Drug Study Cefuroxime
Drug Study Cefuroxime
Drug Study Cefuroxime
Mechanism of Action Bind to bacterial cell wall membrane, causing cell death Indication Treatment of It is effective for the treatment of penicillinaseproduc ingNeisseria gonorrhoea(PPNG). Effectively treats bone and joint infections, bro nchitis, meningitis, gonorrhea, otitis media, pharyngitis/tonsilliti s, sinusiti s, lower respiratory tract infections, skin and soft tissue infections, urinary tract infections, and is used for surgical prophylaxis, reducing or eliminating infection. Contraindications Hypersensitivity to cephalosporins and related antibiotics; pr egnancy (category B), lactation. Side Effects GI: Diarrhea, nausea, antibioticassociated colitis. Skin: Ra sh , p ruritus, urticaria. Urogenital: Increased serum creatinine and BUN, decreased cr eatinine clearance. Hemat: Hemolytic anemia MISC: Anaphylaxis Nursing Responsibilities Before: Determine history Pharmacologic: Second Therapeutic Effects: generation Bactericidal action Cephal osporins Pregnancy Catergory B of hypersensitivity reacti ons to cephalosporins, penicillins, and history of al lergies, particularly to drugs, before therapy is initiated. Maximum Dose: Minimum Dose: Availability: Tablets: 125mg, 250mg, 500mg Powder fo r injection: 750mg, 1.5g, 7.5g Premixed containers: 750 mg/50ml, 1.5g/50ml Sourc e: Davis Drug Guide for Nurses 10th Edition Lab tests: Perform culture and sensitivity tests before initiation of therapy and periodically duri ng therapy if indicated. Therapy may be instituted pending test results. Monitor periodically BUN and creatinine clearance. During: Inspect IM and IV injection sites frequently for signs of phlebitis. Monitor for manifestations of hypersensitivity (see