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    Pharm 222L - Activity 1 - Group5

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    france hambon
    1. The document describes an experiment to detect common elements in 6 drug samples through a series of chemical tests. 2. The tests identify the presence of acids, bases, hydrogen, oxygen, carbon, nitrogen, halogens, sulfur, phosphorus, and benzene rings. 3. The results are recorded through check marks indicating either a positive or negative result for each sample in each test.

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    Pharm 222L - Activity 1 - Group5

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    france hambon
    554 views9 pages
    1. The document describes an experiment to detect common elements in 6 drug samples through a series of chemical tests. 2. The tests identify the presence of acids, bases, hydrogen, oxygen, carbon, nitrogen, halogens, sulfur, phosphorus, and benzene rings. 3. The results are recorded through check marks indicating either a positive or negative result for each sample in each test.

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    PHARM 222L_ACTIVITY 1_GROUP5

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    1. The document describes an experiment to detect common elements in 6 drug samples through a series of chemical tests. 2. The tests identify the presence of acids, bases, hydrogen, oxygen, carbon, nitrogen, halogens, sulfur, phosphorus, and benzene rings. 3. The results are recorded through check marks indicating either a positive or negative result for each sample in each test.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    554 views9 pages

    Pharm 222L - Activity 1 - Group5

    Uploaded by

    france hambon
    1. The document describes an experiment to detect common elements in 6 drug samples through a series of chemical tests. 2. The tests identify the presence of acids, bases, hydrogen, oxygen, carbon, nitrogen, halogens, sulfur, phosphorus, and benzene rings. 3. The results are recorded through check marks indicating either a positive or negative result for each sample in each test.

    Copyright:

    © All Rights Reserved
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    of 9

    PHARM 222L:

    PHARMACEUTICAL AND MEDICINAL


    ORGANIC CHEMISTRY LABORATORY

    ACTIVITY #: 1

    TITLE:
    Detection of Common Elements in Drug
    Samples
    GROUP #: 6
    CONTRIBUTION MEMBERS
    Experiment 1&2 ESTABILLO ANA KRISTA MEJIA
    Experiment 3&4 GANITANO, ANGEL DOMINICA
    TAGELO
    Experiment 5 GARABILES, SOPHIA FRANCHESKA
    BILOG
    Experiment 6 GUMABAY, CHRISTALYN SEGNABEN
    Experiment 7 HAMBON, FRANCELYN BANGO
    ACTIVITY 1
    Detection of Common
    Elements in Drug
    Samples
    Drug Samples:
    Drug Name Chemical Structure
    Aspirin

    Paracetamol

    Na Barbital

    Caffeine

    Sulfamerazine

    Chlorobutanol
    Test Procedures:
    1. Test for acidity and alkalinity
    Place pieces of moistened red and blue litmus papers at the mouth of the test tubes containing 2mL each
    of the sample solutions. Gently heat the solutions and observe for color changes of the litmus papers.

    Litmus paper

    Drug sample

    red to blue blue to red


    blue to blue red to red

    Answer: Place a check mark


    Aspirin Paracetamol Sodium Caffeine Sulfamerazine Chlorobutanol
    Barbital
    Acid    
    Base  
    2. Test for Hydrogen and Oxygen
    Place 0.2 g each of the samples in separate dry test tubes and gently heat. Observe what forms on the
    sides of the tube.

    Positive: The
    appearance of moist in
    the side of the test tube

    Answer: Place a check mark


    Aspirin Paracetamol Sodium Caffeine Sulfamerazine Chlorobutanol
    Barbital
    Positive      
    Negative
    3. Test for Carbon
    Place a pinch of each of the samples in separate test tubes and heat strongly. Observe the residue that
    forms.

    Positive: Formation of a
    black residue

    Answer: Place a check mark

    Aspirin Paracetamol Sodium Caffeine Sulfamerazine Chlorobutanol


    Barbital
    Positive  
    Negative    

    4. Test for Nitrogen


    In dry test tubes, mix 0.2g of the samples with 0.2g of soda lime. Heat the mixture and expose water
    moistened red litmus paper to the fumes. Observe the change that occurs in the red litmus paper and note
    the odor of the fumes formed.
    Red Litmus
    paper
    Positive: Red to blue
    litmus paper and an
    ammonia like odor

    Drug sample w/
    soda lime

    Answer: Place a check mark


    Aspirin Paracetamol Sodium Caffeine Sulfamerazine Chlorobutanol
    Barbital
    Positive    
    Negative  
    5. Test for Halogen
    a. Beilsten Test: Clean a copper wire and then dip into the sample solutions. Perform a flame test and
    observe the color imparted to the flame to identify the specific halogen present.

    Answer: Place a check mark


    Aspirin Paracetamol Sodium Caffeine Sulfamerazine Chlorobutanol
    Barbital

    Positive 

    Negative     

    6. Test for Sulfur and Phosphorus


    Mix 0.2g each of the samples with 0.5g each of potassium nitrate and sodium carbonate in a crucible. Heat until
    oxidation is completed. Allow the mass to cool then dissolve in about 20 mL of distilled water. Acidify the solution using
    dilute nitric acid then divide the solution into two portions. To the second portion, test for phosphorous by adding 3 to
    5 drops of ammonium molybdate T.S. Observe for the formation of precipitate in both solutions.

    First portion: Test for Sulfur Positive: Formation of a White Precipitate


    To the first portion, test the presence of sulfur by adding 3 to 5 drops of barium chloride T.S.
    Answer: Place a check mark
    Aspirin Paracetamol Sodium Caffeine Sulfamerazine Chlorobutanol
    Barbital
    Positive 
    Negative     
    Second Portion: Test for Phosphorus
    Positive: Formation of a Yellow Precipitate

    Answer: Place a check mark


    Aspirin Paracetamol Sodium Caffeine Sulfamerazine Chlorobutanol
    Barbital
    Positive
    Negative      
    7. Test for Phenyl or Benzene Ring
    a. Millon’s Test: To 1mL of the sample solutions, add a few drops of Millon’s reagent and observe the
    color of the solution.

    Positive: reddish-brown coloration or precipitate

    Answer: Place a check mark


    Aspirin Paracetamol Sodium Caffeine Sulfamerazine Chlorobutanol
    Barbital
    Positive 
    Negative     

    b. Ferric Chloride Test: To 1mL of the sample solutions, add a few drops of ferric chloride test solution.
    Observe the color of the resulting solution.

    Positive: formation of a blue, violet, purple, green, or red-brown color or precipitate

    Answer: Place a check mark

    Negative Positive

    Aspirin Paracetamol Sodium Caffeine Sulfamerazine Chlorobutanol


    Barbital
    Positive 
    Negative     

    Scoring:
    1 point each

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