MINISTERUL EDUCAȚIEI NAȚIONALE

Str. Universității nr.16, 700115, Iași, România

www.umfiasi.ro

SYLLABUS

1. Programme Details
1.1. GRIGORE T. POPA UNIVERSITY OF MEDICINE AND PHARMACY IASI
1.2. FACULTY : MEDICINE / DEPARTMENT: MORPHO – FUNCTIONAL SCIENCES - I
1.3. DISCIPLINE: HISTOLOGY
1.4. FIELD of STUDY: HEALTH
1.5. STUDY CYCLE: BACHELOR
1.6. PROGRAMME of STUDY: Medicine - English

2. Discipline Details
2.1. Name of the Discipline: HISTOLOGY
2.2. Teaching staff in charge with lectures: Prof. dr. Cornelia Amalinei, Prof. dr. Carmen Zamfir
2.3. Teaching staff in charge with seminar activities: Prof. dr. Carmen Zamfir, Șef lucr. dr. Grigoras
Adriana, Șef lucr. dr. Ludmila Lozneanu, Șef lucr. dr. Roxana Avădănei, Asist. dr. Gales Cristina, Asist.
dr. Timofte Andrei, Asist. dr. Rusu Andreea
2.4. Year II 2.5. Semester I 2.6. Type of E2 2.7. Mandatory
evaluation Discipline
regimen

3. Overall Time Estimates (hours/semester of didactic activity)

3.1. Number of 4 Of which: 3.2. 2 3.3. seminar/ 2
hours per week lectures laboratory
3.4. Total hours 56 Of which: 3.5. 28 3.6. seminar/ 28
in the curriculum lectures laboratory
Distribution of time
Study time using coursebook materials, bibliography and notes 7 hours
Further study time in the libray, online and in the field 1 hour
Preparation time for seminars / laboratories, homework, reports, portfolios and essays 7 hours
Tutoring 2 hours
Examinations 2 hours
Other activities
3.7. Total hours of individual study 19 hours
3.8. Total hours / semester 56 hours lectures and labs + 19 hours 75 hours

FACULTATEA DE MEDICINĂ
+40 232 301 615 tel / +40 232 301633 fax

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 individual study =
3.9. Number of credits 6 (S1+S2)

4. Prerequisites (where applicable)

4.1. curriculum Cellular and molecular biology concepts (cell,
nucleus, cellular organelles), anatomy, physiology,
and biochemistry fundamental benchmarks.
4.2. competences Optical microscope skills of use.

5. Conditions (where applicable)

5.1. for lecture delivery Lecture hall, equipped with whiteboard and laptop,
videoprojector and suitable software – Power Point
5.2. for seminar / laboratory delivery Seminar room, equipped with whiteboard and
laptop, videoprojector and suitable software –
Power Point

6. Specific Competences Acquired

Professional Competences  Theoretical characterization and microscopic identification of
(knowledge and skills) organism fundamental tissues
 Theoretical characterization and microscopic identification of
specific structures for organism systems
 Ability to establish organ diagnosis, by application of
microscopic criteria of diagnosis
Transversal Competences  Ability of normal microscopy data usage for oral and systemic
(roles, personal and pathology benchmarks understanding
professional development)  Imagination development, by the exercise of organism
tridimensional structural information translation in microscopic
two-dimensional image.

7. Obiectives of the Discipline (related to the acquired competences)

7.1. General Obiective Students instruction regarding tissular and systemic structure of the
human organism in correlation with functionality, by (i) theoretical
concepts covering the fundamental characterization of the main
tissues and systems; (ii) practical activity related the microscopic
elements identification and the formulation of the organ diagnosis.
7.2. Specific Obiectives - Knowledge of organism fundamental tissues components, in
optical microscopy, electron microscopy, and molecular level, and
of structural-functional correlations
- Knowledge of the structure of components which form organism
systems, in optical microscopy, electron microscopy, and
molecular level, and of structural-functional correlations
- Microscopic identification of specialized cellular types
- Tissues microscopic identification
- Organs microscopic identification, by applying diagnostic
algorithms which include successive steps of structural
components recognition
- Accumulation of a background knowledge essential for the
understanding of the systemic pathogenic mechanisms

