New Vision University

Syllabus

This form is used in preparation of the program component. Entries on this form should be transferred to the University Board for
approval. Fields marked blue indicate NVU requested information and shall not be filled (if not meant otherwise), whereas yellow
fields are optional.

1. General Information

Title: General Pathology

School: Medicine

Component leader: Ketevan Gambashidze

Other University academic

NA Outside contributors:
Staff teaching:
Unit code (if already QF Level VI, VII or VIII
MD1101
assigned): (BA/MA/MD/PhD etc.):
Teaching period
Component credits: 8 III Year, Fall
(Spring/Fall):
Programmes for which the
Programmes for which the
Component is compulsory: Medicine NA
Component is optional:

Pre-requisite Body Systems III Pre-requisite

Component(s): Life Sciences III qualifications: NA
(Component code(s)) (text description)
Post-requisite
Component replaces:
Component(s): Systemic Pathology NA
(if any)
(Component code(s))
Component is to be
Fall 2016 Date of proposal: 01.07.16
implemented:
Estimated student
150 Maximum class size: 15
numbers:
Applied for Available for Available to
Work experience/
minor N online N Exchange Y N
placement:
qualification: enrolment students:
Available to Prior
Non-degree N Registration Y Other N Other N
students: Requirement
Teaching and Learning Methods

Method Number Duration Total Student Academic staff

hours each workload hours contact hours
Lectures: 15 1 15 15

Pathophysiology - 15 2 30 30
Practical /small group discussions (SGD): - - - -
Pathanatomy - 5 1 5 5

Quizzes - 14 1 14
Class tests, exams and assessment: Midterm - 1 3 3 20
MCQ Exam - 1 3 3
Independent learning: 170
(give details below)

Total student study hours: (30 hrs per 1 credits): 240

Details of Independent Learning:

Of 170 hrs for independent learning 70 hrs are allocated to accomplish home assignments, 50 for self-learning
in library, 50 preparing for exam, midterm and quizzes.

Weekly Schedule of Student Workload (15 weeks):

1 Week Topic: Introduction to Pathology.

Cell injury. Cell Death and Adaptation.

Content: Pathology, Health and Disease definitions. Disease

stages/periods. Terminal state, agony, clinical death, biological death.
Etiology and Pathogenesis, "vicious circle", Pathological process and
pathological state. Reactivity.
Content: Cell injury - Causes and Mechanism (Ischemic, Toxic).
Reversible cell injury. Types, morphology: Swelling, vacuolation,
hyaline, fatty change. Irreversible cell injury. Apoptosis and Necrosis.
Types of Necrosis. Signs and symptoms. Calcification: Dystrophic and
Metastatic. Amyloidosis: classification, Pathogenesis, Morphology.
Disorders of Pigment and Mineral metabolism such as bilirubin,
melanin, hemosiderin.

Reading: Robbins Basic Pathology: with STUDENT CONSULT Online

Access, 9e (Robbins Pathology) [Hardcover], 2013, Chapter 1, pp.1-
29.
Vinay Kumar MBBS MD FRCPath (Author), Abul K. Abbas
MBBS (Author), Jon C. Aster MD PhD (Author).
2 Week Topic: Cellular injury and Adaptation.
General reactions of organism on disorder

Content: Atrophy, Hypertrophy, Hyperplasia, Hypoplasia,

Metaplasia, Malformation, Agenesis, Dysplasia.
Content: General Adaptation Syndrome (GAS) or Stress reaction.
GAS - definition, stressors, determinants of stress response gravity,
stages of stress reaction (alarm, resistance and exhaustion). Stress
hormones, their effect on cardio-vascular and respiratory system.
Anti-inflammatory and anti-allergic effect of stress hormones. Ways
of protection or displacement activities.

