GERONTOLOGY 310

PHYSIOLOGY OF AGING
Fall 2010

USC Course Catalog Description: GERO 310 Physiology of Aging (4, Fa) Effects of
normative aging processes on homeostatic mechanisms and how these changes relate to
development of disorder and disease in later life. Lecture and discussion. Prerequisite:
BISC 220L or BISC 221L.

Classroom: Gero Smart Classroom, 2nd Floor Time: Mon./Wed. 10:00 a.m. - 11:50 a.m.

Instructors:
Kelvin J. A. Davies, Ph.D., D.Sc.
Phone: (213) 740-8959 Fax: (213) 740-6462 E-mail: kelvin@usc.edu
Office Hours: by appointment

Christian J. Pike, Ph.D.

Phone: (213) 740-4205 Fax: (213) 740-4787 E-mail: cjpike@usc.edu
Office Hours: by appointment

Joanna M. S. Davies, M.D.

Phone: (213) 740-8959 Fax: (213)740-6462 E-mail: jdavies@usc.edu
Office Hours by appointment

Course Description
Examination of human aging with major emphasis in the physiology of the later years and implications
for health maintenance. The goal of the course will be to solidify biological concepts and theories that
underlie the phenomena of human aging. Throughout the course special effort will be made to
differentiate normal aging processes from age-related deterioration caused by disuse, misuse or abuse,
and disease.

Course Objectives
By the conclusion of the course, students are expected to be able to:

1) Provide an informed opinion on key issues in biological gerontology relevant to health care
practitioners, social service professionals, educators, administrators, and policy analysts.

2) Discuss the nature of biological aging as a composite of genetics and environment.

3) Clearly distinguish between normal aging processes and age-associated diseases.

4) Clearly distinguish between problems of disuse, misuse, abuse, and normal aging changes.
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Textbook
The required text book for this course is Human Aging: Biological Perspectives (2nd Edition) by
Augustine G. Digiovanna, and there will be additional assigned readings for some topics. Students are
also expected to use a medical dictionary to assist them in understanding the text and the assigned
readings.

Evaluation
This class is primarily a lecture course with audiovisual presentations, a textbook, and supplementary
reading material. Evaluation in the course will be based on one midterm examination, a term-paper,
and a final examination. The final examination will not be comprehensive. Examinations will consist
of short essay questions designed to give you the opportunity to demonstrate what you have learned.
An outline of the examination schedule is given below:

Test Date Dates/Topics Covered

Midterm October 18 Aug. 23 through Oct. 13
Final Examination December 13 (from 8:00am to 10:00am) Oct. 20 through Dec. 1

Students will be evaluated on the basis of:

1) Midterm Exam. (33%)
2) Final Exam. (33%)
3) Term Paper (34%)

The Term Paper is due on or before the last day of class on Wednesday, December 1

If you are going to miss an examination, you MUST CALL AHEAD of time and reschedule to take the
make-up test within the next week. Anyone who does not call ahead of time to reschedule will receive
an F' for that exam.

Students with Disabilities (the information below was provided by the office of the Provost)

Any student requesting academic accommodations based on a disability is required to
register with Disability Services and Programs (DSP) each semester. A letter of verification for
approved accommodations can be obtained from DSP. Please be sure that the letter is
delivered to any of the Instructors as early in the semester as possible. DSP is located in on
campus in STU 301, and is open from 8:30 a.m. - 5:00 p.m., Monday through Friday. The
phone number for DSP is (213) 740-0776.
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Gero 310
Term Paper Requirements & Guidelines

All students are required to submit a term paper, representing their own original work that provides
an in-depth review of an aspect of the Biology of Aging.

Students will be free to choose their own topics, subject to final approval by the course instructor.

Student papers must be printed (using a word processing program) and must be a minimum of ten
(10) pages in length, using double-spaced type with a 12 point font. Leave a one-line space
between each paragraph, use a one-inch all-around margin, and number each page consecutively.
Be sure to give your term paper an appropriate title, and also make sure to put your own name on
the paper.

