[LL 504] AUGUST 2017 Sub.

Code :5055

M.B.B.S. DEGREE EXAMINATION

FIRST YEAR
PAPER V – BIOCHEMISTRY - I

Q.P. Code: 525055

Time: Three hours Maximum : 50 Marks
Answer All Questions
I. Essay: (1 x 10 = 10)

1. Write in detail about metabolism and regulation of ketone bodies. Add a note on
diabetic ketoacidosis.

II. Write notes on: (5 x 4 = 20)

1. Significance of hexose mono phosphate shunt.

2. Galactosemia.
3. Dietary fiber.
4. Reverse cholesterol transport.
5. Iron absorption.

III. Short answers on: (10 x 2 = 20)

1. Uncouplers of electron transport chain.

2. Beriberi.
3. Niemann-Pick disease.
4. Any two mucopolysaccharides –location and its functions.
5. Rapoport Luebering shunt.
6. Glycated hemoglobin.
7. Essential fatty acids.
8. Reactions catalyzed by biotin.
9. Anti-oxidant vitamins and minerals.
10. Wilson’s disease.
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[LL 504] NOVEMBER 2017 Sub.Code :5055

M.B.B.S. DEGREE EXAMINATION

FIRST YEAR
PAPER V – BIOCHEMISTRY - I

Q.P. Code: 525055

Time: Three hours Maximum : 50 Marks
Answer All Questions
I. Essay: (1 x 10 = 10)

1. Write in detail the investigations required to differentiate various types of

jaundice. Describe the metabolism of bilirubin.

II. Write notes on: (5 x 4 = 20)

1. Obesity.
2. Functions of prostaglandins.
3. Galactosemia.
4. HDL metabolism.
5. Significance of citric acid cycle.

III. Short answers on: (10 x 2 = 20)

1. Substrates for gluconeogenesis.

2. Apo-proteins and its significance.
3. Two isoenzymes and their clinical significance.
4. Significance of 2, 3 bisphosphoglycerate.
5. Importance of HMP shunt pathway.
6. Deficiency manifestation of vitamin B12.
7. Competitive inhibition.
8. Inhibitors of ETC.
9. Functions of mucopolysaccharides.
10. Liposomes.

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 [LN 504] AUGUST 2018 Sub.Code :5055

M.B.B.S. DEGREE EXAMINATION

FIRST YEAR
PAPER V – BIOCHEMISTRY - I

Q.P. Code: 525055

Time: Three hours Maximum : 50 Marks
Answer All Questions
I. Essay: (1 x 10 = 10)

1. Explain the site, steps and energetics of β oxidation of even chain fatty acids. Add
a note on its regulation.

II. Write notes on: (5 x 4 = 20)

1. Biochemical functions of Vitamin B12.

2. Functions of calcium.
3. Glucose transporters.
4. Von Gierke disease.
5. Metabolism in adipose tissue during starvation.

III. Short answers on: (10 x 2 = 20)

1. Functions of endoplasmic reticulum.

2. Dietary fiber.
3. Physiological importance of glycogenolysis.
4. Define B.M.R. Give its value.
5. Antiatherogenic role of high density lipoprotein cholesterol.
6. IUBMB classification of enzymes.
7. Cori cycle.
8. Suicide inhibition of enzymes.
9. Importance of brown fat.
10. Importance of sphingomyelin.

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[LN 504] NOVEMBER 2018 Sub.Code :5055

M.B.B.S. DEGREE EXAMINATION

FIRST YEAR
PAPER V – BIOCHEMISTRY - I

Q.P. Code: 525055

Time: Three hours Maximum : 50 Marks
Answer All Questions
I. Essay: (1 x 10 = 10)

1. What is the normal blood glucose level? Discuss the factors regulating blood
glucose in the fasting and postprandial states. Write the diagnostic criteria for
diabetes mellitus.

II. Write notes on: (5 x 4 = 20)

1. Classify membrane transport mechanisms. Add a note on active transport.

2. Fatty liver.
3. Types of enzyme inhibition with suitable examples.
4. Functions of vitamin B6 and its deficiency manifestations.
5. Biochemical changes in Atherosclerosis.