Reading: Robbins Basic Pathology: with STUDENT CONSULT Online

Access, 9e (Robbins Pathology) [Hardcover], 2013, Chapter 1, pp.1-
29.
Vinay Kumar MBBS MD FRCPath (Author), Abul K. Abbas
MBBS (Author), Jon C. Aster MD PhD (Author).
3 Week Topic: Growth Disturbances and Neoplasia.
General reactions of organism on disorder

Content: Neoplasia: Classification, Histogenesis, Biologic

Behavior : Benign and Malignant; Carcinoma and Sarcoma. Malignant
Neoplasia: Grades and Stages, Local and distant spread.
Carcinogenesis: Environmental carcinogens, chemical, viral,
occupational. Heredity and cellular oncogenes. Tumor and Host
Interactions: Systemic effects including paraneoplastic syndromes,
Tumor immunology. Laboratory diagnosis: Cytology, Biopsy, Tumor
markers.
Content: Shock. Collapse, coma. Etiology and Pathogenesis. Types
of shock, clinical manifestations. Multiple organ dysfunction
syndrome (MODS).

Reading: Robbins Basic Pathology: with STUDENT CONSULT Online

Access, 9e (Robbins Pathology) [Hardcover], 2013, Chapter 5,
pp.161-215.
Vinay Kumar MBBS MD FRCPath (Author), Abul K. Abbas
MBBS (Author), Jon C. Aster MD PhD (Author)
Reading: Robbins Basic Pathology: with STUDENT CONSULT Online
Access, 9e (Robbins Pathology) [Hardcover], 2013, Chapter 3. Pp. 94-
99.
Vinay Kumar MBBS MD FRCPath (Author), Abul K. Abbas
MBBS (Author), Jon C. Aster MD PhD (Author)
4 Week Topic: Hemodynamic Disorders

Content: Types of blood vessels and Hemodynamic principles

(Equation of continuity and Bernoulli's principle). Disorders of local
hemocirculation: Arterial hyperaemia, Venous hyperaemia and
Ischemia (definition, Etio-Pathogenesis. Types and symptoms).
Clinical forms of ischemia: angina pectoris, hemicranias, Reynauds
disease, endarteritis.
Content: Chronic venous congestion: changes in lung, liver, spleen.
Thrombosis and embolism. Formation, fate and effects. DIC. Stasis.
Infarction (types, common sites), Gangrene.

Reading: Robbins Basic Pathology: with STUDENT CONSULT Online

Access, 9e (Robbins Pathology) [Hardcover], 2013, Chapter 3, pp.75-
93.
Vinay Kumar MBBS MD FRCPath (Author), Abul K. Abbas
MBBS (Author), Jon C. Aster MD PhD (Author)
5 Week Topic: Hemodynamic Disorders

Content: Thromboembolism, Disseminated intravascular

coagulation (DIC) - Etiology and Pathogenesis.

Reading: Robbins Basic Pathology: with STUDENT CONSULT Online

Access, 9e (Robbins Pathology) [Hardcover], 2013, Chapter 3, pp.86-
92.
Vinay Kumar MBBS MD FRCPath (Author), Abul K. Abbas
MBBS (Author), Jon C. Aster MD PhD (Author)
6 Week Topic: Disorders of Water metabolism.

Content: Dyshydria. Main types of dyshidria. Hypo hydration.

Hyper-osmotic, hypo-osmotic, iso-osmotic hypohydration.
Hyperhydration. Hyperosmotic, hypoosmotic, isoosmotic
hyperhydration. Pathogenesis of cardiac, renal, inflammatory, toxic,
allergic, nutritional edema.

Reading: Robbins Basic Pathology: with STUDENT CONSULT Online

Access, 9e (Robbins Pathology) [Hardcover], 2013, Chapter 3. Pp.76
-78.
Vinay Kumar MBBS MD FRCPath (Author), Abul K. Abbas
MBBS (Author), Jon C. Aster MD PhD (Author)
7 Week Topic: Inflammation and Repair.

Content: Acute inflammation: Features, causes, vascular and

cellular events. Morphologic variants of acute inflammation.
Inflammatory cells and Mediators.
Content: Chronic inflammation: Causes, types, nonspecific and
Granulomatous with examples. Wound healing by primary and
secondary union, factors promoting and delaying the process.
Healing at specific sites including bone healing.

