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Biotechnology and Its Applications

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BIOTECHNOLOGY AND ITS

APPLICATIONS
What is biotechnology?

• Biotechnology is the use of biology to develop new products,


methods and organisms intended to improve human health and
society.
Biotechnology is an interdisciplinary field
modern practice of biotechnology draws from various disciplines
molecular biology
chemistry
genetic engineering
genomics
nanotechnology
History of biotechnology
• Biotechnology began at least 6,000 years ago with the agricultural
revolution.
• humans learned to connect the biological process of fermentation to
produce bread, alcohol and cheese.
• People also began changing the genetic makeup of domesticated
plants and animals through selective breeding.
History of biotechnology
• 1919. Hungarian scientist Karl Ereky coins the term biotechnology.
• 1928. Alexander Fleming discovers penicillin, the first true antibiotic.
• 1943. Oswald Avery proves DNA carries genetic information.
• 1953. James Watson and Francis Crick discover the double helix structure of DNA.
• 1973. Herbert Boyer and Stanley Cohen develop genetic engineering with the first insertion of
DNA from one bacteria into another.
• 1980s. The first biotech drugs to treat cancer are developed.
• 1982. A biotech-developed form of insulin becomes the first genetically engineered product
approved by the U.S. Food and Drug Administration (FDA).
• 1983. The first genetically modified plant is introduced.
• 1993. GMOs are introduced into agriculture with the FDA approval of growth hormones that
produce more milk in cows.
• 2010. The first synthetic cell is created.
• 2020. mRNA vaccine and monoclonal antibody technology is used to treat the SARS-CoV-2 virus.
Steps in Biotechnology
vectors
• Vectors are an important component of the biotechnology as
these form the basis for the transfer of DNA fragments from one cell
to another. Vectors have particular features that carry the gene
sequences and enable them to survive within the host cell.
Role of Biotechnology in Agriculture
Plant tissue culture
• Plant tissue culture is a collection of techniques used to maintain or
grow plants cell, tissues, or organs under sterilized conditions on a
nutrient culture of known composition.
• Plant tissue culture is widely used to produce clones of a plant in a
method known as micropropagation.
• Choice of explant----The tissue obtained from a plant to be cultured is
called an explant and may include a portion of shoots, leaves, stems,
flowers, roots, and single undifferentiated cells.
• Callus culture----In tissue culture, a callus is a mass of cells that are
undifferentiated, irregular, and totipotent.
Micropropagation
Advantages of biotechnology

• creating healthier, stronger and more-sustainable food products that


boost nutrition and combat food insecurity;
• treating diseases in children before they are born by altering their
genomes;
• designing medicine to boost the health and longevity of people,
animals and plants;
• cutting costs of farm supplies such as pesticides, while increasing crop
yields and profits.
• Disease resistant plants
Disadvantages
• Biological warfare. -----development of pathogens and epidemics that
could be used in a conflict zone to infect populations.
• Loss of soil fertility----Bio-enhanced plants require more nutrients from
soil and yield more crops.
• High costs---Biotechnology products often cost more than traditional
products
• Ethical considerations--- Gene manipulation raises a range of ethical
issues, such as the genetic engineering of humans.
• Safety questions---- Various groups have raised safety concerns about the
health risks of GMOs and biotech-related medical developments, such as
mRNA vaccines.

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