Seat No.: _____ Enrolment No.

_____________

GUJARAT TECHNOLOGICAL UNIVERSITY

B.Ph. - SEMESTER– V• EXAMINATION – WINTER -2022

Subject Code: Medicinal Chemistry II Date:26/12/2022

Subject Name: BP501TT
Time: 10:30AM TO 01:30PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Give synthesis and uses of (i) Diphenhydramine (ii) Methotrexate 06
(b) Write a short note on proton pump inhibitors 05
(c) Classify alkylating agents with structures 05
Q.2 (a) Write a brief note on H2-antagonists. Give synthesis of cimetidine 06
(b) Write a short note on histamine receptors 05
(c) Give brief account on ACE inhibitors 05
Q.3 (a) Give structure and uses of (i) Mannitol (ii) Diltiazem (ii) Nifedipine 06
(b) Write a short note on drugs used in Angina 05
(c) Write a note on Loop diuretics. Give synthesis of Furosemide 05
Q.4 (a) Give synthesis of (i) Methyldopate hydrochloride (ii) Isosorbide dinitrite 06
(b) Classify Anti-arrhythmic Drugs with one structure from each class 05
(c) Write a short note on statins 05
Q.5 (a) Write a short note on Anticoagulants. Give synthesis of Warfarin 06
(b) What do you mean by Congestive Heart Failure? Give brief account on digitalis 05
glycosides
(c) Describe nomenclature and stereochemistry of steroids 05
Q. 6 (a) Give structure and uses of (i) Methimazole (ii) Sildenafil (iii) Diethyl stilbestrol 06
(b) Write a short note on Oral contraceptives 05
(c) Explain the terms with example (i) Glucosidase inhibitors (ii) Glucocorticoids 05
Q.7 (a) Describe the SAR of Local anesthetics 06
(b) Give synthesis and use of (i) Procaine (ii) Tolbutamide 05
(c) Write a brief note on Thiazolidinediones 05

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 Seat No.:

Enrolment No.

GUJARAT TECHNOLOGICAL UNIVERSITY

B.Pharm – SEMESTER V– • EXAMINATION – SUMMER-2021

Subject Code: BP501TT Date: 03/08/2021

Subject Name: Medicinal Chemistry II
Time: 02:30PM to 05:30PM Total Marks: 80
Instructions:
1. Attempt any five questions
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) What are anti-histaminic? Classify H1-antagonist in detail. 06

(b) Write a short note on proton pump inhibitors. 05
(c) Outline the synthesis of a) Diphenyl hydramine b) Cemetidine 05
Q.2 (a) What are antineoplastic agents? Explain alkylating agent in detail. 06
(b) Write a note on antimetabolites. 05
(c) Give structure, uses and synthesis of methotrexate. 05
Q.3 (a) Classify antihypertensive agents. Give at least one structure from each class. 06
(b) Write a short note on anti-anginal agents. 05
(c) What are diuretics? Explain in detail about loop diuretics. 05
Q.4 (a) Classify anti-arrhythmic agents. Give synthesis of disopyramide phosphate. 06
(b) Write a note on anti-hyperlipidemic agents. 05
(c) Explain the chemistry of cardiotonic. 05
Q.5 (a) Explain in detail about nomenclature and stereochemistry of steroids. 06
(b) Write a short note on drug used for erectile dysfunction. 05
(c) Explain about anti-thyroid agents. 05
Q. 6 (a) What is type II diabetes? Classify anti-diabetic agents in detail. 06
(b) Explain the SAR of local anesthetics. 05
(c) Outline the synthesis of a) tolbutamide b) benzocaine. 05
Q.7 (a) Explain briefly coagulant and anti-coagulant agents. 06
(b) Write a note on ACE inhibitors. 05
(c) Write a note on H2 receptor antagonist. 05

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Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY

