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    Preparation #: Divided Powders I. Objectives:: Pharmaceutical Dosage Forms Laboratory Manual

    Uploaded by

    lalag yan
    This document provides instructions for preparing divided powders from a levothyroxine sodium tablet. The objectives are to determine comminution and mixing techniques for powders, understand advantages and disadvantages of powders, and establish USP particle size standards. The procedure involves triturating a levothyroxine tablet, dividing it into 5 equal parts on a tile using a spatula, placing each part in a folded glassine paper, collecting the papers in an envelope, and cleaning the work area. Powders are mixtures of finely divided solids that can be used internally or externally and may be packaged as bulk or divided powders.

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    Preparation #: Divided Powders I. Objectives:: Pharmaceutical Dosage Forms Laboratory Manual

    Uploaded by

    lalag yan
    2K views2 pages
    This document provides instructions for preparing divided powders from a levothyroxine sodium tablet. The objectives are to determine comminution and mixing techniques for powders, understand advantages and disadvantages of powders, and establish USP particle size standards. The procedure involves triturating a levothyroxine tablet, dividing it into 5 equal parts on a tile using a spatula, placing each part in a folded glassine paper, collecting the papers in an envelope, and cleaning the work area. Powders are mixtures of finely divided solids that can be used internally or externally and may be packaged as bulk or divided powders.

    Original Description:

    Powders are mixtures of finely divided solids or chemicals in a dry form.

    Original Title

    Divided Powders

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    This document provides instructions for preparing divided powders from a levothyroxine sodium tablet. The objectives are to determine comminution and mixing techniques for powders, understand advantages and disadvantages of powders, and establish USP particle size standards. The procedure involves triturating a levothyroxine tablet, dividing it into 5 equal parts on a tile using a spatula, placing each part in a folded glassine paper, collecting the papers in an envelope, and cleaning the work area. Powders are mixtures of finely divided solids that can be used internally or externally and may be packaged as bulk or divided powders.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    2K views2 pages

    Preparation #: Divided Powders I. Objectives:: Pharmaceutical Dosage Forms Laboratory Manual

    Uploaded by

    lalag yan
    This document provides instructions for preparing divided powders from a levothyroxine sodium tablet. The objectives are to determine comminution and mixing techniques for powders, understand advantages and disadvantages of powders, and establish USP particle size standards. The procedure involves triturating a levothyroxine tablet, dividing it into 5 equal parts on a tile using a spatula, placing each part in a folded glassine paper, collecting the papers in an envelope, and cleaning the work area. Powders are mixtures of finely divided solids that can be used internally or externally and may be packaged as bulk or divided powders.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
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    Pharmaceutical Dosage Forms Laboratory Manual

    PREPARATION # : DIVIDED POWDERS


    1
    I. Objectives:

    1. Determine the different comminution and mixing techniques.


    2. Know the advantages and disadvantages of powders.
    3. Establish the USP standards for the particle size of powders.
    II. Materials:

    Levothyroxine Na Pill Tile


    (Eltroxin 50 g tablet #1) Stainless Steel Spatula
    Glassine paper
    White bond paper
    Scissors
    Paste/Glue
    Mortar and Pestle
    III. Discussion:

    Powders are mixtures of finely divided solids or chemicals in a dry form. The
    powders may be used internally or externally. Depending on their intended use,
    powders are packaged and dispensed as bulk powders and divided powders.
    On a small scale, the most common comminution techniques are trituration,
    pulverization by intervention, and levigation. On a large scale, various mills and
    pulverizers are used.
    Micromeritics is the study of small particles.
    Divided powders are dispensed in individual doses, usually in folded papers. They
    may also be dispensed in metal foil, small heat-sealed or resealable plastic bags,
    or other containers. The method of preparation is block and divide.

    IV. Formula:

    Ingredient: Original Amount


    Levothyroxine Na (Eltroxin) tablet 50.00 g per tablet

    V. Procedure:

    1. Triturate the tablet using mortar and pestle.


    2. Place the powdered tablet on the pill tile.
    3. Divide into 5 (five) equal parts using the stainless steel spatula.
    4. Place each divided powder in a cut glassine paper. Please check the
    proper procedure on how to fold the glassine paper to form a paper powder.

    1
    Pharmaceutical Dosage Forms Laboratory Manual

    5. Collect all paper tablets and transfer them into a small envelope made of
    a white bond envelope.
    6. Label properly.

    VI. Clean-Up Procedure:

    1. Dispose of the cut papers, e.g., white bond paper and glassine papers,
    into the garbage bin.
    2. Clean the pill tile by washing with soap and water. Wipe dry and return it
    to the laboratory assistant/technician.
    3. Clean your working area before leaving the laboratory.

    VII. References:

    Allen, L.V., Popovich, N.G. & Ansel, H.C. (2018). Powders & Granules In Ansel’s
    Pharmaceutical Dosage Forms and Drug Delivery System (11th edition) (pp. 184-
    202). Philadelphia: Wolters Kluwer/Lippincott Williams and Wilkins.

    Allen, L.V. Powders In Remington: The Science & Practice of Pharmacy (23rd
    edition)(pp. 777-800). Philadelphia: Pharmaceutical Press.

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