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Amyotrophic Lateral Sclerosis: Briana Ibarra Period 2 12/16/15

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Amyotrophic

Lateral Sclerosis
Briana Ibarra
Period 2
12/16/15

WHAT IS
AMYOTROPHIC
SCLEROSIS?

Also known as "ALS" or "Lou Gehrig's Disease"


It is a progressive neurodegenerative that affects the
brain and the spinal cord.

(I know this has to be about muscles. I'm


getting to it!)

Motor neurons reach from the brain to the spinal cord


and eventually to the muscles.

WHAT DOES
IT DO?

The degeneration of the neurons due to ALS causes


the motor neurons to eventually die. Therefore,
causing issues when the brain tries to control the
muscles. The function of the motor neurons are what
provide voluntary muscle movement and control.
People can lose the ability to speak, eat, move, and
even breathe.

FOR 5-15% of cases of ALS determine that the


disorder was inherited by the individuals parents.
There are multiple reasons for ALS that researchers
have found.

CAUSES

Genetic Mutation: No, you won't end up as a


member of the X-Men (UNFORTUNATELY), but
research has found that some cases of ALS can be
attributed to a few genetic mutations and it appears
similar to the inherited form of ALS.
Chemical Imbalance: It was identified that people
who have ALS tend to have higher levels of
glutamate, which is a chemical messenger to the
brain that surrounds nerve cells located in the spinal
fluid.High levels of glutamate can be toxic for some
nerve cells

CAUSES
(CONTINUE
D)

Disorganized Immune Reponses: An individual's


own immune system can misrecognize their body's
own cells for a foreign virus/bacteria and can begin
attacking it. This can lead to the death of nerve cells.
Protein Mishandling: Mishandled proteins within
nerve cells can accumulate abnormal forms of these
proteins in the cells which will eventually cause them
to die.

Sounds painful.

Approximately 5,600 individuals are diagnosed with


ALS in the United States a year. An estimated 30,000
people have it at any time.
60% of people in the ALS Database (yeah, that
exists.) are men and 93% are Caucasian.

WHO CAN
GET ALS?

Most individuals are from the age range of 40-70. BUT


there are cases where there have been individuals
who have been diagnosed in their twenties and
thirties
Half of individuals diagnosed with ALS live 3 or more
years after diagnosis.
20% live five years or more.
10% live ten years or more.

Difficulty walking, excessive tripping, difficulty doing


everyday tasks
Weakness in your ankles, legs, and feet.

SIGNS AND
SYMPTOMS

Hand weakness and clumsiness


Slurred speech and trouble swallowing.
Muscle cramps
Twitching in arms, shoulders, and tongue
Having difficulty keeping good posture.
Difficulty keeping head up.

TREATMENT
S

There is no reversal of ALS so treatments focus on


slowing symptoms, preventing unnecessary
complications, and making the individual more
comfortable.
The drug riluzole has been the only one approved by
the FDA for treatment of ALS. It has shown to slow the
progression of individual's symptoms by reducing the
amount of glutamate.
Physical and Speech Therapy has also shown to help
those diagnosed with ALS.

REMEMBER
THIS?

This was supposed to spread ALS Awareness.


Not serve as a device to gain likes on social
media.

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