Cough Up 3-5ml Sputum
Cough Up 3-5ml Sputum
Cough Up 3-5ml Sputum
• Humans are the only relevant reservoir, • What was the most common strain of the Black Death?-
The Bubonic Plague
• What is Cholera?
• VERY common in RAINY SEASON
• What bought the Black Death from Asia to Europe?-
Rats and their FLEAS traveling on trade routes
• How is Cholera transmitted?
• Answer: Transmission to humans occurs through eating • Where did the Black Death Originate?- Asia,
food (seafood) or drinking water contaminated with predominantly China
Vibrio cholerae from other cholera patients
• Mode of transmission: WATERBORNE and foodborne • Where did the Black Death first arrive in Europe?-
disease. Messina, Italy
• Where is the major reservoir for cholera? • What is another name for the Black Death?- the
• Answer: HUMANS Bubonic Plague
• In its most severe form what effect does Cholera have? Helminths or PARASITES -
• Answer: Severe drop in blood pressure • Helminths - most common is ascariasis , hookworm
,trichuris (whipworm)
• **** EXCEPT = Taeniasis
• What is the major symptom of Cholera?
• Answer: Massive, rice-water diarrhea (Contains mucus) • Beef tapeworm - Taenia saginata- ingestion of
undercooked beef
(up to 10 liters per day!) • Ancylostomiasis/Hookworm – causes anemia - penetration
of skin - walking barefooted
• Pinworms/ enterobiasis .- causes perianal itchiness at
• What is the treatment for Cholera? night best way to diagnose this infection is through a tape
test.
Answer: oral rehydration therapy
water.
Rabies/ Lysa
• Cause by RHABDO VIRUS BY DOGS ,CATS AND
• What is the causative agent of Cholera? BATS CONTAMINATED SALIVA
observe the dog for 14 days. If it dies or shows
Answer: Vibrio Cholerae signs suggestive of rabies, consult a physician.
• Rabies - hydrophobia, a morbid fear of water
• DOG BITE FIRST AID ACTION WASH WITH SOAP AND
BUBONIC PLAQUE – BLACK DEATH RUNNING WATER
• Trichomoniasis
• Rates- relationship between a vital event and those sTrawberry cervix
persons exposed to event FROTHY, foul-smelling ("fishy" smell
• Ratio- relationship between two (2) numerical quantities ) vaginal discharge
• Infant Mortality Rate- good index of the general Trichomona vaginalis, single cell protozoan
HEALTH CONDITION OF A COMMUNITY S/sx: Females: Yellow gray frothy
• Swaroops index- is the proportion of deaths of people discharge
aged 50 years and up. Dx:
• 3 CRITERIA FOR LAM use: - elevated vaginal pH 5.5+ ( alkaline
Amenorrhea Mgmt: Metronidazole (Flagyl);
Fully or nearly fully breast feeding her infant
BF on demand basis (evey 2-4 hrs during the day, 4-6 • Bacterial vaginosis
foul, fishy smelling, thin gray vaginal discharge
hrs at night
presence of CLUE CELLS (CBQ)
Infant is less than 6 mos
• Gonorrhea PHC
Male:purulent yellow penile discharge
Females: - Greenish vaginal discharge LOI 949 - legal basis of PHC
• Goal of PHC:
• Genital Human Papillomavirus Health in the Hands of the People by the Year 2020
HPV Mission of PHC: SELF RELIANCE
condylomata, cauliflower-like warts • PHC- is universal and it extends even to people in the
Acetic acid (vinegar) swabbing (will whiten lesion) hospital, both sick and well.
Condylomata acuminata -Accessible – not more than 5 km to travel
-Available
• Hepatitis B -Affordable
Spread through infected blood and bodily fluids such -Acceptable
as semen -Appropriateness
Tetanus
1. To give care to the sick,
• caused by the bacterium Clostridium tetani,
• present with trismus (“lockjaw”), 2. To assess the living condition
• give TETANUS TOXOID TO PREVENT Clostridium 3. To give health teachings
INFECTION
4. To establish close relationship
5. To make use of the inter-referral system
• L. monocytogenes CAUSES Listeriosis
- BACTERIA Listeria monocytogenes.
- listeriosis after eating contaminated food.
- primarily affects pregnant women, newborns, older adults, and Principles
people with weakened immune systems.
Foods associated with listeria?
Non-pasteurized milk & milk products (soft cheeses, ice cream), hot 1. A home visit must have a purpose or objective.
dogs, deli meats, caramel apples 2. Planning and delivery of care should involve the
individual and family.
