SCI19 Q1 M3 Non Mendelian Patterns of Inheritance
SCI19 Q1 M3 Non Mendelian Patterns of Inheritance
Science
Quarter 1-Module 3
Non-Mendelian Patterns of
Inheritance
Jordan B. Plopino
Mark John D. Bello
1
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
What I Need to Know
The purpose of this module is to help describe the location of genes in
chromosomes, explain the different patterns of non-Mendelian and describe the
molecular structure of the DNA.
After going through this module, you are expected to explain the different
patterns of non-Mendelian inheritance. S9LT-Id-29
What I Know
Read and understand each item carefully and encircle the letter corresponding to
the word or group of words that completes the sentence.
2. For blood types, if one parent is heterozygous A and the other parent is
heterozygous B, what could be the possible blood types of the children?
A. A, B, and O C. A and O
B. A, AB, and A D. A, AB, B, and O
4. The DNA has a double – helix structure forming a twisted ladder. The
backbone and steps of the ladder is composed of individual nucleotides
bonded together. What are the important biological compounds that make
up the backbone of the DNA molecule?
A. nitrogen bases C. pentose and phosphate
B. pentose / 5-carbon sugar D. phosphate group
8. If Roberto’s father has hemophilia and his mother is a carrier, what is the
chance that Roberto would inherit the disease?
A. 25% B. 50% C. 75% D. 100%
2
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
10. Tan colored birds are the result of the cross between a white (W) and a
brown (B) colored bird. If the off springs are 50% tan and 50% white, what
are the genotypes of their parents?
A. BB x BB C. BW x WW
B. BB x WW D. BW x BW
13. It is referred to as the union of egg and sperm cells to form a new organism.
A. mutation C. zygote
B. fertilization D. offspring
14. Which of the following happens to form gametes (sex cells) among male and
female organism?
A. meiosis C. reproduction
B. mitosis D. fertilization
3
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
Lesson
Components and Structure of DNA
1
What’s In
Let us try how much you know about a cell.
CELL MEMBRANE CHLOROPLAST CYTOPLASM
LYSOSOMES MITOCHONDRION NUCLEUS
What’s New
Nucleus is very important part of the cell and the molecule inside the cell’s
nucleus that functions in building and defining the body structure and function of all
organisms in the planet. This biological molecule is called deoxyribonucleic acid
(DNA).
Can you guess the full word or phrase of the following coded texts? Identify as
many as you can. Write your answers on a separate sheet.
What Is It
Deoxyribonucleic acid (DNA) is made up of units called nucleotides that are
bonded together. A nucleotide consists of a nitrogenous base, a pentose sugar and a
4
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
phosphate group as shown in the figure 1. DNA is commonly found inside the cell’s
nucleus that plays a very important role in the body of all organisms. DNA directs
many biological and physical functions in the body of organisms. The body structures,
functions, growth, development, and survival will never be possible without the
presence of this biological molecule in all organisms.
What’s More
Activity 1.1: DNA Modeling
Objectives: At the end of this activity, you should be able to:
1. construct a DNA model through an Origami (paper folding)
2. show the parts and components of a DNA model made.
You will need: copy of the template, coloring materials, pencil
What you will do:
Part I: Coloring
5
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
1. Using the blank template, follow the indicated letters and the specific parts
where to put colors guided by the small letters r = red, y = yellow, b = blue, g =
green.
2. You may photocopy or redraw the blank template.
Part II: DNA Origami Template. Let the folding begin!
1. Fold in half lengthwise. Make all creases as 2. Hold the paper so that the thick lines
firm as possible (use your fingernail!) are diagonal, and the thin lines are
horizontal. Fold the top segment down
and then unfold.
3. Fold the top two segments down along the 4. Repeat for all segments.
next horizontal line. Unfold.
5. Turn the paper over. 6. Fold along the first diagonal line.
Unfold and fold along the second
diagonal line. Repeat for all diagonal
lines
7. Fold the white edge without letters up. 8. Fold the other edge away from you.
Partly unfold both edges.
9. You can now see how the model is 10. Twist and turn the paper while
starting to twist. pushing the ends towards each other.
6
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
The DNA Origami Template
RUBRICS FOR THE MODEL
Criteria Excellent Good Needs Improvement
The model is correctly labelled, The model is labelled, colors The model is not labeled
follows the required colors and are followed but there is properly and some flaws
Accuracy excellently shaped like the minimal flaw with the with the
illustration as guide. shape/appearance. shape/appearance.
