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    Pharmaceutical Dosage Forms Laboratory Manual

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    lalag yan
    This document provides instructions for preparing chocolate-based calcium lozenges. It discusses that lozenges are solid dosage forms intended to dissolve slowly in the mouth. There are three types of lozenges: hard, soft, and chewable gummy gel. This preparation uses a chocolate base, which is made by melting chocolate in heated corn oil and mixing in calcium carbonate. The chocolate mixture is poured into molds, cooled, and wrapped. Proper cleaning of equipment and labeling of the finished lozenges is also covered.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Pharmaceutical Dosage Forms Laboratory Manual

    Uploaded by

    lalag yan
    594 views2 pages
    This document provides instructions for preparing chocolate-based calcium lozenges. It discusses that lozenges are solid dosage forms intended to dissolve slowly in the mouth. There are three types of lozenges: hard, soft, and chewable gummy gel. This preparation uses a chocolate base, which is made by melting chocolate in heated corn oil and mixing in calcium carbonate. The chocolate mixture is poured into molds, cooled, and wrapped. Proper cleaning of equipment and labeling of the finished lozenges is also covered.

    Original Description:

    Lozenges are solid dosage forms that are intended to dissolve in the mouth slowly.

    Original Title

    Chocolate-based Calcium Lozenges

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    © © All Rights Reserved

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    This document provides instructions for preparing chocolate-based calcium lozenges. It discusses that lozenges are solid dosage forms intended to dissolve slowly in the mouth. There are three types of lozenges: hard, soft, and chewable gummy gel. This preparation uses a chocolate base, which is made by melting chocolate in heated corn oil and mixing in calcium carbonate. The chocolate mixture is poured into molds, cooled, and wrapped. Proper cleaning of equipment and labeling of the finished lozenges is also covered.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    594 views2 pages

    Pharmaceutical Dosage Forms Laboratory Manual

    Uploaded by

    lalag yan
    This document provides instructions for preparing chocolate-based calcium lozenges. It discusses that lozenges are solid dosage forms intended to dissolve slowly in the mouth. There are three types of lozenges: hard, soft, and chewable gummy gel. This preparation uses a chocolate base, which is made by melting chocolate in heated corn oil and mixing in calcium carbonate. The chocolate mixture is poured into molds, cooled, and wrapped. Proper cleaning of equipment and labeling of the finished lozenges is also covered.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 2

    Pharmaceutical Dosage Forms Laboratory Manual

    PREPARATION #4: CHOCOLATE-BASED CALCIUM LOZENGES

    I. Objectives:

    1. Compare the different types of lozenge formula.


    2. Know the other uses and methods of preparing lozenges.
    3. Apply at least one process of preparing a lozenge formula (chocolate base
    lozenges).

    II. Materials:

    Calcium carbonate (Food Grade) 250 mL beaker


    Corn oil Evaporating dish
    Chocolate bar Smallest size stirring rod
    Ordinary size stirring rod
    Silicone Chocolate Moulder

    III. Discussion:

    Lozenges are solid dosage forms that are intended to dissolve in the mouth slowly. This
    dosage form is one of the more recent ways to deliver drugs systemically by releasing
    the drug either buccally or sublingually for absorption.
    There are three (3) types of lozenges: 1) Hard Lozenges are made from syrups of sucrose
    and other sugars and/ or carbohydrates that are boiled so that the moisture content in
    the product is 0.5% to 1.5%. The process of preparing hard lozenges is similar to candy
    making; 2) Soft Lozenges can be made from flavored fatty base such as chocolate,
    polyethylene glycol (PEG) base and sugar- acacia base and 3) Chewable gummy gel
    lozenges are glycerinated gelatin base chewable oral drug preparation which was
    made after a candy “gummy worms” or “gummy bears” for children was launched.
    Lozenges can be made either by hand-rolling or fusion, depending on the selected
    compounding method. Special calculations, techniques, and equipment are also
    required to give accurate doses. Hand- rolling is a method used for preparing lozenges
    that do not require particular calculations and equipment, but a pill roller, broad-
    bladed spatula, or any flat nonreactive material can be used for this purpose. Fusion or
    molding is a method used for hard candy, chocolate, and gummy gel chewable
    lozenges. This method requires heat, special mold, skills, and calculations to obtain
    satisfactory preparation. The dosage unit may be determined either by weight or
    volume, or both. Caution must be used when adding heat-sensitive drugs.
    Lozenges are formulated to taste good to enhance patient compliance but are a
    potential danger to children since they may look like candies. Households with children
    should be cautioned to keep the preparation out of their reach.
    IV. Formula:

    Ingredients: Original Amount


    Chocolate bar 6.00 g
    Corn oil 2.00 g lozenge
    Elemental Calcium 333.00 mg

    V. Procedure:

    1. Prepare the chocolate base by weighing corn oil in a previously tared 250- mL
    beaker and heat it in a warm water bath. Break the chocolate bar into pieces
    and add to the heated oil in portions. Stir until the chocolate is completely
    melted and well mixed.
    2. Incorporate the active ingredient and stir to mix well.
    3. Immediately pour the chocolate base into each mold cavity.
    4. The edge of a spatula may be used to level and even out the poured mass.
    5. Cool the poured mass in the refrigerator or freezer for 10-20 minutes.
    6. Remove the lozenges from the mold and cover each chocolate base lozenge
    using an aluminum foil or chocolate candy wrapper.
    7. Wrapped chocolate base lozenges can be stored in a plastic or aluminum
    containers.
    8. Label properly.

    VI. Clean-Up Procedure:

    1. Clean the molders before and after use (e.g., soap and water, and wipe dry).
    Return the molders and other borrowed apparatus to the laboratory technician
    after use.
    2. Likewise, clean the weighing pan and around the weighing area from spilled
    materials such as dipping chocolate, powders, etc., before and after use.
    3. Clean assigned working area before and after laboratory preparation.
    4. Arrange the chairs before leaving the laboratory.

    VII. References:

    Thompson, J.E., and Davidow, L.W (2017). Chapter 26. Capsule, Lozenges, and Other
    Solid Dosage Forms In A Practical Guide to Contemporary Pharmacy Practice, 4th
    edition. Baltimore USA: Lippincott Williams and Wilkins.

    http://pharmlabs.unc.edu/labs/lozenge/soft.htm (Date retrieved: 4/11/2019).

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