B.Pharm- SEMESTER–V EXAMINATION – WINTER -2021

Subject Code: BP501TT Date:13/12/2021

Subject Name: Medicinal Chemistry-II
Time: 10:30am to 01:30pm Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Classify H1-receptor antagonists. Write the structure and use of one drug from 06
each category.
(b) Write a short note on gastric proton pump inhibitors. 05
(c) Write structure and use of following drugs: 05
(a) Ethacrynic acid (b) Benzocaine (c) Metformin (d) Ranitidine
(e) Cetrizine
Q.2 (a) Classify corticosteroids with suitable examples. Write chemical structure of any 06
one drug from each category.
(b) Write an informative note on anti-angial agents. 05
(c) Write a short note on oral anticoagulants. 05
Q.3 (a) What are diuretics? Classify diuretics with examples. Give synthesis of 06
Acetazolamide.
(b) Classify antihyperlipidemic agents with suitable examples and structures in 05
each category.
(c) Write a short note on drugs used for erectile dysfunction. 05
Q.4 (a) What are anti-neoplastic agents? Classify them and write about any one class in 06
detail.
(b) What is Diabetes Mellitus? Write chemical classification of oral hypoglycemic 05
agents with suitable examples and structures in each category.
(c) Outline synthetic scheme and use of following drugs (Any two): 05
(a) Methotrexate (b) Warfarin (c) Tolbutamide
Q.5 (a) Outline the SAR of local anesthetics. 06
(b) What are antihypertensive agents? Classify them and write two chemical 05
structures of each class.
(c) Define and classify anti-arrhythmic agents and explain mode of action of each 05
class.
Q. 6 (a) Write a short note on H2-receptor antagonists. 06
(b) Define and classify antithyroid drugs. Give chemical structure of any one drug 05
from each category.
(c) Write a short note on oral contraceptives. 05
Q.7 (a) What are hormones? Discuss nomenclature and stereochemistry of steroids. 06
(b) Write a short note on Angiotensin Converting Enzyme inhibitors. 05
(c) Write in detail 1,4-dihydropyridine calcium channel blockers. 05

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Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY

B.Ph. - SEMESTER– 5 • EXAMINATION – SUMMER -2020

Subject Code:BP501TT Date: 26-10-2020

Subject Name: Medicinal Chemistry II
Time: 2:30 PM TO 5:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Enlist various histamine receptors. Discuss neurochemistry of histamine. 06

(b) Give the synthesis of Promethazine hydrochloride and diphenhydramine 05
hydrochloride.
(c) Write a note on Nitroglycerin as a Vasodilator. 05
Q.2 (a) Classify Diuretics with one structure in each class. Write mechanism of action, 06
uses and side effect of Acetazolamide.
(b) Write informative note on Anti-hypertensive agents and give the synthesis of 05
Methyldopate hydrochloride.
(c) Write a note on Gastric Proton pump inhibitors. 05
Q.3 (a) Classify Antiarrhythmic agents with one structure in each class. Write synthesis 06
of Disopyramide phosphate.
(b) Write short notes on heparin as anticoagulant and give the synthesis of 05
Warfarin.
(c) Give the synthesis the following: (Any two) 05
(i) Isosorbide dinitrite (ii) Chlorthiazide (iii) Furosemide.
Q.4 (a) Explain in detail the nomenclature and stereochemistry of steroidal compounds. 06
(b) Write a note on Anti-hyperlipidemic agents. 05
(c) Write informative note on Sex hormones. 05
Q.5 (a) Give the synthesis and uses of the following: (Any two) 06
(i) Tobutamide (ii) Benzocaine (iii) Dibucaine.
(b) Write a note on Antithyroid agents. 05
(c) Write a note on the natural products used as antineoplastic agents. 05
Q. 6 (a) Define and classify Antidiabetic agents. Give the synthesis of Procaine. 06
(b) Classify anti neoplastic alkylating agents with relevant examples. 05
(c) Write a note on Oral contraceptives. 05
Q.7 (a) Discuss the SAR of Local anesthetics. 06
(b) Write a note on Drugs used in Congestive Heart Failure. 05
(c) Write a brief note on H2-antagonists. 05

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Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY

B.Ph.- SEMESTER–V • EXAMINATION – WINTER -2019

Subject Code: BP501TT Date: 15/11/2019

Subject Name: Medicinal Chemistry-II
Time: 02:30PM TO 05:30PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Define and classify oral hypoglycemic agents. 06

(b) Explain the SAR of local anesthetic agents. 05
(c) Give detail note on thyroid hormones and write a note on anti-thyroid drugs. 05
Q.2 (a) Write a note on nomenclature and stereochemistry of steroids. 06
(b) Discuss coagulants and anticoagulants. 05
(c) Give detail note on oral contraceptives. 05
Q.3 (a) Define and classify Antiarrhythmic drugs. Explain mode of action in each class. 06
(b) Write a note on proton pump inhibitors. 05
(c) Write a note on drugs used in congestive heart failure. 05
Q.4 (a) Give structure and uses of (i) Diltiazem (ii) Verapamil (iii) Clofibrate 06
(b) Explain types of diabetes and write a note on various insulin preparations. 05
(c) Write a short note on ACE inhibitors. 05
Q.5 (a) What are anti-histaminic? How they act? Classify them with examples. 06
(b) Write a note on HMG Co-A reductase inhibitors. 05
(c) Write a note on H2-antagonists. 05
Q. 6 (a) Define and Classify Antihypertensive agents with examples. 06
(b) Give Synthesis of (i) Diphenhydramine hydrochloride (ii) Furosemide 05
(c) Write a note on potassium sparing diuretics and thiazide diuretics. 05
Q.7 (a) Write detail classification and short mechanism of action of anticancer agents 06
(b) Give Synthesis of (i) Cimetidine (ii) Tolbutamide 05
(c) Write short note on corticosteroids. 05

