1624 MSDS PDF

MATERIAL SAFETY DATA SHEET
Cat# 1624-100, -25, Lapatinib Ditosylate (Tykerb, Tyverb, GW-572016)

SECTION 1: PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: PRODUCT CODES: MANUFACTURER: ADDRESS: Lapatinib Ditosylate (Tykerb, Tyverb, GW-572016) Cat# 1624-100, -25 BioVision, Inc. 155 S. Milpitas Boulevard, Milpitas, CA 95035
MSDS DATE: Feb 29, 2012
EMERGENCY PHONE: 858-373-8066 CHEMTREC PHONE: OTHER CALLS: 408-493-1800 FAX PHONE: 408-493-1801
SECTION 2: COMPOSITION/INFORMATION ON INGREDIENTS Component Lapatinib Ditosylate (Tykerb, Tyverb, GW-572016) SECTION 3: HAZARDS IDENTIFICATION Product Name/Chemical Name Lapatinib Ditosylate (Tykerb, Tyverb, GW-572016) CAS Number 388082-78-8 EC-No. -MW 925.46 Chemical Formula C29H26ClFN4O4S 2C7H8O3S Description Solid Volume 1624-100: 100 mg 1624-25: 25 mg Safety Information See below
Lapatinib Ditosylate (Tykerb, Tyverb, GW-572016): Emergency Overview OSHA Hazards: No known OSHA hazards GHS Classification: Not a dangerous substance according to GHS GHS Label elements, including precautionary statements Pictogram: none Signal word: none Hazard statement(s): none Precautionary statement(s): none HMIS Classification Health hazard: 0 Flammability: 0 Physical hazards: 0 NFPA Rating Health Hazard: 0 Fire: 0 Reactivity Hazard: 0 Potential Health Effects Inhalation: May be harmful if inhaled. May cause respiratory tract irritation. Skin: May be harmful if absorbed through skin. May cause skin irritation. Eyes: May cause eye irritation. Ingestion: May be harmful if swallowed. SECTION 4: FIRST AID MEASURES If inhaled: If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact: Wash off with soap and plenty of water. Consult a physician. In case of eye contact: Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed: Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. 5: FIRE-FIGHTING MEASURES Condition of flammability: Not flammable or combustible. Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special protective equipment for fire-fighters: Wear self-contained breathing apparatus for firefighting if necessary. Hazardous combustion products: Hazardous combustion products formed under fire conditions not available SECTION 6: ACCIDENTAL RELEASE MEASURES Personal precautions: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist, gas, or dust. Ensure adequate ventilation. Environmental precautions: Do not let product enter drains. PAGE 1 OF 3

SECTION 7: HANDLING AND STORAGE Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Normal measures for preventive fire protection. Conditions for safe storage Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20C SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION Contains no substances with occupational exposure limit values. Personal protective equipment Respiratory protection Respiratory protection is not required. Where protection from nuisance levels of dusts are desired, use type N95 (US) or type P1 (EN 143) dust masks. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Hand protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. Eye protection Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin and body protection Choose body protection in relation to its type, to the concentration and amount of dangerous substance, and to the specific workplace. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Hygiene measures General industrial hygiene practice. SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES Property Appearance: pH: Water Solubility: Other Solubility: Specific Gravity (g/ml): Boiling Point (C): Melting Point (C): Flash Point (C): Ignition Temperature (C): Density SECTION 10: STABILITY AND REACTIVITY Property Chemical stability Conditions to avoid: Materials to avoid: Hazardous decomposition products: SECTION 11: TOXICOLOGICAL INFORMATION Lapatinib Ditosylate (Tykerb, Tyverb, GW-572016): Acute toxicity: no data available Skin corrosion/irritation: no data available Serious eye damage/eye irritation: no data available Respiratory or skin sensitization: no data available Germ cell mutagenicity: no data available Carcinogenicity: IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. ACGIH: No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by ACGIH. PAGE 2 OF 3 Lapatinib Ditosylate (Tykerb, Tyverb, GW-572016) Stable under recommended storage conditions No data available Strong acids, strong bases Carbon oxides, nitrogen oxides Lapatinib Ditosylate (Tykerb, Tyverb, GW-572016) Yellow solid No data available Very poorly soluble (1-10 M) DMSO (200 mg/ml) No data available No data available 241-252 oC (465.8-485.6 oF) No data available No data available No data available
Methods for cleaning up: Pick up and arrange disposal without creating dust. Keep in suitable, closed containers for disposal.

NTP:
No component of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP. OSHA: No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by OSHA. Reproductive toxicity: no data available Teratogenicity: no data available Specific target organ toxicity single exposure (GHS): no data available Specific target organ toxicity repeated exposure (GHS): no data available Aspiration hazard: no data available Potential Health Effects Inhalation: May be harmful if inhaled. May cause respiratory tract irritation. Skin: May be harmful if absorbed through skin. May cause skin irritation. Eyes: May cause eye irritation. Ingestion: May be harmful if swallowed. Signs and Symptoms of Exposure: Exposure may cause irritation to eyes, skin, mucous membranes, and upper respiratory tract. Ingestion may result in diarrhea, nausea, abdominal cramping, rash, and fatigue. To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Synergistic effects: no data available Additional information: RTECS: not available SECTION 12: ECOLOGICAL INFORMATION Lapatinib Ditosylate (Tykerb, Tyverb, GW-572016): Persistence and degradability: no data available Toxicity: no data available Bioaccumulative potential: no data available Mobility in soil: no data available PBT and vPvB assessment: no data available Other adverse effects: no data available SECTION 13: DISPOSAL CONSIDERATIONS Product: Observe all federal, state, and local environmental regulations. Contaminated packaging: Dispose of as unused product. SECTION 14: TRANSPORT INFORMATION Lapatinib Ditosylate (Tykerb, Tyverb, GW-572016): DOT (US): Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods. SECTION 15: REGULATORY INFORMATION Lapatinib Ditosylate (Tykerb, Tyverb, GW-572016): OSHA Hazards: No known OSHA hazards SARA 302 Components: SARA 302: No chemical in this material are subject to the reporting requirements of SARA Title III, Section 302. SARA 313 Components: SARA 313: This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title II, Section 313. SARA 311/312 Hazards: No SARA Hazards Massachusetts Right To Know Components: No components are subject to the Massachusetts Right to Know Act. Pennsylvania Right To Know Components: No components are subject to the Pennsylvania Right to Know Act. New Jersey Right To Know Components: No components are subject to the New Jersey Right to Know Act. California Prop. 65 Components: This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm. EU regulations Component Lapatinib Ditosylate (Tykerb, Tyverb, GW-572016) SECTION 16: OTHER INFORMATION DISCLAIMER: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. BioVision, Inc., shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale. Risk Phrases R22 Safety Phrases S22, S24/25, S36/37
PAGE 3 OF 3

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MATERIAL SAFETY DATA SHEET

Cat# 1624-100, -25, Lapatinib Ditosylate (Tykerb, Tyverb, GW-572016)

MSDS DATE: Feb 29, 2012

MATERIAL SAFETY DATA SHEET

MSDS DATE: Feb 29, 2012

MATERIAL SAFETY DATA SHEET

MSDS DATE: Feb 29, 2012

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