Dyslipedemia Short
Dyslipedemia Short
Dr Ayman Morsy
Key point
Hyperlipidaemia is defined as elevated levels of cholesterol and/or
triglycerides.
اضعاف الطبيعي٣ لحدLFT بترفع وظايف الكبد و مسموح استخدامها حتي لو رفعت
hepatic disease ممنوعة في مرضي ال
Fibrates
hepatic and renal disease ممنوعة في مرضي ال
Used to treat increased TG, hyperchylomicronemia
e.g:Lipanthyl 160 mg,300 mg tab
Niacin
مالحظات هامة
● Patients with a high risk of ASCVD (a 10-year risk of at least 7.5%
or 10%, depending on the guideline) should receive statin therapy
for primary prevention.
و مش بيتحمل جرعات عاليةstatins لو المريض مش مستجيب كويس لجرعة متوسطة من ال
)lipidnorm or Ezetrol (االسم التجاريezetimibe جرعةstatins نضيف مع ال
Familial hypercholesterolaemia:
a group of single gene disorders affecting the low‐density lipoprotein
(LDL) receptor and causing deficient or absent uptake of LDL particles,
which therefore accumulate in the bloodstream.
Secondary Hyperlipidaemias
Before deciding whether a hyperlipidaemia is primary, diseases
producing secondary hyperlipidaemias should be excluded:
● Diabetes.
● Hypothyroidism.
● Chronic renal failure or nephrotic syndrome.
● Chronic liver disease, especially alcoholic.
● Chronic biliary obstruction.
● Drugs: steroids, oestrogens.
What is the ASCVD risk score?
1. The ASCVD (atherosclerotic cardiovascular disease) risk score is
a national guideline developed by the American College of
Cardiology.
2. It is a calculation of your 10-year risk of having a cardiovascular
problem, such as a heart attack or stroke.
3. This risk estimate considers age, sex, race, cholesterol levels,
blood pressure, medication use, diabetic status, and smoking
status.
بيعتمد علي
● Age
● Male or Femal
● DM
● HTN
● Lipid profile ,
● Smoker?
● on aspirin or not
● On statin or not
http://www.cvriskcalculator.com
للقراءة
Lipid lowering by diet: reducing fat intake, especially high cholesterol foods (red meat, eggs,
high fat diet, dairy products) lowers cholesterol by 1 mmol/L and reduces body weight.
However, diet alone is insufficient in patients with elevated cholesterol and CAD.
Lipid‐lowering drugs: statins are effective cholesterol‐lowering agents, and should be given
to those with a high (>30% risk over 10 years) or medium (>15%) risk of developing
cardiovascular disease, as assessed from risk prediction charts (e.g. the Joint British
Societies chart found in the British National Formulary), which factor in age, systolic blood
pressure, cholesterol and smoking/diabetes status.