Drug Interaction
Drug Interaction
Drug Interaction
Absorption interactions
is defined as the pharmacological activity of one drug is altered
by the concominant use of another drug or by the presence of Are those where the absorption of the object drug is altered.
some other substance. The net effect of such an interaction is:
Faster or slower drug absorption.
The Drug whose Activity is effected by such an Interaction is More, or, less complete drug absorption.
called as a “Object drug.”
The agent which precipitates such an interaction is referred to Major mechanisms of absorption interactions are:
as the “Precipitant”.
1.Complexation and adsorption.
TYPES OF DRUG INTERACTIONS 2.Alteration in GI pH.
1.Drug-drug interactions. 3.Alteration in gut motility.
2.Drug-food interactions. 4.Inhibition of GI enzymes.
3.Chemical-drug interactions. 5.Alteration of GI micro flora.
4.Drug-laboratory test interactions. 6.Malabsorption syndrome.
5.Drug-disease interactions.
Mostly undesirable
Pharmacokinetic Interactions:
These interactions are those in which adme properties of the
object drug is altered by the precipitant and hence such
interactions are also called as ADME interactions.
The resultant effect is altered plasma concentration of the
object drug.
These are classified as:
1.Absorption interactions
2.Distribution interactions
3.Metabolism interactions
4.Excretion interactions.
EXCRETION INTERACTIONS
Are these where the excretion pattern of the object drug is
altered. Major mechanisms of excretion interactions are:
Alteration in renal blood flow
Alteration of urine PH
Competition for active secretions
Forced diuresis