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    Dopamine

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    Baby Lyn Ann Tanalgo
    Dopamine is a catecholamine found in neurons of the central and peripheral nervous systems. It is formed from the decarboxylation of DOPA and is a precursor of adrenaline and noradrenaline. Dopamine hydrochloride is administered intravenously and takes effect within five minutes, lasting less than ten minutes, and can be used to treat massive phenobarbital overdose through dopamine diuresis. Dopamine increases urine output by activating DA1 receptors in the kidney, which causes renal vasodilation and increased renal blood flow and GFR.

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    Dopamine

    Uploaded by

    Baby Lyn Ann Tanalgo
    194 views9 pages
    Dopamine is a catecholamine found in neurons of the central and peripheral nervous systems. It is formed from the decarboxylation of DOPA and is a precursor of adrenaline and noradrenaline. Dopamine hydrochloride is administered intravenously and takes effect within five minutes, lasting less than ten minutes, and can be used to treat massive phenobarbital overdose through dopamine diuresis. Dopamine increases urine output by activating DA1 receptors in the kidney, which causes renal vasodilation and increased renal blood flow and GFR.

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    Dopamine

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    Dopamine is a catecholamine found in neurons of the central and peripheral nervous systems. It is formed from the decarboxylation of DOPA and is a precursor of adrenaline and noradrenaline. Dopamine hydrochloride is administered intravenously and takes effect within five minutes, lasting less than ten minutes, and can be used to treat massive phenobarbital overdose through dopamine diuresis. Dopamine increases urine output by activating DA1 receptors in the kidney, which causes renal vasodilation and increased renal blood flow and GFR.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    194 views9 pages

    Dopamine

    Uploaded by

    Baby Lyn Ann Tanalgo
    Dopamine is a catecholamine found in neurons of the central and peripheral nervous systems. It is formed from the decarboxylation of DOPA and is a precursor of adrenaline and noradrenaline. Dopamine hydrochloride is administered intravenously and takes effect within five minutes, lasting less than ten minutes, and can be used to treat massive phenobarbital overdose through dopamine diuresis. Dopamine increases urine output by activating DA1 receptors in the kidney, which causes renal vasodilation and increased renal blood flow and GFR.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 9

    DOPAMINE:

    DESCRIPTION
    Dopamine is a catecholamine found in
    neurons of both the central and peripheral
    nervous system. It is a monoamine and is
    a precursor of adrenaline and
    noradrenaline. It is formed from the
    decarboxylation from DOPA

    DOPAMINE:
    PHARMACOKINETICS
    Dopamine in the form of
    dopamine hydrochloride is
    usually administered by
    intravenous infusion
    Onset of action occurs within
    five minutes of intravenous
    administration and with its
    plasma half-life of about two
    minutes, the duration of
    action is less than ten

    DOPAMINE:
    PHARMACOKINETICS
    Phenobarbital intoxication can usually be
    treated by supportive measures and
    administration of large amounts of fluid
    and diuretics to promote renal excretion
    of the drug.
    Treatment of massive phenobarbital
    overdose is possible with dopamine
    diuresis

    DOPAMINE
    MECHANISMS IN
    INCREASING URINE
    OUTPUT

    Activation of -1
    receptors in the
    heart

    DOPAMINE

    Activation of DA-1
    receptors in the
    kidney

    Receptor

    ResultofReceptor Contributionto
    Activation
    TherapeuticEffect

    DA1

    The renal
    vasodilation will
    improve renal blood
    flow and increase
    GFR.
    Produces a positive
    inotropic effect.

    beta1
    alpha1 and alpha2

    This will increase


    urine output and
    decrease fluid
    retention and
    edema.
    Increase in cardiac
    output. This is
    beneficial in CHF.
    Vasoconstriction is This will counteract
    not a desired effect. the beneficial effects
    on renal blood flow.
    In addition,
    increases in TPR
    will negatively affect
    cardiac output.

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