• Middle East respiratory syndrome coronavirus (MERS- 3. The plan should be FLEXIBLE.
CoV)
- CAMEL FLU or SARS of MIDDLE EAST
Steps
• a VIRAL respiratory disease caused by a novel coronavirus
(MERS‐CoV) that was first identified in Saudi Arabia in 1. Greet the patient and introduce yourself.
2012.
2. State the purpose of the visit (Question after
• 1st case - april 2012
Greeting the patient and introducing yourself what
2nd case - sept. 2012
is your next action? = State the purpose of the
• CAMELS - major reservoir host for MERS-CoV and an
animal source of MERS infection in humans visit)
3. Assess or Observe the patient and determine the
• Transmission- human-to-human contact
health needs.
• Highest Risk : IMMUNOSUPRESSION (CANCER)
• Vit.D for calcium absorption prevents RICKETS in children
4. Put the bag in a convenient place and then proceed
and osteomalasia in adult- sources dairy products ,cod
to perform the bag technique. liver oil, fish, milk, cheese , anchovies, salmon, sardines
• VIT C prevents SCURVY
5. Perform the nursing care needed and give health
• Solutions like alcohol must be must be placed in the
teachings. center of the Public health Bag
• IRON- 60 mg per tablet once a day and 400 mcg of folic
6. Record all important date, observation and care acid for 6 months
rendered. • Vitamin A for postpartum – 200,00 IU one dose
• Vitamin A for pregnant– 10,00 IU 2x a week starts at 4
7. Make appointment for a return visit. months
• Vitamin A for Children 12 months and above – 200,00 IU
BAG TECHNIQUE is a tool by which the nurse, during her visit dose every 6 months
• Vitamin capsule colors: RED
will enable her to perform a nursing procedure with ease and • Vitamin A treatment of Xeropthalmia and Measles
deftness, to save time and effort with the end view of rendering • Beta-carotene in vegetables such as carrots and sweet
potatoes is the most common provitamin A.
effective nursing care to clients.
• Dairy products (such as cheese and fortified milk), eggs,
cod, liver oil and halibut are rich sources of preformed
PUBLIC HEALTH BAG is an essential and indispensable vitamin A.
equipment of a public health nurse which she has to carry along
• Plant-based sources of provitamin vitamin A include
during her home visits. pumpkin, broccoli, and dark green, leafy vegetables.
place the bag on the table lined with a clean paper. The clean SOLID WASTE MANAGEMENT
Color coded trash bins
side must be out and the folder part, touching the table Steps
Black - Non-infectious dry waste
Green - Non-infectious wet waste (kitchen, dietary etc.)
BULLETS
Yellow -- Infectious and Pathological waste
• Spacing of pregnancy - 3-5 years Yellow with black band ---Chemical waste including those w/ heavy
metals
💥 💥Orange--- Radioactive waste Asian Flu
💥 💥Red---- Sharps and pressurized containers Spanish flu ( 1918-1919) - 40 to 50 million deaths
Antonine plague
Epidemiology
Meningococcemia
– study of the occurrences,
distribution and determinants of health-related states or A H1N1
events in specified populations.
B lack death / Bubonic plague by Yersinia pestis
– backbone of the prevention of the disease
H IV/AIDS
Epidemiologic Triad: HOST – AGENT – ENVIRONMENT
E bola and COVID – 19 by SARS-CoV-2
1. Host – intrinsic factor (man as primary host)
2. Agent – etiologic factor (virus, bacteria, fungi, parasites etc.
)
3. Environment – extrinsic factor RA 3573 ( Law on reporting of Notifiable Diseases)
John Snow – Anesthesiologist known as “FATHER OF - Report to provincial and duty health office
EPIDEMIOLOGY” - Midwife reports – under supervision of the nurse
- REPORT Measles Polio within 24 hours
• In 1800's - He studied the epidemic of - Tetanus Neonatorum, Severe and acute
CHOLERA erupted in the Golden Square of diarrhea, HIV within a WEEK
Soho district London (1854)
RA 11332 (MANDATORY reporting of Notifiable Diseases)
In Epidemiology:
- Mandatory Reporting of Notifiable Diseases and
1. “DISTRIBUTION” - refers to descriptive epidemiology Health Events of Public Health Concern Act
- It answers the questions WHEN, WHERE, WHO - Surveillance and Response to Notifiable
- time (when), place (where), and person (who) Diseases, Epidemics, and Health Events of
Public Health Concern
2. “DETERMINANTS” - refers to analytic epidemiology.
