Prep 24 - Captropil Suspension

Name: Section: 1BPH
Group No.: 2 Date: 5//22
Captopril Suspension - DATA SHEET
I. Category: Suspension
II. Synonym/s: N/A
III. Description of Final Product: Clear, colorless suspension
IV. Use/s: Captopril is intended for the treatment of essential hypertension; it also
indicated for chronic heart failure
V. Formula:
Ingredients Original Amount Computed Amount
Captopril tablet 270 mg 261 mg
Cherry flavorant 2 mL 2 mL
Disodium edetate 150 mg 150 mg
Syrup a.s ad 150 mL 150 mL
VI. Computations:
Patients Weight: 63.8 lbs

63.8𝑙𝑏𝑠
2.2𝑙𝑏𝑠
× 1𝑘𝑔 = 29 𝑘𝑔
1. Mg/Dose
300 𝑚𝑐𝑔 1 𝑚𝑔
29 𝑘𝑔 × 1 𝑘𝑔
× 1000 𝑚𝑐𝑔
= 8. 7 𝑚𝑔/𝑑𝑜𝑠𝑒
2. Total amount of drug for 10 days

8.7 𝑚𝑔 3 𝑑𝑜𝑠𝑒𝑠
𝑑𝑜𝑠𝑒
× 𝑑𝑎𝑦
× 10 𝑑𝑎𝑦𝑠 = 261 𝑚𝑔
Total no. of doses

3 × 10 = 30 𝑑𝑜𝑠𝑒𝑠
3. Volume of suspension for 10 days using 5 mL/dose

5 𝑚𝐿
𝑑𝑜𝑠𝑒
× 30 𝑑𝑜𝑠𝑒𝑠 = 150 𝑚𝐿
4. Weight of crushed tablet (powder) for 261 mg Captopril
180 𝑚𝑔 × 261 𝑚𝑔
50 𝑚𝑔
= 940𝑚𝑔 𝑝𝑜𝑤𝑑𝑒𝑟𝑒𝑑 𝑡𝑎𝑏𝑙𝑒𝑡𝑠 𝑜𝑟 31 𝑡𝑎𝑏𝑙𝑒𝑡𝑠
VII. Label : White with “Shake well before use”

VIII. Container: Narrow-mouth amber bottle
Name: Section: 1BPH

Group No.: 2 Date: 5//22
Captopril Suspension - POST LAB
1. What are the reasons for preparing suspensions?

- Suspensions are important in fulfilling the needs of patients who do not have their
needed dose available commercially, or who cannot swallow capsules and tablets. Such
patients include infants, children, and geriatrics.
2. Define and differentiate dispersed phase from dispersing phase, and give
examples for each.
- The two components that make up a suspension, which is a two-component system, are
the dispersion phase and the dispersed phase. The dispersed phase contains particles
that are evenly distributed across the dispersion medium. One of the most significant
differences between a scattered phase and a dispersion medium is that the dispersed
phase is a discontinuous phase, whereas the dispersion medium is a continuous
medium. The starch solution and milk of magnesia are two examples of this, in which the
dispersed phases are magnesium hydroxide and starch, respectively, while the
dispersion phase is water.
3. Give examples of official and commercial oral suspensions and their uses.
● Carbamazepine Oral Suspension
○ It is used to control seizures caused by certain types of epilepsy and treat
nerve related pain.
● Phenytoin Oral Suspension, USP
○ It is an anticonvulsant or antiepileptic drug that prevents and controls
seizures.
● Amoxicillin Oral Suspension
○ It is used in treating infections caused by bacteria. It can also be taken
with other medicines to treat stomach ulcers.
● Diazoxide Oral Suspension
○ It is used to treat hypoglycemia.
References:
Amoxicillin 125mg/5ml Oral Suspension BP. (n.d.). Electronic Medicines Compendium.
Retrieved May 20, 2022, from https://www.medicines.org.uk/emc/product/2138/pil#gref
Carbamazepine - Uses, Side Effects, and More. (n.d.). WebMD. Retrieved May 20, 2022, from
https://www.webmd.com/drugs/2/drug-1493-5/carbamazepine-oral/carbamazepine-oral/d
etails
Diazoxide 50 Mg/Ml Oral Suspension Vasodilators - Uses, Side Effects, and More. (n.d.).
WebMD. Retrieved May 20, 2022, from
https://www.webmd.com/drugs/2/drug-6387/diazoxide-oral/details
Phenytoin Suspension, (Final Dose Form) - Uses, Side Effects, and More. (n.d.). WebMD.
Retrieved May 20, 2022, from
https://www.webmd.com/drugs/2/drug-4159-1057/phenytoin-oral/phenytoin-suspension-o
ral/details
4. What are the basic components of suspensions? Give example of each
The dispersed phase is the solute which is an insoluble solid with large particles
above 100 mm in diameter that is suspended in the dispersion medium. Examples of
dispersed phases are carbamazepine and phenytoin.
The continuous phase, also known as the dispersion medium, is a liquid solvent that
serves as the vehicle in which the particles are dispersed. Water and ethanol are two
examples of such.
Finally, a dispersing agent, also known as a suspending agent, is a surface-active

chemical that aids particle separation and inhibits clumping. Methylcellulose and
sodium alginate are examples of suspending agents.

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Name: Section: 1BPH

Group No.: 2 Date: 5//22

Captopril Suspension - DATA SHEET

II. Synonym/s: N/A

III. Description of Final Product: Clear, colorless suspension

Captopril tablet 270 mg 261 mg

Disodium edetate 150 mg 150 mg

Syrup a.s ad 150 mL 150 mL

Patients Weight: 63.8 lbs

2. Total amount of drug for 10 days

Total no. of doses

3. Volume of suspension for 10 days using 5 mL/dose

VII. Label : White with “Shake well before use”

Name: Section: 1BPH

Captopril Suspension - POST LAB

1. What are the reasons for preparing suspensions?

4. What are the basic components of suspensions? Give example of each

Finally, a dispersing agent, also known as a suspending agent, is a surface-active

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