ITD77731 - CPL Diagnostic
ITD77731 - CPL Diagnostic
ITD77731 - CPL Diagnostic
Intended Use:
The test is designed for use as an aid in diagnosis of HLA-B27 associated disease in patients.
Description:
This is a qualitative analysis for detection of HLA B 27 DNA in clinical specimen. The detection is based on the principle of DNA
amplification of specific sequences by Real Time PCR.
The human leukocyte antigen (HLA) is well known as genetic factor for disease sensitivities and plays a key role in transplantation,
transfusions and parentage test. The HLA B27 is closely related to Ankylosing spondylitis (AS) which can cause inflammation of
the spondylarthritis and pericoxitis such as inflammatory rheumatic disease.The 90% of Ankylosing spondylitis patients have the
HLA B27 genes and normal person also has that of 5-7%.
The HLA-B27 subtype, whose frequency in the worldwide population is extremely variable; differ from each other by one or a few
amino acids, and they bind overlapping peptide repertoires. Worldwide population-based studies indicate that, among the widely
distributed subtypes, HLA-B27:02, B27:04 and B27:025 are strongly associated with Ankylosing spondylitis.
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Test Performed at: CLINICAL PATHOLOGY LAB AGRA