The model exceeds the The model follows the The model does not follow
expected appearance and expected appearance. the expected appearance.
Creativity accents/highlights are added.
All labels can be easily seen Labels are seen with Labels are not easily seen
and the model is neatly minimal flaw in the model. and have some flaws in the
Neatness presented. model.
Guide Questions:
1. What are the colors indicated for each nitrogenous base from the constructed
DNA origami?
Adenine - _______________ Guanine - _______________
Cytosine - _______________ Thymine - _______________
2. What are the complementary bases pairs for a DNA molecule?
____________________________________________________________________________
7
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
3. How would you describe the appearance and orientation of a DNA model based
on the model you constructed?
____________________________________________________________________________
4. What do you think is the main function of a DNA molecule in the body of
organisms?
____________________________________________________________________________
8
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
What I Can Do
Complete the flowchart. Supply all the related and important terms about the DNA
molecule that you have learned including its components and structure.
Assessment
Read and understand each item carefully and encircle the letter corresponding to the
word or group of words that completes the sentence.
9
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
4. In a DNA structure, which compounds are responsible for its backbone?
A. nitrogen bases and phosphate C. sugar and nitrogen bases
B. phosphate and sugar D. only nitrogen bases
5. Bases in a DNA are complementary. Which is true about complementary base
pairing if there are 20 Guanine in the DNA strand?
A. there will be 20 Adenine bases. C. only 10 Cytosine, since its helical
B. there will be 20 Cytosine bases. D. cannot be determined
Additional Activities
Complete the crossword puzzle below. All the needed word/s are from the
lessons discussed about DNA.
DOWN ACROSS
1. Specific kind of sugar for DNA 3. It includes guanine and adenine
2. It complements Thymine 4. One of the components of DNA
3. A 5-carbon compound backbone
4. It includes cytosine and 7. The main rule for base pairing
thymine 8. A segment of DNA
5. A single unit of DNA molecule 9. It complements guanine
6. It complements Adenine 10. Nitrogen-
11. Double-
12. Anti-
10
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
Lesson
Genes and Chromosomes
2
What’s In
Rearrange the following jumbled letters to get the correct word guided by the descriptions
/definitions below.
_____________ 1. EILOXBDIEYCORNUC DICA – a double-stranded helical structure
comprised of bases that codes the life of all organisms.
_____________ 2. NNEIDEA – it complements the thymine base in DNA.
_____________ 3. OBEULD IXLHE – a special structure of DNA molecule.
_____________ 4. NORINTEG SBAE – includes A, T, C, and G that forms the steps of the
ladder of a DNA molecule.
_____________ 5. TYCENIOS – it can be paired with guanine.
_____________ 6. EPOTESN – another term for 5 – carbon compound.
_____________ 7. GIEUNAN – it takes cytosine as its complementary base pair.
_____________ 8. ESPPHOHTA – it serves as the backbone of the DNA molecule along
with the sugar compound.
_____________ 9. NHEMTYI – in base pairing, it must always take adenine as its pair.
_____________ 10. IEOECLTNUD – a single unit of DNA molecule with a complete set of
sugar, phosphate, and a base.
What’s New
Observe the following illustrations:
11
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
What Is It
The tiny nucleus of a eukaryotic cell encloses long strands of DNA. They are
neatly wrapped around the histone (a globular protein) forming chromatin. When the
cell is preparing for cell division, histones come together coiling the chromatin and
arranging the DNA into thicker and a denser structure called chromosomes.
What’s More
Activity 2.1: 3D Mode! (Draw – Define – Describe)
Objectives:
1. describe the characteristics of the chromosome, gene, and DNA.
2. draw a simple diagram of the chromosome, gene, and DNA.
12
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
What you need: pencil, ruler, and coloring materials.
What to do:
1. Using the figures previously shown as a guide, draw a chromosome, gene,
and DNA on the blank boxes.
2. In the second column, complete the following sentences to describe your
drawing using your knowledge and keywords inside the box.
A. B.
13
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
A. CHROMOSOME - ____________________________________________________________.
B. GENES - _____________________________________________________________________.
What I Can Do
Answer the following briefly. Please be guided by the concepts learned from the
previous lesson in writing your answers.
