Seat No.: _____ Enrolment No.

_____________

GUJARAT TECHNOLOGICAL UNIVERSITY

B.Pharm - SEMESTER–V • EXAMINATION – WINTER -2022

Subject Code:BP502TP Date: 23/12/2022

Subject Name: Pharmacology – II
Time: 10:30 am to 01:30 pm Total Marks: 80
Instructions:
1. Question -1 is compulsory to attempt.
2. Attempt any 04 questions from Question 2 to 7.
3. Make suitable assumptions wherever necessary.
4. Figures to the right indicate full marks.

Q.1 Answer the following questions. (1 mark each) 16

I. Which is cardioselective β-blocker drug?

a. Atenolol b. propranolol c. Betaxolol d. carteolol
II. Low concentration of nitrates cause dilation of ____________.
a. Large arteries b. Veins c. Precapillary sphincters d. Arterioles
III. The specific antidote for Heparin is;
a. Pralidoxime b. Protamine sulfate c. Vitamine K d. EDTA
IV. Which of the following drugs provide significant relaxation of smooth muscles of
both venules and arterioles?
a. Nifedipine b. Sodium nitropruside c. Monoxidil d. Diazoxide
V. Bromocriptine is _____________.
a. Alpha antagonist b. D2 antagonist c. D1 antagonist d. D2 agonist
VI. The following 5-HT receptor is not a G-protein coupled receptor:
a. 5-HT1 b. 5-HT2 c. 5-HT3 d. 5-HT4
VII. Which of following prostaglandin analogue used in pulmonary hypertension?
a. Alprostadil b. Misoprostol c. Epoprostenol d. latanoprost
VIII. Which of the following drugs only inhibits COX-2 enzyme?
a. Aspirin b. Nimesulide c. Rofecoxib d. Naproxen
IX. Pigeon method is used for the bioassay of ____________.
a. Insulin b. Acetylcholine c. Digitalis d. Oxytocin
X. Which of the following drugs is not used for the management of congestive heart
failure?
a. Enalapril b. Nifedipine c. Propranolol d. Digoxin
XI. This drug inhibits the digestion of sugars in the digestive tract.
a. Metformin b. Voglibose
c. Bile acid sequesterants d. Orlistat
XII. Which of the following are useful in the therapy of hypercalcemia, except
a. Calcitonin b. Glucocorticoids

Page 1 of 2
 c. Vitamin D d. Parenteral infusion of phosphate
XIII. Octreotide is a long acting synthetic analogue of:
a. Prolactin b. Growth hormone
c. Somatostatin d. Gonadotropin releasing hormone
XIV. Plasma expanders are used in the following conditions except:
a. Extensive burns b. Multilating injuries
c. Congestive cardiac failure d. Endotoxin shock

XV. Which of the following drugs is a H1 receptor agonist?

a. 4-methyl histamine b. Impromidine
c. 2-Thiazolyl ethylamine d. Chlorpheniramine
XVI. The cellular mechanism action of digoxin is inhibition of ____________.
a. cAMP synthesis b. β-Adrenergic stimulation
c. ATP degradation d. Sodium pump

Q.2 (a) Classify antiarrhythmic drugs. Discuss the pharmacology of quinidine. 06

(b) Discuss the mechanism and pharmacological actions of digitoxin. 05
(c) Classify antihypertensive drugs. Explain mechanism and adverse effects of Captopril. 05

Q.3 (a) Classify diuretics according to potency. Discuss the mechanism and uses of 06
furosemide.
(b) Explain the electrophysiology of heart. 05
(c) Write a note on plasma expanders. 05

Q.4 (a) Discuss the mechanism and uses of Amrinone, Spironolactone, Carbimazole. 06
(b) Write a note on 5-HT receptors. 05
(c) Discuss the pharmacological actions and uses of H1 blocker drugs. 05

Q.5 (a) Discuss the mechanism and uses of Desmopressin, warfarin, Atorvastatin. 06
(b) Discuss the various types of DMARDs. Explain any one in details. 05
(c) Define bioassay. Explain various types of it. 05

