Course Curriculum

Course Curriculam
Course Code: GCMB320 Credit Units L T P/S SW AS/DS FW No. of PSDA Total Credit Unit
Course Level UG 3 0 2 2 0 0 0 5
Course Title Structural Biology and Molecular Biophysics
The course seeks to Impart knowledge of the basic principles of Biophysics and Structural Biology, and incorporate the biophysical
Course concepts. Explain thorough comprehension of the core concepts of biology, chemistry, and physics and how they interconnect in
Description : biophysical systems
Course Objectives :
SN
Objectives
.
The course seeks to Impart knowledge of the basic principles of Biophysics and Structural Biology, and incorporate the biophysical concepts. Explain
1
thorough comprehension of the core concepts of biology, chemistry, and physics and how they interconnect in biophysical systems
Pre-Requisites : General
SN. Course Code Course Name
Course Contents / Syllabus :
SN. Module Descriptors / Topics Weightage

Detail structure of Double-Stranded DNA, Structural and biological significance of Major and Minor groove, Effect pf
Structural
pH, temperature and cations on DNA structure, Polymorphic, DNA, helix parameters, Differences in helix parameters
1 Properties 25.00
on different forms of DNA, Parallel DNA, DNA-protein interaction, overview of higher-order DNA structure like cruciform
of DNA
DNA, triple-stranded DNA, four-stranded DNA.
Biophysical Elementary introduction to biophysical methods such as UV-VIS spectroscopy, quantification of DNA, RNA and
2 10.00
Methods protein, DNA-Drug interaction, X-ray crystallography, fluorescence spectroscopy etc.
Membrane transport, diffusion, electro-diffusion, types of transportation, chemical potential, osmotic pressure, water
Membrane
3 permeability, cellular mechanisms of volume regulation, structure, selectivity & permeability of ion channels, Voltage- 20.00
transport
gated channels, ligand-gated channels, stretch-activated channels, Na+ , K+ and Ca2+ channels, pumps as channels.
Conduction of the electrical activity, spread of electrical signals, Donnan equilibrium, the resting membrane potential,
Bio-
Nernst equation, Goldman equation, Hodking-Kartz experiment, Voltage clamp, membrane impedance and
4 Electrical 25.00
capacitance, transmembrane potential, electrochemical potential, chemical synapse, post synaptic potential, action
properties
potential, properties of Action potential
Cell surface charge, resting membrane potential, action potential and its properties, Permeability changes during
Membrane
5 action potential, ion channels, Action potential in cardiac muscle fibres, The Nernst equation, The Goldman equation, 20.00
properties
The Hodgkin-Katz experiments, role of K+ and Na+
Course Learning Outcomes :
SN. Course Learning Outcomes

1 Demonstrate a clear understanding of basic physics principles underlying the dynamics of life
2 Understand the concept of Structural & molecular properties of different biomolecules
3 Compare and contrast the different types of functional relationships, and molecular transport within the cell and across membranes
4 Analyze and differentiate different types of electrical properties of the cell and their usefulness
5 Apply the concepts of thermodynamic and kinetic modelling to describe the intra- and intermolecular interactions of proteins and DNA
Pedagogy for Course Delivery :
SN. Pedagogy Methods

1 Lectures
2 Guest Lectures
3 Discussion/interactions
4 Practicals
5 Assignments
Theory /VAC / Architecture Assessment (L,T & Self Work): 80.00 Max : 100
Attendance+CE+EE : 5+25+70
SN. Type Component Name Marks

1 Attendance 5.00
2 End Term Examination (OMR) 70.00
3 Internal CLASS TEST 15.00
4 Internal INTEGRATED ASSIGNMENT 10.00
Lab/ Practical/ Studio/Arch. Studio/ Field Work Assessment : 20.00 Max : 100
Attendance+CE+EE : 5+25+70
SN. Type Component Name Marks

1 Attendance 5.00
2 External END SEMESTER PRACTICAL EXAMINATIONS 70.00
3 Internal VIVA VOCE 15.00
4 Internal PRACTICAL / LAB RECORDS 10.00
Lab/ Practical details, if applicable :
SN. Lab / Practical Details

1 • Quantification of DNA using UV spectroscopy
2 • Quantification of protein using UV spectroscopy
3 • Effect of cations on DNA structure and its stability.
4 • Effect of cations on Protein structure and its stability
5 • DNA-Drug interaction using UV spectroscopy
List of Professional skill development activities :
No.of PSDA : 2
SN. PSDA Point
1 • