UNICOOL R-404A

Wilhelmsen Ships Service AS

Catalogue number: 905623 Issue Date: 08/07/2019
Version No: 4.4 Print Date: 30/10/2019
Safety Data Sheet (Conforms to Regulation (EU) No 2015/830) L.REACH.NOR.EN

SECTION 1 IDENTIFICATION OF THE SUBSTANCE / MIXTURE AND OF THE COMPANY / UNDERTAKING

1.1. Product Identifier

Product name UNICOOL R-404A

Synonyms Product Part Number: 905623 (9.5 kg), 905606 (45 kg)
REFRIGERANT GAS R 404A (Pentafluoroethane, 1,1,1- trifluoroethane, and 1,1,1,2- tetrafluoroethane zeotropic mixture with
Proper shipping name
approximately 44% pentafluoroethane and 52% 1,1,1- trifluoroethane)
Other means of
905623, 905606, 905623
identification

1.2. Relevant identified uses of the substance or mixture and uses advised against
The use of a quantity of material in an unventilated or confined space may result in increased exposure and an irritating
Relevant identified uses
atmosphere developing. Before starting consider control of exposure by mechanical ventilation.
Uses advised against Not Applicable

1.3. Details of the supplier of the safety data sheet

Outback (M)SDS portal:
Registered company name Wilhelmsen Ships Service AS http://jr.chemwatch.net/outb/account Wilhelmsen Ships Service AS*
/autologin?login=wilhelmsen
--------Use our Outback portal to obtain our
(M)SDSs in other languages and/or
Strandveien 20 Lysaker 1366 format.--------- For questions relating to our Willem Barentszstraat 50 Rotterdam
Address
Norway SDSs please use Email: Netherlands
WSS.GLOBAL.SDSINFO@wilhelmsen.com
--------- Norway
Telephone +47 67 58 40 00 Not Available +31 10 4877 777
Fax Not Available Not Available +31 10 4877888
Website http://www.wilhelmsen.com/ Not Available http://www.wilhelmsen.com
Email wss.norway.cs@wilhelmsen.com Not Available wss.rotterdam@wilhelmsen.com

1.4. Emergency telephone number

American Chemistry Council 24hrs
Association / Organisation Giftinformasjonssentralen - 24 timer Dutch nat. poison centre
- Chemtrec
Emergency telephone
+47 22591300 +1 703 527 3887 + 31 30 274 88 88
numbers
Other emergency
Not Available (800) 424 9300 Not Available
telephone numbers

SECTION 2 HAZARDS IDENTIFICATION

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UNICOOL R-404A

2.1. Classification of the substance or mixture

Considered a hazardous mixture according to Reg. (EC) No 1272/2008 and their amendments. Classified as Dangerous Goods for
transport purposes.

Classification according to
regulation (EC) No H315 - Skin Corrosion/Irritation Category 2, H280 - Gas under Pressure (Liquefied gas)
1272/2008 [CLP] [1]
Legend: 1. Classified by Chemwatch; 2. Classification drawn from Regulation (EU) No 1272/2008 - Annex VI

2.2. Label elements

Hazard pictogram(s)

SIGNAL WORD WARNING

Hazard statement(s)
H315 Causes skin irritation.
H280 Contains gas under pressure; may explode if heated.

Supplementary statement(s)
EUH044 Risk of explosion if heated under confinement.

CLP classification (additional)

Not Applicable

Precautionary statement(s) Prevention

P280 Wear protective gloves/protective clothing/eye protection/face protection.

Precautionary statement(s) Response

P321 Specific treatment (see advice on this label).
P302+P352 IF ON SKIN: Wash with plenty of water and soap.
P332+P313 If skin irritation occurs: Get medical advice/attention.

Precautionary statement(s) Storage

P410+P403 Protect from sunlight. Store in a well-ventilated place.

Precautionary statement(s) Disposal

Not Applicable

2.3. Other hazards

Inhalation may produce health damage*.

Cumulative effects may result following exposure*.

May produce discomfort of the respiratory system*.

Repeated exposure potentially causes skin dryness and cracking*.

Vapours potentially cause drowsiness and dizziness*.

REACh - Art.57-59: The mixture does not contain Substances of Very High Concern (SVHC) at the SDS print date.

SECTION 3 COMPOSITION / INFORMATION ON INGREDIENTS

3.1.Substances
See 'Composition on ingredients' in Section 3.2

3.2.Mixtures
1.CAS No
2.EC No %[weight] Name Classification according to regulation (EC) No 1272/2008 [CLP]
3.Index No
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4.REACH No
1.354-33-6
2.206-557-8
44 pentafluoroethane Gas under Pressure (Liquefied gas); H280, EUH044 [1]
3.Not Available
4.01-2119485636-25-XXXX

1.811-97-2
2.212-377-0
4 1,1,1,2-tetrafluoroethane Gas under Pressure (Liquefied gas); H280, EUH044 [1]
3.Not Available
4.01-2119459374-33-XXXX

1.420-46-2
2.206-996-5
52 1,1,1-trifluoroethane Flammable Gas Category 1; H220, EUH044 [1]
3.Not Available
4.01-2119492869-13-XXXX

Legend: 1. Classified by Chemwatch; 2. Classification drawn from Regulation (EU) No 1272/2008 - Annex VI; 3. Classification drawn from
C&L; * EU IOELVs available

SECTION 4 FIRST AID MEASURES

4.1. Description of first aid measures

If product comes in contact with eyes remove the patient from gas source or contaminated area.
Take the patient to the nearest eye wash, shower or other source of clean water.
Open the eyelid(s) wide to allow the material to evaporate.
Gently rinse the affected eye(s) with clean, cool water for at least 15 minutes. Have the patient lie or sit down and tilt the
head back. Hold the eyelid(s) open and pour water slowly over the eyeball(s) at the inner corners, letting the water run out of
the outer corners.
The patient may be in great pain and wish to keep the eyes closed. It is important that the material is rinsed from the eyes to
prevent further damage.
Eye Contact Ensure that the patient looks up, and side to side as the eye is rinsed in order to better reach all parts of the eye(s)
Transport to hospital or doctor.
Even when no pain persists and vision is good, a doctor should examine the eye as delayed damage may occur.
If the patient cannot tolerate light, protect the eyes with a clean, loosely tied bandage.
Ensure verbal communication and physical contact with the patient.
DO NOT allow the patient to rub the eyes
DO NOT allow the patient to tightly shut the eyes
DO NOT introduce oil or ointment into the eye(s) without medical advice
DO NOT use hot or tepid water.

If skin contact occurs:

Immediately remove all contaminated clothing, including footwear.
Flush skin and hair with running water (and soap if available).
Seek medical attention in event of irritation.
In case of cold burns (frost-bite):
Move casualty into warmth before thawing the affected part; if feet are affected carry if possible
Bathe the affected area immediately in luke-warm water (not more than 35 deg C) for 10 to 15 minutes, immersing if possible
Skin Contact
and without rubbing
DO NOT apply hot water or radiant heat.
Apply a clean, dry, light dressing of "fluffed-up" dry gauze bandage
If a limb is involved, raise and support this to reduce swelling
If an adult is involved and where intense pain occurs provide pain killers such as paracetomol
Transport to hospital, or doctor
Subsequent blackening of the exposed tissue indicates potential of necrosis, which may require amputation.
Following exposure to gas, remove the patient from the gas source or contaminated area.
NOTE: Personal Protective Equipment (PPE), including positive pressure self-contained breathing apparatus may be
required to assure the safety of the rescuer.
Prostheses such as false teeth, which may block the airway, should be removed, where possible, prior to initiating first aid
procedures.
If the patient is not breathing spontaneously, administer rescue breathing.
If the patient does not have a pulse, administer CPR.
Inhalation
If medical oxygen and appropriately trained personnel are available, administer 100% oxygen.
Summon an emergency ambulance. If an ambulance is not available, contact a physician, hospital, or Poison Control Centre
for further instruction.
Keep the patient warm, comfortable and at rest while awaiting medical care.
MONITOR THE BREATHING AND PULSE, CONTINUOUSLY.
Administer rescue breathing (preferably with a demand-valve resuscitator, bag-valve mask-device, or pocket mask as
trained) or CPR if necessary.

Not considered a normal route of entry.

Avoid giving milk or oils.
Ingestion
Avoid giving alcohol.
For advice, contact a Poisons Information Centre or a doctor.
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4.2 Most important symptoms and effects, both acute and delayed
See Section 11

4.3. Indication of any immediate medical attention and special treatment needed
for intoxication due to Freons/ Halons;
A: Emergency and Supportive Measures
Maintain an open airway and assist ventilation if necessary
Treat coma and arrhythmias if they occur. Avoid (adrenaline) epinephrine or other sympathomimetic amines that may precipitate ventricular arrhythmias.
Tachyarrhythmias caused by increased myocardial sensitisation may be treated with propranolol, 1-2 mg IV or esmolol 25-100 microgm/kg/min IV.
Monitor the ECG for 4-6 hours
B: Specific drugs and antidotes:
There is no specific antidote
C: Decontamination
Inhalation; remove victim from exposure, and give supplemental oxygen if available.
Ingestion; (a) Prehospital: Administer activated charcoal, if available. DO NOT induce vomiting because of rapid absorption and the risk of abrupt onset CNS
depression. (b) Hospital: Administer activated charcoal, although the efficacy of charcoal is unknown. Perform gastric lavage only if the ingestion was very
large and recent (less than 30 minutes)
D: Enhanced elimination:
There is no documented efficacy for diuresis, haemodialysis, haemoperfusion, or repeat-dose charcoal.
POISONING and DRUG OVERDOSE, Californian Poison Control System Ed. Kent R Olson; 3rd Edition
Do not administer sympathomimetic drugs unless absolutely necessary as material may increase myocardial irritability.
No specific antidote.
Because rapid absorption may occur through lungs if aspirated and cause systematic effects, the decision of whether to induce vomiting or not should be
made by an attending physician.
If lavage is performed, suggest endotracheal and/or esophageal control.
Danger from lung aspiration must be weighed against toxicity when considering emptying the stomach.
Treatment based on judgment of the physician in response to reactions of the patient
For frost-bite caused by liquefied petroleum gas:
If part has not thawed, place in warm water bath (41-46 C) for 15-20 minutes, until the skin turns pink or red.
Analgesia may be necessary while thawing.
If there has been a massive exposure, the general body temperature must be depressed, and the patient must be immediately rewarmed by whole-body
immersion, in a bath at the above temperature.
Shock may occur during rewarming.
Administer tetanus toxoid booster after hospitalization.
Prophylactic antibiotics may be useful.
The patient may require anticoagulants and oxygen.
[Shell Australia 22/12/87]
For gas exposures:
--------------------------------------------------------------
BASIC TREATMENT
--------------------------------------------------------------
Establish a patent airway with suction where necessary.
Watch for signs of respiratory insufficiency and assist ventilation as necessary.
Administer oxygen by non-rebreather mask at 10 to 15 l/min.
Monitor and treat, where necessary, for pulmonary oedema .
Monitor and treat, where necessary, for shock.
Anticipate seizures.
--------------------------------------------------------------
ADVANCED TREATMENT
--------------------------------------------------------------
Consider orotracheal or nasotracheal intubation for airway control in unconscious patient or where respiratory arrest has occurred.
Positive-pressure ventilation using a bag-valve mask might be of use.
Monitor and treat, where necessary, for arrhythmias.
Start an IV D5W TKO. If signs of hypovolaemia are present use lactated Ringers solution. Fluid overload might create complications.
Drug therapy should be considered for pulmonary oedema.
Hypotension with signs of hypovolaemia requires the cautious administration of fluids. Fluid overload might create complications.
Treat seizures with diazepam.
Proparacaine hydrochloride should be used to assist eye irrigation.
BRONSTEIN, A.C. and CURRANCE, P.L.
EMERGENCY CARE FOR HAZARDOUS MATERIALS EXPOSURE: 2nd Ed. 1994

