Noradrenaline (Norepinephrine) : 1mg/mL

What is Noradrenaline (Norepinephrine) and its
uses?
 Norepinephrine is a drug that belongs to the group of
adrenergic and dopaminergic agent.
 The drug is indicated for the emergency restoration of
blood pressure in cases of acute hypotension.
 Norepinephrine may also be used for purposes not
listed in this medication guide such as cardiac surgery,
shock, cardiac arrest (Chen et al., 2018).
Noradrenaline
(Norepinephrine)
1mg/mL
Things to Consider before Taking Norepinephrine How is norepinephrine given?
Norepinephrine cannot be administered if:
 The patient is hypersensitive or allergic to

Noradrenaline preparations or to any form of this drug.
Special care will be taken if the patient (Drugs.com, 2019):
 Elderly
 Have low levels of oxygen in the blood  Norepinephrine is provided as an infusion into a vein.
 A healthcare provider will give an injection of this
 Have a type of angina (chest pain) called Prinzmetal’s drug.
angina  Norepinephrine is normally given for as long as needed
until your body responds to the medication.
 Suffer from high blood pressure
 Some people must receive norepinephrine for several
 Have low blood pressure following a heart attack days.
 Have an over-active thyroid Dosage
 Have clots or obstructions in the blood vessels  Initial dose: 8 to 12 mcg/min continuous IV infusion
supplying the heart, intestines, or other parts of the  Maintenance dose: 2 to 4 mcg/min continuous IV
body infusion
 Duration of therapy: Continue infusion until adequate
 Hypotensive (have a low blood pressure) that has been blood pressure and tissue perfusion are maintained
caused by hypovolaemia (low blood volume) without therapy (Drugs.com, 2019).
 Have high levels of carbon dioxide in the blood

Interactions Pregnancy and Breast-feeding
A number of medicines are known to increase the toxic effects  Noradrenaline may harm the unborn baby
of Norepinephrine  No information is available on the use of noradrenaline
during lactation.
 Anesthetics: Increase cardiac automatic irritability and  The medicinal product must be stored out of the sight
sensitize the myocardium to the action of intravenously and reach of children (Chen et al., 2018).
administered Norepinephrine, thus, the risk of
generating fibrillation.
 Inhibitors and antidepressants: Norepinephrine
should be taken with extreme caution in patients using
antidepressants such as monoamine oxidase inhibitors
and tricyclic antidepressants, because it may result in
prolonged hypotension (Drugs.com, 2019).
Possible Side Effects

Inform the doctor immediately if you experience:
 Pain and/or swelling at the injection spot

 Instant itchy rash or a feeling that you are going to faint
Other side effects include: Nursing Considerations/Patient Teaching
 Abnormal heart rhythm
 Norepinephrine should not be used after the expiry
 Pain in the extremities
date, which is stated on the label.
 Slow heart rate
 Once it is opened, the product should be used instantly.
 Cold extremities
 The drug should not be used if the color of the solution
 Anxiety
is darker or pink or comprise a precipitate.
 Breathing difficulties
 Do not store the medicine in an environment with
above 25° C.
 If overdose occurs, discontinue norepinephrine and
administer fluid and electrolyte replacement therapy.
 An alpha-adrenergic blocking agent (phentolamine 5–
10 mg) may be administered intravenously to treat
hypertension.
 The drug should not be thrown in an open area or in
water.
References
Chen, Y. et al. (2018). Norepinephrine Administration Is

Associated with Higher Mortality in Dialysis Requiring Acute
Kidney Injury Patients with Septic Shock. Journal of clinical
medicine, 7(9), 274. doi:10.3390/jcm7090274
Drugs.com. (2019). Norepinephrine Uses, Side Effects &

Warnings - Drugs.com. Retrieved 29 August 2019, from
https://www.drugs.com/mtm/norepinephrine.html

Noradrenaline (Norepinephrine) : 1mg/mL

Uploaded by

Copyright:

Available Formats

Noradrenaline (Norepinephrine) : 1mg/mL

Uploaded by

Document Information

Original Title

Copyright

Available Formats

Share this document

Share or Embed Document

Sharing Options

Did you find this document useful?

Is this content inappropriate?

Copyright:

Available Formats

Noradrenaline (Norepinephrine) : 1mg/mL

Uploaded by

Copyright:

Available Formats

What is Noradrenaline (Norepinephrine) and its

 The patient is hypersensitive or allergic to

Special care will be taken if the patient (Drugs.com, 2019):

 Have an over-active thyroid Dosage

 Have high levels of carbon dioxide in the blood

Possible Side Effects

 Pain and/or swelling at the injection spot

Chen, Y. et al. (2018). Norepinephrine Administration Is

Drugs.com. (2019). Norepinephrine Uses, Side Effects &

You might also like