Q. 6 (a) Classify oral hypoglycemic agents. Explain the mechanism, uses and adverse effects of 06
metformin.
(b) Write a note on SERMs. 05
(c) Write a note on oral contraceptives. 05

Q.7 (a) Classify NSAIDs. Discuss the complete pharmacology of aspirin. 06

(b) Enlist the various methods for bioassay of Insulin. Explain any one in detail. 05
(c) Discuss the mechanism and uses of Alteplase, allopurinol, nitroglycerine. 05

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Page 2 of 2
Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY

B.Pharm – SEMESTER V– • EXAMINATION – SUMMER-2021

Subject Code:BP502TP Date: 04/08/2021

Subject Name: PHARMACOLOGY-II
Time: 02:30 PM TO 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 Given answers in one line 16

1. Write any two examples of L-type calcium channels blocker.

2. Which drug causes most frequently ‘Coronary steal phenomenon’
3. Which antihypertensive drug causes loss of taste sensation as a side effect?
4. Write any two examples of potassium retaining diuretic
5. Write any two examples of K+ channel openers
6. Give example of Heparin antagonist
7. Which H1 antagonist used in motion sickness
8. What are the uses of Desmopressin
9. What are the uses of Streptokinase
10. What are the uses of Propylthiouracil
11 Write any two examples of PPAR agonist
12 Give example of Aromatase inhibitors
13. What is the mechanism of Allopurinol
14. Write any two examples of DMARDs
15. Write any two examples of Selective cox-2 inhibitors
16. What is mechanism of Sumatriptan

Q.2 (a) Classify anti arrhythmic drugs. Write role of amiodarone in the treatment of 06
arrhythmia.
(b) Write a short note on anti-platelet drugs. 05
(c) Write a short note on NITRATES. 05

Q.3 (a) Classify antihypertensive drugs. Explain the role of ACE inhibitors in the 06
treatment of hypertension.
(b) Write a short note on anticoagulants. 05
(c) Explain treatment of CHF. 05

Q.4 (a) Classify diuretics. Give the mechanism of action and therapeutic uses of 06
Furosemide.
(b) Write a short note on STATINS. 05
(c) Write a short note on plasma volume expanders. 05

Q.5 (a) Explain oral hypoglycaemic drugs. 06

(b) Write a short note on H1- receptor antagonists. 05
(c) Explain bioassay of oxytocin. 05
Q. 6 (a) Classify 5-HT antagonists. Write use and adverse effects of ondansetron. 06
(b) Write pharmacology of corticosteroids. 05
(c) Write principle and types of bioassay. 05

Q.7 (a) Classify NSAIDs. Write adverse effects of NSAIDs. 06

(b) Write a short note on anti rheumatic drugs. 05
(c) Write a short note on hormone replacement therapy. 05

***************
Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY

B. Ph. - SEMESTER– V• EXAMINATION – WINTER-2021

Subject Code: BP502TP Date: 15/12/2021

Subject Name: Pharmacology II
Time: 10:30am to 01:30pm Total Marks: 80
Instructions:
I. Question No. 1 is compulsory.
II. Attempt any FOUR Questions from Question No. 2 to 7.
III. Make suitable assumptions wherever necessary.
IV. Figures to the right indicate full marks.

Q.1 Questions 16
1. Which of the following is INCORRECT for Warfarin:
A Oral anticoagulant B Interfere with hepatic synthesis of Vitamin K.
C Does not absorb orally D Require frequent blood test to individualize dose
2. Which of the following hormones is produced by the thyroid gland?
A Thyroxine B Thyroid-stimulating hormone
C Thyrotropin-releasing hormone D Thyroglobulin
3. Which of the following is characteristic action of Tocolytics
A Prevent uterine atony B Delay labor
C Induce labor D Control and prevent postpartum hemorrhage
4. Which of the following is HMG Co-A reductase inhibitor used to treat
hyperlipidemia?
A Profibrate B Pravastatin
C Pralatrexate D Pralidoxime
5. Which of the following is a nonselective beta adrenoreceptor antagonist used in
treatment of hypertension?
A Atenolol B Metoprolol
C Acebutolol D Propranolol
6. Which of the following biological agent is used in treatment of rheumatoid arthritis:
A Ibuprofen B Infliximab
C Ibutilide D Inamrinone
7. Which of the following is selective 5-HT3 antagonists that have shown remarkable
efficacy in controlling nausea and vomiting:
A Clozapine B Risperidone
C Ergotamine D Ondansatron
8. Which of the following is INCORRECT statement with respect to cardiac glycoside?
A They act by inhibiting the activity of B They increase intracellular
the Na+/K+-ATPase concentrations of calcium in
myocytes
C Digoxin has a longer half-life than D They increase vagal tone
digitoxin