SECTION 5 FIREFIGHTING MEASURES

5.1. Extinguishing media

SMALL FIRE: Use extinguishing agent suitable for type of surrounding fire.
LARGE FIRE: Cool cylinder.
DO NOT direct water at source of leak or venting safety devices as icing may occur.

5.2. Special hazards arising from the substrate or mixture

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Avoid contamination with oxidising agents i.e. nitrates, oxidising acids, chlorine bleaches, pool chlorine etc. as ignition may
Fire Incompatibility
result

5.3. Advice for firefighters

--------------------------------------------------------------
GENERAL
--------------------------------------------------------------
Fire Fighting
Alert Fire Brigade and tell them location and nature of hazard.
Wear breathing apparatus and protective gloves.
Fight fire from a safe distance, with adequate cover.

Containers may explode when heated - Ruptured cylinders may rocket

Fire exposed containers may vent contents through pressure relief devices.
High concentrations of gas may cause asphyxiation without warning.
May decompose explosively when heated or involved in fire.
Decomposition may produce toxic fumes of:
,
carbon monoxide (CO)
Combustion products include:
Fire/Explosion Hazard
,
carbon dioxide (CO2)
,
hydrogen fluoride
,
other pyrolysis products typical of burning organic material.
Contains low boiling substance: Closed containers may rupture due to pressure buildup under fire conditions.
Vented gas is more dense than air and may collect in pits, basements.

SECTION 6 ACCIDENTAL RELEASE MEASURES

6.1. Personal precautions, protective equipment and emergency procedures

See section 8

6.2. Environmental precautions

See section 12

6.3. Methods and material for containment and cleaning up

Avoid breathing vapour and any contact with liquid or gas. Protective equipment including respirator should be used.
Minor Spills
DO NOT enter confined spaces where gas may have accumulated.
Clear area of all unprotected personnel and move upwind.
Alert Emergency Authority and advise them of the location and nature of hazard.
Wear breathing apparatus and protective gloves.
Major Spills Remove leaking cylinders to a safe place.
Fit vent pipes. Release pressure under safe, controlled conditions
Burn issuing gas at vent pipes.
DO NOT exert excessive pressure on valve; DO NOT attempt to operate damaged valve.

6.4. Reference to other sections

Personal Protective Equipment advice is contained in Section 8 of the SDS.

SECTION 7 HANDLING AND STORAGE

7.1. Precautions for safe handling

·Consider use in closed pressurised systems, fitted with temperature, pressure and safety relief valves which are vented
for safe dispersal. Use only properly specified equipment which is suitable for this product, its supply pressure and
temperature
·The tubing network design connecting gas cylinders to the delivery system should include appropriate pressure
Safe handling
indicators and vacuum or suction lines.
·Fully-welded types of pressure gauges, where the bourdon tube sensing element is welded to the gauge body, are
recommended.
DO NOT transfer gas from one cylinder to another.
Fire and explosion
See section 5
protection

·Do NOT store halogenated aliphatics in areas containing alkali or alkaline earth metals such as powdered aluminum,
zinc, or beryllium
Other information
Cylinders should be stored in a purpose-built compound with good ventilation, preferably in the open.
Such compounds should be sited and built in accordance with statutory requirements.
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The storage compound should be kept clear and access restricted to authorised personnel only.