- discovers causes, risk factors, modes of CHAIN OF INFECTION
transmission
1. Agent – Any micro-organism capable of producing an
- It answers the WHY and HOW
agent (Bacteria, virus, fungi, parasites)
- includes the causes (including agents), risk
factors (including exposure to sources) Killing the microorganism by :
Descriptive vs. Analytic epidemiology DISINFECTION: Killing of micro organism but NOT their spores
1. Descriptive epidemiology can identify patterns among STERILIZATION: Killing of ALL MICROORGANISM including spores
cases and in populations by time, place and person.
Survey are used to find out the nature of the AUTOCLAVING –15 pounds pressure, moist heat and 250
population affected by a particular disease noting the degrees Fahrenheit.(121°C)
age, sex and occupation. Black strips suggest successful autoclave
2. Analytic epidemiology is concerned with the search for 2. Reservoir
causes and effects, or the why and the how. - natural HABITAT in which the agent normally
lives, grows, and multiplies.
Patterns of Occurrence and Distribution - It includes, humans, animals, and environment
1. SPORADIC – intermittent occurrence of a few isolated - Human reservoirs : Measles, mumps, HIV and
(scattered) and unrelated cases STI
- Animal reservoir: anthrax (sheep) and rabies
2. ENDEMIC – continuous occurrence throughout a period of time (dogs)
of the usual number of cases in a given LOCALITY. - Environment reservoirs: Histoplasmosis (soil)
Endemic refers to the constant presence and/or usual prevalence of TAKE NOTE:
a disease or infectious agent in a population within a geographic area
Carrier—A person or animal that harbors a specific infectious
3. EPIDEMIC – unusual large number of cases in a relatively agent WITHOUT discernible clinical disease and serves as a
SHORT period of time usually in weeks potential source of infection
Point source – food poisonings 3. Portal of exit – path by which a pathogen leaves its host.
Cyclical pattern – dengue fever - Many portals of exit are identical to portals of
Secular trend – influenza entry
Propagated - HIV/AIDS - Influenza and TB exit the respiratory tract and
Cholera bacteria exit in in feces
4.PANDEMIC – simultaneous occurrence of epidemic on the same
disease in SEVERALCOUNTRIES affecting large number of
4. Modes of transmission - Considered as the WEAKEST
population
link
Pandemic diseases: - Can be easily break by HAND WASHING
- Hand washing is the NUMBER ONE way to stop
M ERS cov the transmission of infections
Hand Hygiene is the single MOST effective and important - Some studies in 2003 suggested that smallpox
technique to use in preventing and controlling transmission of and SARS could reach persons located 6 feet or
infection more from the source. (Some examples- flu,
rhinovirus, SARS, group a strep, Neisseria
Handwashing / hand hygiene meningitis.)
3 elements of Handwashing: DROPLET PRECAUTION
A. Soap – (1 - 3 ml) Streptococcal infection and scarlet fever
B. Water – running clean water Pertussis, pneumonia, parvovirus B-19
C. Friction – MOST important element Influenza
HANDWASHING TIME: (40–60 sec) Diptheria
Minimum time each hands: 15 seconds Epiglottitis
Average time: 20 seconds each hands Rubella
BEST time:30 seconds Mumps,measles,mycoplasma, meningitis
Adenovirus infection
• Alternative to soap and water: Hand based Novel coronavirus ( COVID-19) Sars-Cov-2
sanitizer with at least 60% ethanol content
3. Airborne transmission
MODE OF TRANSMISSIONS - Droplet nuclei are dried residue of LESS than 5
1. Contact transmission – MOST frequent means of microns in size.
transmitting infections in healthcare facilities. Can be by - Particles are suspended in the air for a LONG
direct or indirect. PERIOD OF TIME or when dust particles contain
A. Direct contact – occurs through. skin-to-skin pathogens
contact, kissing, and sexual intercourse - MTV- Measles, TB, Varicella
• contact with soil or vegetation harboring
infectious organisms. 4. Vectorborne Transmission
- Vectors are non human carriers that transmit
• infectious mononucleosis (“kissing disease”) and
organisms from 1 host to another and can be
gonorrhea are spread from person to person by
biologic or mechanical. (mosquitoes, animals,
direct contact.
fleas, and ticks)
• Hookworm is spread by direct contact with
- Deer ticks – lymes disease
contaminated soil.
- Mosquitos – dengue, malaria, filariasis
B. Indirect transmission – transfer of an infectious
- Rat flea – black death/bubonic plague
agent from a reservoir to a host by suspended air
- Dogs– rabies
particles, inanimate objects (vehicles), or animate
- Snail – schistosomiasis
intermediaries (vectors).
