Dds Laboratory Preparation 2: Magnesium Citrate Oral Solution

Stimulates fluid
DDS LABORATORY
excretion by peristalsis
PREPARATION 2: MAGNESIUM CITRATE and attract water into
ORAL SOLUTION
intestine to induce
defecation
--- INTRODUCTION ---
Quickens the
evacuation of stool
Magnesium Citrate Oral Alters the tonicity of
Official Title
Solution, USP the bowel by moving
Cathartic; Saline from high conc. to low
Cathartic conc.
- Agents that are
Category
used to
stimulate ORAL SOLUTIONS:
evacuation of
the  Liquid preparations for oral
bowel administration containing one or
Citrate, Citrate of more active ingredients dissolved
Magnesia, in a suitable vehicle.
Synonyms
Trimagnesium Dicitrate,  Contain flavorants and colorants
Citroma, Citronesia to make them more appealing to
As Laxative used for the patient;
constipation and bowel  Contain stabilizers and antimicrobial
Uses cleaners before preservatives;
medical procedures  Usually formulated such that a usual
such as colonoscopy dose is contained in a conveniently
Magnesium Citrate Oral administered volume but some have
Solution is a sterilized unusually large doses or small
or pasteurized solution doses.
containing, in each 100  Liquid preparations for oral use are
mL, not less than 7.59g often the dosage form of choice for
of anhydrous citric acid pediatric use.
Official Definition (C6H8O7) and an  Liquid preparations for oral use
amount of magnesium may be supplied as multidose or
citrate equivalent to not as single-dose preparations.
less than 1.55g and not
more than 1.9g of TYPE OF ORAL SOLUTIONS:
magnesium oxide
(USP).  Syrup – Sugar in water solution.
 Mainly works  Elixir – Hydroalcoholic solution.
through  Tinctures – Viscous solution used in
magnesium’s treating cough.
Mechanism of Action property of high  Spirits – Solution of aromatic
osmolality which materials in alcohol.
will draw large  Oral Rehydration Solutions – An
amounts of aqueous solution composed of
glucose and electrolytes.
FORMU --- INGREDIENTS---
LA:
COMPU TATION:
--- PROCEDURES---
1. Dissolve 2.74 g anhydrous Citric Acid in

15.00 mL of hot Purified Water in a suitable dish
Ingredients Amount Use
RFIS – Hot purified water id for killing
old spores Magnesium 15 g
Laxative agent
Carbonate and cathartic - To increase solubility
Reacts with 2. Mix 1.50 g Magnesium
magnesium Carbonate with 10.00 mL of
carbonate to Purified Water and stir until it
form is dissolved.
magnesium 3. Slowly add the two mixtures,
Anhydrous
27.4 g citrate then add the Syrup, heat the
Citric Acid
Reacts with mixed liquids to the boiling
potassium point,
bicarbonate to RFIS – To remove
form carbonic impurities or kill any
acid pathogenic
Adds microorganisms
Syrup 60 mL sweetness 4. Triturate 0.01 mL Lemon Oil with 0.5 g Talc
Used to RFIS – Talc is used as
remove clarifying agent which filters
impurities in out impurities.
Talc 5g
the solution - Also aids in adding the
Dispensing volatile lemon oil to
agent the aqueous solution
Lemon Oil 0.1 mL Adds flavor 5. Mix the Citric Acid and
Carbonates Magnesium Carbonate and
the solution to immediately add the Lemon Oil
Potassium
2.5 g make it previously triturated with Talc
Carbonate
pleasant for then filter the mixture, while
the patient hot, into a strong bottle of
Purified Water, suitable capacity
sufficient 6. Add boiled Purified Water
350 mL The solvent
quantity to to make the product
make measure 35.00 mL.
7. Allow to cool, add the
Potassium Bicarbonate, then
use Purified Cotton as a
stopper for the bottle.
8. Finally, shake the solution
occasionally until the
Potassium Bicarbonate is
dissolved,
9. Use a cork to seal the bottle,
and sterilize or pasteurize the
solution.
RFIS – To prevent bacterial or mold
growth
- Preve
nt
carbo
n gas
from
gettin
g out
(effer
vesce
nce)
- Keeps palatability
--- QUALITY CONTROL / PACKAGING ---
Official title Magnesium Citrate

Oral Solution
Clear to yellow
Appearance solution;
effervescent liquid
Unidentified floating
objects, mold
Instability/IES
formation, particle
deposition
Pourability Easily poured
pH 1.5-7.5
Preserve at controlled
Packaging and room temperature or
Storage in a cool place, in
bottles containing not
less than 200 mL;
flint bottles; cork
For oral use only;
Labelling Keep out of
reach of children.

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Dds Laboratory Preparation 2: Magnesium Citrate Oral Solution

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Stimulates fluid

1. Dissolve 2.74 g anhydrous Citric Acid in

--- QUALITY CONTROL / PACKAGING ---

Official title Magnesium Citrate

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