7.2. Conditions for safe storage, including any incompatibilities

DO NOT use aluminium or galvanised containers
Cylinder:
Suitable container Ensure the use of equipment rated for cylinder pressure.
Ensure the use of compatible materials of construction.
Valve protection cap to be in place until cylinder is secured, connected.
As a general rule, hydrofluorocarbons tend to be flammable unless they contain more fluorine atoms than hydrogen atoms.
Haloalkanes:
are highly reactive:some of the more lightly substituted lower members are highly flammable; the more highly substituted may
be used as fire suppressants, not always with the anticipated results.
may react with the lighter divalent metals to produce more reactive compounds analogous to Grignard reagents.
Storage incompatibility may produce explosive compounds following prolonged contact with metallic or other azides
may react on contact with potassium or its alloys - although apparently stable on contact with a wide rage of halocarbons,
reaction products may be shock-sensitive and may explode with great violence on light impact; severity generally increases
with the degree of halocarbon substitution and potassium-sodium alloys give extremely sensitive mixtures .
Compressed gases may contain a large amount of kinetic energy over and above that potentially available from the energy of
reaction produced by the gas in chemical reaction with other substances

+ X + O + + +

X — Must not be stored together

0 — May be stored together with specific preventions
+ — May be stored together

7.3. Specific end use(s)

See section 1.2

SECTION 8 EXPOSURE CONTROLS / PERSONAL PROTECTION

8.1. Control parameters

DNELs PNECs
Ingredient
Exposure Pattern Worker Compartment
Inhalation 16 444 mg/m³ (Systemic, Chronic)
pentafluoroethane Not Available
Inhalation 1 753 mg/m³ (Systemic, Chronic) *

Inhalation 13 936 mg/m³ (Systemic, Chronic)

1,1,1,2-tetrafluoroethane Not Available
Inhalation 2 476 mg/m³ (Systemic, Chronic) *

Inhalation 38 800 mg/m³ (Systemic, Chronic)

1,1,1-trifluoroethane Not Available
Inhalation 10 700 mg/m³ (Systemic, Chronic) *

* Values for General Population

OCCUPATIONAL EXPOSURE LIMITS (OEL)

INGREDIENT DATA

Source Ingredient Material name TWA STEL Peak Notes

Not Available Not Available Not Available Not Available Not Available Not Available Not Available

EMERGENCY LIMITS

Ingredient Material name TEEL-1 TEEL-2 TEEL-3

1,1,1,2-tetrafluoroethane HFC 134a; (Tetrafluoroethane, 1,1,1,2-) Not Available Not Available Not Available

Ingredient Original IDLH Revised IDLH

pentafluoroethane Not Available Not Available

1,1,1,2-tetrafluoroethane Not Available Not Available

1,1,1-trifluoroethane 2,000 ppm Not Available

MATERIAL DATA
Sensory irritants are chemicals that produce temporary and undesirable side-effects on the eyes, nose or throat. Historically occupational exposure standards for
these irritants have been based on observation of workers' responses to various airborne concentrations. Present day expectations require that nearly every
individual should be protected against even minor sensory irritation and exposure standards are established using uncertainty factors or safety factors of 5 to 10 or
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more.
May act as a simple asphyxiants; these are gases which, when present in high concentrations, reduce the oxygen content in air below that required to support
breathing, consciousness and life; loss of consciousness, with death by suffocation may rapidly occur in an oxygen deficient atmosphere.
CARE: Most simple asphyxiants are odourless or possess low odour and there is no warning on entry into an oxygen deficient atmosphere. If there is any doubt,
oxygen content can be checked simply and quickly.

8.2. Exposure controls

Engineering controls are used to remove a hazard or place a barrier between the worker and the hazard. Well-designed
engineering controls can be highly effective in protecting workers and will typically be independent of worker interactions to
8.2.1. Appropriate
provide this high level of protection.
engineering controls
The basic types of engineering controls are:
Process controls which involve changing the way a job activity or process is done to reduce the risk.

8.2.2. Personal protection

Chemical goggles.
Eye and face protection Full face shield may be required for supplementary but never for primary protection of eyes.
Contact lenses may pose a special hazard; soft contact lenses may absorb and concentrate irritants.

Skin protection See Hand protection below

Butyl rubber gloves

·Butyl rubber gloves should be used when handling halogenated aliphatics .
·Nitrile, PVC-coated nitrile, and PVC protective equipment are not recommended
When handling sealed and suitably insulated cylinders wear cloth or leather gloves.
Hands/feet protection
Insulated gloves:
NOTE: Insulated gloves should be loose fitting so that may be removed quickly if liquid is spilled upon them. Insulated gloves are
not made to permit hands to be placed in the liquid; they provide only short-term protection from accidental contact with the
liquid.

Body protection See Other protection below

·Halogen-selective detectors use a specialized sensor that allows the monitor to detect compounds containing fluorine,
chlorine, bromine, and iodine with-out interference from other species.These detectors are typically easy to use, feature
higher sensitivity than the nonselective detectors (detection limits are typically <5 ppm when used as an area monitor
and <1.4 gm/yr [<0.05 oz/yr] when used as a leak pinpointer).
Other protection ·Compound-Specific Detectors are typically capable of detecting the presence of a single compound without
interference from other compounds.
Protective overalls, closely fitted at neck and wrist.
Eye-wash unit.
Ensure availability of lifeline in confined spaces.