1. A gene is a segment of DNA molecule that codes and directs a certain trait or
characteristic of an organism. What do you think will happen if the codes for a
trait are incorrectly reproduced in the body of an organism?
____________________________________________________________________________
2. Why do you think there is a need for a DNA molecule to be coiled tightly?
____________________________________________________________________________
3. If every cell in the human body can host 46 chromosomes, does it mean that it
has also 46 strands of DNA? Prove your answer.
____________________________________________________________________________
Assessment
Read and understand each item carefully and encircle the letter corresponding to the
word or group of words that completes the sentence.
1. Which BEST describes a gene?
A. it is a DNA C. it is a segment of DNA
B. it is smaller than DNA D. it is a tightly coiled DNA
2. Which is TRUE about a chromosome?
A. it is a double helix molecule C. it is a segment of DNA
B. it is a protein-packed DNA D. it is smaller than a gene
14
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
Additional Activities
Chromosome and Gene Model
Objectives: Apply the knowledge gained from the lesson on chromosome and gene.
Make a simple model of chromosomes and genes.
What you need:
blue, green and red yarn with 50-cm measure each
glue
8x8 inches cardboard or “karton”
What to do:
1. Let the yarn represent the DNA molecule.
2. Connect the three yarns.
3. Coil it (see Figure 6) on the cardboard to form a single Figure 6. Chromosome
chromosome using the glue. and Gene Model
4. Each color will represent the gene for a trait. Label each color a
with the following traits: blue – wavy hair, green – fair skin color, red – brown eyes.
15
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
Lesson Incomplete Dominance and
3 Co-dominance
What’s In
Match column A with the appropriate description on column B.
A B
_____1. Visible expression of a genotype. e.g., brown eyes or A. Punnett Square
attached earlobes.
______2. Alternative form of a gene; alleles occur at the same B. Homozygous
locus or homologous chromosomes. C. Dominant
_____3. Allele that exerts its phenotypic effect in the heterozygote; D. Phenotype
it masks the expression of the recessive allele. E. Genotype
______4. Allele that exerts its phenotypic effect only in the F. Heterozygous
homozygote; its expression is masked by a dominant allele. G. Recessive
______5. Possessing two identical alleles for a particular trait. H. Allele
______6. Possessing unlike alleles for a particular trait. I. Monohybrid
______7. Genes of an organism for a particular trait or traits;
often designated by letters – for example Bb or Aa.
______8. Visual representation developed by Reginald Punnett
that is used to calculate the expected results of simple
genetic crosses.
What’s New
Read the text carefully and do the task that follows.
Incomplete dominance is when one allele for a certain trait is not completely
dominant over the other. The result, which is seen in offspring, may be a merged
phenotype. What does this mean? The traits of each parent are neither dominant
nor recessive. The two alleles in a partial dominance, resulted in third phenotype
and it is a blended of phenotypes of the two homozygotes; this is often described as
an “intermediate form of inheritance.” The alleles do not blend, but partial
dominance is often referred to as “blending” because traits are mixed and happen to
be “blended.”
16
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
Atoy can have black, white, or gray hair. The allele that controls this trait is
INCOMPLETELY DOMINANT, where gray hair is produced by the heterozygous
condition. A cross between a black hair & a white hair produce offspring that are
gray hair. The color hair is determined by just two alleles.
What Is It
Read this comic strip and find out more about the Non-Mendelian Patterns of
Inheritance.
17
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
18
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
Identify the terms being described below.
1. A pattern of inheritance that does not follow the Mendelian Principle of
Inheritance.
___________________________________________________________________________
2. It occurs when the phenotype of a heterozygote offspring is somewhere in between
the phenotypes of both homozygous parents.
___________________________________________________________________________
3. It occurs when both alleles are expressed equally in the phenotype of a
heterozygote.
___________________________________________________________________________
4. When a cross between a red and white four o’clock flower plant is done it resulted
to offspring with ________________________________________ flowers
5. A roan cow offspring is produced when a cross between a __________________ and
white cow is done.
What’s More
Objectives:
Explain incomplete dominance.
Illustrate incomplete dominance through a Punnett square
What to do:
19
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
2. Using the Punnett square show the probable outcome of the
cross between a white flower plant and pink flower plant.
Guide Questions:
1. What are the genotypes of the parents in the problem?
________________________________________________________________________
2. What is the phenotype of a heterozygous snapdragon flower plant?
________________________________________________________________________
3. What are the probable phenotypes of the offspring after the cross of the
parents on the given problem?
