response and changes in glial cell dynamics in cortical and subcortical regions.

Simultaneous editing of the NCF1 and its pseudogenes in p47^phox-deficient chronic granulomatous disease is associated with homologous recombination and chromosomal rearrangements due to presence of multiple targets of high sequence similarity.

Comparison of single cell whole genome amplification methods using human brain nuclei determines suitability for detection of large somatic copy number variants by low coverage whole genome sequencing aligned to different reference genome versions.

HES1, a well-known transcriptional repressor, promotes NFAT5-dependent transcription in the context of a high salinity/hyperosmotic environment and contributes to high salt stress response.

Dr. Guifen Liu, now an Associate Professor at ZhangLab, Tongji University, began her research in epigenetic regulation using zebrafish as a model, first as a postdoctoral researcher and then as a research scientist. She established the zebrafish culturing system at the Department of Informatics, Tongji University, Shanghai, China. Dr. Qi Wang is an Assistant Professor at ZhangLab, Tongji University, and she is in charge of the cell culture part of the lab and has broad expertise in high-throughput experimental research on chromatin structure. They are the only two experimental biologists in a dry lab focusing on different research topics. At present, they are in the transition period from experimental scientists to computational scientists. Current Lab Members-Yong Zhang Lab (tongji.edu.cn).

In this Q&A, Brianna Bibel, also known as the Bumbling Biochemist, talks to the journal about how social media can be harnessed to relay scientific information to other researchers, while making it fun and accessible.

Conducting research at the interface of chemistry, microbiology and marine biology, Constanze Kuhlisch reports on challenges in science due to COVID and the situation in Israel, while preparing grants to start her own research group.

Embracing the underlying principles and processes of informed proxy consent or relational autonomy consent in human ancient DNA research can transform research.

This comment reports on work done at Harvard Medical School to identify areas for improvement in research rigor, reproducibility, and responsibility in pursuit of continued research excellence.