Pharmaceutical Dosage Forms, Drug Delivery Systems and Medical Devices Pharm 201L Name:Tallod, Emerson John L. Group:11 Year/Section:Q2A Final Rating

Pharmaceutical Dosage Forms, Drug Delivery Systems and Medical Devices
Pharm 201L
Name:Tallod, Emerson John L. Group:11

Year/Section:Q2A Final Rating:
PREPARATION No. 01
PARACETAMOL DIVIDED POWDERS
A. WRAP-UP GUIDE QUESTIONS:
Synonym/s: Acetaminophen pulveres

Uses of Preparation: Analgesic and antipyretic
Method/s of Preparation used: Spatulation and trituration
Method/s of Administration: May be taken with or without food.
Packaging material/s used in the preparation: Glassine, vegetable parchment, waxed, bond
paper
Particular Equipment (if any):
Ideal temperature and storage conditions: Store at temperatures not exceeding 30°C. Protect
from light.
Description of Finished Product: A white crystalline fine powder, odorless, and enclosed in a
white elegant paper
B. Facsimile label:
Each 800mg contains: Lot No: 0920S0111

Mfg Date: 09/03/2020
Exp Date: 09/03/2022
300mg Paracetamol Amount: 800mg
500mg Lactose
PARACETAMOL
O-Payne
Indication:
Mild to moderate pain
and fever. 300mg TABLET
ANTIPYRETIC
Manufactured by:
ECE Pharmaceuticals Inc.
UPH-DJGTMU College of Pharmacy
Storage: Keep tightly
Direction: closed in a cool and dry
PO 0.5-1 g 4-6 hourly place.
Pharm 201L
Formula based on preparation:

Raw Materials Quantity Physical Appearance Uses
Paracetamol 300mg x 5 = Odorless white crystalline Antipyretic and
1500mg solid. Bitter taste. pH analgesic effects.
(saturated aqueous
solution) about 6.
Lactose 500mg x 5 = White hard crystalline Humectant
2500mg powder
C. Calculation(s):
ORIGINAL QUANTITIES NEEDED + COMPUTED
INGREDIENTS ORIGINAL QUANTITY COMPUTED QUANTITY

Paracetamol 3g 1.5g (2.5g x 3g / 5 g)
Lactose 5g 2.5g (5pap x 5g / 10pap)
TO MAKE 10 papelitos 5 papelitos
D. Attachment(s) of actual laboratory activity: (if any)
E. CRUSHED LACTOSE (IT’S

PARACETAMOL ACTUALLY A
Self- FOOT POWDER) AFTER CRUSHING OF BOTH INTO FINE
Reflection: POWDERS, BOTH ARE MIXED.
• What have you learned from the activity?

Today, I have learned how to be able to crush Paracetamol with what I have, basically,
and that I am able to learn how to produce a division of a powdered paracetamol as a
method of drug compounding.
THE MIXED POWDER IS THEN DIVIDED INTO FIVE

Pharm 201L
• Based on the discussion, what specific topic will surely be useful on your future
chosen career?
It is very essential to me, first and foremost, to be able to crush the Paracetamol, or any
other drugs that are in a tablet dosage form, as some may be hard to crush, while there are
some that can be crushed easily. It is also important to be able to completely make them
look like as if they were powders before mixing them with lactose.
• How will this benefit you as future pharmacist?

This drug preparation is beneficial to me, as most of our population take antipyretics like
paracetamol. It is essential that by compounding a powdered form of these, the efficacy
must be maintained even after being administered their users.
POST-LAB QUESTIONS
1. Give examples of apparatus/equipment used in the laboratory.
a. SPATULA – used for scraping, transferring, or applying powders and pastes

b. PILL TILE – used for placing and rolling solid dosage forms like tablets and pills.
c. MORTAR AND PESTLE – a pair used for crushing and grinding solid dosage forms into
Pharm 201L
fine powders or granules
2. What is the definition of powders based on USP?
- In compounding, "powder" refers to a dosage formulation that is solid in physical state. But
the formulation may be composed of only the active drug or may be a mixture of the active
drug and other ingredients.
3. What are the types of paper intended to be use in the preparation of divided powders?
- Glassine, vegetable parchment, waxed, bond paper
4. Give the advantage and disadvantage of powders.
• ADVANTAGES
a. each dose can contain a different amount of active drug