9. Which of the following drug is/are characteristic Uricosuric agent:

I. Allopurinol II. Probenicid III. Sulfinpyrazole IV. Febuxostat
A I and II B I and III
C II and III D I and IV

10. Calcitonin administration are indicated for the following conditions, EXCEPT:
A Paget's disease B Hypercalcemia
C Osteoporosis D Hypophosphatemia

PAGE 1 OF 2
 11. Which of the following organs is a main target for prolactin?
A Mammary gland B Adrenal cortex
C Thyroid D Liver
12. __________________ is a used as abortifacient as per Medical Termination of
Pregnancy Act.
A Tamoxifen B Mifepristone
C Metformin D Macimorelin
13. __________________ is a Class IA antiarrhythmic agent:
A Atenolol B Quinidine
C Propranolol D Nifedipine
14. _________________________ vasodilator category of agent is used for the treatment
of emergency hypertension.
A Quinidine B Minoxidil
C Propranolol D Verapamil
15. Which of the following drug possesses significant Antidiuretic property?
A Oxytocin B Vasopressin
C Oxacarbazepine D Verapamil
16. Which of the following is centrally acting antihypertensive agent?
A Saralasin B Captopril
C Clonidine D Nebivolol

Q.2 (a) Classify Non-steroidal anti-inflammatory agents. Differentiate between COX1 6

and COX2 inhibitors with suitable examples.
(b) Explain the therapeutic uses of calcium channel blockers with their mechanism 5
of action.
(c) Write mechanism of action, pharmacokinetics, therapeutic uses and adverse 5
effects of nitroglycerin.
Q.3 (a) Classify Antiarrythmic agents. Write a note on Quinidine. 6
(b) Write a note on plasma volume expanders. 5
(c) Differentiate between Fibrinolytic and anti-platelet agents with suitable 5
examples.
Q.4 (a) Classify antihyperlipidemic agents. Explain the role of fibrates as lipid 6
lowering agent.
(b) What is Congestive Cardiac Failure? Write mechanism of action, 5
pharmacological actions and adverse effects of cardiac glycosides.
(c) Classify diuretics. Write mechanism of action and adverse effects of thiazide 5
diuretics.
Q.5 (a) Classify antihypertensive agents. Write a note on ACE inhibitors. 6
(b) What are autacoids? Write a note on H1 receptor antagonists. 5
(c) Explain in brief: Disease modifying antirheumatic drugs (DMARDs). 5
Q. 6 (a) Classify oral hypoglycemic agents. Write a note on Metformin. 6
(b) Explain in brief bioassay of vasopressin and oxytocin 5
(c) Write the role of Parathormone, calcitonin and Vitamin D in regulation of 5
plasma calcium level.
Q.7 (a) What are contraceptives? Explain pharmacology of female oral contraceptives. 6
(b) Write a note on thromboxanes inbibitors 5
(c) Write therapeutic uses and adverse effects of corticosteroids 5

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PAGE 2 OF 2
Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY

B.Ph. – SEMESTER - V • EXAMINATION – WINTER -2019

Subject Code: BP502TP Date: 18/11/2019

Subject Name: Pharmacology - II
Time: 02:30PM TO 05:30PM Total Marks: 80
Instructions:
1. Question no. 1 is compulsory.
2. Attempt any four questions from question no. 2 to 7.
3. Make suitable assumptions wherever necessary.
4. Figures to the right indicate full marks.

