MISCELLANEOUS BLOOD GROUPS

BLOOD GROUP EXPRESSION/ ENZ/DDT

ANTIGENS C LOCATION EFFECT MORE ON ANTIGENS Antibody HTR HDN COMMENTS

DIEGO DI (010)
Anion exchange protein – Dia Anti-Dib Mod to Sev Mod to - dosage
a
Di (low) 17 1 R to all - useful tool in anthropologic Sev
(AE – 1)/ protein band 3 studies of Mongolian Anti-Dia
b
Di (high) ancestry
- higher freq. in Native
Wra (low) Americans anti - Wra Mild to Sev Mild to Sev - may also be IgM
(IgG1)
Wrb (high) Wra & Wrb (Wright)
- not present in cells w/o GPA Anti - Wrb
- no Di(a-b-) phenotype
CARTWRIGHT YT (011)
Acetylcholinesterase Yta
Yta (high) - enzyme in R to trypsin - cord blood: Yt(a-) Anti-Yta rare NO
7 neutotransmission present - strongly immunogenic in IgG1 & IgG4
Ytb (low) in RBC & nerve cells adults
Ytb
- poor immunogen Anti-Ytb No No
- well-developed at birth

*no Yt (a-b-) phenotype

XG (012)
R to DTT 0.2 Xg(a+) – 89% of females
Xga by XG gene M only Xg(a-) – 66% of males Anti-Xga No No IgG
Xp *Lyon’s hypothesis
CD99 (new ag) Receptor and cell adhesion
By MIC2 gene on most cells XG2

SCIANNA SC (013)

Sc1 (high) Anti-Sc1 No No Both IgG but Sc1 binds

Anti-Sc2 “ mild complement
Sc2 (low) RBC adhesion protein R to enzymes
C1 ERMAP in humans only Anti-Sc3 mild No Reacts with all cells
Sc3 (high) except Sc:-1,-2 (Sc
Anti-Rd Mild (asso) null); IgG
Radin (low)
DOMBROCK DO (014)

Doa R to Anti-Doa No No Binds optimally with

ficin/papain Anti-Dob “ “ PEG & enzymes in IAT
Dob only
Gya - immunogenic Anti-Gya Acute to No but w/ Produced by all Gy(a-)
a
Gregory (Gy ) C12 GPI-linked proteins Gy(a-) delayed (+) DAT
= also neg for Doa, Dob, Hy &
Holley (Hy) Joa
= null phenotype (Donull)
Joseph (Joa) = seen in PNH III
= white and Japanese

COLTON CO (015)

Coa Integral protein Aquaporin- High frequency Anti-Coa

1 (AQP1)
Cob C7 Or water channel Present in 10% Anti-Cob Acute to No Weak binding to
R to all delayed complete
Co3 (high) Tissues of PCT & DCT of (+) in Co(a+) or Co(b+)
collecting ducts of kidneys mild
Co(a-b-) =Conull = no AQP1 Anti-Co3 severe Potent IgG ;
- linked w/ monosomy 7 of BM binds C’
(myeloid L & DMPS) Reacts w/ all cells
except Co(a-b-)
CHIDO/RODGERS CH/RG (017)
9 Ags = 6CH, 2RG, C’4 deletion – CH & RG null HTLA *Problem in Ab tests –
1WH Present in C’ 4 Adsorbed phen No No wk reacting & not
from plasma R to DTT only - asso w/ SLE, Grave’s & *but severe reproducible results &
CH1, CH2, CH3 C6p Associated with HLA RA anaphylactic mask the presence of
(100%) – C4A gene system (C6) rxns in pxs other significant Abs
RG1 & RG2 (98%) *serum w/ Abs to CH/RG transfused
C4B gene ags had Abs to WBC ags w/ large 2 Procedures to
amounts of Confirm:
FFP & plts a. Ab screen with C4-
coated RBCs
b. plasma inhibition
GERBICH GE (020)
(High) GE ags: Phenotypes:
Ge2, Ge3, Ge4 - GPC &/or GPD on RBC R to DDT only a. GE: -2, 3, 4 – Yus – w/ anti- Anti-Ge2 Acute & No IgM,
C2 membrane; asso w/ *Ge3 is also R Ge2 Anti-Ge3 delayed Formation of autoabs
(Low) protein 4.1 to ficin/papain b. GE: -2, -3, 4 – Gerbich – w/
Wb, Lsa, Ana, Dha abs to Ge2 & Ge3
c. GE: -2,-3,-4 – Leach;PL & LN
– w/ abs to Ge2 & Ge3
– asso with elliptocytosis/
 SEA ovalocytosis
CROMER CROM (021)
High: RBCs, plts, lymphs, placental
Cra, Tca, Dra, Esa, Carried by DAF & CD55 S to tissue, & lower quantities in Anti-IFC by Antibodies are weak
IFC, UMC, WESB & C1 chymotrypsin plasma & urine Inab that react in IAT
GUTI DAF - attachment site of E. & pronage Neutralized by serum,
Low: coli in epithelial cells only Inab = null phenotype = no DAF plasma & urine
Tcb, Tcc, & WESa - linked w/chronic
intestinal conditions &
PNH III
Dr(a-) phenotype shows weak
expression of CROMER Ags

KNOPS KN (022)
8 Ags:
Kna, Knb, McCa
(McCoy), S11 (Swain- Ags on CR1 (CR1/CD35) – R to ficin & Depressed in pxs with
Langley), Yka(York), C3b receptor in cells papain autoimmune dses and w/
McCb, S12(Vil), S13 In(Lu) gene HTLA

High: Kna, McCa, S11 C1

& Yka

Low: Knb

INDIAN IN (023)

Ina(low) CD44 glycoprotein (most S to all Effective immunogens

C11 tissues) Inb – depressed by In(Lu) gene No No IgG
Inb (high) Ina – 11% in Iranians & Arabs

Ok OK (024)
a
Anti-Ok -
Ok 19p.13. CD147 R to all No IgG
OKGV 3 Ab cause reduced
51
OKGV survival of Cr-labeled
Ok(a+)
Raph MER (025)
MER2
11p15 CD151 R to all Yes No

JOHN MILTON HAGEN JMH (026)

JMH(-) –seen in elderly – asso HTLA
JMH – high freq Ag C15 Semaphoring CDw108 R to sialidase w/ aging & w/ auto anti-JMH IgG4
(GPI-linked protein) - also in PNH III

WBC ANTIGENS Bg (Bennett - Goodspeed

Bga Gene products of MHC I & HLA-B7
Bgb II ags; HLA-A,B & C in HLA-B17
Bgc MHC I HLA-A28
GILL GIL (029)

GIL C 9p13 AQP3 R to DTT and GILnull – results from a Anti- GIL Yes No DAT (+)
glycerine- frameshift and a premature
acid EDTA stop codon
treatment
RH-Associated Glycoprotein (030)

*RhAG Does not have an Rh antigens

but needed for the full
expression of Rh Antigens

*high – high incidence C – chromosome HTLA – high titer low avidity

low – low incidence C’ – complement plasma inhibition – removal of Abs by Ag(+) plasma or serum