III. Short answers on: (10 x 2 = 20)

1. What are metalloenzymes? Give two examples.

2. What is glycemic index? Mention two examples of high glycemic index food.
3. Limiting aminoacids with examples.
4. Mechanism of action of methotrexate and dicoumarol.
5. Fluorosis.
6. Hemochromatosis.
7. Serum lipid profile.
8. Refsum’s disease.
9. Essential pentosuria.
10. Lecithin sphingomyelin ratio.
 

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[LP 504] AUGUST 2019 Sub.Code :5055

M.B.B.S. DEGREE EXAMINATION

FIRST YEAR
PAPER V – BIOCHEMISTRY - I

Q.P. Code: 525055

Time: Three hours Maximum : 50 Marks
Answer All Questions
I. Essay: (1 x 10 = 10)

1. Explain the glycogen metabolism and its regulation. Add a note on associated
disorders.

II. Write notes on: (5 x 4 = 20)

1. Lactic acidosis.
2. Explain why B12 deficiency causes macrocytic anemia.
3. How are dietary lipids distributed after digestion and absorption?
4. Phospholipids.
5. Types, functions, tissue specificity and physiological relevance of glucose
transporters relevant to insulin secretion and action.

III. Short answers on: (10 x 2 = 20)

1. Importance of HbA1c testing.

2. Wernicke-Karsakoff syndrome.
3. What is the effect of non-competitive inhibition of Km and Vmax?
4. Schematic representation of the electron transport chain.
5. Carnitine transport.
6. Vitamin K cycle.
7. Metabolic basis of role of aspirin as an anti-platelet agent.
8. How will you interpret following conditions?
a) Elevated Alkaline phosphatase.
b) Elevated Acid phosphatase.
9. Proteasome.
10. How do enzymes reduce the activation energy of a reaction?

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[LP 504] NOVEMBER 2019 Sub.Code :5055

M.B.B.S. DEGREE EXAMINATION

FIRST YEAR
PAPER V – BIOCHEMISTRY - I

Q.P. Code: 525055

Time: Three hours Maximum : 50 Marks
Answer All Questions
I. Essay: (1 x 10 = 10)

1. Iron – Dietary sources, factors affecting dietary iron absorption, transport and
storage, causes and clinical features of Iron deficiency anemia.

II. Write notes on: (5 x 4 = 20)

1. Diagnostic criteria for diabetes mellitus and laboratory investigation in diabetes

mellitus.
2. Functions of prostaglandins.
3. Absorption of lipids.
4. Mucopolysaccharides with examples.
5. Metabolism of LDL with clinical importance.

III. Short answers on: (10 x 2 = 20)

1. Biochemical manifestations in protein energy malnutrition.

2. Steatorrhea.
3. Ionophores – types with example.
4. Therapeutic uses of enzymes.
5. Lactose intolerance – cause and treatment.
6. Classes of enzymes with one example each.
7. Formation of Vitamin D and the formation of its active form.
8. Lung surfactants and their significance.
9. Name two lipid storage diseases (spingolipidoses) and their enzyme defect.
10. Role of brown adipose tissue in heat generation. 

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 [LR 504] AUGUST 2020 Sub.Code :5055

M.B.B.S. DEGREE EXAMINATION

FIRST YEAR
PAPER V – BIOCHEMISTRY - I

Q.P. Code: 525055

Time: Three hours Maximum : 50 Marks
Answer All Questions
I. Essay: (1 x 10 = 10)

1. Write in detail about the Galactose Metabolism and its Applied aspects.

II. Write notes on: (5 x 4 = 20)

1. Fatty Liver-Causes including role of Lipotrophic Factors

2. Vitamin C-Sources, RDA, Functions and Deficiency Manifestations
3. PDH
4. Dyslipidemias
5. Passive Transport Mechanisms

III. Short answers on: (10 x 2 = 20)

1. Define active site of enzymes

2. Glycosidic Bond and Clinically important Glycosides
3. Name two Functions of endo plasmic recticulum
4. Name three essential fatty acids
5. Name the enzyme require for Glucuronidation of bilirubin
6. Daily requirement of Vitamin A for an adult
7. Name the defect in Menke’s disease
8. Name the enzyme defect in Von-gierke’s disease
9. Name one Role of Phospholipase A
10. Name three vitamins involved in PDH complex

