This document outlines an organic chemistry course covering retrosynthetic analysis, protecting functional groups, heterocyclic compounds, green chemistry, natural products, and bioorganic molecules. The course aims to teach modern synthetic methods and strategies as well as heterocyclic synthesis and biosynthesis.
This document outlines an organic chemistry course covering retrosynthetic analysis, protecting functional groups, heterocyclic compounds, green chemistry, natural products, and bioorganic molecules. The course aims to teach modern synthetic methods and strategies as well as heterocyclic synthesis and biosynthesis.
This document outlines an organic chemistry course covering retrosynthetic analysis, protecting functional groups, heterocyclic compounds, green chemistry, natural products, and bioorganic molecules. The course aims to teach modern synthetic methods and strategies as well as heterocyclic synthesis and biosynthesis.
This document outlines an organic chemistry course covering retrosynthetic analysis, protecting functional groups, heterocyclic compounds, green chemistry, natural products, and bioorganic molecules. The course aims to teach modern synthetic methods and strategies as well as heterocyclic synthesis and biosynthesis.
CH1017 Organic Chemistry – IV Hours / week (4 Credits)
Objectives To know modern synthetic methods and synthetic strategies. This help in planning the synthesis of any types of organic compounds. To learn the synthesis and bio-synthesis of heterocyclic products.
Unit - I: Retrosynthetic Analysis-I 12 Hours
Basic guidelines and terminology of retrosynthesis (synthons, FGI, disconnection approach), Important functional group interconversions synthesis of aromatic compounds-, one group C-X disconnections and two group C-X disconnections, one group C-C disconnections and two group C- C disconnections, important strategies of retrosynthesis.
Unit - II: Retrosynthetic Analysis-II and Protecting Functional Groups 12 Hours
Amine and alkene synthesis, umpolung carbonyl group reactivity in synthesis,Protection and deprotection of hydroxy, carbonyl, amine and carbon-carbon multiple bonds; chemo- and regioselective protection and deprotection; illustration of protection and deprotection in synthesis.
Unit - III: Chemistry of heterocyclic compounds 12 Hours
Numbering of heterocyclic compounds, structure, preparation and reactions of heterocyclic compounds (pyrrole, furan, thiophene, 1,2- and 1,3-azoles, triazoles, pyridine, pyryliums, diazines, triazine), Fused heterocycles containing one or more heteroatoms (indoles, benzofurans, benzothiophene, benzenellated azoles, quinolines, isoquinolines, benzopyrones).
Unit - IV: Green chemistry and Natural Products Chemistry 12 Hours
Green chemistry:Importance and synthetic reactions of green solvents as reaction medium (water, ScCO2, Polyethylene glycol)- Ionic liquids (alkylation and coupling reactions)-microwave assisted organic synthesis. Steroids:Sterols and bile acids, estrogens, androgens: Alkaloids: Structure, synthesis Reserpine, Morphine.Terpenoids:Zingiberene, Squalene. Natural Pigments: structural confirmations of flavones, flavanones, isoflavones, xanthones, quinones.
Unit - V: Bioorganic Molecules 12 Hours
Molecular structure and numbering of Purines (Uric acid, Cytosine, Adenine, Guanine) &Pyrimidines (Uracil, thymine & Cytosine).Nucleic acids-Functions of nucleic acids- Structural features of nucleosides and nucleosides- structure and biological implications of DNA and RNA (m- RNA, t-RNA and r-RNA) - replication of DNA - Genetic code and informational theory. Proteins – standard amino acids - peptide synthesis-End group analysis (Sanger’s method, Edmon’s degradation) - primary, secondary, tertiary structure and quaternary structure of proteins and their determination.
References 1. William Caruthers and Iain coldham, Modern methods of organic synthesis, IV Edition, Cambridge university press, 2004. 2. Michael B Smith, Organic Synthesis, Tata Mc Graw Hill, 1994. 3. Stuart warren, Organic synthesis the disconnection approach,Wiley India edition, 2004. 4. V K Ahluwalia and Renuagarwal Organic synthesis special techniques, second edition, Narosa Publishing House, 2007. 5. J.March, Advanced Organic Chemistry, 4thEdn, Wiley Publications, 1992. 6. Gurdeep R Chatwal, Organic Chemistry of Natural Products, Vol 1 & 2, revised Edn., Himalaya Publications, 2009. 7. O.P Agarwal, Chemistry of Organic Natural Products, Vol 1 & 2, Goel Publications, 28thEdn., 2002. 8. S.P.Bhutani, Chemistry of Biomolecules, Ane Books, 2009. 9. George S. Zweifet, Michael H Nantz, Modern Organic Synthesis – an introduction, W.H.Freeman and Company, 2007. 10. Raj K Bansal, Heterocyclic chemistry, fourth edition, New Age International Publishers, 2005.
Learning Outcomes: Any types of organic compounds synthesis were learned by the students, through modern synthetic methods and strategies. Synthesis and bio-synthesis of heterocyclic products were also learned by the students