• 5 F’s — Fingers/hands, Fomites(inanimate Mode of transmission continuation
object), Foods, Feces, Flies
5. Portal of entry – refers to the manner in which a pathogen
Contact transmission enters a susceptible host.
Multidrug resistant organism (methicillin) For example:
Respiratory infections
Skin infections (leprosy, ringworm, scabies) • Respiratory tract (Influenza virus)
• Fecal -oral (gastroenteritis)
Wound infections (tetanus) and STI’s (HIV/AIDS) • Skin (hookworm)
Enteric infections (Gastrointestinal diseases) • Mucous membranes (syphilis)
Eye infections ( conjunctivitis) • Blood (hepatitis B, HIV).
Vehicle Transmission –Involves the transfer or microorganisms by Donning(putting on): from bottom up (shoe cover ni GowMa
way of vehicles, or contaminated items that pathogens, GoGlo)
Ex. Milk and dairy foods carrying LISTERIOSIS (L. Boot covers
Monocytogenes) Gown/Apron
Mask
• Food carrying salmonella, water carrying Goggles
Legionella, blood borne hepatitis B and C, Gloves (when hands raised above head)
drugs can carry bacteria from contaminated
infusion supplies. Doffing (taking off): alphabetical order
• Contaminated Blood, food, water, inanimate Boot covers
objects are vehicles of transmission. Gloves
Goggles
Gown
2. Droplets transmission – Droplets are body fluids. Mask
- It refers to spray with relatively large, short-range
aerosols produced by sneezing, coughing, or 4. Host - The FINAL link in the chain of infection is a
even talking. susceptible host.
- Droplets DO NOT remain suspended in the air - Compromised host - Host with lowered
for very long and seldom travel more than 3 resistance to infection and disease for any
feet around the patient.
reason (for example, malnutrition, illness,
trauma, or immunosuppression). 2. Artificial Active - introduction of a killed or weakened form of the
disease organism through vaccination (Aray Aray like turok ng EPI
STAGES OF INFECTIOUS DISEASE: vaccines)
– Incubation period – time period between exposure to 3. Natural Passive - IgA found in human colostrum and milk and IgG
an infection and the appearance of the FIRST tranplacental (Nanay Pasuso(breastfeeding) and Nay Papasa ng IgG
symptoms (latency, no signs and symptoms) from placenta in pregnancy)
*Communicability period – time when disease are MOST *Natural passive last only for 6 to 12 months
contagious & easily transmitted to others.
4. Artificial Passive
- Provides immediate protection, but short-term protection by
injection of antibodies, (may last 2 – 3 weeks)
- Injection of gamma globulin, rabies antibodies, anti
2. Prodromal period – the time from the onset of nonspecific tetanus serum
symptoms until specific symptoms begin to manifest (mild signs
and symptoms)
COMMUNICABLE DISEASES
Acute Illness
3. Stage of illness – Most severe stage of an infectious disease
- Less than 6 months
- Signs and symptoms are MOST evident and MOST SEVERE at this
time - Symptoms often are sever and appears suddenly or abruptly,
subside quickly
4. Stage of decline - Body gradually returns to a normal state of
health - Good prognosis
- Signs and symptoms subside - Example: Dengue fever, measles
- The immune response and antibody titers normally peak
3. Filariasis/ elephantiasis
Treatment: • Lymphatic filariasis, commonly known as elephantiasis, is a
neglected tropical disease.
Doxycycline – Drug of choice and prophylactic drug to prevent
leptos Vector: Aedes poecillus mosquito
Breeding sites: water-filled leaf axils of abaca, banana, taro (gabi)
P – Pen -G
and
E – Erythromycin
screw pine (pandan/pandamus).