Q.1 Each sub questions carry one mark. Answers are to be given in one line 16
(i) Which enzyme is inhibited by Enalapril to give its anti-hypertensive action?
(ii) Give the name of anticoagulant substance which is naturally found in liver.
(iii) Which enzyme is inhibited by Acetazolamide to give its diuretic action?
(iv) Which enzyme is inhibited by Celecoxib to give its analgesic action?
(v) Which substance’s synthesis is inhibited by Allopurinol to give its anti-gout
action?
(vi) Methimazole is an example of which category of drug?
(viii) Which enzyme is inhibited by Digoxin to give its cardiotonic action?
(viii) Give the name of drug used in hypertension which is α2 adrenoceptor agonist.
(ix) Urokinase is an example of which category of drug?
(x) Which receptor is inhibited by Diphenhydramine?
(xi) Pioglitazone is potent agonist for which receptor?
(xii) Give the name of drug which is used in migraine as 5-HT1D receptor agonists.
(xiii) Give the name of natural mineralocorticoids.
(xiv) Which enzyme is inhibited by Simvastatin to give anti-hyperlipidemic action?
(xv) Ticlopidine comes under which category of drug?
(xvi) Which receptor is inhibited by Montelukast?

Q.2 (a) Give the mechanism of action, adverse effects and therapeutic uses of 06
Simvastatin.
(b) Give the pharmacological actions of digoxin. 05
(c) Classify the anti-hypertensive agents. 05

Q.3 (a) Give the mechanism of action, adverse effects and therapeutic uses of 06
Amiodarone.
(b) Give the therapeutic uses and adverse effect of Warfarin Sodium. 05
(c) Give the classification of diuretics according to potency and site of action. 05
Page 1 of 2
Q.4 (a) Give the pharmacological actions of salicylates 06
(b) Write a short note on plasma volume expanders 05
(c) Give the adverse effect and therapeutic uses of H1 receptor antagonist 05

Q.5 (a) Give the mechanism of action and therapeutic uses of Allopurinol. 06
(b) Write a short note on SERMs 05
(c) Classify the anti-thyroid drugs. Give the adverse effect of methylthiouracil. 05

Q. 6 (a) Give the pharmacological actions of insulin. 06

(b) Give the principles and applications of bioassay. 05
(c) Give the mechanism of action and adverse effect of Nitrites. 05

Q.7 (a) Give the mechanism of action and adverse effect of glucocorticoids. 06
(b) Give the therapeutic uses and adverse effects of oxytocin. 05
(c) Explain the mechanism of action and adverse effect of Sulfonylureas. 05

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Page 2 of 2
Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY

B.Ph. - SEMESTER– V EXAMINATION – WINTER -2020

Subject Code: BP502TP Date: 05/01/2021

Subject Name: Pharmacology – II
Time: 10:30AM TO 12:30PM Total Marks: 54
Instructions:
1. Attempt any THREE questions from Q-1 to Q-6.
2. Q.7 is compulsory to attempt.
3. Make suitable assumptions wherever necessary.
4. Figures to the right indicate full marks.

Q.1 Answer the followings in one line. (1 mark each) 16

(a) Define autacoids.
(b) Quinidine toxicity includes all of the following EXCEPT –
a. Thrombocytopenia
b. Diarrhea
c. Cinchonism
d. Hypertension
(c) Which is the precursor for the synthesis of 5-HT?
(d) Cushing’s syndrome is the adverse effect of ………………….
(e) Write mechanism of action of desmopressin.
(f) Testosterone is secreted by ……………… cells of testes.
(g) Write mechanism of action of finasteride.
(h) Write two examples of 5-HT3 antagonists which are used as antiemetics.
(i) Effect of minoxidil persists for more than 24 hrs due to its active metabolite
……………………
(j) Nitrates reduce the platelet aggregation by activating ………………….. in the
platelets and thus increasing the c-GMP.
(k) Chlorthiazide is useful in the treatment of
a. Hypertention
b. CHF
c. Prevention of calcium stone
d. All of the above
e. None of the above
(l) Aspirin at ……….dose produces anti-platelet action.
(m) Which is the drug of choice for the treatment of paroxysmal supraventricular
tachycardia?
(n) Write mechanism of action of eplerenone.
(o) Renin is synthesized in ……….. cells of ………….
(p) Nonsteroidal anti-inflammatory agent block the hypotensive effect of ACE
inhibitors by -
a. Causing retention of salt and water
b. Blocking bradykinin mediated vasodilatation
c. Inhibiting the vasodilator effect of ACE inhibitors
d. Causing vasoconstriction

