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Longitudinal snRNA-seq 5â in a Mecp2e1 mutant mouse model reveals sex-specific gene expression differences in specific cell types, with mutant females showing early and dynamic transcriptional changes linked to disease progression, enhancing our understanding of RTT.
An expanded PRS (EPRS) approach combining polygenic risk scores and rare variant clustering enhances cancer risk stratification for breast and prostate cancers. High-PRS groups with rare high-impact gene variants have up to 15- and 22-fold higher risk for breast and prostate cancers, respectively, compared to intermediate-PRS groups without rare variants.
Acute manipulations of neuronal activity of cortical projection neurons using DREADDs affects synaptic connectivity and leads to rapid response and changes in glial cell dynamics in cortical and subcortical regions.
Simultaneous editing of the NCF1 and its pseudogenes in p47phox-deficient chronic granulomatous disease is associated with homologous recombination and chromosomal rearrangements due to presence of multiple targets of high sequence similarity.
Comparison of single cell whole genome amplification methods using human brain nuclei determines suitability for detection of large somatic copy number variants by low coverage whole genome sequencing aligned to different reference genome versions.
HES1, a well-known transcriptional repressor, promotes NFAT5-dependent transcription in the context of a high salinity/hyperosmotic environment and contributes to high salt stress response.
Standardized indices of obesity are associated with alterations in neural oscillatory activity and functional connectivity in brain regions supporting abstract reasoning and fluid intelligence in typically developing youth.
Dual spatial gene expression assay in tissues with chronic lung infection by Mycobacterium abscessus paves the way for the simultaneous detection of host and bacterial transcriptomes in pathological tissues.
Creation of chimeric renal organoids using human iPSC technology with fetal pig kidneys demonstrates inter-species coexistence and codevelopment in early kidney development, paving the way for humanized xenogeneic kidney creation for clinical use.
Population study of whole genomes of wild uakary monkeys (Cacajao genus) exposes how the dynamic and highly heterogeneous Amazon basin may have shaped complex connectivity patterns and driven fast population differentiation on these.
Human skin equivalents respond to UV stimulation by upregulating inflammatory and oxidative stress pathways in macrophages, representing a model to study skin immune responses to external stimuli.
The deubiquitinase USP24 stabilizes Beclin1 by decreasing its K48-linked ubiquitination. The interaction between USP24 and Beclin1 represents a key molecular mechanism that promotes autophagy related ferroptosis in HCC.
An E3 ligase TRAF7 regulates time-of-the-day-dependent expression of DBP proteins via the ubiquitin-proteasome system, providing insight into the posttranslational regulation of clock proteins in the mammalian circadian clockwork.
Evolutionary dynamics and population stratification analysis of whole genomes of the cattle flu Influenza D virus reveal its high evolution rate, extensive diversification and global dissemination, stressing the need for targeted surveillance.
Calcium waves underpin smooth muscle contractions in the gut. The authors examine their developmental dynamics, molecular properties and their impact on differentiation of smooth muscle and interstitial cells of Cajal in the mouse embryo.
Leveraging bioinformatics, proteomics, and cryogenic electron microscopy, this study deciphers the architecture and design principles of the therapeutic Pseudomonas phage Pa193.
Systematic identification and comparison of biosynthetic gene clusters among Termitomyces species provides insight into their evolutionary history and potential functions of BGCs and the chemicals synthesized by these pathways.
Antimicrobial peptides with membrane-induced structure generate diffusion potential across the E. coli cytosolic membrane at subinhibitory concentrations. The differential ion permeability generates bacterial hyperpolarization.
Multi-dimensional analysis of gene expression, myofiber types and metabolic activity in whole skeletal muscle reveals specific regionalization of gene expression and metabolites related to the glycolytic and oxidative potential of myofibers