*****
[LT 504] NOVEMBER 2020 Sub.Code :5055
M.B.B.S. DEGREE EXAMINATION
FIRST YEAR
PAPER V – BIOCHEMISTRY - I

Q.P. Code: 525055

Time: Three hours Maximum : 50 Marks
Answer All Questions
I. Essay: (1 x 10 = 10)

1. Explain the Regulation of Blood Glucose in Starvation and well fed state.

II. Write notes on: (5 x 4 = 20)

1. Reverse Cholesterol Transport and Anti - Atherogenic effect of HDL.

2. Wald’s Visual Cycle and Deficiency Manifestation of Vitamin A.
3. IsoEnzymes - Definition and Examples.
4. Active Transport with Examples.
5. Metabolism of Ketone Bodies.

III. Short answers on: (10 x 2 = 20)

1. Name of difference between Coenzyme and Cofactor.

2. Insulin and its Clinical importance.
3. Name a) Vth complex of ETC .
b) One inhibitor of complex III
4. a) Chylomicrons are rich in ___________
b) Apo Protein of chylomicron are _________
5. Write 2 important difference between Ricketes and Ostomalacia.
6. What is the role of gamma - Carboxylation in coagulations.
7. Name the enzyme defect in 1) Niemann Pick disease 2) Gaucher disease.
8. Name two components of metabolic syndrome.
9. Name the enzyme defect in Pentosuria.
10. Name of the defect in Refsum’s Disease.

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[MBBS 0821] AUGUST 2021 Sub.Code :5055

M.B.B.S. DEGREE EXAMINATION

FIRST YEAR
PAPER V – BIOCHEMISTRY - I

Q.P. Code: 525055

Time: Three hours Maximum : 50 Marks
Answer All Questions
I. Essay: (1 x 10 = 10)

1. Write in detail Essay on β Oxidation of Palmitic Acid including Eneregetics.

II. Write notes on: (5 x 4 = 20)

1. Brief the Inhibitors and Uncouples of Electron Transport Chain and Oxidative
Phosphorylation.
2. Explain Anaplerotic and Amphibolic Role of TCA Cycle.
3. Folate Trap.
4. What are Isoenzymes? Give Examples. Explain any one.
5. Vitamin – A – Sources, (RDAs), Wald’s Visual Cycle and Functions.

III. Short answers on: (10 x 2 = 20)

1. Rapoport Luebering Cycle.

2. Polyol Pathway.
3. Marasmus – Any Four Salient Features.
4. Chemi Osomotic Theory.
5. Define BMR. Give Normal Value.
6. Name any Two Phospholipids. Write their Significance.
7. Iron Overload-Explain.
8. Lipoprotein (A).
9. Nieman Pick Disease.
10. Zellweger Syndrome.
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 THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY

[MBBS 0222] FEBRUARY 2022 Sub.Code :5055

M.B.B.S. DEGREE EXAMINATION

(For the candidates admitted from the Academic Year 2018-2019)
FIRST YEAR
PAPER V – BIOCHEMISTRY - I

Q.P. Code: 525055

Time: Three hours Maximum : 50 Marks
Answer All Questions
I. Essay: (1 x 10 = 10)

1. Write in Detail about the Fatty Acids Oxidation and add a note on Bioenergetics
of Oxidation of 1 mol of Palmitic acid.

II. Write notes on: (5 x 4 = 20)

1. Significance of HMP Pathway.

2. Calcium Homeostasis.
3. Chemiosmotic Theory of Oxidative Phosphorylation.
4. Role of Folic Acid in One Carbon Metabolism.
5. Uniport, Symport, Antiport systems in Membrane Transport.

III. Short answers on: (10 x 2 = 20)

1. Name One Suitable Example for Suicidal Inhibition of Enzymes.

2. Definition of Dietary Fibres.
3. Name the Defect in I Cell Disease.
4. Normal Reference Range of A) LDL Cholesterol B) HDL Cholesterol.
5. One Non – Nutritional Cause of Pellagra like Manifestation.
6. Action of Warfarin and other Dicoumaral Derivatives.
7. Write one role of Lipoprotein (a) in causing atheroselerosis.
8. Name two functions of Peroxisomes.
9. Name the Enzyme Defect in 1) Hereditary Fructose Intolerance 2) Essential
Fructosuria.
10. Name two shuttles of ETC in Mitochondria.

*****