Q.P. Code: 105001 Reg. No.: First Professional MBBS Degree Supplementary Examinations February 2017

Q.P. Code: 105001 Reg. no.
: …………………
First Professional MBBS Degree Supplementary Examinations
February 2017
BIOCHEMISTRY- PAPER I
Time: 3 Hours Total Marks: 50
• Answer all questions
• Draw diagrams wherever necessary
Essay (10)
1. Explain the oxidation of palmitate in mitochondria. Describe how the process is
regulated. Mention the number of high energy phosphate bonds generated in
palmitate oxidation (5+3+2=10)
Short essays (2x5=10)

2. Explain the digestion and absorption of proteins
3. What are enzymes. Explain briefly the factors affecting the velocity of enzyme
catalyzed reactions.
Short notes (5x3=15)

4. Mucopolysaccharides
5. Lipoproteins
6. Phenylketonuria
7. Glucose transporters
8. Trans methylation reactions
Answer briefly (5x2=10)
9. Uncouplers
10. Glutathione
11. Albinism
12. Galactosemia
13. Cori’s cycle
Give precise answers: (5x1=5)
14. Name the substrates for gluconeogenesis

15. Normal blood level of urea and glucose
16. Name the important compounds formed from glycine
17. Therapeutic uses of enzymes
18. Benedict’s test
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Sample output to test PDF Combine only

Q.P. Code: 105001 Reg. no.: …………………
First Professional MBBS Degree Examinations July 2017
Essay (10)
1. Define enzymes. Classify enzymes according to IUB system with one example each.
Discuss about three enzymes commonly estimated after myocardial infarction.
(1+3+6=10)

2. Diagrammatic representation of mitochondrial electron transport chain and location of
ATP synthesis (3+2=5)
3. Define transamination and explain by giving two examples. (1+4=5)

4. What are lipotropic factors. Enumerate three lipotropic factors.
5. Phenylketonuria
6. Enumerate irreversible steps of glycolysis with the enzymes involved.
7. Functional classification of proteins.
8. Carnitine shuttle
9. Enumerate essential amino acids

10. What is HbA1C and mention its clinical importance.
11. Two co-enzyme roles of NADPH
12. Four functions of phospholipids
13.Define gluconeogenic. Name the fluconeogenic substrates
14. Bond not broken in denaturation of protein

15. Enzyme deficiency in Cori’s disease
16. Plasma lipoprotein which is inversely correlated with coronary heart disease
17. One sulphur containing amino acid
18. Enzyme defect in alkaptonuria
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Q.P. Code: 105001 Reg. no.: …………………
First Professional MBBS Degree Examinations - August 2016
Essay (10)
1. Trace the pathway of gluconeogenesis starting from alanine. Mention the key
enzymes and how they are regulated. (5+3+2=10)
2. Define carnitine and explain its role in oxidation of fatty acids.

3. Explain different types of enzyme inhibition giving suitable examples
4. Essential fatty acids.

5. Name different lipases involved in lipid metabolism and mention its functions .
6. Transamination
7. Heat coagulation
8. Michaelis Menten constant
9. Pro-enzymes
10. Invert sugar
11. Von Gierke’s disease
12. Essential pentosuria
13. Substrate level phosphorylation
Give precise answers (5x1=5)
14. Name the rate-limiting enzyme in fatty acid synthesis

15. What is GABA and mention its function
16. Mention the enzyme deficient in Tay Sach’s disease
17. Mention any two compounds derived from cholesterol
18. Name two carbon dioxide releasing steps in the TCA cycle.
***************

Q.P. Code: 105001 Reg. no.: …………………
First Professional MBBS Degree Supplementary Examinations -
February 2016
Essay (10)
1. Mention the normal blood urea level. Add a note on formation & detoxification of
ammonia and the related disorders. (1+5+4= 10 )
3. Functions of phospholipids
4. Brown adipose tissue

5. Bile salts
6. Lipotropic factors
7. Pyruvate dehydrogenase complex
8. Isoenzymes

9. Mention the rate limiting step and the inhibitors of cholesterol synthesis
10. Enzyme defect and abnormal metabolites in phenyl ketonuria
11. Carnitine deficiency
12. Rapaport Leubering pathway
13. Specialized products of tryptophan
14. Mention the features of classic galactosemia