b. can be administered easily to infants and young children who cannot swallow tablets or
capsules
c. drug will have a rapid onset of action since disintegration is not required
d. can be applied to many body cavities such as ears, nose, tooth socket, throat
e. drugs tend to most stable as a solid
f. can be made into many different dosage formulations (capsules, tablets, powders for
reconstitution, dusting powders, bulk powders, powders for inhalation, etc.)
• DISADVANTAGES
a. As compared to other dosage forms, powders are time consuming to compound.

b. Volatile, hygroscopic, oxidizing and deliquescent drugs create obvious difficulties when
dispensed as powders.
c. Dose inaccuracy.
ACTIVITY 1
I. WEIGHING PAPER
Pharm 201L
II. PRESCRIPTION DRUG
Formulation Amount Lot no: 2009S0116

Manufacturing date:
:
Pharm 201L
Each… contains…
Expiry date:
GENERIC NAME
Brand Name RX
Dosage Form and Strength
Pharmacological Category
Indication :
Manufactured by:
ECE Pharmaceuticals Inc.
UPHDJGTMU – College of Pharmacy

Direction for use: closed in a cool and dry
place.
III. NON-PRESCRIPTION DRUG
Lot no: 2009S0116

Formulation Amount: Manufacturing date:
Each… contains… Expiry date:

GENERIC NAME
Brand Name
Indication :
Dosage Form and Strength
Pharmacological Category
Manufactured by:
Direction for use: ECE Pharmaceuticals Inc. closed in a cool and dry
UPHDJGTMU – College of place.
Pharmacy
Pharm 201L
REFERENCES:
MIMS Philippines (n.d.). Biogesic Dosage and Drug Information. Retrieved September 4, 2020
from https://www.mims.com/philippines/drug/info/biogesic.
National Center for Biotechnology Information (2020). PubChem Compound Summary for CID
1983, Acetaminophen. Retrieved September 4, 2020 from
https://pubchem.ncbi.nlm.nih.gov/compound/Acetaminophen.
National Center for Biotechnology Information (2020). PubChem Compound Summary for CID
6134, beta-Lactose. Retrieved September 5, 2020 from
https://pubchem.ncbi.nlm.nih.gov/compound/beta-Lactose.
Sharma, M. (n.d.). What are the Advantages and Disadvantages of Powder Medicine? Retrieved
September 5, 2020 from https://www.preservearticles.com/education/what-are-the-
advantagesand-disadvantages-of-powder-medicine/16927.
The UNC School of Pharmacy Compounding Lab (n.d.). Powders. Retrieved September 5, 2020
from https://pharmlabs.unc.edu/labs/powders/properties.htm.

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Pharmaceutical Dosage Forms, Drug Delivery Systems and Medical Devices

Name:Tallod, Emerson John L. Group:11

A. WRAP-UP GUIDE QUESTIONS:

Synonym/s: Acetaminophen pulveres

Each 800mg contains: Lot No: 0920S0111

Formula based on preparation:

INGREDIENTS ORIGINAL QUANTITY COMPUTED QUANTITY

D. Attachment(s) of actual laboratory activity: (if any)

E. CRUSHED LACTOSE (IT’S

• What have you learned from the activity?

THE MIXED POWDER IS THEN DIVIDED INTO FIVE

• How will this benefit you as future pharmacist?

1. Give examples of apparatus/equipment used in the laboratory.

a. SPATULA – used for scraping, transferring, or applying powders and pastes

fine powders or granules

2. What is the definition of powders based on USP?

- Glassine, vegetable parchment, waxed, bond paper

4. Give the advantage and disadvantage of powders.

a. each dose can contain a different amount of active drug

a. As compared to other dosage forms, powders are time consuming to compound.

II. PRESCRIPTION DRUG

Formulation Amount Lot no: 2009S0116

Storage: Keep tightly

III. NON-PRESCRIPTION DRUG

Lot no: 2009S0116

Each… contains… Expiry date:

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