Student papers must include at least ten (10) literature references, not including the course
textbook. Students are encouraged to use the campus libraries and the internet to find appropriate
background information and references. The references used should primarily be published journal
articles from the bio-medical literature, rather than books, unpublished opinions from the internet,
or popular magazines. Use numbers to quote your references directly in the text of your term paper;
like this (1). Number each reference in the order it appears in the text.

Extensive direct quotations are not appropriate for this term paper, and copying without giving
credit is never acceptable. If you really want to include a quote or two, it/they should be no longer
than three (3) lines long, and should be set inside quotation marks. Remember to fully reference the
source of any quote you use in your reference list.

All term papers will be due no later than the end of the last class. Term papers may also be given to
the instructor at any time before this date.

Journal References should look like this:

1. Pacifici, R.E. and Davies, K.J.A. (1991) Protein, lipid, and DNA repair systems in oxidative stress:
the free radical theory of aging revisited. Gerontology 37, 166-180.

Reference to a chapter in a book should look like this:

2. Crawford, D.R. and Davies, K.J.A. (1999) Regulation of Gene Expression During Oxidative Stress.
In: Free Radicals in Physiology & Medicine (Sies, H., ed.) Chapter 2, pp. 21-35, Academic Press,
New York.

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GERONTOLOGY 310 - PHYSIOLOGY OF AGING - FALL 2010

Month Date Day Topic Instructor

Aug. 23 Mon. Introduction to class and structure/evaluation Christian Pike

Aug. 25 Wed. Aging and disease an overview Joanna Davies
Aug. 30 Mon. Endocrine system in aging I Christian Pike
Sept. 1 Wed. Endocrine system in aging II Christian Pike
Sept 6 Mon. LABOR DAY HOLIDAY NO CLASS
Sept. 8 Wed. Neurobiology of aging I Christian Pike
Sept. 13 Mon. Neurobiology of aging II Christian Pike
Sept. 15 Wed. Neurobiology of aging III Christian Pike
Sept. 20 Mon. Neurobiology of aging IV Christian Pike
Sept. 22 Wed. Principles of Gerontology Kelvin Davies
Sept. 27 Mon. Theories of biological aging Kelvin Davies
Sept. 29 Wed. Free Radical Theory of aging Kelvin Davies

Oct. 4 Mon. Integument I Kelvin Davies

Oct. 6 Wed. Integument II Kelvin Davies

Oct. 11 Mon. Skeletal system in aging Kelvin Davies
Oct. 13 Wed. Muscular system in aging Kelvin Davies
Oct. 18 Mon. MID-TERM EXAMINATION Kelvin Davies
Oct. 20 Wed. Sensory systems in aging I Christian Pike
Oct. 25 Mon. Sensory systems in aging Christian Pike
Oct. 27 Wed. Reproductive system in aging I Christian Pike
Nov. 1 Mon. Reproductive system in aging II Christian Pike
Nov. 3 Wed. Urinary system in aging Christian Pike
Nov. 8 Mon. Immune system in aging I Christian Pike
Nov. 10 Wed. Immune system in aging II Christian Pike
Nov. 15 Mon. Digestive system in aging Kelvin Davies
Nov. 17 Wed. Nutrition in aging Valter Longo
Nov. 22 Mon. Caloric Restriction & Aging Valter Longo
Nov. 24 Wed. Heart and circulatory system in aging Kelvin Davies
Nov. 29 Mon. Respiratory systems in aging Kelvin Davies
Dec. 1 Wed. Coordination & Integration of the Cardiovascular system Kelvin Davies
Dec. 13 Mon. FINAL EXAMINATION 8 a.m. to 10 a.m. Kelvin Davies

Gero 310 Class Schedule 2010

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Gero. 310 Fall 2010 DESCRIPTION OF CLASS TOPICS

August 23 ORIENTATION AND INTRODUCTION TO THE STUDY OF AGING

Instructor: Dr. Christian Pike
- Class structure and evaluation, Course Objectives
Students are expected to have a background in basic cell biology, molecular biology, and biochemistry. Those
whose background is not strong in these areas should undertake serious self-study of the following topics in
Chapter 2 of the course textbook: Human Aging: Biological Perspectives (2nd Edition) by Augustine G.
Digiovanna
- Basic organization of cells, tissues, and organs
- The genome
- The information chain: transcription & translation
- Cancer the uncontrolled cell
- Mendelian genetics and disease inheritance
- DNA repair
- RNA and protein synthesis
- Proliferation potential of cells in vitro