15. Site of oxidation of very long chain fatty acids
16. Name the enzyme defect in Gaucher’s disease
17. Mention the enzyme is elevated in alcoholic cirrhosis
18. Name two uncouplers of oxidative phosphorylation
***************

Q.P. Code: 105001 Reg. no.: …………………
Essay (10)
1. Enumerate the components of electron transport chain. Describe the synthesis of
ATP. Indicate the site specific inhibitors. Mention two examples for uncouplers.
(4+2+2+2=10)

2. Gluconeogenesis
3. Diagnostic significance of serum enzymes

4. Digestion of carbohydrates
5. Essential fatty acids
6. Denaturation
7. Principle of chromatography
8. Name three glycogen storage diseases and its biochemical defect
9. Role of carnitine
10. Define isoelectric pH. State properties of a protein at its isoelectric pH
11. Importance of HMP shunt pathway
12. Sources of ammonia
13. Allosteric enzymes
14. Name the biochemical defect in Nieman-pick disease

15. Zymogen activation
16. Mention the reaction catalyzed by ATP-citrate lyase
17. Mention two biologically active peptides
18. Mention one therapeutic use of enzyme
***************

Q.P. Code: 105001 Reg. no.: …………………
February 2015
Essay (10)
1. Explain the reactions of glycogenesis and glycogenolysis in flow diagrams. Describe
how these processes are regulated. (4+4+2=10)
2. Describe the role of lipoproteins in cholesterol transport.

3. Chemiosmotic mechanism of ATP synthesis.
4. What is active methionine. Mention two examples of transmethylation reaction.

5. What is glucose alanine cycle and mention its significance.
6. Fatty liver
7. Name different types of specificity shown by enzymes with examples.
8. Denaturation of proteins.
9. Define Km value and state its importance.

10. What is the role of bile salts in fat digestion and absorption.
11. What is phenylketonuria and name the enzymatic defect.
12. Dietary fibre
13. Bence Jones protein
14. List two examples of mucopolysaccharides.

15. Name four essential amino acids.
16. Name two therapeutic enzymes.
17. List any four high energy compounds.
18.Mention the biochemical defect in fructosuria
***************

Q.P. Code: 105001 Reg. no.: …………………
First Professional MBBS Degree Examinations, August 2014
Essay (10)
1. Define beta oxidation.Explain the reactions of beta oxidation of palmitic
acid.Add a note on its energetics (1+6+3=10)
2. Tricarboxylic Acid Cycle

3. Important compounds derived from glycine.
4. Enumerate three types of enzyme specificity.

5. Lactose intolerance.
6. Transamination
7. Significance of the HMP shunt
8. Uncouplers of oxidative phosphorylation
9. Active methionine
10. Biological action of glutathione
11. Hartnup’s disease
12. Clinical significance of ALP
13. Alkaptonurea
14. Name the deficient enzyme in Niemann Pick disease

15. Mention the normal level of serum creatinine
16. What is iso-electric pH
17. Mention any two key enzymes of glycolysis
18. Name four lipotropic factors
***************

Q.P. Code: 105001 Reg. no.: …………………
First Professional MBBS Degree Supplementary Examinations, February 2014
Essay (10)
1. Explain in detail glycogensis and glycogenolysis. Mention the enzyme defects in any two
of glycogen storage disorders. (4+4+2= 10)
2. Name the ketone bodies. Describe the process of ketogenesis. List the conditions that
lead to ketoacidosis.
3. Mention the normal blood urea level. Explain how urea is synthesized in the body
4. What is meant by suicide enzyme inhibition. Explain with one example.

5. Discuss about phenyl ketonurias.
6. What are glycosamino glycans. List two examples with its functions .
7. Discuss the primary structure of human insulin.
8. Discuss the significance of gluconeogenesis
9. Functions of phospholipids
10. Name the poly amines and mention its functions.
11. Significances of km values.
12. Name the lung surfactant and mention its components
13. List the functions of Rapaport Leubering cycle.
14. Why starch can be utilized by humans but not cellulose.

15. What are cathepsins.
16. List two clinical examples of competitive inhibition.
17. Why alcohol ingestion causes fatty liver.
18. List the compounds formed from arginine.
***************

Q.P. Code: 105001 Reg. no.: …………………

January 2018
 Answer all questions
 Draw diagrams wherever necessary
Essay (10)
1. Name the site where beta oxidation of fatty acid occurs. Describe the steps involved in
beta oxidation of fatty acids. Explain how much energy is released in beta oxidation of
one molecule of palmitic acid. (1+6+3)
2. What are isoenzymes. Discuss the diagnostic importance of isoenzymes.

