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Finally Vaccine (Uw + MTB) By: Araki

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Finally VACCINE ( UW + MTB )

By : Araki
----------------------------------------All patients undergoing Splenectomy should vaccinated against
encapsulated organisms.
either prior to or immediately following surgery
S.pneumonia - N.meningifidis - H.influenza
.
Vaccination against meningococcus :asplenia, those living in
dormitories or barracks, people traveling to or living in areas where
meningococcal infection is endemic, and for college-bound
individuals. traveling to some Asian countries and to sub-Saharan
Africa. make the Haj to Mecca, Saudi Arabia.
.
pneumococcal vaccine be given to all healthy adults once at age 65.
Patients under the age of 65 with chronic medical conditions
(chronic lung disease, chronic cardiovascular diseases, DM, chronic
liver disease, chronic renal disease, asplenia, and
immunosuppression Alcoholism - CSF leak - Cochlear implants )
may be vaccinated once followed by a booster 5 years later
# polyvalent pneumococcal - individuals over age 65
polysaccharides of the 23 most prevalent types of pneumococcus ,
polysaccharides cannot be presented to T-cells. Thus,
polysaccharide vaccines yield a B-cell only, T-cell-independent
response
T-cell-independent 8-cell response
# heptavalent pneumococcal vaccine - use in children
is conjugated with protein and induces active immunity via a T-celldependent B-cell response
T-cell-dependent 8-cell response
.
Hepatitis A Vaccination : All children + high risk adults : Chronic
liver D - traveling to endemic areas - sewer workers IV drug users food handlers - homosexual men
.

Salmonella typhi vaccinations


pt traveling to endemic countries for a prolonged period of time.
pt with SCD are at increased risk for Salmonella osteomyelitis.
.
The Td vaccine : should be given at least every 10 years.
it is recommending a one-time TdaP booster for adults aged > 18
years due to waning immunity against pertussis.
.
Influenza vaccination : is recommended for all adults every year ,
Either intranasal or injected
All adults aged >50 years with comorbid conditions should receive
the intramuscular vaccine.
.
HPV vaccine (Grdasil) : males 9-26 y and females aged 8-26 years
.
For those traveling to North Africa : give hepatitis A ( 2 dose ) hepatitis B - typhoid vaccines as well as a polio booster vaccine
.
Yellow fever : it is a mosquito-borne viral hemorrhagic fever ,
Vaccination is in general recommended for those traveling to subSaharan African and equatorial South American countries
.
Patients exposed to hepatitis B
# patient has documented immunity against hepatitis B , ( HBsAbpositive) , Reassurance
# pt not develop immunity with the first two doses of HB vaccine.
give second vaccination course
# unknown vaccination history should receive both passive and
active immunity.
Passive immunity (HBIG) shortly after exposure (e.g. within 24
hours).
Active immunity is provided by administering the hepatitis B vaccine
.

Vaccines for chronic liver disease


Td/Tdap : Tdap once as substitute for Td booster, then Td every 10 y
Influenza : Every year
Pneumococcal vaccine : 1 dose with repeat 5 years later
Hepatitis A : 2 doses 6 months apart in patients with initial negative
serology
Hepatitis B : 3 doses at 0 months, 1 month, and 4 months with initial
negative serologies
.
# Certain vaccines induce a predominantly lgA response. The best
known example is the oral polio
vaccine, which promotes the development of anti-poliovirus lgA
antibodies in the Gl tract
.
any baby from mother with +ve HBsAg ...take 1st dose of HBV
vaccine +IG , 2nd dose after the 1st dose by one ms , (only vaccine)
, 3rd dose >> after 1st dose by 6ms (vaccine) ##
.
if.baby.is less than.2 kg, and mom is HBV.neg. U should delay dose
up to one month or discharge
If less than 2 kg, but mom is sero positive or status unknown,
give.vaccine.plus.IG within 12 hrs. And total of 4 doses are given
----------------------------------------------------------------------------

This part by : Ahmed Zaghloul


obligatory vaccines for children in USA is 15 ( 9 viral + 6 bacterial )
the 9 viral is three three MMR (measles mumps rubella) HHV ( hep
A Hep B varicella ) IIR (IPV Inactivated infuenza Rota )
the 6 bacterial DTap + 3 capsulated (meningio + pnemo + H flu B )
.
live viral vaccines like MMR and varicella are contraindicated in
immune suppresion with some exceptions like HIV with CD4 and
Bruton x linked agammaglobulinemia they can be given
.
HIV we give live Vac if CD more than 200

MMR - Varicella - Zoster


.
live bacterial vaccine are contraindicated in Chronic granulomatous
disease
.
complement def is not contraindication to any vaccine
.
reaction to DTap of fever less than 105 is not contraindication to
DTap
if suizer stop pertussus and give only DT ?
.
egg allergy : contra to infuenza and yellow fever
neomycin anaphylaxis : contra MMR and IPV
.
pregnant female can only take 3 vaccines DT and inactivated
influenza vaccine in the 2nd and 3rd trimester
.
if the patient take IVIG dont give live viral vaccine for the next 3
months
.
Mild acute illness - antibiotic intake - family history of seizure -family
history of Sudden infant death _ prematurity are not
contraindication to vaccines and are distractors

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