___________________________________________________________________________
4. What are the probable genotypes of the offspring after the cross of the
parents in the problem?
___________________________________________________________
Guide Questions:
1. What are the possible phenotypes of the foal horse for each problem?
_________________________________________________________________________________
2. Do you think Mang Pedro and Mang Marcelino will be happy about the outcome?
_________________________________________________________________________________
3. How would you apply what you have learned on breeding livestock in your area?
_________________________________________________________________________________
20
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
What I Have Learned
Place a checkmark on the box if the statement describes INCOMPLETE DOMINANCE
OR CO-DOMINANCE.
INCOMPLETE CO-
DOMINANCE DOMINANCE
Appearance of a third (new) phenotype in the
heterozygous form as a COMBINATION of the dominant
and recessive phenotypes.
In the heterozygous condition, both alleles are expressed
with NO mixing!
Pink 4o’clock flowers are obtained from a cross betweeen
pure bred red flower plant (RR) and white flower(WW)
plant.
A chestnut and white colored horse produces a
palomino,a creamy golden horse.
A cross among a black cat & a tan cat gives a tabby
design (black & tan hair together).
A homozygous black bird is cross over with a homozygous
white bird. The offspring are all bluish gray.
Roan cow has a coat with primarily red with white hairs is
an offspring of red and white cow.
It is a condition where two non-identical alleles of a pair
specify two different phenotypes, yet one cannot mask the
expression of the opposite (blood types in humans)
What I Can Do
Analyze the given situation and solve the following problems.
Ligaya loves growing flowers for her pal Luna! She prefers rose flowers of red, blue,
and purple colors.
21
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
c. What percentage of the plants would have purple flowers? ______________________
d. What number of the plants would have blue flowers? __________________________
3. In some chickens, the gene for feather color is dominated by co-dominance. The
allele for black is B while the allele for white is W. The heterozygous phenotype is
erminette (black and white spotted).
a. What's the genotype for black chickens? _______________________________________
b. What's the genotype for white chickens?
________________________________________
c. What's the genotype for erminette chickens? ___________________________________
4. If an erminette chicken and a white chicken are crossed, what is the probability
that:
a. they may have a black chick? _________________________________________________
b. they may have a white chick? _________________________________________________
c. they would have an erminette chick?___________________________________________
Assessment
Read and understand each item carefully and encircle the letter corresponding to the
word or group of words that completes the sentence.
1. A cross between a black cat and a tan cat produces a tabby pattern (black & tan fur
together). What pattern of inheritance does this illustrate?
A. codominance C. Mendelian inheritance
B. incomplete dominance D. my own inheritance
2. In the heterozygous condition, both alleles are expressed equally with NO blending!
It is represented by using two DIFFERENT capital letters.
A. codominance C. Mendelian inheritance
B. incomplete dominance D. my own inheritance
3. A third (new) phenotype appears in the heterozygous condition as a BLEND of the
dominant and recessive phenotypes is a condition called_______.
A. codominance C. mendelian inheritance
B. incomplete dominance D. my own inheritance
4. Which of the following is an example of co-dominance pattern of inheritance?
A. When a long-furred Angora rabbit and a short-furred Rex rabbit reproduce, the
result can be a rabbit with fur longer than a Rex, but shorter than an Angora.
B. When a black and a white chicken reproduce and neither allele is completely
dominant, the result is a blue-feathered bird.
C. About dogs, lots of labradoodles have wavy hair. Just like humans, that comes
from having straight-haired and curly-haired parents. The result is an
intermediate inheritance: the wavy-haired labradoodle.
D. In some chickens, the heterozygous genotype leads to a phenotype known as
erminette, feathers which are speckled with both black AND white.
22
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
5. In shorthorn cattle, when a red bull (RR) is crossed with a white cow (WW), all the
offspring are roan (RW) a spotted, red and white or milky red color. What is the
percentage of the offspring will produce a roan cow if the parents are a red bull and a
roan cow respectively?
A. 25 % B. 50% C. 75% D. 100%
Lesson
Multiple Alleles
4
What’s In
Can you recall the incomplete dominance and co-dominance pattern of
inheritance and describe each one of them?