3. Discuss the regulation of glycogen metabolism
5. Mention the enzyme defective in galactosemia. Add a note on the clinical features of
galactosemia.
6. Formation and functions of nitric oxide.
7. ATP synthesis.
8. Monitoring of diabetes mellitus.

9. GABA.
10. Dietary fiber.
11. Primary hyper oxaluria
12. Mention the significance of hexose monophosphate shunt pathway.
13. Reverse cholesterol transport.
14. Name two lipid storage disorders.

15. Name the vitamin and amino acid formed from tryptophan
16. Why sucrose is a non-reducing sugar.
17. Why orotic aciduria occur in type II hyper ammonemia
18.Name two acidic amino acids.
***************

Q.P.Code 106001 Reg. No.:…………………

February 2017
BIOCHEMISTRY - PAPER II
Time : 3 hrs Max marks : 50

Essay (10)
1. Mention the salient features of genetic code. Discuss in detail about the various types
of mutation. (3+7=10)

2. Un-conjugated hyperbilirubinemias
3. Plasma buffers

4. Thalassemias
5. Lesch Nyhan syndrome
6. Phase II reactions of detoxification
7. Wilson’s disease
8. Vitamin K cycle

9. Restriction endonuclease
10. Acute intermittent porphyria
11. Function and deficiency manifestations of vitamin E
12. Post translational modifications
13. Western blot technique

14. DNA helicase
15. Disorder of defect in excision nucleotide repair
16. Mention the copper containing enzymes
17. Hormones involved in regulation of blood calcium level
18. Bence Jones protein
***************

Q.P.Code 106001 Reg. No.:…………………
First Professional MBBS Degree Examinations July 2017

Essay (10)
1. Discuss the process of translation and add a note on post translational modifications.
(7+3)

2. Porphyrias presenting with photosensitivity
3. Metabolic acidosis

4. Sickle cell anemia
5. Gout
6. Phase I reactions of detoxification
7. Menke’s disease
8. Folate trap

9. Apoptosis
10. Factors influencing absorption of iron
11. Active forms of vitamin A and the deficiency manifestations
12. Post transcriptional modifications
13. Southern blot technique

14. Molecular scissors.
15. Disorder of defect in mismatch repair
16. Mention the zinc containing enzymes
17. Wobble hypothesis.
18. Mention the acute phase reactants
***************

Q.P.Code 106001 Reg. No.:…………………
First Professional MBBS Degree Examinations -August 2016

Essay (10)
1. Define transcription and explain in detail the transcription in prokaryotes. Add
a note on post transcriptional modifications (1+5+4=10)

2. Metabolic acidosis
3. Structure of immunoglobulin

5. Obstructive jaundice
6. Role of calcitonin in regulation of calcium homeostasis
7. Define tumor markers and mention four examples
8. Lesch Nyhan syndrome

9. Functions of vitamin K
10. Functions of magnesium
11. Four applications of recombinant DNA technology
12. Biochemical functions of thiamine
13. Mention two examples for detoxification by reduction

14. Important buffer in intracellular fluid
15. Co-enzyme form of pyridoxine
16. Major storage form of iron
17. Enzyme deficient in Wilson's disease.
18. The end product of purine metabolism in human
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Q.P.Code 106001 Reg. No.:…………………

February 2016

Essay (10)
1. Describe the salvage pathways for purine and pyrimidine synthesis. Explain the
biochemical basis of Lesch-Nyhan syndrome and Von Gierke’s disease. (5+5=10)

2. Define clearance and how it is estimated. Add a note on its diagnostic importance.
3. Genetic code.

4. Draw a neat labeled diagram of DNA structure
5. Role of kidney in blood pH regulation
6. Mitochondrial DNA
7. Enumerate three post translational modifications of proteins with one example
each
8. Principle of ELISA and two clinical applications in clinical diagnosis

9. One example each of detoxification by oxidation and conjugation
10. Enumerate two glomerular function tests
11. Enumerate primary and secondary bile acids
12. Four functions of plasma proteins
13. Two clinical conditions of hyper gammaglobinaemia

