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Brugada Syndrome

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Brugada Syndrome

Antzelevitch C et al. Brugada Syndrome: Report of the Second Consensus Conference. Circulation. 2005; 111:659-670. Genetically linked, cardiac sodium channelopathy High risk for sudden death in young, healthy adults because VTach/VFib Mean age of sudden death = 41 15 years Higher prevalence in males and Asian descent Atrial fibrillation associated in 10-20% cases EKG findings: 3 types Type 1 Most specific for Brugada Syndrome Highest risk for symptoms of syncope and sudden death

Differential diagnosis: After electrical cardioversion Arrhythmogenic RV dysplasia Atypical right BBB Acute MI, esp RV infarct Acute myopericarditis Compression of RV outflow tract Disorders of central/auton nerv systems Dissecting aortic aneurysm Duchenne muscular dystrophy

Friedreich ataxia Early repolarization, especially in athletes Hypothermia Pericardial effusion Pulmonary embolism Left ventricular hypertrophy Mediastinal tumor Pectus excavatum

Treatment: Implantable cardiac defibrillator for Brugada Type 1 PLUS: Aborted sudden cardiac death Syncope, seizure, or noctural agonal respirations without alternative cause Family hx of sudden cardiac death (likely from Brugada) AND positive EPS study A positive EPS study -- Otherwise: close followup with cardiologist

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