1. _________________________________________________________________
2. _________________________________________________________________
Incomplete dominance and Co-dominance involve a combination of alleles to
express a certain trait. This time, you will be dealing with more than two alleles for the
inheritance of a trait. An example of this is the blood types in humans. How can a
person inherit blood types of his/her parent and have an A, B, AB, or O blood types?
What’s New
Just Give It A Try! Since we will be talking about blood types, can you guess the
possible blood type of a child, given the blood types of both parents?
23
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
What Is It
If there will be more than two alleles available, it will also lead to more than two
phenotypes expressed. This type of inheritance is called multiples alleles or multiple
allelism. The ABO blood group system is a very common example of inheritance with
multiple alleles.
24
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
What’s More
Activity 4.1: Blood Type Analysis
Objectives:
1. Identify the possible blood types of a person given the blood types of their family
members.
2. Solve genetics problems on multiple alleles.
What you need: pen, paper
What to do:
1. Complete the table by identifying the possible blood types (phenotypes) of the mother
given the blood types of the father and child.
2. Let’s Cross It! Solve the following genetics problems using a Punnett square and
identify the resulting phenotypes.
a. If the mother has a blood type of A and the father has AB, what
could be the resulting blood types of the children. (Note that
there are two possible crosses)
b. If the father has blood type O and the mother has AB, what could
be the possible blood types of the children? (Note that only one
cross can be made)
Guide Questions:
1. What are the possible resulting blood types on the first problem (a)?
_________________________________________________________________________________
2. Give the possible genotypes and blood types on the last cross (b). Include the
percentage probability of the resulting blood types.
_________________________________________________________________________________
25
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
4. Give all the genotypes from your answer in question #3.
_____________________________________________________________________________
5. Which blood type can be compatible with all the other blood types?
_____________________________________________________________________________
What I Can Do
Solve the mystery! Candara has blood type A and his husband, Caslon, has type B.
They were shocked when they found out that their first child has type O and thought
that a switch at the hospital might have happened. Can the baby be theirs? Explain
and perform a cross (Punnett square) to show your results.
Assessment
Read and understand each item carefully and encircle the letter corresponding to the
word or group of words that completes the sentence.
1. Which is TRUE about inheritance with multiple alleles?
A. It uses only the dominant allele.
B. It involves two alleles for a single trait.
C. It involves more than two alleles for a trait.
D. None of the choices
2. Which is TRUE about blood type O?
A. It has a heterozygous allele. C. It is a universal donor.
B. It has only A antigen. D. It has A and B antigens.
5. A father of four children has blood type A. The mother has blood type O. Predict
the possible blood type(s) of the children:
A. blood Type A Only C. blood Type B & O
B. blood Type O Only D. blood Type A & O
Additional Activities
Problem Solving: Read and analyze the problem below:
A. Corsiva has type A blood and her husband Roman has type B
blood. Their first child, Lucida, has type O blood. Their second
child, Perpetua, has type AB blood.
1. What is Corsiva’s genotype? _____________
26
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
2. What is Roman’s genotype? _____________
3. Show and prove your answers using a Punnett square.
Lesson
Sex Determination
5
What’s In
Supply the missing letters to complete the words guided by the
descriptions/definitions below.
1. __ __ __ O __ __ __ O __ __ It is a rod-shaped structure inside the cell’s
nucleus that carries the genes.
What’s New
Complete the paragraph by supplying correct words/concept/numbers on the space
provided guided by the words inside the box.
23 46 nucleus body sex 92 male
27
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
The 1.) _____ of the human cell contains a total of 2.) _____ chromosomes that
may also come in pair. Both males and females have 3.) _____ pairs. The 22 pairs are
classified as somatic or 4.) _____ chromosomes while the 23rd pair consists of 5.) _____
chromosomes.
Male organisms that include humans and other mammals have non-identical
sex chromosomes. The indication for male sex chromosome is XY. Females on the other
hand have identical sex chromosomes indicated as XX. Now the question is, how is the
sex of an organism determined and inherited? What is the chance that a mother and a
father can produce a female or male offspring?
What Is It
Study the table below:
Table 1. Formation of gamete of the sex chromosomes.
Take note of the gamete formation
as shown in table 1. Let us indicate first
the sex chromosomes of the male and
female. After meiosis, all egg cells both
received X chromosomes while the sperm
cells, half of it received an X and the
other half with Y chromosomes.
