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Pathophysiology of Cerebrovascular Accident: Predisposing Factors: Precipitating Factors: - HPN

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Pathophysiology of cerebrovascular accident

PREDISPOSING FACTORS: -Age -Gender -Race - Hereditary

PRECIPITATING FACTORS: -HPN -Physical inactivity

-Heavy drinking and smoking

Obstruction of blood vessels

Decreased cerebral blood flow

Decrease O2 supply

Stimulation of Mitochondria

Production of lactic acid

Change in pH level (acidic)

Anaerobic Environment

Decreasedproduction of ATP by neurons

INFARCTION Decreased depolarization

Increase cellular death Medial aspect of one frontal lobe or both Lateral hemisphere and deeper structures of frontal, parietal and temporal Occipital lobe, anterior and medial portion of temporal lobe, thalmus involvement

Cerebral penducle, cerebellum and brainstem

Paralysis of foot/leg; impaired gait; problems in decision making or performing acts voluntarily; slowness of thought; urinary incontinence; cognitive and affective disorders

Contralatral hemiplegia (face and arm); aphasia; homonymous hemanopsia; altered consciousness; left-right confusion

Homonymous hemianopsia and other visual defects like color blindness; loss of central vision and visual hallucinations; memory deficits; loss of sensory modalities; spontaneous pain; aphasia

Oculomotor nerve palsy, visual disturbance such as diplopia, dystaxia; vertigo; dysphagia

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