MSDS Number: P2015 * * * * * Effective Date: 04/02/07 * * * * * Supercedes: 02/16/06

PHENOLPHTHALEIN

1. Product Identification
Synonyms: 3,3-bis(p-hydroxyphenyl) phthalide; 3,3-bis(4-hydroxyphenyl)-1(3H)-isobenzofuranore
CAS No.: 77-09-8
Molecular Weight: 318.33
Chemical Formula: C20H14O4
Product Codes:
J.T. Baker: 2870, 2872
Mallinckrodt: 6600

2. Composition/Information on Ingredients

Ingredient CAS No Percent Hazardous

--------------------------------------- ------------ ------------ ---------

Phenolphthalein 77-09-8 100% Yes

3. Hazards Identification
Emergency Overview
--------------------------
WARNING! HARMFUL IF SWALLOWED. SUSPECT CANCER HAZARD. CONTAINS PHENOLPHTHALEIN WHICH MAY CAUSE CANCER. Risk of
cancer depends on level and duration of exposure.

SAF-T-DATA(tm) Ratings (Provided here for your convenience)

-----------------------------------------------------------------------------------------------------------
Health Rating: 2 - Moderate (Cancer)
Flammability Rating: 1 - Slight
Reactivity Rating: 0 - None
Contact Rating: 1 - Slight
Lab Protective Equip: GOGGLES; LAB COAT; VENT HOOD; PROPER GLOVES
Storage Color Code: Green (General Storage)
-----------------------------------------------------------------------------------------------------------

Potential Health Effects

----------------------------------

Inhalation:
Nuisance dust. May cause coughing and sneezing.
Ingestion:
Cathartic. Very active, even in small amounts (30-100 mg). May cause purging, collapse, and fall of blood pressure or an itching skin rash that can become ulcerous.
Other systemic effects are not well known.
Skin Contact:
Not classified as an irritant but may be absorbed via moist or oily surfaces. Symptoms may resemble those from ingestion exposure.
Eye Contact:
Slight irritant.
Chronic Exposure:
Suspect cancer hazard; contains phenolphthalein which may cause cancer. Risk of cancer depends on level and duration of exposure.
Aggravation of Pre-existing Conditions:
Persons with pre-existing skin disorders or impaired respiratory function may be more susceptible to the effects of the substance.

4. First Aid Measures

 Inhalation:
Remove to fresh air. Get medical attention for any breathing difficulty.
Ingestion:
Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact:
Wash exposed area with soap and water. Get medical advice if irritation develops.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids occasionally. Get medical attention if irritation persists.

5. Fire Fighting Measures

Fire:
As with most organic solids, fire is possible at elevated temperatures or by contact with an ignition source.
Explosion:
Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard.
Fire Extinguishing Media:
Dry chemical, foam or carbon dioxide.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other
positive pressure mode.

6. Accidental Release Measures

Remove all sources of ignition. Ventilate area of leak or spill. Wear appropriate personal protective equipment as specified in Section 8. Spills: Clean up spills in a
manner that does not disperse dust into the air. Use non-sparking tools and equipment. Reduce airborne dust and prevent scattering by moistening with water. Pick up
spill for recovery or disposal and place in a closed container.

7. Handling and Storage

Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect against physical damage. Containers of this material may be hazardous when empty since
they retain product residues (dust, solids); observe all warnings and precautions listed for the product.

8. Exposure Controls/Personal Protection

Airborne Exposure Limits:
None established.
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can
control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation,
A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator (NIOSH type N95 or better filters) may
be worn. If oil particles (e.g. lubricants, cutting fluids, glycerine, etc.) are present, use a NIOSH type R or P filter. For emergencies or instances where the exposure levels
are not known, use a full-face positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators do not protect workers in oxygen-deficient atmospheres.
Where respirators are required, you must have a written program covering the basic requirements in the OSHA respirator standard. These include training, fit testing,
medical approval, cleaning, maintenance, cartridge change schedules, etc. See 29CFR1910.134 for details.
Skin Protection:
Wear protective gloves and clean body-covering clothing.
Eye Protection:
Use chemical safety goggles. Maintain eye wash fountain and quick-drench facilities in work area.

