Pharm Exam Agian

DAPH 721 Dr.
Gail Galasko Pharmacology Fall 2002 Test 4 - B
NAME _____________________
Part I - Multiple Choice. Each question is worth two points. 1. To reduce a patient's salivary flow, a dentist has prescribed atropine. As a result of this medication, the patient might experience which of the following side effects? a. b. c. d. e. 2. sedation diarrhea bradycardia blurred vision stomach cramping
Administration of succinylcholine to a patient deficient in serum cholinesterase would most likely result in a. b. c. d. e. convulsions. hypertension. prolonged apnea. acute asthmatic attack. none of the above
3.
Which of the following is a non-depolarizing muscle relaxant? a. b. c. d. e. succinylcholine ipratropium tropicamide atracurium all of the above
4.
Which of the following drugs could be used to treat severe hypertension? a. b. c. d. e. atropine scopolamine botulinis toxin trimethaphan none of the above
5.
Which of the following drugs may cause muscarinic effects such as bradycardia?
a. b. c. d. e. 6.
d-tubocurare succinylcholine vecuronium none of the above (b) and (c)
With an overdose of a cholinergic drug, one would expect to see each of the following signs EXCEPT one. Which one is this EXCEPTION? a. b. c. d. e. sweating urination mydriasis bradycardia copious serous saliva
7.
Atropine is useful in treating poisoning by organophosphate insecticides because a. b. c. d. e. it reactivates inhibited acetylcholinesterase. it stimulates nicotinic receptors. it inhibits normal ganglionic transmission. it blocks actions of acetylcholine at both central and peripheral sites. all of the above
8.
The cause of death from organophosphate "nerve gas" poisoning would probably be a. b. c. d. e. gastrointestinal bleeding. hypertension. respiratory failure. congestive heart failure. cardiac arrhythmia.
9.
A 30-year-old man has been treated with several autonomic drugs. He is now showing signs of drug toxicity. Which of the following signs would distinguish between an overdose of a ganglion blocker verses a muscarinic blocker? a. b. c. d. e. mydriasis tachycardia hypotension blurred vision dry mouth, constipation
10.
In the human eye, echothiophate can cause all of the following EXCEPT a. b. miosis. ciliary spasm.
c. d. e. 11.
reversal of the cycloplegic action of atropine. decrease in the incidence of cataracts. reduction in intraocular pressure.
When a dose-response study of atropine is carried out in young adults, which of the following effects may be observed? a. b. c. d. e. bradycardia tachycardia central nervous system stimulation, e.g., hallucinations central nervous system depression, e.g., sedation all of the above
12.
All of the following may cause cycloplegia (paralysis of accommodation) when used topically in the eye EXCEPT a. b. c. d. e. atropine. physostigmine. tropicamide. homatropine scopolamine.
13.
Potential therapeutic uses of neuromuscular blockers include a. b. c. d. e. diagnosis of myasthenia gravis. control of ventilation during surgery. endotracheal intubation. (b) and (c) are correct. All of the above are correct.
14.
Succinylcholine blocks neuromuscular transmission by a. b. c. d. e. inhibiting cholinesterase. inhibiting the central nervous system. depolarizing the motor endplate of skeletal muscle. inducing formation of cholinesterase at the endplate. blocking release of acetylcholine at the endplate.
15.
Which of the following is an endogenous catecholamine? a. b. c. d. ephedrine amphetamine dopamine isoproterenol
e. 16.
all of the above
Which of the following is/are true for epinephrine? a. b. c. d. e. Given exogenously it acts rapidly. It has bronchodilator and vasoconstrictor properties. It is the drug of choice to treat anaphylaxis. (a) and (c) (a), (b) and (c)
17.
Which of the following effects of epinephrine would be blocked by phentolamine but not by metoprolol? a. b. c. d. e. relaxation of bronchial smooth muscle cardiac stimulation contraction of radial smooth muscle in the iris increase of cAMP in fat relaxation of the uterus
18.
When pupillary dilation, but not cycloplegia, is desired, a good choice is a. b. c. d. e. homatropine. pilocarpine. isoproterenol. tropicamide. phenylephrine.
19.
Stimulation of -adrenergic receptors causes all of the following EXCEPT a. b. c. d. e. decreased peripheral resistance. increased heart rate. increased release of glucose from the liver. mydriasis. bronchodilation.
20.
Which of the following is MOST apt to cause DECREASED release of norepinephrine? a. b. c. d. e. prazosin phentolamine clonidine isoproterenol amphetamine
21.
Phentolamine and tolazoline a. b. c. d. e. are inactive by the oral route. induce vasospasm in large doses. cause tachycardia. cause hypertension. block both alpha and beta receptors.
22.
Which of the following binds covalently to its receptor? a. b. c. d. e. epinephrine phenoxybenzamine propranolol terbutaline amphetamine
23.
Which of the following is a 2-selective drug used in acute asthmatic bronchoconstriction. a. b. c. d. e. epinephrine isoproterenol norepinephrine phenylephrine albuterol
24.
The use of epinephrine for local hemostasis during surgery might result in a. b. c. d. e. hypoglycemia. cardiac arrhythmia. an acute asthmatic attack. a drastic drop in blood pressure. any of the above
25.
Which of the following combinations of agents would be necessary to block the cardiovascular effects produced by the injection of a sympathomimetic drug? a. b. c. d. e. atropine and prazosin atropine and propranolol prazosin and propranolol phenoxybenzamine and curare amphetamine and propranolol
26.
Injection of a pressor dose of norepinephrine may result in a decreased heart rate because of
a. b. c. d. e. 27.
activation of baroreceptor reflexes. direct stimulation of receptors. direct stimulation of 1 receptors. direct stimulation of 2 receptors. direct stimulation of muscarinic receptors.
Adverse effects of -adrenergic blocking agents include a. b. c. d. e. dizziness. postural hypotension. tachycardia. (a) and (b) (a), (b) and (c)
28.
Which of the following drugs will be most likely to increase airway resistance in a patient with pulmonary obstructive disease? a. b. c. d. e. isoproterenol atenolol bitolterol terbutaline nadolol
29.
Which of the following drug(s) is/are are non-selective antagonists? a. b. c. d. e. Propranolol Timolol Metoprolol Atenolol (a) and (b)
30.
Activation of parasympathetic nervous system results in which of the following responses? a. b. c. d. e. an increase in heart rate vasoconstriction bronchoconstriction relaxation of ureters relaxation of GIT
31.
Fill in the blank. What group of drugs cause bradycardia, hypotension and bronchial constriction?
_______________________________
32.
Fill in the blank. What group of drugs cause vasodilation, orthostatic hypotension, tachycardia and lower blood pressure?
________________________________

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DAPH 721 Dr.

Gail Galasko Pharmacology Fall 2002 Test 4 - B

d-tubocurare succinylcholine vecuronium none of the above (b) and (c)

Which of the following is an endogenous catecholamine? a. b. c. d. ephedrine amphetamine dopamine isoproterenol

all of the above

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