14. First pharmaceutical product of recombinant DNA technology for human use
15. Vitamin deficiency in beriberi
16. Anti hemorrhagic vitamin
17. Two radio isotopes used in the diagnosis and treatment
18. Active form of vitamin D
***************

Q.P.Code 106001 Reg. No.:…………………

Essay (10)
1. Describe the process of transcription. What are the post transcriptional

modifications. Mention two inhibitors of transcription. (6+3+1=10)

2. Describe uric acid formation and mention the clinical significance of its
estimation.
3. Mention the normal level of serum calcium. Explain the hormonal regulation of
serum calcium

4. Acute intermittent porphyrias.
5. Mention the normal sodium level and clinical manifestation of hyponatremia.
6. Applications of radio activity.
7. Metabolic acidosis.
8. Creatinine clearance test.

9. List two reactions where the folic acid is the co-enzyme.
10. Principles of colorimetry.
11. How benzoic acid and sulfanilamide are detoxified in human body.
12. Explain why edema develops in hypo albuminemia.
13. List the different classes of immunoglobulins and mention the functional role of
any one.

14. List anti vitamins and mention one example.
15. Co-enzyme functions of biotin.
16. Name two biochemical markers of cancer.
17. Reverse transcriptases.
18. Proto-oncogenes.
***************

Q.P.Code 106001 Reg. No.:…………………

February 2015

Essay (10)
1. What is transcription. Enumerate the steps in transcription and add a note on post
transcriptional modifications (2+4+4=10)

2. How purine nucleotides are degraded. Add a note on abnormalities due to
excessive purine catabolism. ( 3+2=5)
3. Biochemical functions and deficiency manifestations of vitamin B12 (3+2=5)

4. Detoxification by conjugation
5. What are the salient features of genetic code
6. Respiratory acidosis
7. Name any two trace elements and mention the biological functions of each of
them
8. Functions of albumin

9. Salvage pathway of purine synthesis
10. Urea clearance test
11. Restriction enzymes
13. Principle of radioimmunoassay

14. Folate trap
15. Define BMR
16. What is ceruloplasmin.
17. Oncogenes
18. What is the normal serum level range of sodium and potassium
***************

Q.P.Code 106001 Reg. No.:…………………

Essay (10)
1. Define replication. Describe in detail the replicative process in prokaryotes with the help
of diagrams (1+ 6+ 3= 10)

2. Discuss the structure and functions of Immunoglobulins
3. Discuss the co-enzyme role of thiamine and the deficiency disorder.

4. Differences between metabolic acidosis and respiratory acidosis.
5. PCR technique
6. Blood and urinary findings in various types of jaundice
7. List the functions of selenium.
8. Frame shift mutation

9. Calcitriol
10. Congenital erythropoietic porphyria
11. Wobble hypothesis
12. Spliceosomes
13. Creatinine clearance

14. Mention the normal serum albumin level and list two conditions where serum albumin is
decreased
15. Mention any two features of p53 gene
16. How glycine is used in detoxification reactions.
17. Enumerate the functions of zinc in the body.
18. Name the amino acids involved in the synthesis of pyrimidine
***************

Q.P.Code 106001 Reg. No.:…………………

Essay (10)
1. Describe the source, dietary requirements, biochemical functions and deficiency
manifestations of vitamin A. (1+1+4+4=10)

2. Explain briefly on blood buffers and add a note renal mechanism of maintaining acid
base balance. (2+3=5)
3. Describe the process of DNA replication. (5)

4. Abnormal hemoglobins
5. Tumor markers
6. Liver function tests
7. Immunoglobulins
8. Gene therapy

9. Folate antagonists
10. Normal serum concentration of sodium and potassium
11. ELISA ( Enzyme linked immunosorbent assay )
12. What is the normal serum calcium level. Name the hormones regulating serum calcium
13. Enzyme defect in lesch-nyhan syndrome and orotic aciduria

14. Deficiency of vitamin C
15. Examples for point mutation
16. What are BJP(Bence jones proteins)
17. Name two oncogenes
18. Normal serum uric acid level
***************

Q.P.Code 106001 Reg. No.:…………………
January 2018
Time: 3 hrs Max marks : 50
 Answer all questions

 Draw diagrams wherever necessary
Essay (10)
1. Describe the sources, RDA, functions and deficiency disorders associated with
vitamin D. (1+1+4+4)