Reading: Robbins Basic Pathology: with STUDENT CONSULT Online

Access, 9e (Robbins Pathology) [Hardcover], 2013, Chapter 2, pp.29-
75.
Vinay Kumar MBBS MD FRCPath (Author), Abul K. Abbas
MBBS (Author), Jon C. Aster MD PhD (Author)
8 - Week Topic: Immunopathology

Content: Hypersensitivity reactions. Antibody and cell mediated

tissue injury. Type I-II-III and IV Hypersensitivity reactions. Etiology
and pathogenesis.
Autoimmunity and Immune Deficiencies

Reading: Robbins Basic Pathology: with STUDENT CONSULT Online

Access, 9e (Robbins Pathology) [Hardcover], 2013, Chapter 4, pp.99-
121.
Vinay Kumar MBBS MD FRCPath (Author), Abul K. Abbas
MBBS (Author), Jon C. Aster MD PhD (Author)
9 Week Topic: Environmental and Forensic Pathology

Content: Mechanical injuries - Concussion, Contusion, and

Compression of the brain. Definition, etiology and pathogenesis,
symptoms, complications and outcome, treatment. Epidural,
subdural and intracranial bleeding.

Reading: Robbins Basic Pathology: with STUDENT CONSULT Online

Access, 9e (Robbins Pathology) [Hardcover], 2013, Chapter 7,
pp.287-293; 821-822
Vinay Kumar MBBS MD FRCPath (Author), Abul K. Abbas
MBBS (Author), Jon C. Aster MD PhD (Author)
10 Week Topic: Environmental Pathology

Content: Effect of acceleratory forces on the body - Kinetosis.

Definition, etio-pathogenesis and manifestations. Space flights and
overload. Effects of +G and -G on the body.
Electrical injury. Determinants of outcome gravity. Pathogenesis of
disorders. local and general manifestations of electrical injury. Effects
of Ionizing radiation.

Reading: Robbins Basic Pathology: with STUDENT CONSULT Online

Access, 9e (Robbins Pathology) [Hardcover], 2013, Chapter 7, pp.289
- 293.
Vinay Kumar MBBS MD FRCPath (Author), Abul K. Abbas
 MBBS (Author), Jon C. Aster MD PhD (Author)

11 Week Topic: Environmental Pathology

Content: Effect of low and high partial pressure on organism.

Mountain sickness and Caisson disease. Acute effects of hypoxia.
Manifestations and compensatory reactions. Reactions providing
acclimatization. Chain-Stocks respiration. Blood test. Mountain
disease. Acute mountain sickness - acute cerebral edema and acute
pulmonary edema, pathogenesis. Chronic mountain sickness and
clinical manifestations.
Clinical manifestations of compression. Effects of nitrogen and
oxygen saturation at high pressure, nitrogen narcosis, effect of
hyperoxia, oxygen free radicals and antioxidant enzymes, local
asphyxia. Caisson disease. Clinical manifestations of decompression
sickness.

Reading: Robbins Basic Pathology: with STUDENT CONSULT Online

Access, 9e (Robbins Pathology) [Hardcover], 2013, Chapter 7,
pp.288-293 Vinay Kumar MBBS MD FRCPath (Author), Abul K. Abbas
MBBS (Author), Jon C. Aster MD PhD (Author)
12 Week Topic: Environmental Pathology

Content: Disorders of Thermoregulation. Affects of high and low

temperature on organism. Hyperthermia, heat cramps, heat stroke,
heat exhaustion, malignant hyperthermia, drug induced
hyperthermia. Pathogenesis, supporting conditions and clinical
manifestations. Fever - Definition, Etiology and pathogenesis of fever.
Hypothermia. Supporting conditions, compensatory reactions -
vasoconstriction, shivering, non-shivering thermo genesis.

Reading: Robbins Basic Pathology: with STUDENT CONSULT Online

Access, 9e (Robbins Pathology) [Hardcover], 2013, Chapter 7, pp.
288-293
Vinay Kumar MBBS MD FRCPath (Author), Abul K. Abbas MBBS
(Author), Jon C. Aster MD PhD (Author)
 13 Week Topic: Environmental Pathology

Content: Thermal injuries. Pathophysiology of Burn disease,

degrees of burn - I and II partial thickness, superficial and deep
partial thickness burns, III full thickness injury, characteristics,
outcome of I, II, and III degree burns. Major determinants of severity
of burn injury, rule of the nines. Pathogenesis of burn disease, organs
and systems involved - CNS, cardio-vascular system, blood system,
blood proteins, immune system, kidney, and gastro-intestinal
system. Burn shock (hypovolemic and neurogenic shock), toxemia,
infections and other complications (heart failure, renal failure,
autoimmune reactions, gastro-intestinal ulcerations and bleeding,
anemia).