Respiratory protection
Cartridge respirators should never be used for emergency ingress or in areas of unknown vapour concentrations or oxygen content.
The wearer must be warned to leave the contaminated area immediately on detecting any odours through the respirator. The odour may indicate that the mask
is not functioning properly, that the vapour concentration is too high, or that the mask is not properly fitted. Because of these limitations, only restricted use of
cartridge respirators is considered appropriate.
Cartridge performance is affected by humidity. Cartridges should be changed after 2 hr of continuous use unless it is determined that the humidity is less than
75%, in which case, cartridges can be used for 4 hr. Used cartridges should be discarded daily, regardless of the length of time used
Positive pressure, full face, air-supplied breathing apparatus should be used for work in enclosed spaces if a leak is suspected or the primary containment is to
be opened (e.g. for a cylinder change)
Air-supplied breathing apparatus is required where release of gas from primary containment is either suspected or demonstrated.

8.2.3. Environmental exposure controls

See section 12

SECTION 9 PHYSICAL AND CHEMICAL PROPERTIES

9.1. Information on basic physical and chemical properties

Appearance Liquefied pressure gas

Relative density (Water =

Physical state Liquified Gas 10
1)

Partition coefficient
Odour Not Available Not Available
n-octanol / water

Auto-ignition temperature
Odour threshold Not Available >700
(°C)
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Decomposition
pH (as supplied) Not Applicable Not Available
temperature
Melting point / freezing
<-100-760 Viscosity (cSt) Not Available
point (°C)
Initial boiling point and
-46.6-760 Molecular weight (g/mol) Not Available
boiling range (°C)
Flash point (°C) Not Available Taste Not Available

Evaporation rate Not Available Explosive properties Not Available

Flammability Not Available Oxidising properties Not Available

Surface Tension (dyn/cm
Upper Explosive Limit (%) Not Available Not Available
or mN/m)
Lower Explosive Limit (%) Not Available Volatile Component (%vol) Not Available

Vapour pressure (kPa) 690 Gas group Not Available

Solubility in water Immiscible pH as a solution (1%) Not Available

Vapour density (Air = 1) 3.42 VOC g/L Not Available

9.2. Other information

Not Available

SECTION 10 STABILITY AND REACTIVITY

10.1.Reactivity See section 7.2

Unstable in the presence of incompatible materials.
Product is considered stable.
10.2. Chemical stability
Hazardous polymerisation will not occur.
Extremely high temperatures.
10.3. Possibility of
See section 7.2
hazardous reactions

10.4. Conditions to avoid See section 7.2

10.5. Incompatible
See section 7.2
materials
10.6. Hazardous
See section 5.3
decomposition products

SECTION 11 TOXICOLOGICAL INFORMATION

11.1. Information on toxicological effects

The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified by EC Directives
using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control
measures be used in an occupational setting.
Exposure to high concentrations of fluorocarbons may produce cardiac arrhythmias or cardiac arrest due sensitisation of the
heart to adrenalin or noradrenalin. Deaths associated with exposures to fluorocarbons (specifically halogenated aliphatics) have
occurred in occupational settings and in inhalation of bronchodilator drugs.
Bronchospasm consistently occurs in human subjects inhaling fluorocarbons.
Acute intoxication by halogenated aliphatic hydrocarbons appears to take place over two stages. Signs of a reversible narcosis
are evident in the first stage and in the second stage signs of injury to organs may become evident, a single organ alone is
(almost) never involved.
Inhaled
Depression of the central nervous system is the most outstanding effect of most halogenated aliphatic hydrocarbons. Inebriation
and excitation, passing into narcosis, is a typical reaction. In severe acute exposures there is always a danger of death from
respiratory failure or cardiac arrest due to a tendency to make the heart more susceptible to catecholamines (adrenalin)

Material is highly volatile and may quickly form a concentrated atmosphere in confined or unventilated areas. The vapour may
displace and replace air in breathing zone, acting as a simple asphyxiant. This may happen with little warning of overexposure.
Symptoms of asphyxia (suffocation) may include headache, dizziness, shortness of breath, muscular weakness, drowsiness and
ringing in the ears. If the asphyxia is allowed to progress, there may be nausea and vomiting, further physical weakness and
unconsciousness and, finally, convulsions, coma and death. Significant concentrations of the non-toxic gas reduce the oxygen
level in the air.
Not normally a hazard due to physical form of product.
Ingestion
Considered an unlikely route of entry in commercial/industrial environments

Skin Contact Evidence exists, or practical experience predicts, that the material either produces inflammation of the skin in a substantial
number of individuals following direct contact, and/or produces significant inflammation when applied to the healthy intact skin of
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animals, for up to four hours, such inflammation being present twenty-four hours or more after the end of the exposure period.
Skin irritation may also be present after prolonged or repeated exposure; this may result in a form of contact dermatitis
(nonallergic). The dermatitis is often characterised by skin redness (erythema) and swelling (oedema) which may progress to
blistering (vesiculation), scaling and thickening of the epidermis.
The material may accentuate any pre-existing dermatitis condition
Skin contact is not thought to have harmful health effects (as classified under EC Directives); the material may still produce
health damage following entry through wounds, lesions or abrasions.