T – Tetracycline
Peak Biting time: 10 pm to 2 am (Best time to collect blood sample
Causative agent: Wuchereria Bancrofti
Prevention:
Watch out for: Icterus and Shock – refer to secondary or tertiary Management:
facility
Diethyl carbamazine citrate or Hetrazan (6mg/kg)
Chemoprophylaxis –chloroquine taken at WEEKLY interval, Ivermectin (200mcg/kg) + albendazole
starting from 1-2 weeks before entering the endemic area. Albendazole (400mg) 2x a year
Anti-malarial drugs: sulfadoxine, quinine sulfate, tetracycline, No treatment can reverse elephantiasis
quinidine
Treatment for pregnant and infants: sulfadoxine-pyrimethamine
TAKE NOTE: HETRAZAN is the DRUG OF CHOICE. (Side effect is
NOT malaria drug – Amoxicillin
fever)
Preventive measures:
PREVENTIVE MEASURES
Others signs:
Preventive measures
F – feces and urine proper disposal or use of sanitary toilets. L – low platelet
A – avoid bathing and washing in infested waters A – abdominal pain, loss of appetite, vomiting and diarrhea
R – rubber boots to avoid skin penetration in agricultural places M – muscle and joint pain
M – molluscicides use O – onset of fever
E – emphasize importance of hand washing
C – capillary refill longer than 2 seconds.(POOR TISSUE • direct fluorescent antibody (DFA) test, which looks for the
PERFUSION) presence of rabies virus antigens in brain tissue .
Normal capillary refill is 1 – 2 seconds. • Human rabies can be confirmed intra-vitam and post
mortem by various diagnostic techniques that detect whole
Hermann's sign (petechial rash) – pathognomonic sign of dengue.
viruses, viral antigens, or nucleic acids (negri bodies) in
TAKE NOTE: Cold and clammy skin is a sign of dengue infected tissues (brain, skin or saliva)
hemorrhagic fever
Signs and symptoms:
BITES ON HEAD OR FACE has the SHORTEST INCUBATION CATEGORIES OF DOG BITE
PERIOD
Category I - touching or feeding animals, animal licks on intact skin
• less than 50 days is the incubation if the patient is bitten (no exposure)
on the head Category II - nibbling of uncovered skin, minor scratches or
• Bites or scratches in hands is longer incubation less abrasions without bleeding (exposure) – GIVE ACTIVE VACCINES
than 1 year Category III - single or multiple transdermal bites or scratches,
contamination of mucous membrane or broken skin with saliva from
Rabies is the deadliest zoonotic disease that threatens humans and
animal licks, exposures due to direct contact with bats (severe
animals on all continents except Antarctica.
exposure) – GIVE ACTIVE AND PASSIVE (RIG vaccine)
Vector: DOG – principal animal vector (99%)
Virus can be transmitted by Saliva
RABIES IMMUNIZATION
Causative Agent: VIRUS – Rabies lyssavirus, formerly Rabies virus
of the rhabdovirus family. 1. ACTIVE IMMUNIZATION – develops antibody that gives 2
Incubation period: 2 – 8 weeks (2-3 months) – 3 years protection
FACTS on RABIES
Example:
• Asia and Africa are worst affected as more than 95% of PCEC (Purified Chick Embryo Vaccine)
rabies associated human deaths. PDEV (Purified Duckling Embryo Vaccine)
• Bat rabies is responsible for most human rabies deaths in RABIPUR and VERORAB OR VEROWELL(cheap)
the United States of America and Canada Purified Vero cell rabies vaccine (PVRV)
• 40% of people bitten by suspect rabid animals are Dose:
children under 15 years of age. ID - 0.1 ml
IM - 0.5 ml
Mode of transmission: Dog bite
Example: 2. SALMONELLOSIS
Sign and symptoms
ERIG (Equine rabies Immunoglobulin) – derived from HORSE • Acute onset of fever
serum. • Abdominal pain/cramps
• Acute Diarrhoea
HRIG (human Rabies Immunoglobulin)
• Anorexia, nausea and vomiting.
Standard ROUTE: Intramuscular
PVRV dose: 0.5 ml 📍Ensure food is properly cooked and still hot when served.
PCECV dose: 1.0 ml 📍Avoid raw milk and products made from raw milk. Drink only
pasteurized or boiled milk.
Site of injection: One deltoid or anterolateral thigh in Infants 📍Avoid ice unless it is made from safe water.
📍When the safety of drinking water is questionable, boil it
📍Wash hands thoroughly and frequently using soap
Prevention: 📍Wash fruits and vegetables carefully
R – responsible pet ownership (Republic Act 9482)
A – anti-rabies immunization of pets beginning at age 3 months 3. Hepatitis A
YEARLY
• Hepatitis A is an inflammation of the liver that can cause
B – bathe, feed them with safe and clean food and water
mild to severe illness.
I – if you are bite , scratched or licked by dog – wash the site
• The hepatitis A virus (HAV) is transmitted through ingestion
immediately for 15 minutes.
of contaminated food and water or through direct contact
E – ensure that pets are NOT roaming in the streets (your pet action
with an infectious person.
is your responsibility.)