9. Physical and Chemical Properties

Appearance:
White to pale yellow crystals.
Odor:
Odorless.
Solubility:
Slightly soluble in water.
Density:
1.299
pH:
No information found.
% Volatiles by volume @ 21C (70F):
No information found.
Boiling Point:
Not applicable.
Melting Point:
258 - 262C (496 - 504F)
Vapor Density (Air=1):
No information found.
 Vapor Pressure (mm Hg):
No information found.
Evaporation Rate (BuAc=1):
No information found.

10. Stability and Reactivity

Stability:
Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products:
Carbon dioxide and carbon monoxide may form when heated to decomposition.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Strong oxidizing agents.
Conditions to Avoid:
Incompatibles.

11. Toxicological Information

No LD50/LC50 information found relating to normal routes of occupational exposure. Investigated as a tumorigen and mutagen.

--------\Cancer Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient Known Anticipated IARC Category
------------------------------------ ----- ----------- -------------
Phenolphthalein (77-09-8) No Yes None

12. Ecological Information

Environmental Fate:
No information found.
Environmental Toxicity:
No information found.

13. Disposal Considerations

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing, use or contamination of this
product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused
contents in accordance with federal, state and local requirements.

14. Transport Information

Not regulated.

15. Regulatory Information

--------\Chemical Inventory Status - Part 1\---------------------------------
Ingredient TSCA EC Japan Australia
----------------------------------------------- ---- --- ----- ---------
Phenolphthalein (77-09-8) Yes Yes Yes Yes

--------\Chemical Inventory Status - Part 2\---------------------------------

--Canada--
Ingredient Korea DSL NDSL Phil.
----------------------------------------------- ----- --- ---- -----
Phenolphthalein (77-09-8) Yes Yes No Yes

--------\Federal, State & International Regulations - Part 1\----------------

-SARA 302- ------SARA 313------
Ingredient RQ TPQ List Chemical Catg.
----------------------------------------- --- ----- ---- --------------
Phenolphthalein (77-09-8) No No No No

--------\Federal, State & International Regulations - Part 2\----------------

-RCRA- -TSCA-
Ingredient CERCLA 261.33 8(d)
----------------------------------------- ------ ------ ------
Phenolphthalein (77-09-8) No No No

Chemical Weapons Convention: No TSCA 12(b): No CDTA: No

SARA 311/312: Acute: Yes Chronic: Yes Fire: No Pressure: No
Reactivity: No (Pure / Solid)

WARNING:
THIS PRODUCT CONTAINS A CHEMICAL(S) KNOWN TO THE STATE OF CALIFORNIA TO CAUSE CANCER.

Australian Hazchem Code: None allocated.

Poison Schedule: None allocated.
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by
the CPR.

16. Other Information

NFPA Ratings: Health: 1 Flammability: 1 Reactivity: 0
Label Hazard Warning:
WARNING! HARMFUL IF SWALLOWED. SUSPECT CANCER HAZARD. CONTAINS PHENOLPHTHALEIN WHICH MAY CAUSE CANCER. Risk of cancer
depends on level and duration of exposure.
Label Precautions:
Wash thoroughly after handling.
Label First Aid:
If swallowed, induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person. Get medical attention.
Product Use:
Laboratory Reagent.
Revision Information:
MSDS Section(s) changed since last revision of document include: 3.
Disclaimer:
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Mallinckrodt Baker, Inc. provides the information contained herein in good faith but makes no representation as to its comprehensiveness or accuracy. This
document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals
receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. MALLINCKRODT BAKER,
INC. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY
WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH
HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT BAKER, INC. WILL NOT BE
RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS INFORMATION.
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Prepared by: Environmental Health & Safety
Phone Number: (314) 654-1600 (U.S.A.)