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    Preparation Ointment

    Uploaded by

    Lyanlie Minamoto
    This document provides instructions for preparing a topical analgesic formulation containing six active ingredients for the treatment of muscle and joint pain. The method involves heating polyethylene glycol to dissolve the mephenesin and capsicum oleoresin, then adding other ingredients like methyl salicylate, menthol, camphor and methyl nicotinate. The preparation is packaged and labeled for external use and can provide pain relief through different mechanisms of action over a 6 month shelf life if stored properly. Quality control testing may include assays of ingredients, pH and physical properties.

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    Preparation Ointment

    Uploaded by

    Lyanlie Minamoto
    170 views1 page
    This document provides instructions for preparing a topical analgesic formulation containing six active ingredients for the treatment of muscle and joint pain. The method involves heating polyethylene glycol to dissolve the mephenesin and capsicum oleoresin, then adding other ingredients like methyl salicylate, menthol, camphor and methyl nicotinate. The preparation is packaged and labeled for external use and can provide pain relief through different mechanisms of action over a 6 month shelf life if stored properly. Quality control testing may include assays of ingredients, pH and physical properties.

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    ointment content

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    Preparation ointment

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    This document provides instructions for preparing a topical analgesic formulation containing six active ingredients for the treatment of muscle and joint pain. The method involves heating polyethylene glycol to dissolve the mephenesin and capsicum oleoresin, then adding other ingredients like methyl salicylate, menthol, camphor and methyl nicotinate. The preparation is packaged and labeled for external use and can provide pain relief through different mechanisms of action over a 6 month shelf life if stored properly. Quality control testing may include assays of ingredients, pH and physical properties.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    170 views1 page

    Preparation Ointment

    Uploaded by

    Lyanlie Minamoto
    This document provides instructions for preparing a topical analgesic formulation containing six active ingredients for the treatment of muscle and joint pain. The method involves heating polyethylene glycol to dissolve the mephenesin and capsicum oleoresin, then adding other ingredients like methyl salicylate, menthol, camphor and methyl nicotinate. The preparation is packaged and labeled for external use and can provide pain relief through different mechanisms of action over a 6 month shelf life if stored properly. Quality control testing may include assays of ingredients, pH and physical properties.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 1

    Method of Preparation: Calculate the quantity of each ingredient for the amount to be

    prepared. Accurately weigh or measure each ingredient. Heat the polyethylene glycol (PEG)
    4,000 to about 75°C. Add the mephenesin powder and stir until dissolved. Add the capsicum
    oleoresin and stir until dissolved. Add the PEG 400, mix well, and cool to about 60°C. In a
    separate vessel, mix the methyl salicylate, menthol, camphor, and methyl nicotinate and stir
    until dissolved. Add this solution to the PEG mixture and mix well. Cool to room temperature
    while mixing. Package and label.

    Use: This preparation has been used in the treatment of muscle pain and arthritis.

    Packaging: Package in tight, light-resistant containers.

    Labeling: For external use only. Keep out of the reach of children. Discard after ____ [time
    period].

    Stability: A beyond-use date of up to 6 months may be used for this preparation.1

    Quality Control: Quality-control assessment can include theoretical weight compared with
    actual weight, pH, specific gravity, active drug assay, color, texture–surface, texture–spatula
    spread, appearance, feel, rheologic properties, and physical observations.2

    Discussion: Muscle and skeletal pain are often treated by combination therapy. This
    preparation contains six active ingredients that have various mechanisms of relieving pain.

    Mephenesin (Tolserol, C10H14O3, MW 182.22) occurs as white, odorless or almost odorless,


    crystals or crystalline aggregates with a slightly bitter, numbing taste. It is soluble 1 in 100 in
    water and 1 in 8 of alcohol. It has been used topically, usually with rubefacients.3

    Methyl salicylate (C8H8O3, MW 152.15) occurs as a colorless, yellowish, or reddish liquid


    with the characteristic odor and taste of wintergreen. It is slightly soluble in water and is
    soluble in alcohol and glacial acetic acid. Methyl salicylate should be preserved in tight
    containers; certain plastic containers (polystyrene) are unsuitable for liniments or ointments
    containing methyl salicylate. Methyl salicylate is absorbed through the skin and is applied
    topically in rheumatic conditions.2,3

    Menthol (C10H20O, MW 156.27) occurs as colorless, hexagonal crystals, usually needlelike or


    in fused masses, or as a crystalline powder. It has a pleasant, peppermintlike odor. Menthol is
    slightly soluble in water and highly soluble in alcohol. It is freely soluble in fixed and volatile
    oils.4

    Camphor (C10H16O, MW 152.23) occurs as colorless or white crystals, granules, or


    crystalline masses or as colorless to white translucent, tough masses. It has a penetrating,
    characteristic odor and a pungent, aromatic taste. Camphor will slowly volatilize at room
    temperature. It is slightly soluble in water, highly soluble in alcohol, and soluble in fixed and
    volatile oils. Topically, camphor is used as a rubefacient and mild analgesic.1,3

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