ABAS, ALEXANDER MIGUEL 04/01/20

NCM 109 RLE (NICU, MA’AM EVIA)

DRUG STUDY ABOUT CARBAMAZEPINE, AN ANTICONVULSANT DRUG GIVEN TO DOWN SYNDROME

PATIENTS WITH SEIZURE ATTACKS.
GENERIC/BRAN MECHANISM OF INDICATION CONTRAIND SIDE EFFECTS/ NURSING RESPONSIBILITY
D NAME ACTION I-CATION ADVERSE
EFFECTS
GENERIC NAME: • Carbamazepine • PO Epilepsy • Patients w/ • Dizziness • Use only for classifications listed. Do
• Carbamazepine depresses • Trigeminal AV block, • Drowsiness not use as a general analgesic. Use
activity in the Neuralgia history of • Ataxia only for epileptic seizures that are
BRAND NAME: nucleus • Prophylaxis bone • Nausea refractory to other safer agents.
• Carbastal ventralis of the Of Bipolar marrow • Vomiting • Give drug with food to prevent GI
• Carbilepp thalamus, Disorder depression • Dry Mouth upset.
• Epazin reduces synaptic • Rectal or history of • Abdominal Pain • Do not mix suspension with other
• Epikor propagation of Epilepsy hepatic medications or elements—
• Anorexia
• Lestremor excitatory porphyrias. precipitation may occur.
• Diarrhoea Or
• Mezacar impulses or • WARNING: Reduce dosage,
Constipation
• Tegrepin decreases • Concurrent discontinue, or substitute other
summation of • Mild Skin
• Tegretol use w/ or antiepileptic medication gradually.
temporal Reactions
w/in 14 Abrupt discontinuation of all
stimulation days of • Disturbances Of
Cerebellar And antiepileptic medication may
leading to MAOI use. precipitate status epilepticus.
neural discharge Oculo-Motor
Function • Suspension will produce higher peak
by limiting • Concurrent levels than tablets—start with a lower
influx of Na use w/ • Transient
Leucopenia dose given more frequently.
ions across cell nefazodone.
 membrane or • Eosinophilia • Ensure that patient swallows ER
other unknown • Leukocytosis tablets whole—do not cut, crush, or
mechanisms. • Thrombocyte- chew.
paenia • Arrange for frequent liver function
• It stimulates the • Purpura tests; discontinue drug immediately if
release of • Lymphadeno- hepatic dysfunction occurs.
antidiuretic pathy • WARNING: Arrange for patient to
hormone (ADH) • Splenomegaly, have CBC, including
and potentiates Pneumonitis platelet, reticulocyte counts, and
its action in • Abonormalities serum iron determination, before
promoting of Liver And initiating therapy; repeat weekly for
reabsorption of Kidney the first 3 mo of therapy and monthly
water. Function thereafter for at least 2–3 yr.
• Hepatitis Discontinue drug if there is evidence
• Cholestatic of marrow suppression, as follows:
Jaundice • Arrange for frequent eye
• Hyponatraemia examinations, urinalysis, and BUN
• Oedema determinations.
• Paraesthesia • Arrange for frequent monitoring of
serum levels of carbamazepine and
• Headache
other antiepileptics given
• Arrhythmias concomitantly, especially during the
And Heart first few weeks of therapy. Adjust
Block dosage on basis of data and clinical
• Impotence response.
• Male Infertility • Counsel women who wish to become
• Gynaecomastia pregnant; advise the use of barrier
• Galactorrhoea contraceptives.
• Dystonias • Evaluate for therapeutic serum levels
• Dykinesias W/ (usually 4–12 mcg/mL).
Asterixis
• Local Irritation Teaching points
W/ Rectal Use. • Take drug with food as prescribed.
Swallow ER tablets whole, do not cut,
• Potentially crush, or chew them.
Fatal: • Do not discontinue this drug abruptly
o HLA- or change dosage, except on the
B*1502 And advice of your physician.
HLA- • Avoid alcohol, sleep-inducing, or
A*3101 Allele OTC drugs; these could cause
: dangerous effects.
§ Serious • Arrange for frequent checkups,
Dermatolog including blood tests, to monitor your
ic Reactions response to this drug. Keep all
(E.G. appointments for checkups.
Stevens- • Use contraceptives at all times; if you
Johnson wish to become pregnant, you should
Syndrome, consult your physician.
Toxic • Wear a medical alert tag at all times
Epidermal so that any emergency medical
Necrolysis). personnel will know that you have
epilepsy and are taking antiepileptic
§ Apalastic medication.
Anaemia, • You may experience these side
Agranulocy effects: Drowsiness, dizziness, blurred
tosis, CV vision (avoid driving or performing
Effects other tasks requiring alertness or
(E.G. CHF). visual acuity); GI upset (take the drug
 with food or milk; eat frequent small
meals).
• Report bruising, unusual bleeding,
abdominal pain, yellowing of the skin
or eyes, pale feces, darkened urine,
impotence, CNS disturbances, edema,
fever, chills, sore throat, mouth ulcers,
rash, pregnancy.