8. Contents
8.1. Lecture Teaching methods Comments

1. Epithelial tissue - Active-interactive 2 hours

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General features, classification. Lining epithelial tissue: presentation
histoarchitectonical types (simple, stratified, - ppt support
pseudostratified), intercellular jonctions. Basement
membrane.
2. Epithelial tissue - Active-interactive 2 hours
Glandular epithelial tissue – classification. Exocrine presentation
glandular epithelia: cytological particularities, secretory - ppt support
cycle, means of discharge, types of exocrine glands.
Endocrine glandular epithelia: cytological particularities,
hormones and receptors, types of endocrine glands.
3. Connective tissue - Active-interactive 2 hours
General features, classification. Components: cells presentation
(proper, migrate). - ppt support
4. Connective tissue - Active-interactive 2 hours
Components: amorphous and fibrillary extracellular matrix. presentation
- ppt support
5. Connective tissue - Active-interactive 2 hours
Varieties: proper connective tissues, special properties presentation
connective tissues (histological structure, localization). - ppt support
6. Connective tissue - Active-interactive 2 hours
Cartilage: general histological structure, types (hyaline presentation
cartilage, elastic cartilage, fibrous cartilage). Bone: - ppt support
general histological structure.
7. Connective tissue - Active-interactive 2 hours
Bone: types (compact bone, spongy bone), histophysiology. presentation
Processes of osteogenesis, osteolysis, ossification and bone - ppt support
growth (intramembranous and endochondral ossification),
bone remodelling and repair. Joints.
8. Muscle tissue - Active-interactive 2 hours
General features, classification. Skeletal striated muscle presentation
tissue: skeletal striated muscle cell, mechanism of - ppt support
contraction, heterogeneity, innervation, myo-tendinous
junction.
9. Muscle tissue - Active-interactive 2 hours
Cardiac striated muscle tissue: cardiac striated muscle cell, presentation
innervation. Smooth muscle tissue: smooth muscle cell, - ppt support
mechanism of contraction, innervation.
10. Nervous tissue - Active-interactive 2 hours
General features. Neurone: structure, types. Nervous presentation
fibers: types, myelin sheath formation. Synapse: structure, - ppt support
types, histophysiology. Supporting cells: types, functions.
Histophysiology of nervous tissue.
11. Nervous system - Active-interactive 2 hours
Central nervous system: histoarchitectony, meninges, presentation
blood-brain barrier. Peripheral nervous system: peripheral - ppt support
nerve, nervous ganglia. Somatic and autonomic nervous
system.
12. Blood - Active-interactive 2 hours
Cells: red blood cell, platelet, polymorphonuclear presentation
neutrophil, eosinophil, basophil, monocyte, lymphocyte. - ppt support
Plasma.
13. Hematopoesis - Active-interactive 2 hours
Stem cells. Progenitor cells. Eritropoesis. presentation
Granulocytopoesis. Trombocytopoesis. Lymphopoesis. - ppt support
Monocytopoesis
14. Circulatory system - Active-interactive 2 hours
Heart: histoarchitectony, conducting myocardial tissue, presentation
myocardial endocrine cells. Types of blood vessels: - ppt support
classification, histological structure, functions,
microcirculation particularities.
Compulsory bibliography

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Amalinei C, Balan R, Cotutiu C, Histology – Microscopic Diagnosis of Organs, Ed. Cantes, 2000
Luca CI, Histology Organs and Systems, Ed. Dosoftei Iaşi, 2000
Ross MH, Pawlina W, Histology, A Text and Atlas, 7th. ed, Wolters Kluwer, Lippincott Williams & Wilkins,
Philadelphia, 2015
Supplimentary bibliography
Gartner L.P., Hiatt I. L., Color Textbook of Histology, Saunders Elsevier, Philadelphia, third edition, 2007
Junqueira LC, Carneiro J, Basic Histology. Text and Atlas, 11th. ed., McGraw-Hill Companies, New-York,
2005
8.2. Seminar / Laboratory Teaching methods Comments

