SUMMARY DOCTORAL DISSERTATION: Experience sampling methodology, in which participants are repeatedly questioned via smartphone apps, is popular for studying psychological constructs or “factors” (e.g., well-being or depression) within persons over time. The validity of such studies (e.g., concerning treatment decisions) may be hampered by distortions of the measurement of the relevant constructs due to response styles or item interpretations that change over time and differ across persons. In this PhD project, we developed a new approach to evaluate person- and time-point-specific distortions of the construct measurements, taking into account the specific characteristics of (time-intensive) longitudinal data inherent to experience sampling studies. Our new approach, latent Markov factor analysis, extends mixture factor analysis and clusters time-points within persons according to their factor model. The factor model describes how well items measure the constructs. With the new approach, researchers can examine how many and which factor models underlie the data, for which persons and time-points they apply, and thus which observations are validly comparable. Such insights can also be interesting in their own right. In personalized healthcare, for example, detecting changes in response styles is critical for accurate decisions about treatment allocation over time, as response styles may be related to the occurrence of depressive episodes.