2. Porphyrias.
3. Describe post transcriptional modifications and its significance with examples.

4. Okazaki fragments.
5. Name three factors regulating plasma calcium levels
6. Chloride shift
7. Absorption of iron
8. Bence-Jones proteins

9. Ceruloplasmin
10. Fluorosis
11. Vanden Berg reaction
12. Base-pairing rule
13. Oncogenes

14. Name the deficient enzyme in Lesch-Nyhan syndrome
15. Mention the function of spliceosomes
16. Name two DNA repair mechanisms
17. Tumor markers
18. Albumin-globulin ratio
***************

QP Code 1501 Reg. No.:…………………
First Professional MBBS Degree Examinations - September 2011

BIOCHEMISTRY - PAPER I

Essay (10)
1. Define β-oxidation. Explain the reactions of β-oxidation of palmitic acid. Add a note
on its energetics. (2+5+3=10)
Discuss the following: (2x5=10)

2. Define and classify enzymes. Give one example for each class and mention the
reaction catalysed.
3. Define Urea cycle and describe the reactions of urea cycle.
Write short notes on: (5x3=15)

4. Phenylketonuria.
5. Classify lipoproteins and mention the function of each.
6. What is substrate level phosphorylation and mention two examples.
7. Define transamination and give two examples.
8. Define HMP shunt pathway and mention its significance.
Answer briefly: (5x2=10)
9. Name two plasma transport proteins and mention their role.
10. Mention two glycogen storage diseases with their deficient enzyme.
11. Write the clinical significance of glycated heamoglobin estimation
12. Name the bile salts and mention its functional significance
13. What is Gaucher’s disease. Mention two clinical features.
14. Linkage present in sucrose.
15. Name two sulphur containing aminoacids.
16. Mention the enzyme defect in Galactosemia.
17. Mention the chemical name of lecithin.
18. Define Km value.
***************

Q.P.Code 106001 Reg. No.:…………………

Essay (10)
1. Discuss in detail the mechanism by which kidney maintains the blood pH. What is meant
by metabolic acidosis and how it is compensated. (1+6+3=10)

2. Explain the degradation of haem
3. Discuss the process of transcription in prokaryotes

4. Cytochrome p450
5. List the different functions of plasma proteins.
6. Describe the Wald’s visual cycle.
7. Antioxidants
8. Discuss the base repair mechanism of DNA

9. Pellagra
10. Factors affecting iron absorption
11. DNA finger printing
12. Define gout and name three drugs used to treat gout.
13. Orotic aciduria

14. Mention two features of mitochondrial DNA
15. List the functions of restriction endonucleases.
16. Define tumor markers and mention one example
17.The normal albumin-globulin ratio and mention a condition in which it is reversed
18. Mention the examples of partially acceptable missense mutation and unacceptable
missense mutation
***************

QP Code 106001 Reg. No.:…………………


Essay (10)
1. Describe the sources, RDA, biochemical functions and deficiency manifestations of
vitamin D. (2+1+5+2=10)

2. Describe the salvage pathway of purine nucleotide synthesis with its significance.
Describe the disorder associated with it.
3. Describe the structure and functions of tRNA.

4. Define metabolic acidosis. Mention the causes and biochemical finding in metabolic
acidosis.
5. Define replication and mention four inhibitors of replication.
6. Marasmus.
7. Mention the functions of zinc.
8. Cause and clinical features of acute intermittent porphyria.

9. Define nucleotide. Name two adenosine nucleotide derivatives.
10. Point mutation
11. Name the liver function tests.
12. Functions of biotin.
13. Define thalassemia and mention the different types of thalassemias.

14. Name two tumor suppressor genes.
15. Define genetic code.
16. Name two hormones causing increased levels of cyclic AMP.
17. Name the coenzyme required for transamination reactions.
18. Mention the normal serum calcium level.
***************

QP Code 1601 Reg. No.:…………………
First Professional MBBS Degree Examinations - September 2011


Essay (10)
1. Describe how protein is synthesized in body. Name any two inhibitors of protein
biosynthesis. Add a note on post translational modifications. (6+2+2=10)

2. Outline the degradation of heme. Add a note on fate of conjugated bilirubin in
intestine.
3. Write briefly on storage and absorption of iron from intestine.