In common with other halogenated aliphatics, fluorocarbons may cause dermal problems due to a tendency to remove natural
oils from the skin causing irritation and the development of dry, sensitive skin. They do not appear to be appreciably absorbed.
Open cuts, abraded or irritated skin should not be exposed to this material
Entry into the blood-stream through, for example, cuts, abrasions, puncture wounds or lesions, may produce systemic injury with
harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.
Vapourising liquid causes rapid cooling and contact may cause cold burns, frostbite, even through normal gloves. Frozen skin
tissues are painless and appear waxy and yellow. Signs and symptoms of frost-bite may include "pins and needles", paleness
followed by numbness, a hardening an stiffening of the skin, a progression of colour changes in the affected area, (first white,
then mottled and blue and eventually black; on recovery, red, hot, painful and blistered).

Although the material is not thought to be an irritant (as classified by EC Directives), direct contact with the eye may produce
Eye transient discomfort characterised by tearing or conjunctival redness (as with windburn).
Direct contact with the eye may not cause irritation because of the extreme volatility of the gas; however concentrated
atmospheres may produce irritation after brief exposures..
Long-term exposure to the product is not thought to produce chronic effects adverse to health (as classified by EC Directives
Chronic using animal models); nevertheless exposure by all routes should be minimised as a matter of course.
Principal route of occupational exposure to the gas is by inhalation.

TOXICITY IRRITATION
UNICOOL R-404A
Not Available Not Available

TOXICITY IRRITATION
pentafluoroethane
Inhalation (rat) LC50: 2910 mg/l/4H[2] Not Available

TOXICITY IRRITATION
1,1,1,2-tetrafluoroethane
Inhalation (rat) LC50: 1500 mg/l/4h[2] Not Available

TOXICITY IRRITATION
1,1,1-trifluoroethane
Inhalation (rat) LC50: >53.938386 mg/l/4H[2] Not Available

Legend: 1. Value obtained from Europe ECHA Registered Substances - Acute toxicity 2.* Value obtained from manufacturer's SDS.
Unless otherwise specified data extracted from RTECS - Register of Toxic Effect of chemical Substances

PENTAFLUOROETHANE Cardiac sensitisation threshold limit >245400 mg/m3 Anaesthetic effects threshold limit 490800 mg/m3 * DuPont SDS

1,1,1,2- * with added oxygen - ZhongHao New Chemical Materials MSDS Excessive concentration can have a narcotic effect; inhalation
TETRAFLUOROETHANE of high concentrations of decomposition products can cause lung oedema.

NOTE: Substance has been shown to be mutagenic in at least one assay, or belongs to a family of chemicals producing damage
1,1,1-TRIFLUOROETHANE
or change to cellular DNA.
Disinfection by products (DBPs) re formed when disinfectants such as chlorine, chloramine, and ozone react with organic and
UNICOOL R-404A &
inorganic matter in water. The observations that some DBPs such as trihalomethanes (THMs), di-/trichloroacetic acids, and
1,1,1,2-
3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) are carcinogenic in animal studies have raised public concern over
TETRAFLUOROETHANE
the possible adverse health effects of DBPs. To date, several hundred DBPs have been identified.

Acute Toxicity Carcinogenicity

Skin Irritation/Corrosion Reproductivity

Serious Eye
STOT - Single Exposure
Damage/Irritation

Respiratory or Skin
STOT - Repeated Exposure
sensitisation

Mutagenicity Aspiration Hazard

Legend: – Data either not available or does not fill the criteria for classification
– Data available to make classification

SECTION 12 ECOLOGICAL INFORMATION

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UNICOOL R-404A

12.1. Toxicity

ENDPOINT TEST DURATION (HR) SPECIES VALUE SOURCE

UNICOOL R-404A Not Not Not
Not Available Not Available
Available Available Available

ENDPOINT TEST DURATION (HR) SPECIES VALUE SOURCE

LC50 96 Fish 43.427mg/L 3

pentafluoroethane EC50 48 Crustacea >97.9mg/L 2

EC50 72 Algae or other aquatic plants >114mg/L 2

NOEC 96 Fish 10mg/L 2

ENDPOINT TEST DURATION (HR) SPECIES VALUE SOURCE

LC50 96 Fish 29.671mg/L 3

1,1,1,2-tetrafluoroethane EC50 48 Crustacea 980mg/L 5

EC50 96 Algae or other aquatic plants 97.260mg/L 3

NOEC 72 Algae or other aquatic plants ca.13.2mg/L 2

ENDPOINT TEST DURATION (HR) SPECIES VALUE SOURCE

1,1,1-trifluoroethane LC50 96 Fish 22.095mg/L 3

EC50 96 Algae or other aquatic plants 70.891mg/L 3

Legend: Extracted from 1. IUCLID Toxicity Data 2. Europe ECHA Registered Substances - Ecotoxicological Information - Aquatic Toxicity
3. EPIWIN Suite V3.12 (QSAR) - Aquatic Toxicity Data (Estimated) 4. US EPA, Ecotox database - Aquatic Toxicity Data 5.
ECETOC Aquatic Hazard Assessment Data 6. NITE (Japan) - Bioconcentration Data 7. METI (Japan) - Bioconcentration Data 8.
Vendor Data

In addition to carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O), the greenhouse gases mentioned in the Kyoto Protocol include synthetic substances
that share the common feature of being highly persistent in the atmosphere and exhibiting very high specific radiative forcing (radiative forcing is the change in the
balance between radiation coming into the atmosphere and radiation out; a positive radiative forcing tends on average to warm the surface of the earth). These
synthetic substances include hydrocarbons that are partially fluorinated (HCFs) or totally fluorinated (PFCs) as well as sulfur hexafluoride (SF6).
The greenhouse potential of these substances, expressed as multiples of that of CO2, are within the range of 140 to 11,700 for HFCs, from 6500 to 9,200 for
PFCs and 23,900 for SF6.