August 25 AGING AND DISEASE

Instructor: Dr. Joanna Davies
- Giant Cell (Temporal) Arteritis and Polymyalgia Rheumatica
- Diseases of the Integument
- Cardiovascular Diseases
- Respiratory Diseases
- Digestive Diseases
- Genitourinary Diseases
- Diseases of Muscle & Bone Muscle Fatigue, Sarcopenia, Rheumatoid Arthritis,
Osteoarthritis, Osteoporosis, Lumbar stenosis, Gout, Pseudogout (CPPD) Pagets Disease,
Giant Cell (Temporal) Arteritis and Polymyalgia Rheumatica, Dermatomyositis.

August 30 THE ENDOCRINE SYSTEM I

Instructor: Dr. Christian Pike
- The endocrine glands and associated hormones
- Hormone functions
- Mechanism of hormone action
Text: Chapter 14

Sept. 1 THE ENDOCRINE SYSTEM II

Instructor: Dr. Christian Pike
- Age changes in endocrine system and hormone levels
- Diabetes, insulin insensitivity and glucose regulation
- GH, IGF-1 and longevity regulation
Text: Chapter 14

Sept. 6 LABOR DAY NO CLASS

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Sept. 8 THE NERVOUS SYSTEM I
Instructor: Dr. Christian Pike
- Basic anatomy and organization of the nervous system
- Neural cell types and functions
- The synapse: target of drug therapy and drug abuse
- Neural transmission: how neurons communicate
Text: Chapter 6

Sept. 13 AGE-RELATED CHANGES OF THE NERVOUS SYSTEM II

Instructor: Dr. Christian Pike
- Normal age-related changes in the nervous system
- Age changes in neural structure and integrity
- Age changes in neural function and cognitive abilities
- Effects of aging on neural plasticity
Text: Chapter 6

Sept. 15 AGE-RELATED DISEASES OF THE NERVOUS SYSTEM III

Instructor: Dr. Christian Pike
- Stroke
- Parkinsons disease
Text: Chapter 6

Sept. 20 AGE-RELATED DISEASES OF THE NERVOUS SYSTEM IV

Instructor: Dr. Christian Pike
- Dementias
- Alzheimers disease
Text: Chapter 6

Sept. 22 Principles of Gerontology

Instructor: Dr. Kelvin Davies
- Why the study of aging is important to your future
- Human life expectancy
- Demography of aging
- The role of aging in disease
- The importance of scientific method in natural science research
a. type of studies in aging research b. role of statistical analyses
- Criteria for age-related changes
- Single vs multi-dimensional model of biological aging
Text: Chapter 1

Sept. 27 BIOLOGICAL AGING THEORIES

Instructor: Dr. Kelvin Davies
-Classes of aging theories - Programmed, Stochastic, Network
- Evolutionary theories of aging
- Disposable soma (body) theory
- Antagonistic pleiotropy theory
- Accumulation of late-acting error theory
- Physiological theories of aging
- Genetic theories - genetic timers, genetic clock theory, death gene theory, telomere
theory, heterochromatin loss theory, limited gene usage somatic mutation theory,
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faulty DNA repair theory
- Non-genetic theories - error catastrophe, rate of living, free radical theory of aging,
mitochondrial theory, mitochondrial DNA theory, clinker theories, cross-linkage,
hormonal theories, calcium theories, immune system theories, wear and tear theory
- Network theories of aging
Text: Chapter 2 and Richard A. Millers Kleemeier Award Lecture: Are there Genes for
Aging? Journal of Gerontology - Biological Sciences (1999) Vol. 54A (No. 7) pp. B297-
B307.