• Almost everyone recovers fully from hepatitis A with a
S – support and mobilize community participation
lifelong immunity. However, a very small proportion of
people infected with hepatitis A could die from fulminant
FIVE TIPS TO AVOID DOG BITES: hepatitis.
• The risk of hepatitis A infection is associated with a lack of
P – pet the dog gently by stroking back first and allowing dog to sniff safe water and poor sanitation and hygiene (such as
hands first. contaminated and dirty hands).
E – eye to eye contact must be avoided • A safe and effective vaccine is available to prevent
T – try to stand still like a tree trunk (DO NOT RUN) hepatitis A.
M – make sure all dogs are vaccinated against rabies yearly. Agent: hepatitis A virus (HAV)
E – eating, playing, sleeping or scared dog should NEVER BE
DISTURBED. MOT: faecal-oral route — foodborne or waterborne that is
contaminated with the faeces of an infected person.
Incubation Period: Symptoms usually appear within 12 to 36 hours • Clonorchiasis and opisthorchiasis — praziquantel
(within a minimum and maximum range of 4 hours to 8 days) after • Fascioliasis — triclabendazole
exposure • Paragonimiasis — triclabendazole or PRAZIQUANTEL
Misdiagnosed as: stroke, Guillain-Barré syndrome, or myasthenia 6.Taeniasis/cysticercosis – intestinal infection with
gravis. tapeworms.
• 📍HANDWASHING
7.LISTERIOSIS:
• 📍WHO FOOD SAFETY
Agent: bacteria — Listeria (L. monocytogenes.) • 📍TYPHOID VACCINE
MOT: Foodborne • 📍Access to safe water and Adequate sanitation
– Fever Asymptomatic
– Fatigue Breathing difficulty (DOB/SOB)
– Muscle pain Cough
– Headache Diarrhea
– Sore throat Episodes of Nausea and vomiting
Fever
– 35% mortality among patients
– This is followed by: – 80% of cases are from Saudi Arabia
– Vomiting – South Korea —largest MERS outbreak outside the
– Diarrhoea Middle East.
– Rash Treatment:
Symptoms of impaired kidney and liver function – NO CURE
In some cases, both internal and external bleeding (for example, – Oxygen therapy and mechanical ventilator
oozing from the gums, or blood in the stools). – Treatment for MERS-CoV focuses on relieving symptoms
and includes rest, fluids, pain relievers and, in severe
Laboratory findings include low white blood cell and platelet counts cases, oxygen therapy.
and elevated liver enzymes.
PREVENTION
Diagnosis:
Minimize close contact to camels and symptomatic person
– antibody-capture enzyme-linked immunosorbent assay Emphasize importance of handwashing at least 20secs.
(ELISA) Report any suspected cases to local health authority
– antigen-capture detection tests Sneezing into a sleeve, flexed elbow, or a tissue
– serum neutralization test
– reverse transcriptase polymerase chain reaction (RT- Cook meats and any food properly
PCR) assay Observe and follow a contact precaution
– electron microscopy Visit a health facility for immediate medical attention for acute
– ·virus isolation by cell culture. respiratory illness
Treatment:
CHRONIC DISEASE
Supportive care - rehydration with oral or intravenous fluids - and
treatment of specific symptoms improves survival. – Tuberculosis / PTB /Koch's disease: 6th leading cause
of morbidity and mortality
Two monoclonal antibodies (Inmazeb and Ebanga) were approved
for the treatment of Zaire ebolavirus (Ebolavirus) Tuberculosis (TB) is caused by bacteria (Mycobacterium
tuberculosis) that most often affect the lungs. Tuberculosis is curable
Vaccine: Ervebo vaccine, Zabdeno-and-Mvabea and preventable.
Emphasize importance of handwashing discovered the agent causing Cholera, Anthrax and
B urial ceremony is NOT allowed Tuberculosis(1882)
O Utbreak containment measures Causative Agent: Mycobacterium Tuberculosis (BACTERIA)
L aboratory and health workers PPE
Apply STANDARD PRECAUTION to all patients BACTERIA
SPUTUM COLLECTION:
Days Samples Explanation
o Should preferably have 3 specimen, three specimens are Day 1 Sample 1 (Spot) Patient provides an ‘on the spot’
enough to confirm the diagnosis. sample under supervision.
o 2 specimens should be collected spot-spot 1-hour apart or (Patient is then given the sputum
spot-early morning collection. container to take home for an
o Collect 3 – 5 ml of sputum (NOT Less than 3 ml) (CBQ) early morning sample (sample 2)
o If TWO (2) of the first three sputum smears are positive. for the following day.