1. Epithelial tissue - Real time 2 hours

Lining epithelial tissue: squamous simple epithelia demonstrations based on
(capillary/endothelium, peritoneum/mesothelium, kidney – the microscopic images
loop of Henle), cuboidal simple epithelia (liver – billiary transmission from the
canaliculi). central microscope to the
screen
- ppt presentations
including images
collections
- assisted and individual
microscopy study based
on histologic specimens
2. Epithelial tissue - Real time 2 hours
Lining epithelial tissue: columnar simple epithelia demonstrations based on
(stomach, jejunum, fallopian tube, epididimis), the microscopic images
pseudostratified epithelium (trachea), transitional transmission from the
epithelium (urinary bladder/urothelium). central microscope to the
screen
- ppt presentations
including images
collections
- assisted and individual
microscopy study based
on histologic specimens
3. Epithelial tissue - Real time 2 hours
Lining epithelial tissue: keratinized squamous stratified demonstrations based on
epithelium (skin/epidermis), nonkeratinized squamous the microscopic images
stratified epithelium (esophagus), cuboidal stratified transmission from the
epithelium (sweat gland – interlobular duct), columnar central microscope to the
stratified epithelium (male urethra). screen
- ppt presentations
including images
collections
- assisted and individual
microscopy study based
on histologic specimens
4. Epithelial tissue - Real time 2 hours
Exocrine glandular epithelial tissue (jejunum – Lieberkuhn demonstrations based on
gland, stomach – pyloric gland, skin – sweat gland, the microscopic images
sebaceous gland, mixed salivary gland – serous acinus, transmission from the
mucous acinus, mixed acinus). Endocrine glandular central microscope to the
epithelial tissue (thyroid, adrenal gland). screen
- ppt presentations
including images
collections
- assisted and individual
microscopy study based
on histologic specimens
5. Recapitulation. - Real time 2 hours
demonstrations based on
the microscopic images
transmission from the

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 central microscope to the
screen
- ppt presentations
including images
collections
- assisted and individual
microscopy study based
on histologic specimens
6. Connective tissue. - Real time 2 hours
Components: fibroblast, fibrocyte, white adipocyte, brown demonstrations based on
adipocyte, macrophage, plasma cell, mast cell the microscopic images
(demonstrative slide – toluidine blue); colagen fibers, transmission from the
elastic fibers (demonstrative slide - orcein), reticulin fibers central microscope to the
(demonstrative slide – silver salts). screen
- ppt presentations
including images
collections
- assisted and individual
microscopy study based
on histologic specimens
7. Connective tissue - Real time 2 hours
Connective tissue varieties: loose connective tissue – demonstrations based on
skin/superficial dermis, jejunum/lamina propria (MALT), the microscopic images
endometrium/lamina propria; irregular dense connective transmission from the
tissue – skin/deep dermis; regular dense connective tissue - central microscope to the
cornea, tendon, aponeurosis; white adipose tissue – screen
tongue; brown adipose tissue - thymus; mucoid connective - ppt presentations
tissue – ombilical cord; reticular connective tissue – lymph including images
node (demonstrative slide – silver salts), elastic connective collections
tissue – aorta (demonstrative slide – orcein). Cartilage: - assisted and individual
hyaline cartilage – trachea; elastic cartilage – ear pavilion; microscopy study based
fibrocartilage – intervertebral disc. on histologic specimens
8. Connective tissue - Real time 2 hours
Compact and spongy bone slides of ground sections and demonstrations based on
decalcified bone). Intramembranous ossification. the microscopic images
Endochondral ossification. transmission from the
central microscope to the
screen
- ppt presentations
including images
collections
- assisted and individual
microscopy study based
on histologic specimens
9. Muscle tissue - Real time 2 hours
Striated muscle tissue– tongue. Smooth muscle tissue – demonstrations based on
stomach, jejunum. Cardiac muscle tissue – myocardium the microscopic images
(demonstrative slide – iron haematoxylin). transmission from the
central microscope to the
screen
- ppt presentations
including images
collections
- assisted and individual
microscopy study based
on histologic specimens
10. Revision. - Real time 2 hours
demonstrations based on
the microscopic images
transmission from the
central microscope to the
screen
- ppt presentations