What’s More
Activity 5.1: What Sex Is It? (The word GENDER must not be used)
Objectives:
1. Determine the probability or chance to have male or female sex.
2. Make a Punnett square to show the cross between the parents.
What you need: pen, paper
28
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
What to do:
1. Identify the correct indication of sex chromosomes for male
and female.
2. Make a Punnett square to cross the male and female
parents using the indicated sex chromosomes.
MALE (XY) x FEMALE (XX)
Guide Questions: Write your answers on a separate sheet of paper.
1. How many percent in the cross resulted to female? Male?
_____________________________________________________________________________
2. What will be the sex of the child if an egg cell is fertilized by a sperm with Y
chromosome?
_____________________________________________________________________________
3. What type of sperm cell is needed to fertilize an egg that will result in a female
child?
_____________________________________________________________________________
4. Give the sex chromosome that is present on both male and female.
_____________________________________________________________________________
29
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
What I Can Do
Answer the following briefly.
1. What do you think will happen if there will be an extra chromosome in the human
cell making it 47? Would this condition be still normal for a human? Why?
___________________________________________________________________________________
___________________________________________________________________________
2. Do you think the sex chromosomes of females (XX) makes it an advantage for them
to produce more female offspring than the male one? Why?
___________________________________________________________________________________
___________________________________________________________________________
Assessment
Read and understand each item carefully and encircle the letter corresponding to the
word or group of words that completes the sentence.
1. Which of the following concepts is CORRECT?
A. males and females have 44 sex chromosomes
B. females have 2 sex chromosomes, XY
C. females have 2 body chromosomes, XX
D. males have 2 sex chromosomes, XY
2. Which conditions will result to a female child?
A. an egg cell is fertilized by a sperm with X chromosome
B. a sperm that is fertilized by an egg with Y chromosome
C. an egg that is fertilized by a sperm with Y chromosome
D. none of the choices
3. It is referred to as the union of egg and sperm cells to form a new organism.
A. mutation B. fertilization C. zygote D. offspring
4. Which happens to form gametes (sex cells) among male and female organism?
A. meiosis B. mitosis C. reproduction D. fertilization
30
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
Additional Activities
Find all the science words listed below that are hidden on the puzzle grid. The words
maybe hidden in any direction.
N O I T A Z I L I T R E F I K
H O H E R E D I T Y T S E T L
F F Z Y G O T E K I L A W L O
S F X V E D I K E L A M E F S
E S E N E G F E S G H C A F E
T P S S A D G A F O M D F L R
E R D F G H Y C C R M V O Q E
M I S L L E C X E S R A F T T
A N G H J K Y P E L E E T G H
G G G A B G S D D E L R K I H
R O L E S E M O S O M O R H C
31
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
Lesson Sex – Linked and Sex – Influenced
6 Traits
What’s In
You have already talked about how sex (male or female) is determined and
inherited. Humans have a total of 46 chromosomes in each cell which also exist as a
pair. Meaning, there are 23 pairs of chromosomes for both male and female. The 22
pairs are called somatic or body cells while the remaining 1 pair (23rd pair) is called
sex chromosomes. These sex chromosomes are indicated by letters X and Y. For male,
it has a pair of XY while for female it would be XX. Write your answers on a separate
sheet of paper.
1. What type of chromosome is in pair number 23? ________________________
2. What is the genotype of a female human? Male? _________________________
3. How many pairs of chromosomes are in a human cell? __________________
What’s New
Rearrange the following jumbled letters to form science words that you will be using in
understanding the succeeding lesson. The first and last letters are given as a hint.
What Is It
SEX – LINKED TRAIT
Genes located on the X chromosomes are called X-linked genes. Genes on the Y
chromosomes are called Y-linked genes. An example of an X-linked trait in humans is
hemophilia. A person suffering from hemophilia could die from loss of blood even from
a small wound because the blood either clots very slowly or does not clot at all (as
shown in fig. 2 &3). Another example of an X-linked trait is color blindness.
32
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
Figure 7. Colorblindness Figure 8. Bleeding associated with
https://bit.ly/3AfiYsW acquired hemophilia A
https://bit.ly/35ZjqgO
There are some people who have difficulty in recognizing specific colors (as
shown in fig. 1), depending on the severity of their condition. Some can only see mono
color, while some have only difficulty in perceiving certain colors like red, blue, green
and the like.
