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Antepartum Hemorrhage

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ANTEPARTUM HEMORRHAGE

Definition: Vaginal bleeding after 24 weeks of gestation


A 27 years old female, pregnant at 33 weeks of gestation presented to the ER with vaginal bleeding. How to
manage her?
NO PELVIC/RECTAL until previa ruled out
ABC's first: continuous fetal monitoring, intravenous access, Keep maternal oxygen saturation >95 percent,
Draw blood for a complete blood count, blood type and Rh, and coagulation studies, Notify the anesthesia
team
DDx:

Vasa previa

Placenta previa

Abruptio placenta

Uterine rupture

Bloody show

Cervical (cervicitis, polyp, cancer)

Vaginal (post-coital)

Non-gyne (hematuria, BRBPR)

Abruptio Placenta

Classification: concealed vs apparent

Presentation: pain with bleeding, pain is sudden/constant, localized to back and uterus, and Uterine
Contractions are usually high frequency and low amplitude, but a contraction pattern typical of labor
is also possible and labor may proceed rapidly

Risk Factors:

HTN, Preeclampsia/Pregnancy induced hypertension, Eclampsia.

Previous abruption

Large uterus (macrosomia, polyhydramnios, multiple gest)

EtOH, smoking, cocaine

Uterine anomaly

Trauma

Multiparity

Premature rupture of membranes

Chorioamnionitis

Consequences:

Maternal:

Excessive blood loss and DIC generally necessitate blood transfusion and can lead to
hypovolemic shock, renal failure, adult respiratory distress syndrome, multiorgan
failure, peripartum hysterectomy and, rarely, death.

Emergency cesarean delivery for fetal or maternal indications

Fetal and neonatal:

Perinatal morbidity and mortality related to hypoxemia, asphyxia, low birth weight,
and/or preterm delivery.

Fetal growth restriction (with chronic abruption).

DIAGNOSIS: The diagnosis is primarily clinical, but findings from imaging (retroplacental
hematoma).

Management:

Maternal stabilization

Severe abruption at any gestational age and nonsevere abruption at >36 weeks: Deliver.

Nonsevere abruption at 34 to 36 weeks (fetal status reassuring, maternal vital signs normal,
laboratory tests normal or mildly abnormal, mild to moderate bleeding): Deliver. Since these
patients remain at risk of developing a sudden severe abruption.

Minor abruption at 34 to 36 weeks: They should be monitored closely and delivered if they
have recurrent bleeding.

Nonsevere abruption at <34 weeks: Expectant management of abruption in pregnancies.


Corticosteroids to promote fetal lung maturation should be administered to pregnancies at 23
to 34 weeks of gestation, given the increased risk of need for preterm delivery

Recurrence risk: several-fold higher risk of abruption in a subsequent pregnancy

Placenta previa

Classification: partial vs complete vs marginal vs low-lying placenta


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Presentation: In the second half of pregnancy, the characteristic clinical presentation is painless
vaginal bleeding.

Risk Factors:

Previous placenta previa

Previous cesarean delivery

Multiple gestation

Multiparity

Advanced maternal age

Infertility treatment

Previous abortion

Previous intrauterine surgical procedure

Maternal smoking, cocaine use.

Associated conditions:

Placenta accreta

Preterm labor and rupture of the membranes

Malpresentation

Intrauterine growth restriction

Vasa previa and velamentous umbilical cord

Congenital anomalies

Amniotic fluid embolism

DIAGNOSIS:

Sonographic determination of placental location before digital vaginal examination is


performed because palpation of the placenta can cause severe hemorrhage.

Echogenic homogeneous placental tissue covering or proximate to the internal cervical os (a


distance greater than 2 cm from the os excludes the diagnosis of previa).

Management:

ACUTE CARE:

Assessment:

Maternal: BP, HR, Urine output, estimation of vaginal blood loss (Soaked
pads)

Fetal: fetal heart rate

Intravenous access and crystalloid One or two large bore intravenous lines are
inserted and crystalloid is infused to achieve/maintain hemodynamic stability and
adequate urine output (at least 30 mL/hour).

Transfusion: begin red cell transfusions in hypotensive patients whose blood pressure
fails to improve after two liters of crystalloid have been rapidly infused.

Tocolysis: reduce or eliminate uterine contractions, which may promote placental


separation and bleeding. Prolong pregnancy and result in an increase in birthweight

Magnesium sulfate neuroprotection in patients with preterm (24 to 32 weeks) placenta


previa in whom a decision has been made to deliver within 24 hours, but not
emergently.

Antenatal corticosteroids A course of antenatal corticosteroid therapy should be


administered to symptomatic women between 23 and 34 weeks of gestation to
enhance fetal pulmonary maturity.

Admit and observe if: minimal bleeding, <36wks, fetus stable, no contractions

Indications for delivery Cesarean delivery is indicated if any of the following occur:

A nonreassuring fetal heart rate tracing unresponsive resuscitative measures

Life-threatening refractory maternal hemorrhage

Significant vaginal bleeding after 34 weeks of gestation

C/S if: previa unstable, fetal distress, >36wks

RECURRENCE: Placenta previa recurs in 4 to 8 percent of subsequent pregnancies

Vasa previa
Definition: fetal blood vessels are present in the membranes covering the internal cervical os. The
membranous vessels may be associated with a velamentous umbilical cord (membranous umbilical vessels at
the placental insertion site, no Wharton's jelly)

Presentation: painless bleeding, tachycardia, bradycardia, severe variables

Risk Factors:

Velamentous insertion of cord on low lying cervix

Diagnosis:

Ultrasonographic evidence of vasa previa

Painless vaginal bleeding upon rupture of membranes


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Fetal heart rate abnormalities

Positive Apt, Ogita, or Loendersloot tests

Management:

Recommend inpatient observation starting at 32 weeks. Inpatient observation allows for emergent
caesarean in event of nonreassuring fetal testing, preterm labor, or preterm premature ruptured
membranes. Empiric delivery at approximately 35 weeks of gestation without confirmation of lung
maturity via amniocentesis is also recommended

Uterine rupture

Presentation: painful bleeding, during labour: suprapubic pain, contractions stop, vaginal bleeding,
hemoperitoneum

Risk Factors:

Prior uterine surgery

Trauma

Uterine distension (macrosomia, polyhydramnios, multiple gest)

Uterine anomolies

Choriocarcinoma, difficult labor (forceps, vag breech, shoulder


dystocia

Diagnosis: clinical

Management: two options: repair of the rupture site and hysterectomy

Complications of Antepartum Hemorrhage


Maternal
Shock
DIC
Anemia
C-section
Uterine atony > PPH
Hysterectomy
Death
Fetal
HR abnormalities
Hypoxia > Cerebral Palsy
Prematurity
Death
References:

CURRENT Diagnosis & Treatment: Obstetrics & Gynecology, 11e


Placental abruption: Clinical features and diagnosis (UPTODATE)
Placental abruption: Management (UPTODATE)
Clinical features, diagnosis, and course of placenta previa (UPTODATE)
Management of placenta previa (UPTODATE)
Velamentous umbilical cord insertion and vasa previa (UPTODATE)

Good Luck Dalal AlEesa


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