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 including images
collections
- assisted and individual
microscopy study based
on histologic specimens
11. Nervous tissue - Real time 2 hours
Neurones – spinal cord, cerebral cortex, cerebellum. Glial demonstrations based on
cells – spinal cord, cerebellar cortex. Spinal ganglion. the microscopic images
Autonomic ganglion/vegetative sympathetic. Autonomic transmission from the
ganglion/vegetative parasympathetic (jejunum, stomach – central microscope to the
Auerbach nervous plexus). Peripheral nerve; myelin sheath screen
(demonstrative slide – osmium salts. - ppt presentations
including images
collections
- assisted and individual
microscopy study based
on histologic specimens
12. Blood - Real time 2 hours
Blood smear: red blood cells, polymorphonuclear demonstrations based on
neutrophils, polymorphonuclear eosinophils, the microscopic images
polymorphonuclear basophils, lymphocytes, monocytes, transmission from the
platelets. central microscope to the
screen
- ppt presentations
including images
collections
- assisted and individual
microscopy study based
on histologic specimens
13. Circulatory system - Real time 2 hours
Cord: endocardium, myocardium, pericardium. Vessels: demonstrations based on
aorta (demonstrative slide – orcein), muscular the microscopic images
arteries/arterioles/venules (tongue, trachea), sinusoid transmission from the
capillaries (liver). central microscope to the
screen
- ppt presentations
including images
collections
- assisted and individual
microscopy study based
on histologic specimens
14. Revision. - Real time 2 hours
demonstrations based on
the microscopic images
transmission from the
central microscope to the
screen
- ppt presentations
including images
collections
- assisted and individual
microscopy study based
on histologic specimens
Compulsory bibliography
Amalinei C, Balan R, Cotutiu C, Histology – Microscopic Diagnosis of Organs, Ed. Cantes, 2000
Luca CI, Histology Organs and Systems, Ed. Dosoftei Iaşi, 2000
Ross MH, Pawlina W, Histology, A Text and Atlas, 7th. ed, Wolters Kluwer, Lippincott Williams & Wilkins,
Philadelphia, 2015
Supplimentary bibliography
Gartner L.P., Hiatt I. L., Color Textbook of Histology, Saunders Elsevier, Philadelphia, third edition, 2007
Junqueira LC, Carneiro J, Basic Histology. Text and Atlas, 11th. ed., McGraw-Hill Companies, New-York,
2005

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9. Correlations between the contents of the discipline and the expectations of the
epistemic community, of profesional associations and of employers in the field
Knowledge and abilities are established as didactic objectives and specified as such in the analytic
programs that are revised yearly. After their analysis by the study discipline staff, these are discussed and
approved in the Curricular Committee, towards curricular harmonization among the various study
disciplines. Along this entire process systematic evaluation is performed, directly if possible, regarding the
correspondence of the contents to the expectations of the academic community and of the representatives
of the social community, professional associations, and employers. As primary goal the discipline intends to
offer the students optimal background for the following years of study in the program for License in
Medicine, in the perspective of successfully hiring, immediately after graduation, in Medicine residence
programs from Romania and other EU countries.

10. Evaluation
Type of activity 10.1. Evaluation criteria: 10.2. Methods of 10.3.
evaluation Percentage of
final grade

10.4. Lecture Grade for multiple choice test standardized 50%

multiple choice test
10.5. Seminar /Average grade of ongoing ongoing evaluation 10%
Laboratory examinations
Grade for practical examination practical exam 40%
Minimum standard of performance: at least grade 5 to pass the discipline

Date:
14.10.2019 Signiture of Didactic Co-ordinator
Prof. dr. Irina-Draga Căruntu

Signiture of Department Director

Conf. dr. Cristinel Stan

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