12.2. Persistence and degradability

Ingredient Persistence: Water/Soil Persistence: Air
pentafluoroethane HIGH HIGH

1,1,1,2-tetrafluoroethane HIGH HIGH

1,1,1-trifluoroethane HIGH HIGH

12.3. Bioaccumulative potential

Ingredient Bioaccumulation

pentafluoroethane LOW (LogKOW = 1.5472)

1,1,1,2-tetrafluoroethane LOW (LogKOW = 1.68)

1,1,1-trifluoroethane LOW (LogKOW = 1.7393)

12.4. Mobility in soil

Ingredient Mobility

pentafluoroethane LOW (KOC = 154.4)

1,1,1,2-tetrafluoroethane LOW (KOC = 96.63)

1,1,1-trifluoroethane LOW (KOC = 48.64)

12.5.Results of PBT and vPvB assessment

P B T

Relevant available data Not Applicable Not Applicable Not Applicable

PBT Criteria fulfilled? Not Applicable Not Applicable Not Applicable
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UNICOOL R-404A

12.6. Other adverse effects

No data available

SECTION 13 DISPOSAL CONSIDERATIONS

13.1. Waste treatment methods

Evaporate residue at an approved site.
Product / Packaging
Return empty containers to supplier. If containers are marked non-returnable establish means of disposal with manufacturer
disposal
prior to purchase.

Waste treatment options Not Available

Sewage disposal options Not Available

SECTION 14 TRANSPORT INFORMATION

Labels Required

Marine Pollutant NO

Land transport (ADR)

14.1. UN number 3337

14.2. UN proper shipping REFRIGERANT GAS R 404A (Pentafluoroethane, 1,1,1- trifluoroethane, and 1,1,1,2- tetrafluoroethane zeotropic mixture with
name approximately 44% pentafluoroethane and 52% 1,1,1- trifluoroethane)

14.3. Transport hazard Class 2.2

class(es) Subrisk Not Applicable

14.4. Packing group Not Applicable

14.5. Environmental
Not Applicable
hazard

Hazard identification (Kemler) 20

Classification code 2A

14.6. Special precautions Hazard Label 2.2

for user Special provisions 662

Limited quantity 120 ml

Tunnel Restriction Code 3 (C/E)

Air transport (ICAO-IATA / DGR)

14.1. UN number 3337

14.2. UN proper shipping

Refrigerant gas R 404A
name

ICAO/IATA Class 2.2

14.3. Transport hazard
ICAO / IATA Subrisk Not Applicable
class(es)
ERG Code 2L

14.4. Packing group Not Applicable

14.5. Environmental
Not Applicable
hazard

Special provisions Not Applicable

Cargo Only Packing Instructions 200

14.6. Special precautions
Cargo Only Maximum Qty / Pack 150 kg
for user
Passenger and Cargo Packing Instructions 200

Passenger and Cargo Maximum Qty / Pack 75 kg

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UNICOOL R-404A

Passenger and Cargo Limited Quantity Packing Instructions Forbidden

Passenger and Cargo Limited Maximum Qty / Pack Forbidden

Sea transport (IMDG-Code / GGVSee)

14.1. UN number 3337

14.2. UN proper shipping

REFRIGERANT GAS R 404A
name

14.3. Transport hazard IMDG Class 2.2

class(es) IMDG Subrisk Not Applicable

14.4. Packing group Not Applicable

14.5. Environmental
Not Applicable
hazard

EMS Number F-C , S-V

14.6. Special precautions
Special provisions Not Applicable
for user
Limited Quantities 120 mL

Inland waterways transport (ADN)

14.1. UN number 3337
14.2. UN proper shipping REFRIGERANT GAS R 404A (Pentafluoroethane, 1,1,1- trifluoroethane, and 1,1,1,2-tetrafluoroethane zeotropic mixture with
name approximately 44% pentafluoroethane and 52% 1,1,1-trifluoroethane)
14.3. Transport hazard
2.2 Not Applicable
class(es)
14.4. Packing group Not Applicable
14.5. Environmental
Not Applicable
hazard

Classification code 2A
Special provisions 662
14.6. Special precautions
Limited quantity 120 ml
for user
Equipment required PP
Fire cones number 0

14.7. Transport in bulk according to Annex II of MARPOL and the IBC code
Not Applicable

SECTION 15 REGULATORY INFORMATION

15.1. Safety, health and environmental regulations / legislation specific for the substance or mixture

PENTAFLUOROETHANE IS FOUND ON THE FOLLOWING REGULATORY LISTS

Europe ADN - European Agreement concerning the International Carriage of European Union - European Inventory of Existing Commercial Chemical
Dangerous Goods by Inland Waterways Substances (EINECS)
Europe EC Inventory European Union (EU) Transport of Dangerous Goods by Road - Dangerous
Europe ECHA Registered Substances - Classification and Labelling - Goods List
DSD-DPD International Air Transport Association (IATA) Dangerous Goods Regulations
Europe European Agreement concerning the International Carriage of International Maritime Dangerous Goods Requirements (IMDG Code)
Dangerous Goods by Road Regulations concerning the International Carriage of Dangerous Goods by
Europe European Customs Inventory of Chemical Substances Rail - Table A: Dangerous Goods List - RID 2019 (English)
European Chemical Agency (ECHA) Classification & Labelling Inventory - United Nations Recommendations on the Transport of Dangerous Goods
Chemwatch Harmonised classification Model Regulations