4. What is gout. Mention the causes of primary gout.
5. What is the role of kidney in acid base regulation.
6. What are restriction endonucleases. What are their uses.
7. Write principle and application of polymerase chain reaction.
8. Write the structure of IgG molecule and indicate its function.

9. Name the coenzyme forms of niacin and write important functions for each one
of them.
10. Wilson’s disease.
11. What is metabolic acidosis. Give one example of a disease associated with it.
12. Give two examples of detoxification by conjugation.
13. What is post hepatic jaundice. How is it diagnosed biochemically.

14. What is provitamin. Give one example.
15. Clinical features of rickets.
16. Give one example for point mutation.
17. What are the enzymes commonly used in ELISA Technique.
18. Xeroderma pigmentosum is due to deficiency of what process.
***************

QP Code 106001 Reg. No.:…………………

Essay (10)
1. Describe how protein is synthesized in body. Name any two inhibitors of protein
biosynthesis. Add a note on post translational modifications. (6+2+2=10)

2. Outline the degradation of heme. Add a note on fate of conjugated bilirubin in
intestine.
3. Explain briefly on storage and absorption of iron from intestine.

4. Define gout. Mention the causes of primary gout.
5. Explain the role of kidney in acid base regulation.
6. List the restriction endonucleases and mention its uses.
7. Mention the principle and application of polymerase chain reaction.
8. Explain the structure of IgG molecule and indicate its function.

9. Name the coenzyme forms of niacin and write important functions for each one of
them.
10. Wilson’s disease.
11. What is metabolic acidosis. Mention one example of a disease associated with it.
12. List two examples of detoxification by conjugation.
13. What is post hepatic jaundice and how it is diagnosed biochemically.

14. Pro vitamin and mention one example.
15. Clinical features of rickets.
16. One example for point mutation.
17. Enzymes commonly used in ELISA technique.
18. Xeroderma pigmentosum is due to deficiency of.
***************

Q.P. Code: 105001 Reg. no.: …………………
Essay (10)
1. Discuss the metabolism of phenylalanine.

2. Digestion and absorption of lipids.
3. Describe glycogen metabolism.

4. Mutarotation
5. Essential fatty acids.
6. Isoenzymes.
7. Co-enzyme Q
8. Fate of pyruvate.
9. Regulation of cholesterol synthesis.
10. LDL receptor.
11. GABA
12. Albinism.
13. Ketogenic amino acids.
14. What are epimers.
15. What is lecithin and mention its use.
16. Define iso-electric pH.
17.Name two transport proteins.
18. Mention two examples of biologically important peptides.
***************

Q.P. Code: 1501 Reg. no.: .................... .
First Professional MBBS Degree Supplementary Examinations, March 2012
Essay (10)
t: Define Kreb's cycle. Describe the reactions of Kreb's cycle. Add a note on its
energetics and significance. (1+6+1+2=10)
2. Describe the reactions of ketogenesis and its regulation.

3. Define secondary structure of proteins and mention its types. Describe about
a-helix.
4. Define mucopolysaccharides and give two examples.

5. Describe the functions of mitochondria.
6. Define phospholipids and how are they classified.
7. Define feed back inhibition and give two examples
8. What are uncouplers . Give two examples
9. Define epimers and give two examples

10. Define optimum pH and give one example
11. What are isomerases and give an example indicating the reaction catalysed
12.What is Cori's disease and mention the enzyme defect in it
13. Mention the four functions of albumin
14. Name the defective enzyme in galactosemia

15. Name two polyunsaturated fatty acids
16. Define active site of an enzyme
17. Name two conditions causing increased urea level
18. Name the enzyme defect in Maple syrup urine disease
**************

Code: 105001 Reg. no.: …………………
Essay (10)
1. Mention the reactions by which glycine is synthesized and catabolized. Add a note
on the specialized products formed and mention the disorders associated with glycine
metabolism. (2+6+2=10)
2. Fatty acid synthase complex.

3. Describe the reactions of urea cycle. Discuss the interrelationship between urea
cycle and citric acid cycle.
4. Mention three examples of transmethylation reactions.

5. Ketosis
6. Secondary structure of proteins.
7. Importance of glutamine.
8. Covalent modification.
9. Hartnup’s disease.
10. Classification of glycolipids.
11. Uncouplers of oxidative phosphorylation.
12. Functions of cholesterol.
13. Significance of HMP shunt
14. Enzyme defect in maple syrup urine disease.