Let us study tables 1 and 2 below. Hemophilia is caused by a recessive sex –
linked gene represented by Xh. As for colorblindness, a recessive sex – linked gene is
represented by Xc.
33
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
secreted by women. Thus, they do not go bald unless they carry both alleles for the
trait.
Male Genotypes Male Phenotypes
XYBB Male bald
XYBb Male bald
XYbb Male non-bland
Female Genotypes Female Phenotypes
XXBB Female bald
XXBb Female non-bald
XXbb Female non-bald
Table 3. Expression for pattern baldness.
What’s More
Activity 6.1: It’s a Cross: Colorblind and Hemophilia
Objective:
1. Solve problems related to sex-linked traits.
What you need: pen and paper
What to do:
1. Read the given problem:
A. Color blindness is a recessive, sex-linked disorder in humans. A man who is
color blind has a child with a woman who is a carrier of the disorder.
B. A man who has hemophilia has a child with a woman who is non-hemophilic.
KEY: XC= normal vision Xc = color blind
XH= non hemophilic Xh = hemophilic
2. Illustrate using a Punnett square the probability of having children who will have
normal vision and children who will be color-blind.
34
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
Activity 6.2: Who’s Bald and Who’s Not?
Objective:
1. Solve problems related to sex-influenced traits.
What you need: pen and paper
What to do:
1. Read the given problem:
A. A bald male (XYBB) is crossed with a female who is heterozygous non-bald
(XXBb).
B. A man who is heterozygous bald (XYBb) is crossed with a female who is bald
(XXBB)
2. Illustrate using a Punnett square the probability of having children who will have
normal vision and children who will be color-blind.
35
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
Figure 10. Queen Victoria Pedigree Carriers
https://bit.ly/3qsZ6xK
As for hemophilia, it has been called a "royal disease". Figure 6 shows the
Pedigree analysis of Queen Victoria’s lineage. Of her children, one son, Leopold, had
hemophilia, and two daughters, Alice and Beatrice, were carriers. Beatrice's daughter
married into the Spanish royal family. She passed the gene to the male heir to the
Spanish throne.
36
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
What I Have Learned
Compare and contrast: Put a check on a box that correctly corresponds to the
description or examples for sex – linked and sex – influenced traits.
SEX –
Description/Examples SEX -LINKED INFLUENCED
1. Targets sex chromosomes
2. Targets body chromosomes
3. Color – blindness
4. Pattern baldness
5. Hemophilia
6. Hypertrichosis pinnae auris
7. Is affected by male hormone(testosterone)
8. Usually produces a carrier for a trait.
What I Can Do
Read and solve the following genetic problem. Make a Punnett square for each item.
Indicate the percentage probability of a trait to be inherited by the children.
KEY: XC= normal vision Xc = color blind
X = non hemophilic Xh = hemophilic
H
1. (Color blindness) A man who is normal is crossed with a woman who is colorblind.
2. (Hemophilia) A man who has hemophilia is crossed with a woman who is a carrier.
3. (Baldness) A man who is normal is crossed with a woman who bald.
Assessment
Read and understand each item carefully and encircle the letter corresponding to the
word or group of words that completes the sentence.
1. Which is an example of sex - influenced trait among humans?
A. pattern baldness B. colorblindness C. hemophilia D. sex-linked
2. It is an inheritance that is both expressed on both sexes but more frequently in one
than in the other sex.
A. sex-influenced B. colorblindness C. hemophilia D. all of the choices
37
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
3.What happens when sex chromosomes of males have a gene for colorblindness?
A. males sometimes become colorblind or carrier
B. males have still normal vision and not colorblind
C. males will become colorblind
D. males are normal vision
Additional Activities
Solve the following crosses and identify the correct phenotypes and percentage using a
Punnett square.
1. If a father is hemophilic and a mother is non-hemophilic but carrier, what could
be the possible phenotypes and its percentage (children)?
2. If a father has normal vision and a mother is colorblind, what could be the
possible phenotypes and its percentage (children)?
3. If a father is heterozygous for baldness and a mother is heterozygous non-bald,
what could be the possible resulting phenotypes and its corresponding percentages
(children)?
Posttest
Read and understand each item carefully and encircle the letter corresponding to the
word or group of words that completes the sentence.
1. Bases in a DNA are complementary. Which is true of its complementary base if
there are 35 Thymine in the DNA strand?