1,1,1,2-TETRAFLUOROETHANE IS FOUND ON THE FOLLOWING REGULATORY LISTS

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UNICOOL R-404A

Europe ADN - European Agreement concerning the International Carriage of European Union - European Inventory of Existing Commercial Chemical
Dangerous Goods by Inland Waterways Substances (EINECS)
Europe EC Inventory European Union (EU) Transport of Dangerous Goods by Road - Dangerous
Europe ECHA Registered Substances - Classification and Labelling - Goods List
DSD-DPD International Air Transport Association (IATA) Dangerous Goods Regulations
Europe European Agreement concerning the International Carriage of International Maritime Dangerous Goods Requirements (IMDG Code)
Dangerous Goods by Road Regulations concerning the International Carriage of Dangerous Goods by
Europe European Customs Inventory of Chemical Substances Rail - Table A: Dangerous Goods List - RID 2019 (English)
European Chemical Agency (ECHA) Classification & Labelling Inventory - United Nations Recommendations on the Transport of Dangerous Goods
Chemwatch Harmonised classification Model Regulations

1,1,1-TRIFLUOROETHANE IS FOUND ON THE FOLLOWING REGULATORY LISTS

Europe ADN - European Agreement concerning the International Carriage of European Union - European Inventory of Existing Commercial Chemical
Dangerous Goods by Inland Waterways Substances (EINECS)
Europe EC Inventory European Union (EU) Transport of Dangerous Goods by Road - Dangerous
Europe ECHA Registered Substances - Classification and Labelling - Goods List
DSD-DPD International Air Transport Association (IATA) Dangerous Goods Regulations
Europe European Agreement concerning the International Carriage of International Maritime Dangerous Goods Requirements (IMDG Code)
Dangerous Goods by Road Regulations concerning the International Carriage of Dangerous Goods by
Europe European Customs Inventory of Chemical Substances Rail - Table A: Dangerous Goods List - RID 2019 (English)
European Chemical Agency (ECHA) Classification & Labelling Inventory - United Nations Recommendations on the Transport of Dangerous Goods
Chemwatch Harmonised classification Model Regulations

This safety data sheet is in compliance with the following EU legislation and its adaptations - as far as applicable - : Directives 98/24/EC, - 92/85/EEC, - 94/33/EC,
- 2008/98/EC, - 2010/75/EU; Commission Regulation (EU) 2015/830; Regulation (EC) No 1272/2008 as updated through ATPs.

15.2. Chemical safety assessment

No Chemical Safety Assessment has been carried out for this substance/mixture by the supplier.

National Inventory Status

National Inventory Status
Australia - AICS Yes
Canada - DSL Yes

Canada - NDSL No (pentafluoroethane; 1,1,1,2-tetrafluoroethane; 1,1,1-trifluoroethane)

China - IECSC Yes
Europe - EINEC / ELINCS /
Yes
NLP
Japan - ENCS Yes

Korea - KECI Yes

New Zealand - NZIoC Yes

Philippines - PICCS Yes

USA - TSCA Yes

Taiwan - TCSI Yes

Mexico - INSQ Yes

Vietnam - NCI Yes

Russia - ARIPS Yes

Yes = All CAS declared ingredients are on the inventory
Legend: No = One or more of the CAS listed ingredients are not on the inventory and are not exempt from listing(see specific ingredients
in brackets)

SECTION 16 OTHER INFORMATION

Revision Date 08/07/2019

Initial Date 18/06/2016

CONTACT POINT
- For quotations contact your local Customer Services - http://wssdirectory.wilhelmsen.com/#/customerservices - - Responsible for safety data sheet Wilhelmsen
Ships Service AS - Prepared by: Product HSE Manager, - Email: Email: WSS.GLOBAL.SDSINFO@wilhelmsen.com - Telephone: Tel.: +31 10 4877775

Full text Risk and Hazard codes

H220 Extremely flammable gas.
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UNICOOL R-404A

SDS Version Summary

Version Issue Date Sections Updated
3.4.1.1.1 08/07/2019 Physical Properties, Synonyms

Other information
Classification of the preparation and its individual components has drawn on official and authoritative sources as well as independent review by the Chemwatch
Classification committee using available literature references.

The SDS is a Hazard Communication tool and should be used to assist in the Risk Assessment. Many factors determine whether the reported Hazards are Risks
in the workplace or other settings. Risks may be determined by reference to Exposures Scenarios.

For detailed advice on Personal Protective Equipment, refer to the following EU CEN Standards:
EN 166 Personal eye-protection
EN 340 Protective clothing
EN 374 Protective gloves against chemicals and micro-organisms
EN 13832 Footwear protecting against chemicals
EN 133 Respiratory protective devices

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