(CBQ) Day 2 Sample 2 Patients produces and brings
o The ONLY contraindication for sputum collection is: ‘early morning sample’ to the
HEMOPTYSIS clinic
Sample 3 (Spot) Patient produces another ‘on the
spot’ sample under
supervision
Collection of Sputum Specimens:
SPUTUM
▪ Tell patient NOT to touch inside of the container at any ▪ Sputum is thick and mucoid and comes from the lungs
time. ▪ The color is white to green or bloody.
▪ As soon as you wake up in the morning (before you eat or ▪ Sputum is NOT saliva or nasal secretions which are
drink anything), brush your teeth and rinse your mouth with runny and clear
WATER. Do not use toothpaste or mouthwash.
▪ Take a very deep breath and hold the air for 5 seconds. Patient Instructions for Collection of Sputum Specimens: (CBQ)
Slowly breathe out. Take another deep breath and cough
hard until some sputum comes up into your mouth. 1. Tell patient NOT to touch inside of the container at
▪ Spit the sputum into the plastic tube. any time.
▪ Take another deep breath and cough hard and spit the 2. As soon as you wake up in the morning (before you
sputum into the plastic tube. Keep doing this until the eat or drink anything), brush your teeth and rinse your
mouth with WATER. Do not use toothpaste or
sputum reaches the 5 mL line on the tube. (3mL is the
mouthwash.
minimum volume necessary for this test
3. Take a very deep breath and hold the air for 5
Treatment: TB is a treatable and curable disease. Active, drug- seconds. Slowly breathe out. Take another deep breath
susceptible TB disease is treated with a standard 6-month course and cough hard until some sputum comes up into your
mouth.
of 4 antimicrobial drugs. (CBQ)
4. Spit the sputum into the plastic tube.
Direct Observed Treatment Short Course (DOTS) – 5. Take another deep breath and cough hard and spit the
comprehensive strategy to detect and cure TB patients that was sputum into the plastic tube. Keep doing this until the
sputum reaches the 5 mL line on the tube. (3mL is the
started in the country in year 1996 (FREE drugs)
minimum volume necessary for this test.
Direct Observed Treatment Short Course (DOTS) Ethambutol (E) Optic toxicity Children below 6
▪ comprehensive strategy to detect and cure TB patients that Optic neuropathy years must NOT
was started in the country in year 1996 (FREE drugs) Vision loss be given
(CBQ) Ethambutol due
to the risk of
▪ It has five basic elements damage to the
(a) availability of quality assured Eyes(CBQ)
sputum microscopy
(b) uninterrupted supply of anti-TB Streptomycin (S) Giddiness Reduce dosage
drugs (staggering / loss by one quarter,
(c) supervised treatment of balance) but if it persists for
(d) patient and program monitoring Ototoxicity more than one
(e) political will. ▪ Ringing of week STOP and
ears Refer!
DOTS (Direct Observed Treatment Short Course) (CBQ) (tinnitus)
Category Classification ▪ Hearing DO NOT give
Category I N – NEW smear (+) TB patient(CBQ) loss streptomycin
E – Extensive lesion shown in CXR (-) smear drug to pregnant
patient client it may
W – with Extra pulmonary TB, PLHIV, and damage the ear
severe concomitant disease of baby.
Category II R – remission
E – Extra-pulmonary TB, new (CNS/bones or Drug formulations
joints) 1. Fixed–dose combination (FDCs)
S – sputum smear positive patients who have; ▪ Two or more first-line anti-TB drugs are combined in one
T – treatment failure tablet.
A – after treatment interruption.
R – relapse of disease(CBQ) BLISTER PACKS:
T – treatment after default/return after default 2 drug fixed-dose combination – Rifampicin(R) and Isoniazid (H).
3 drug fixed-dose combination – Rifampicin, Isoniazid and
Category III New smear (-) PTB with minimal lesion shown Ethambutol (CBQ)
on X-ray result. 4 drug fixed-dose combination – Rifampicin, Isoniazid,
Pyrazinamide and Ethambutol.
Category IV Multi drug-resistant TB (MDR)
Chronic TB who are still sputum (+) after 2. Single drug formulation (SDF)
supervised re-treatment. ▪ Each drug is prepared individually, either as tablet,
Needs REFERAL for 2nd line treatment drugs capsule, syrup or injectable (Streptomycin) form.
“Category IV regimens”.
