© Emad Ezzeddin Histopathological Features In Anemia Disorders

Disorder RBC Size Hb Content RBC Shape Intracelular Components RBC Type WBC Type Erythropoeitic Changes
( ℗ = Present ) Basophilic Howell-Jolly Pappenheimer Ring Hypersegmented Extramedullary Erythroid
Normocytic Macrocytic Microcytic Anisocytosis Normochromic Hypochromic Central Pallor Polychromasia Target Cells Poikilocytosis Ovalocytes Spherocytes Pencil Cells Burr Cells Spur Cells Schistocytes Teardrop Cells Sickle Cells Bite Cells Rouleaux Heinz Bodies Precipitates Reticulocytosis Erythroblastosis Erythrocytosis Normoblastosis Leukoblastosis
S.N Stippling Bodies bodies Sideroblasts Neutrophils Hematopoeisis Hyperplasia
1 Acute Blood Loss ℗ During recovery

2 Autoimmune HA ℗ ℗ ℗
Reticulocyt-
3 Chronic Disease Anemia ℗ Maybe ℗ openia
Methemo-
4 G6PD Deficiency ℗ ℗ globin
℗
Dense
5 Hemoglobin C Disease ℗ ℗ ℗ Rhomboidal
Crystals of HbC
Oval-
6 Hereditary Elliptocytosis ℗ ℗ elliptical
Minimal
No (appear
7 Hereditary Spherocytosis ℗ Hyperchro- ℗ ℗ ℗ ℗
matic)
Reticulocyt-
8 Leukemia ℗ openia
Marrow Infiltration
9
(Myelophthisic) Anemia
℗ ℗ ℗ ℗ ℗ ℗ Liver + Spleen

Reticulocyt-
10 Myelofibrosis ℗ ℗ openia
Reticulocyt-
11 Renal Disease Anemia ℗ ℗ ℗ ℗ openia
Paroxysmal Nocturnal
12
Hemoglobinuria
℗ ℗
Pure Red Cell Aplasia Reticulocyt- Hypoplasia (<5%
13
(Erythroblastopenia)
℗ ℗ No
openia of BM celularity)

14 Sickle Cell Disease ℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗

15 Warm Antibody AIHA ℗ ℗ ℗ ℗
Reticulocyto- Hypoplasia (all
16 Aplastic Anemia ℗ ℗ ℗ penia BM cells)
17 Liver Disease (Alcoholic ~) (℗) ℗
18 Megaloblastic Anemia ℗ ℗ ℗ ℗ ℗ No ℗
5% Hb Bart in
19 Alpha-thalassemia Trait Mild ℗ Infancy
Beta-thalassemia
20 (Heterozygous/Carrier ℗ Minimal ℗ ℗ ℗ ℗ Increased
State)
Beta-thalassemia
Crew Cut app. +
21 (Homozygous/Cooley ℗ ℗ ℗ ℗ ℗ ℗ ℗ ℗ Chipmunk Facies
Anemia)
HbH, 25% Hb
22 HbH Disease Moderate ℗ ℗ Bart in Infancy

23 Hemoglobin E Disease ℗ ℗ ℗ ℗
24 Microangiopathic HA Moderate ℗ ℗ ℗ ℗
25 Iron Deficiency ℗ ℗ ℗ ℗ ℗ ℗ No ℗
26 Sideroblastic Anemia ℗ ℗
27 Abetalipoproteinemia ℗
28 Acanthocytosis No ℗
Alpha-thalassemia Carrier Hb Bart in
29
(Silent) Infancy
30 Asplenism ℗
31 Erythroblastosis Fetalis ℗
Increased Hb
32 Hb Bart (Hydrops Fetalis) ℗ ℗ ℗ Bart
Hepatosplenomegally

33 Hemolytic Anemias ℗ ℗
34 Lead Poisoning ℗
35 Multiple Myeloma ℗
36 Reticulocytosis ℗ ℗
37 Splenectomy ℗
Micro-
38 Thermal Burns ℗ spherocytes
℗