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    Chemistry-Theory (Cyi 101) Organic Chemistry

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    Prasann Katiyar
    1. The document is an organic chemistry course syllabus covering topics like aromaticity, stereochemistry, pericyclic reactions, and macromolecules. 2. It provides an overview of the units to be covered, including aromatic, non-aromatic, and anti-aromatic compounds, concepts of chirality, and polymerization techniques. 3. Recommended textbooks are listed and COVID-19 management strategies like hydroxychloroquine, favipiravir, and dexamethasone are briefly mentioned.

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    Chemistry-Theory (Cyi 101) Organic Chemistry

    Uploaded by

    Prasann Katiyar
    53 views15 pages
    1. The document is an organic chemistry course syllabus covering topics like aromaticity, stereochemistry, pericyclic reactions, and macromolecules. 2. It provides an overview of the units to be covered, including aromatic, non-aromatic, and anti-aromatic compounds, concepts of chirality, and polymerization techniques. 3. Recommended textbooks are listed and COVID-19 management strategies like hydroxychloroquine, favipiravir, and dexamethasone are briefly mentioned.

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    BTech-Sec G-H-07-12-2020

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    1. The document is an organic chemistry course syllabus covering topics like aromaticity, stereochemistry, pericyclic reactions, and macromolecules. 2. It provides an overview of the units to be covered, including aromatic, non-aromatic, and anti-aromatic compounds, concepts of chirality, and polymerization techniques. 3. Recommended textbooks are listed and COVID-19 management strategies like hydroxychloroquine, favipiravir, and dexamethasone are briefly mentioned.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    53 views15 pages

    Chemistry-Theory (Cyi 101) Organic Chemistry

    Uploaded by

    Prasann Katiyar
    1. The document is an organic chemistry course syllabus covering topics like aromaticity, stereochemistry, pericyclic reactions, and macromolecules. 2. It provides an overview of the units to be covered, including aromatic, non-aromatic, and anti-aromatic compounds, concepts of chirality, and polymerization techniques. 3. Recommended textbooks are listed and COVID-19 management strategies like hydroxychloroquine, favipiravir, and dexamethasone are briefly mentioned.

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    of 15

    CHEMISTRY-THEORY(CYI 101)

    Organic Chemistry
    Parthasarathi Das
    Department of Chemistry
    Indian Institute of Technology (ISM) Dhanbad
    Dhanbad-826004
    Email: partha@iitism.ac.in
    9419227993

    7th Dec 2020/Sec G/H


    CYI 101 CHEMISTRY-THEORY (Common) (3-0-0)

    UNIT –II

    Aromaticity [2L]
    Aromatic, non-aromatic and anti-aromatic compounds

    Stereochemistry [4L]
    Concept of chirality, Axial chirality, enantiomers and diastereomers, specific rotation,
    optical purity, Racemic modification and resolution, R/S, D/L and E/Z nomenclature

    Pericyclic reactions [4L]


    Definitions, Classifications, photochemical [2+2] and thermal [4+2] cycloaddition,
    Sigmatropic rearrangement

    Macromolecules [4L]
    Introduction to peptides and proteins. Basics of Polymer Chemistry, Polymerization
    techniques, natural and synthetic polymer
    Recommended Books:
    1. Organic Chemistry, J. Clayden, N. Greeves, S. Warren, P. Wother, Oxford University
    Press, 2000.
    2. Principles of polymerization, George G. Odian, 4th Edn, John Wiley & Sons, Inc.,
    Publication, 2004.
    3. Lehninger Principles of Biochemistry 6th Edition by David L. Nelson; Michael M.
    Cox, Macmillan International Higher Education
    COVID-19 Management

    Hydroxy
    chloroquine Favipiravir

    Dexamethasone

    Remdesivir
    Paracetamol
    Aspirin

    Dichlorodiphenyltrichloroethane (DDT)/
    Insecticide Azo dye
    Kekulé’s First Structure of Benzene

    1865 - Proposes a cyclic structure


    for benzene with alternating single
    and double bonds

    1890- Benzene Fest - Kekulé’s Dream


    August Kekulé
    (1829-1896)
    Aromaticity
    Aromatic/Heteroaromatic
    Aromaticity
    • The molecule must be Cyclic
    • Every atom in the ring must be conjugated
    • The molecule must be Flat
    • The molecule must contain 4n+2 p electron

    Hückel's Rule
    Among planar, cyclic, completely conjugated polyenes, only those with 4n + 2
    p electrons possess special stability are aromatic

    So for n = 0 , we have [4 (0) + 2] = 2


    for n = 1 , we have [4 (1) + 2 ] = 6
    for n = 2, we have [4 (2) + 2 ] = 10
    for n = 3, we have [4 (3) +2 ] = 14
    for n=4, we have [4 (4) +2 ] = 18
    Aromaticity

    • Where [4n + 2] is a formula describing the number series: 2, 6, 10, 14, 18, 22, 26….
    • These are “magic numbers” for aromaticity; the number of pi electrons in the molecule in order for the
    molecule to be aromatic
    (We often call number must be in this series in this series, “Huckel numbers”)
    Heterocyclic
    Anti-Aromaticity
    Cyclopentadiene Vs Cyclopentadienyl anion

    Base

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