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Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY

B.Ph. - SEMESTER–V • EXAMINATION – WINTER-2020

Subject Code:BP501TT Date: 02/01/2021

Subject Name: Medicinal Chemistry II
Time: 10:30AM TO 12:30PM Total Marks: 54
Instructions:
1. Attempt any THREE questions from Q-1 to Q-6.
2. Q.7 is compulsory to attempt.
3. Make suitable assumptions wherever necessary.
4. Figures to the right indicate full marks.

Q.1 (a) Enlist various histamine receptors. Discuss neurochemistry of histamine. 06

(b) Short note on oral contraceptives. 05
(c) Write synthesis of following 05
i) i) Promethazine hydrochloride ii) Cimetidine
Q.2 (a) Discuss in detail about proton pump inhibitors along with its mechanism of 06
action.
(b) Short note on H2 receptor antagonist. 05
(c) What do you mean by Diuretics? Classify and give the synthesis of Furesemide. 05
Q.3 (a) Short note on Antiarithmetic agents 06
(b) Write short notes on coagulants and anticoagulants. 05
(c) Write Synthesis of following 05
i) Nitroglycerin ii) Methyldopa
Q.4 (a) SAR of local anaesthetic. 06
(b) Write Synthesis of following 05
i) Tolbutamide ii) Benzocaine
(c) Define and classify Antianginal agents with the synthesis of Isosobide dinitrate. 05
Q.5 (a) Discuss the various factors which are affecting on blood coagulation and write 06
a note on Warfarin.
(b) Define antihypertensive agents with its classification and write a 05
note on calcium channel blockers.
(c) Write Synthesis of following 05
i) Chlorthiazide ii) Acetazolamide
Q. 6 (a) Write short notes on stereochemistry of steroids. 06
(b) Short note on testesteron. 05
(c) Give detail account on various corticosteroids. 05
Q.7 (a) What is Diabetes? Classify antidiabetics with examples and give their 06
mechanism of action.
OR
(a) Write a note on antithyroid drugs. 06
OR
(a) What is obesity? Write a note on antiobesity drugs. 06

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Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY

B.Pharm - SEMESTER– V-EXAMINATION – SUMMER -2022

Subject Code: BP501TT Date: 15/06/2022

Subject Name: Medicinal Chemistry II
Time: 02:30pm to 05:30pm Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Write a short note on H2 receptor antagonist. 06

(b) Discuss in detail about gastric proton pump inhibitors along with its mechanism 05
of action.
(c) Classify H1-receptor antagonist. Write the structure, IUPAC nomenclature and 05
use of one drug from each category.
Q.2 (a) Write chemical structure, mechanism of action and therapeutic use of any three 06
drugs from anti-cancer alkylating agents.
(b) Describe drugs used for erectile dysfunction. 05
(c) Write the chemical structure and use of following drugs: 05
(i) Cromolyn sodium (ii) Cetirizine (iii) Thiotepa (iv) Cyclophosphamide
(v) Diethyl stilbesterol
Q.3 (a) Classify anti-hypertensive agents with suitable examples. 06
(b) Write a short note on oral anticoagulants. 05
(c) Give synthetic scheme and use of (i) Acetazolamide (ii) Warfarin 05
Q.4 (a) Classify corticosteroids with relevant examples. Give chemical structures of 06
any three drugs from each category.
(b) Describe chemistry of cardiac glycosides. 05
(c) Write the chemical structure and IUPAC nomenclature of following drugs: 05
(i) Tolbutamide (ii) Phenytoin Sodium (iii) Benzocaine (iv) Furosemide
(v) Ethacrynic acid
Q.5 (a) What is Diabetes Mellitus? Write chemical classification of oral hypoglycemic 06
agents with suitable examples and two structures from each class.
(b) Define and classify anti-arrythmic agents and explain mode of action of each 05
class.
(c) Write a short note on anti-hyperlipidemic agents. 05
Q. 6 (a) Classify anti-anginal agents. Describe the mechanism of action and use of 06
nitrates.
(b) Write the chemical structure and use of following drugs: 05
(i) Methyl Dopa (ii) Mannitol (iii) Captopril (iv) Metformin (v) Nitroglycerin
(c) Give synthetic scheme of following drugs: 05
(i) Diphenhydramine hydrochloride (ii) Methotrexate
Q.7 (a) What are diuretics? Classify diuretics with suitable examples. 06
(b) Write an informative note on antithyroid drugs. 05
(c) Outline the SAR of local anesthetics. 05

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