Reading: Robbins Basic Pathology: with STUDENT CONSULT Online

Access, 9e (Robbins Pathology) [Hardcover], 2013, Chapter 7, pp.
288-293
Vinay Kumar MBBS MD FRCPath (Author), Abul K. Abbas MBBS
(Author), Jon C. Aster MD PhD (Author)
14 Week Topic: Genetic and Pediatric Diseases. Presentations.

Content: Autosomal and sex-linked disorders with examples.

Metabolic disorders.
Toxicity of Chemical Agents, Environmental Pollution, Effects of Tobacco, Effects
of Alcohol, Injury by Therapeutic, Drugs and Drugs of Abuse, Nutritional Diseases,
Malnutrition, Protein - Energy Malnutrition, Anorexia Nervosa and Bulimia, Vitamin
Deficiencies, Obesity.

Reading: Robbins Basic Pathology: with STUDENT CONSULT Online

Access, 9e (Robbins Pathology) [Hardcover], 2013, Chapter 6.
Pp.237-243
Vinay Kumar MBBS MD FRCPath (Author), Abul K. Abbas
MBBS (Author), Jon C. Aster MD PhD (Author)
Reading: Robbins Basic Pathology: with STUDENT CONSULT Online Access, 9e (Robbins
Pathology) [Hardcover], 2013, Chapter 7, pp.269-287; 293-306 Vinay Kumar MBBS MD FRCPath
(Author), Abul K. Abbas MBBS (Author), Jon C. Aster MD PhD (Author)

15 Week Midterm

Preparation and MCQ exam

Participation in
Exams

Monitoring of student progress:

 Students will be evaluated according to 3 main components:
a) Academic activity during semester (quizzes); b) Midterm; and c) Comprehensive Final exam.
The following pattern is applied for evaluation of a students achievements:
Academic activity at SGD (14 quiz, 3% each) - 42%
Midterm - 18%
Final examination - 40%

4. Methods of assessment:

Final Exam (compulsory)

Specify the type and timing of formal University examinations (exempt Coursework Assessment)

Type of exam Duration When set Resit % of formal assessment

(hours) (usually 16-19 week) (usually 20-22 week) (not exceeding 40)
MCQ Exam 3 40

Other information about

exam assessment
(including timetable, resit
arrangements):

Mid-Term Exams (where applicable)

Specify the type and timing of mid-term examinations (1-2 respectively)

Type of exam Duration (hours) When set Resit % of formal assessment
(usually 6-9/12-15 week) (Y/N) (not exceeding 40)
1 MCQ Quiz 3 Y 18

Other information about

exam assessment
(including timetable, resit arrangements):

Rationale for assessment and relationship of assessment methods to learning outcomes (this information is not
published):

The component includes lectures and practicals/small group discussions (SGD). The latter ones comprise
interactive workshops, case-based discussions, using various histological and immunohistological images.
Lectures highlight important concepts and facts in each major topic.

5. Resources

Reading list: Please indicate by checking the box specifying if a reading list is required for this Component.
This information is to be used by the library to manage resources:

Reading list is Required Reading List NOT required

Other resource needs essential for delivery of this Component:
 1. Robbins Basic Pathology: with STUDENT CONSULT Online Access, 9e (Robbins Pathology), 2013
Vinay Kumar, Abul K. Abbas, Jon C. Aster
2. McCance, K.L., & Huether, S.E. - Pathophysiology: The biologic basis for disease in adults and children
3. Rapid Review Pathology, 4e, 2013, Edward Goljan
4. Robbins and Cotran Review of Pathology, 3e, 2009, Edward C. Klatt

Comments:
(Use this box to make any additional notes. This information is not published).