Multidrug-resistant tuberculosis (MDR-TB) is a Category Intensive phase
form of TB caused by bacteria that do not I 2 months (Rifampicin and Isoniazid) (CBQ)
respond to isoniazid and rifampicin, the 2 II 2 months RIPES/1 month RIPE
most effective first-line anti-TB drugs. III 2 months RIPE
Monitoring treatment:
2. Multibacillary Leprosy (MB)
▪ Sputum microscopy: Examine sputum for AFB at ▪ Lepromatous leprosy
specified intervals ▪ Infectious type
▪ Clinical: Conduct clinical assessment including weight ▪ Shows 6 or more lesions, nodules, plaques,
assessment ▪ thickened dermis and involvement of the nasal mucosa.
▪ Drug intake: Assess patient’s records for regularity. ▪ Treated for 12 months to 18months
(Blister packs)
▪ Two sputum smear examinations (taken as two early
morning samples within 2 days)
Signs and Symptom:
• For smear-positive patients:
EARLY signs:
- End of the 2nd month for new cases or 3rd
month for re-treatment cases E – enlarged nerve especially elbow, knee, neck (painful thickened
- End of 5th month nerves) (CBQ)
- End of 7th month
For smear-negative patients only at the end of the 2nd month A – anesthetic (numbness or loss of sensation) (CBQ)
Tuberculosis prevention: (CBQ) R – redness to copper colored skin (skin color changes)
B – BCG vaccination
C – clean and fresh air, Adequate rest and exercise L – loss of muscle strength (muscle weakness)
G – good personal Hygiene, and well balanced diet. Y – you may also find nodules, patches and ulcers that do not heal.
MOST IMPORTANT HEALTH TEACHING: STRICT compliance
to treatment regimen
LATE signs:
3. Dapsone
Types of Leprosy: This drug is very safe in the dosage used in MDT
1. Paucibacillary leprosy(PB) Main side effect is allergic reaction, causing itchy skin rashes and
▪ Tuberculoid leprosy and intermediate exfoliative dermatitis. DO NOT GIVE to patients known to be allergic
▪ Non infectious type of leprosy to any sulpha drugs
▪ Less than 5 hypopigmented, anesthetic skin lesions
▪ Treated up to 6 to 9 months
MUST KNOWS: Agent: RETROVIRUS (HIV)
Aims to find leprosy cases in high prevalence areas through skin *HIV weakens the immune system,destroying a type of WBC (CD4
consultation. or T-helper cells)
▪ All patients who have complied w/ MDT are considered AIDS is manifested 2 to 10 years after HIV onset.
cured and no longer regarded as a case of leprosy, even if
some sequelae of leprosy remain. Diagnosis
▪ Untreated, leprosy can cause progressive and permanent ▪ EIA/ELISA — Screening test for HIV antibodies
damage to the skin, nerves, limbs, and eyes. (CBQ) ▪ Western Blot - confirmatory testing for HIV antibodies.
▪ RA 4073 – An Act further liberalizing the treatment of ▪ Western blot is the confirming test for people who initially
leprosy tested antibody-positive in the screening ELISA test for
▪ World Leprosy Day (Every last Sunday of January) HIV.
▪ Leprosy Control Week (Every 4th week of February) ▪ The Western blot test is unlikely to generate a false-
▪ National Skin Disease Detection and Prevention Week positive result.
(Every 2nd week of November) ▪ This will be used to confirm or refute the ELISA test results
Note: it is the HIV ANTIBODIES being tested not the actual virus
3. HIV/AIDS: itself
▪ HIV (human immunodeficiency virus) is a virus that attacks CD4 CELL COUNT:
the body’s immune system. If HIV is not treated, it can lead
to AIDS (acquired immunodeficiency syndrome). ▪ A normal CD4 count is from 500 to 1,400 or 500 to 1500
▪ There is currently no effective cure. Once people get cells per cubic millimeter of blood. CD4 counts decrease
HIV, they have it for life. over time in persons who are not receiving ART.
▪ But with proper medical care, HIV can be controlled. ▪ Less than 200 cells/mm³ is AIDS
People with HIV who get effective HIV treatment can live
long, healthy lives and protect their partners
MODE of Transmission:
▪ HIV infection in humans came from a type of chimpanzee V — Vaginal sex (male to female)
in Central Africa. O— Oral sex
▪ The chimpanzee version of the virus (called simian
immunodeficiency virus, or SIV) was probably passed to N — Needles (sharing and pricks) — 4%
humans when humans hunted these chimpanzees for meat
and came in contact with their infected blood.
▪ Studies show that HIV may have jumped from 20% – OFW
chimpanzees to humans as far back as the late 1800s.
MAJORITY is male.