15. Epimer of glucose.
16. Normal level of serum albumin.
17. Name the biochemical test for phenylketonuria.
18. Important product of Rapaport- Leubering cycle in RBC
***************

QP Code: 105001 Reg. no.: …………………

Essay (10)
1. Describe by a flow diagram the reactions of glycolysis giving names of enzymes
involved. Explain its regulation and add a note on the energetic in aerobic & anaerobic
conditions. (6+2+2=10)

2. What are essential fatty acids. Enumerate them. List two functions and one deficiency
manifestation. (1+2+2=5)
3. Explain the digestion and absorption of carbohydrates. (2+3=5)

4. Alpha helix
5. Explain, why blood is collected in a fluoride tube for glucose estimation.
6. Glucose Alanine cycle
7. Enzymes as markers of myocardial infarction
8. Transamination
9. What is substrate level phosphorylation. Mention one example.
10. What are lipotropic factors. Name any two lipotropic agents.
11. Four functions of cholesterol
12. Why TCA cycle is called amphibolic.
13. Two co-enzymes roles of NADPH
14. One therapeutic use of enzyme
15. Compound that facilitates the release of O2 from oxyhaemoglobin
16. Lipoprotein involved in reverse cholesterol synthesis
17. Enzyme deficiency in Mc Ardle syndrome
18. Enzyme defect in Lactose intolerance
***************

Q.P.Code 1601 Reg. No.:.................... .
First Professional MBBS Degree Supplementary Examinations - March 2012
BIOCHEMISTRY- PAPER II
Time: 3 hrs Max marks : 50

Essay (10)
1. Describe about sources , RDA, biochemical functions and deficiency manifestations of
vitamin A. (1+1+6+2=10)

2. Define protein energy malnutrition and compare marasmus and kwashiorkor
3. Describe the salvage pathway of purine nucleotide synthesis with its significance.
Describe the disorder associated with it.

4. Describe any four functions of calcium
5. Structure of DNA
6. Define metabolic acidosis. Mention the causes and biochemical finding in metabolic
acidosis.
7. Define Reverse transcription and mention its significance
•
8. Name the tests to measure GFR and define creatinine clearance.

9. Mention few unusual bases and mention where it is present.
10. Name the buffer systems in the body.
11. Mention the cause and clinical features of pellagra.
12.What is gout and mention few clinical features of gout.
13. Mention two diagnostic uses of radioactive isotopes.

14. Name the hormones causing increased cyclic AMP production.
15. Enzyme used as tumor marker.
16. Mention the normal level of serum creatinine.
17. Mention the enzyme deficient in severe combined immunodeficiency disorder.
18.What type of mutation occurs in sickle cell anemia and what is the biochemical defect
in sickle cell anemia.
***************

Q.P. Code: 105001 Reg. No.: First Professional MBBS Degree Supplementary Examinations February 2017

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Q.P. Code: 105001 Reg. No.: First Professional MBBS Degree Supplementary Examinations February 2017

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Q.P. Code: 105001 Reg. no.

Short essays (2x5=10)

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14. Name the substrates for gluconeogenesis

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Short essays (2x5=10)

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9. Enumerate essential amino acids

14. Bond not broken in denaturation of protein

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2. Define carnitine and explain its role in oxidation of fatty acids.

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4. Essential fatty acids.

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14. Name the rate-limiting enzyme in fatty acid synthesis

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4. Brown adipose tissue

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14. Mention the features of classic galactosemia

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14. Name the biochemical defect in Nieman-pick disease

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2. Describe the role of lipoproteins in cholesterol transport.

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4. What is active methionine. Mention two examples of transmethylation reaction.

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9. Define Km value and state its importance.

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14. List two examples of mucopolysaccharides.

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2. Tricarboxylic Acid Cycle

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4. Enumerate three types of enzyme specificity.

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14. Name the deficient enzyme in Niemann Pick disease

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4. What is meant by suicide enzyme inhibition. Explain with one example.

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14. Why starch can be utilized by humans but not cellulose.

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First Professional MBBS Degree Supplementary Examinations

Short essays (2x5=10)

2. What are isoenzymes. Discuss the diagnostic importance of isoenzymes.

Short notes (5x3=15)

Answer briefly (5x2=10)

Give precise answers: (5x1=5)