1
Q.2 (a) Enlist ACE inhibitors. Write about its mechanism of action, therapeutic uses 06
and adverse effects.
(b) Explain pharmacology of 5-HT3 antagonists. 05
(c) Write a note on plasma volume expanders. 05
Q.3 (a) Write mechanism of action and therapeutic uses of followings: 06
(i) Ranolazine (ii) Nicorandil (iii) Prasugrel
(b) Discuss about the role of aldosterone antagonists and PDE 3 inhibitors in CHF. 05
(c) Write a note on synthesis, storage and secretion of thyroid hormones. Enlist 05
anti-thyroid drugs.
Q.4 (a) Classify drugs used in angina. Write pharmacology of nitrates. 06
(b) Explain the pathophysiological role of histamine. 05
(c) Write a note on anti-rheumatoid drugs. 05
Q.5 (a) Explain mechanism of action, therapeutic uses and adverse effects of 06
prednisolone.
(b) Write a note on oral contraceptives. 05
(c) Classify H1 antihistaminic drugs. Write a note on its therapeutic uses and side 05
effects.
Q. 6 (a) Classify NSAIDs. Write mechanism of action, therapeutic uses and adverse 06
effects of aspirin.
(b) Write a note on oral hypoglycemic drugs. 05
(c) Classify antihypertensive drugs. Enlist the antihypertensive drugs which are 05
safe during pregnancy.
Q.7 (a) Define Hematinics. Write a note on oral and parenteral preparations of iron. 06
OR
(a) Classify 5-HT receptors. Write a note on its distribution and functional role. 06
OR
(a) Define bioassay. Explain different types of bioassay. Write a note on insulin 06
bioassay.

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2
Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY

B.Ph. - SEMESTER– 5• EXAMINATION – SUMMER -2020

Subject Code:BP502TP Date: 27-10-2020

Subject Name:PHARMACOLOGY-II
Time: 2:30 PM TO 5:30 PM Total Marks: 80
Instructions:
1. Q:1 is compulsory
2. Attempt any four questions from remaining six questions (Q:2 to Q:7)
3. Make suitable assumptions wherever necessary.
4. Figures to the right indicate full marks.

Q.1 Given answers in one line 16

1. Write any two example of AT1 Receptors blocker.
2. Write selective estrogens receptor modulator most commonly used for the
treatment of breast cancer.
3. Write main side effects of ACE inhibitors.
4. Write Alpha 2 agonist used in pregnant women with hypertension.
5. Write major two side effects of HMG COA reductase inhibitors.
6. Write vitamin K dependent anticoagulant with zero-order kinetics of
elimination.
7. Write name of diuretic used as prophylactic for mountain sickness and
glaucoma.
8. Write diuretic used to reduce intracranial pressure.
9. Write most serious side effect of metformin.
10. Write mechanism of action of sildenafil.
11 Write any two example of DMARDs.
12 Write anti dote of paracetamol toxicity.
13. Write any two examples of H1 antihistamines used for motion sickness.
14. Write drug of choice for management of acute ventricular tachycardia.
15. Write Agent that inhibits xanthine oxidases and used to treat chronic gout.
16. Write 5HT-1A receptor partial agonist indicated for generalized anxiety
disorder; due to longer onset of action, is less effective for acute anxiety.
Q.2 (a) Give the mechanism of action, therapeutic uses and adverse effects of 06
anti anginal drugs nitrates.
(b) Explain the pharmacology of Warferin 05
(c) Write a short note on HMG CoA reductase inhibitors 05
Q.3 (a) Classify diuretics. Give the mechanism of action and therapeutic uses of 06
Thiazides.
(b) Enlist various throbolytic agents. Describe in brief the pharmacology of 05
streptokinase.
(c) Explain the role of calcium channel blockers in the treatment of hypertension 05
and arrhythmias.
Q.4 (a) Write adverse effects and uses of H1- receptor antagonists. 06
(b) Describe the role of digoxin in congestive cardiac failure. 05
(c) Write a short note on plasma volume expanders. 05
Q.5 (a) Enlist different preparations of insulin and Explain pharmacological actions. 06
(b) Classify male and female sex hormones and explain about estrogens. 05
(c) Describe the pharmacology of thyroid hormones. 05
Q. 6 (a) Classify 5-HT receptors. Discuss in detail about pharmacology of 5-HT. 06
(b) Write a note on replacement therapy using corticosteroids. 05
(c) Write a short note on oral contraceptives. 05
Q.7 (a) Write principle and types of bioassay 06
(b) Classify NSAIDs. Write adverse effects of Aspirin. 05
(c) Explain bioassay of insulin and digitalis 05

