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    Vii. Drug Study

    Uploaded by

    Sarah Benjamin
    This document provides information about the drug Chlorpromazine (brand name Thorazine), including its classification as an antiemetic and antipsychotic, mechanism of action altering dopamine in the central nervous system, indications for use such as schizophrenia and nausea/vomiting, contraindications like hypersensitivity and liver/heart disease, common adverse reactions like sedation and extrapyramidal effects, typical dosages ranging from 10-400 mg orally or IM, and nursing responsibilities like monitoring for side effects and ensuring the patient takes the medication correctly.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd

    Vii. Drug Study

    Uploaded by

    Sarah Benjamin
    55 views2 pages
    This document provides information about the drug Chlorpromazine (brand name Thorazine), including its classification as an antiemetic and antipsychotic, mechanism of action altering dopamine in the central nervous system, indications for use such as schizophrenia and nausea/vomiting, contraindications like hypersensitivity and liver/heart disease, common adverse reactions like sedation and extrapyramidal effects, typical dosages ranging from 10-400 mg orally or IM, and nursing responsibilities like monitoring for side effects and ensuring the patient takes the medication correctly.

    Original Description:

    Thorazine Drug study for schizophrenic ptient

    Original Title

    Thorazine

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    This document provides information about the drug Chlorpromazine (brand name Thorazine), including its classification as an antiemetic and antipsychotic, mechanism of action altering dopamine in the central nervous system, indications for use such as schizophrenia and nausea/vomiting, contraindications like hypersensitivity and liver/heart disease, common adverse reactions like sedation and extrapyramidal effects, typical dosages ranging from 10-400 mg orally or IM, and nursing responsibilities like monitoring for side effects and ensuring the patient takes the medication correctly.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    55 views2 pages

    Vii. Drug Study

    Uploaded by

    Sarah Benjamin
    This document provides information about the drug Chlorpromazine (brand name Thorazine), including its classification as an antiemetic and antipsychotic, mechanism of action altering dopamine in the central nervous system, indications for use such as schizophrenia and nausea/vomiting, contraindications like hypersensitivity and liver/heart disease, common adverse reactions like sedation and extrapyramidal effects, typical dosages ranging from 10-400 mg orally or IM, and nursing responsibilities like monitoring for side effects and ensuring the patient takes the medication correctly.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 2

    VII.

    DRUGSTUDY

    GENERIC/BRA
    ND/CLASSIFIC
    ATION
    Generic:
    Chlorpromazine

    BRAND:
    Thorazine

    CLASSIFICATI
    ON:
    Antiemetics,
    Antipsychotics

    MECHANISMOF
    ACTION
    Alterseffectsof
    dopamine(D2)in
    CNS.Has
    significant
    anticholinergic/
    alphaadrenergic
    blockingactivity.

    INDICATION

    CONTRAINDICATIO
    N

    ADVERSEREACTION

    DOSAGE

    NURSING
    RESPONSIBILITY

    RATIONALE

    Schizophreniaand
    psychoses.
    Hyperexcitable,
    combative,explosive
    behaviorinchildren.
    Hyperactivechildwith
    conductdisorder.
    Acutemania.Nausea
    andvomiting.
    Intractablehiccups.
    Preoperative
    apprehension.Acute
    intermittentporphyria.

    Hypersensitivity;
    hypersensitivityto
    sulfites(injectable)or
    benzylalcohol(SR
    capsules);cross
    sensitivitywithother
    phenothiazinesmay
    occur;angleclosure
    glaucoma;bone
    marrowdepression;
    severeliver/CV
    disease;concurrent
    pimozideuse.

    CNS:NEUROLEPTIC
    MALIGNANT
    SYNDROME,sedation,
    extrapyramidal
    reactions,TD.
    EENT:Blurredvision,
    dryeyes,lensopacities.
    CV:Hypotension(
    withIM,IV),
    tachycardia.
    GI:Constipation,dry
    mouth,anorexia,
    hepatitis,ileus,
    priapism.
    GU:Urinaryretention.
    Derm:photosensitivity,
    pigmentchanges,
    rashes.
    Endo:Galactorrhea,
    amenorrhea.
    Hemat:
    AGRANULOCYTOSIS
    ,leukopenia.
    Metab:Hyperthermia.
    Misc:Allergic
    reactions.

    Usual:
    PO(Adults):
    Psychoses:1025
    mg24timesdaily;
    mayevery34
    days
    (usualdoseis200
    mg/day;upto1
    g/day)or30300
    mg13timesdaily
    asextendedrelease
    capsules.

    1.Assessmentalstatusprior
    toandperiodicallyduring
    therapy.

    Sothatthenursecan
    determinemajororminor
    changesafterdrughasbeen
    taken.

    2.MonitorBPandpulse
    priortoandfrequently
    duringtheperiodofdosage
    adjustment.MaycauseQT
    intervalchangesonECG.

    Toobserveforanychanges
    relevant.

    3.Thedrugmaybetaken
    withorwithoutfood.

    Maybetakenw/mealsto
    reduceGIdiscomfort.

    4.Observepatientcarefully
    whenadministering
    medication.

    Toensurethatmedicationis
    actuallytakenandnot
    hoarded.

    5.MonitorI&Oratiosand
    dailyweight.

    Assesspatientforsignsand
    symptomsofdehydration.

    OffLabelUse:
    Vascularheadache.
    Bipolardisorder.

    IM(Adults):
    Severepsychoses:
    2550mginitially,
    mayberepeatedin
    1hr;tomaximum
    of400mgevery3
    12hrifneeded(up
    to1g/day).

    Actual:

    6.Monitorfordevelopment tobeabletowatchoutfor
    ofneurolepticmalignant
    anychanges,andreportto
    syndrome(fever,respiratory physicianthesechanges
    distress,tachycardia,
    seizures,diaphoresis,
    hypertensionorhypotension,
    pallor,tiredness,severe
    musclestiffness,lossof
    bladdercontrol.Report
    symptomsimmediately.May
    alsocauseleukocytosis,
    elevatedliverfunctiontests,
    elevatedCPK.
    7.Advisepatienttotake
    medicationasdirected.Take

    Misseddosesmayrequire

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