Sept. 29 FREE RADICAL THEORY OF AGING

Instructor: Dr. Kelvin Davies
Oxygen and Oxidative stress
Protein, lipid, DNA, RNA oxidation
Antioxidants Compounds, Enzymes
Repair systems
Inducible defense and repair
Text: Chapter 2 + class handouts

Oct. 4 THE INTEGUMENT SYSTEM I

Instructor: Dr. Kelvin Davies
- Main functions for homeostasis
- The epidermis, age changes in the epidermis
- Epidermal accessory structures
Text: Chapter 3

Oct. 6 THE INTEGUMENT SYSTEM II

Instructor: Dr. Kelvin Davies
- The dermis
- Boundary between epidermis and dermis
- Vitamin D production
- Subcutaneous layer
- Cosmetic age changes, abnormal changes
Text: Chapter 3

Oct. 11 THE SKELETAL SYSTEM

Instructor: Dr. Kelvin Davies
- Contraction and movement
- Age-related changes in muscles
- Age-related changes in activity and physical performance
Text: Chapter 8

Oct. 13 THE MUSCLE SYSTEM

Instructor: Dr. Kelvin Davies
- Anatomy and physiology of bone
- Age-related changes in bone
Text: Chapter 9

Oct. 18 MID-TERM EXAMINATION

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Oct. 20 SENSORY SYSTEMS IN AGING I
Instructor: Dr. Christian Pike
- Olfaction and the effects of age
- The auditory system: basics of normal functioning and the effects of age
- Age-related diseases of the auditory system
Text: Chapter 7

Oct. 25 SENSORY SYSTEMS IN AGING II

Instructor: Dr. Christian Pike
- The visual system: basics of normal functioning and the effects of age
- Age-related diseases of the visual system
- Gustation and the effects of age
Text: Chapter 7

Oct. 27 REPRODUCTIVE SYSTEM I

Instructor: Dr. Christian Pike
- Anatomy and functioning of the female reproductive system
- The ovarian cycle and menopause
- Normal age changes and age-related disorders in the female reproductive system
- Hormone therapies in postmenopausal women
Text: Chapter 13

Nov. 1 REPRODUCTIVE SYSTEM II

Instructor: Dr. Christian Pike
- Anatomy and functioning of the male reproductive system
- Normal age changes in the male reproductive system
- Erectile dysfunction, prostate cancer and other age-related diseases
Text: Chapter 13

Nov. 3 URINARY SYSTEM

Instructor: Dr. Christian Pike
- Anatomy and physiology of the kidney and urinary system
- Structural and functional age-related changes in the urinary system
- Incontinence, end stage renal insufficiency, and other age-related disorders
- Alterations of drug metabolism in the elderly
Text: Chapter 12

Nov.8 THE IMMUNE SYSTEM I

Instructor: Dr. Christian Pike
- Basic components of the immune system
- Key cell types and functions
- Innate and acquired immune responses
Text: Chapter 15

Nov. 10 THE IMMUNE SYSTEM II

Instructor: Dr. Christian Pike
- Age-related changes in the immune system
- Thymic involution
- Vaccination and aging
Text: Chapter 15
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Nov. 15 THE DIGESTIVE SYSTEM

Instructor: Dr. Kelvin Davies
- Breakdown of foods
- Passage of foods through GI system
- Absorption of food elements
Text: Chapter 10

Nov. 17 NUTRITION IN AGING

Instructor: Dr. Valter Longo
- Guidelines for healthy eating
- Current recommendations for persons over 55
- Current research on nutrition in the elderly
Text: Chapter 11

Nov. 22 CALORIC RESTRICTION & AGING

Instructor: Dr. Valter Longo
Text: Chapter 11 + class handouts

Nov. 24 THE HEART & CIRCULATION

Instructor: Dr. Kelvin Davies
- Anatomy and physiology of the cardiovascular system
- Hypertension, atherosclerosis, arteriosclerosis
Text: Chapter 4

Nov. 29 RESPIRATION
Instructor: Dr. Kelvin Davies
- Anatomy and physiology of the respiratory system
- Age-related disorders of the respiratory system
Text: Chapter 5

Dec. 1 COORDINATION & INTEGRATION OF THE CARDIOVASCULAR SYSTEM

Instructor: Dr. Kelvin Davies
- How circulation and respiration combine to deliver oxygen to tissues, remove carbon dioxide
and metabolic wastes, and maintain pH
- Normal age-related changes, and abnormal disease states
Text: Chapters 4 and 5

Dec. 13 FINAL EXAMINATION 8am 10am

Gero 310 Syllabus 2010