Reviews & Analysis

  • Methods to manufacture layered hybrid superlattices composed of alternating crystalline atomic layers and self-assembled atomic or molecular interlayers are described, to make use of their combined strengths and produce designable quantum solids.

    • Zhong Wan
    • Qi Qian
    • Xiangfeng Duan
    Perspective
  • This Perspective discusses the strengths and limitations of future biobank sampling strategies based on oversampling close relatives as opposed to the current population-based approach.

    • Neil M. Davies
    • Gibran Hemani
    • Matthew C. Keller
    Perspective
  • A new approach to designing robotic systems that interact closely with people, called human-in-the-loop optimization, can improve human–robot interaction, but many important research questions remain before it can reach its full potential.

    • Patrick Slade
    • Christopher Atkeson
    • Steven H. Collins
    Perspective
  • Understanding how extreme solar storms affect radiocarbon dating has made it possible to obtain calendar ages with annual precision, and future studies could yield insights into archaeology, solar physics and Earth science.

    • T. J. Heaton
    • E. Bard
    • I. Usoskin
    Perspective
  • The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

    • Jesse M. Engreitz
    • Heather A. Lawson
    • Ella K. Samer
    Perspective
  • Implementation of new pricing and business structures and improved licensing and manufacturing processes could reduce the per-patient cost of gene therapy tenfold.

    • Melinda Kliegman
    • Manar Zaghlula
    • Jennifer A. Doudna
    Perspective
  • Evidence from neuroscience and related fields suggests that language and thought processes operate in distinct networks in the human brain and that language is optimized for communication and not for complex thought.

    • Evelina Fedorenko
    • Steven T. Piantadosi
    • Edward A. F. Gibson
    Perspective
  • This Perspective considers the implications of advances in human physiology, single-cell and spatial transcriptomics and long-term culture of resected human brain tissue for the study of network-level activity in human neuroscience.

    • Anthony T. Lee
    • Edward F. Chang
    • Tomasz J. Nowakowski
    Perspective
  • The current ‘second space age’ has enabled multiple studies on the effects of spaceflight on human physiology and health, which are contributing to the development of measures that will be needed to maintain astronaut health in future space missions.

    • Christopher E. Mason
    • James Green
    • Afshin Beheshti
    Perspective
  • This Perspective identifies common misperceptions regarding the harms of online misinformation, finding that exposure to false and inflammatory content is rare and concentrated among a small minority of people who already have extreme views.

    • Ceren Budak
    • Brendan Nyhan
    • Duncan J. Watts
    Perspective
  • Efforts to find renewable alternatives to fossil fuels that might enable a carbon-neutral society by 2050 are described, as well as outlining a possible roadmap towards a refinery of the future and evaluating its requirements.

    • Eelco T. C. Vogt
    • Bert M. Weckhuysen
    Perspective
  • To reduce voltage drops—the depreciation of the cost–benefit profile when scaling up solutions to social problems—sufficient policy-based evidence must be generated before policymakers scale up the project.

    • John A. List
    Perspective
  • Four future greenhouse gas emission scenarios for the global plastics system are investigated, with the lead scenario achieving net-zero emissions, and a series of  technical, legal and economic interventions recommended.

    • Fernando Vidal
    • Eva R. van der Marel
    • Charlotte K. Williams
    Perspective
  • By casting large-language-model-based dialogue-agent behaviour in terms of role play, it is possible to describe dialogue-agent behaviour such as (apparent) deception and (apparent) self-awareness without misleadingly ascribing human characteristics to the models.

    • Murray Shanahan
    • Kyle McDonell
    • Laria Reynolds
    Perspective
  • This Perspective reviews successful applications of functional magnetic resonance imaging (fMRI) and presents a case for fMRI as a central hub on which to integrate the dispersed subfields of systems, cognitive, computational and clinical neuroscience.

    • Emily S. Finn
    • Russell A. Poldrack
    • James M. Shine
    Perspective