***************
Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY

B.Pharm - SEMESTER–V • EXAMINATION – SUMMER 2022

Subject Code: BP502TP Date: 02/06/2022

Subject Name: Pharmacology – II
Time: 02:30pm to 05:30pm Total Marks: 80
Instructions:
1. Question -1 is compulsory to attempt.
2. Attempt any 04 questions from Question 2 to 7.
3. Make suitable assumptions wherever necessary.
4. Figures to the right indicate full marks.

Q.1 Answer the following questions. (1 mark each) 16

I) Define bioassay.
II) Give the name of anticoagulant substance which one is naturally found in
liver.
III) Define the term autacoid.
IV) Timolol is an example of which category of drug ?
V) Give the name of two drugs which is used in gout.
VI) Write the mechanism of action of thiazides.
VII) What are the two main hormones secreted by Thyroid gland?
VIII) An autoimmune disease of the thyroid tissue is called
IX) Which hormone is a major contributor to the symptoms of inflammation?
X) The risk factors for type 2 diabetes mellitus include.
XI) This is _____________ disease involves a long-term endocrine disorder in
which the adrenal glands do not produce enough steroid hormones
XII) What Are the Types of Arrhythmias?
XIII)
Drug not used in Prinzmental Angina ?
a. Propranolol
b. Verapamil
c. Nitrates
d. Isosorbidedinitrate
XIV) Celecoxib inhibit ___________________enzyme to give analgesic action.
XV) Give the name of oral contraceptives.
XVI) Which receptor is inhibited by Montelucast?
Q.2 (a) Classify anti-hypertensive agents. 06
(b) Give the mechanism of action and adverse effect of atorvastatin. 05
(c) Classify drugs used in angina. Write pharmacology of nitrates. 05
Q.3 (a) Classify NSAIDs. Write mechanism of action of aspirin. 06
(b) Write a note on oral hypoglycemic drugs. 05
(c) Classify antiarrythmic agents. Write a note on Quinidine. 05
Q.4 (a) Write a note on plasma volume expanders. 06
(b) Differentiate between Fibrinolytic and Anti-platelet agents with suitable 05
examples.
(c) What are autacoids? Write a note on H1 receptor antagonist. 05
Q.5 (a) Write a note on cardiac glycosides. 06
(b) Explain in brief about bioassay of oxytocin and vasopressin. 05
(c) Write therapeutic uses and adverse effects of corticosteroids. 05
Q. 6 (a) Write a note on DMARDs. 06
(b) Write a note on synthesis, storage and secretion of thyroid hormones. Enlist 05
anti thyroid drugs.
(c) Write a note on anti-rheumatoid drugs. 05
Q.7 (a) Classify 5-HT receptors. Write a note on its distribution and functional role 06
(b) Explain the pathophysiological role of histamine. 05
(c) Classify diuretics. Write mechanism of action and adverse effects of thiazide 05
diuretics.

***************