A. there will be 35 Guanine bases
B. there will be 35 Adenine bases
C. only 25 Adenine, since a DNA is helical
D. cannot be determined
38
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
3. If Roberto’s father has hemophilia and his mother is a carrier, what is the
chance that Roberto would inherit the disease?
A. 25% B. 50 %* C. 75% D. 100%
5. Tan colored birds are the result of the cross between a white (W) and a brown
(B) colored birds. If the off springs are 50% tan and 50% white, what are the
genotypes of their parents?
A. BB x BB B. BB x WW C. BW x WW D. BW x BW
8. It is referred to as the union of egg and sperm cells to form a new organism.
A. mutation C. zygote
B. fertilization D. offspring
9. Which of the following happens to form gametes (sex cells) among male and
female organism?
A. meiosis C. reproduction
B. mitosis D. fertilization
39
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
12. For blood types, if one parent is heterozygous A and the other parent is
heterozygous B, what could be the possible blood types of children?
A. A, B, and O C. A and O
B. A, AB, and A D. A, AB, B, and O
13. How many percent would be the chance of the children to inherit hemophilia if a
mother has hemophilia (XhXh) and the father is non-hemophilic (XHY)?
A. 0% C. 50%
B. 25% D. 75%
14. The DNA has a double – helical structure forming a twisted ladder. The
backbone and steps of the ladder is composed of individual nucleotides bonded
together. What important biological compounds that make up the backbone of
the DNA molecule?
A. nitrogen bases C. pentose and phosphate
B. pentose / 5-carbon sugar D. phosphate group
Answer Key
LESSON 1
40
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
LESSON 2
LESSON 3
LESSON 4
41
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
LESSON 5
LESSON 6
References
“19 Health Problems in Men: Snoring, Hair Loss, and More: Color Blind, What Are
Colours, Colour Blindness Chart.” Pinterest. Accessed July 16, 2020.
https://www.pinterest.ph/pin/210191507595273824/?nic_v1=1a1SHbZE2u
VDyEjCOgUanTgjH99KEjV83rhGPMfDlFbIzgO8CZW8kS5kggvZWEXNQt.
42
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
“ABO Blood Types - Is There a Relationship between Malaria and ABO Blood Type?”
Google Sites. Accessed July 16, 2020.
https://sites.google.com/site/padraigmcdowelln9738142/evidence-for.
“Blood Groups Stock Illustrations – 436 Blood Groups Stock Illustrations, Vectors
& Clipart.” Dreamstime. Accessed July 16, 2020.
https://www.dreamstime.com/illustration/blood-groups.html.
“DNA – Double Helix.” Detailed page of the structure of DNA and its double helix.
Accessed July 16, 2020. https://mammothmemory.net/biology/dna-genetics-
and-inheritance/dna-base-pairing/dna-double-helix.html.
“DNA, Chromosomes and Gene Expression.” Science Learning Hub. Accessed July
16, 2020. https://www.sciencelearn.org.nz/resources/206-dna-
chromosomes-and-gene-expression.
Finegold, David N., By, and Last full review/revision Oct 2019| Content last
modified Oct 2019. “Genes and Chromosomes - Fundamentals.” MSD Manual
Consumer Version. MSD Manuals. Accessed July 16, 2020.
https://www.msdmanuals.com/home/fundamentals/genetics/genes-and-
chromosomes.
“Hemophilia: Coagulation and How Blood Clots.” Medical News Today. MediLexicon
International. Accessed July 16, 2020.
https://www.medicalnewstoday.com/articles/323671.
43
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
“Keyword Analysis & Research: Incomplete Dominance Worksheet.” counter hit
xanga. Accessed July 16, 2020.
https://www.linkddl.com/search/incomplete-dominance-worksheet.
“Men's Fashion: Best Haircut + Hairstyle Guide.” Maxim Online. Accessed July 16,
2020. https://maximonline.com/style/men-hairstyles/.
Woods, Douglas. “Ishihara Test for Color Blindness - Ppt Video Online Download.”
SlidePlayer, July 18, 2017. https://slideplayer.com/slide/10876424/.
44
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE
Development Team of the Module
Writers: Jordan B. Plopino
Mark John D. Bello
Editors:
Content Editors: Jenalyn M. Salonga
Robert J. Gaviola
Jessica S. Mateo
Dr. Nancy E. Suegay
45
City of Good Character
DISCIPLINE • GOOD TASTE • EXCELLENCE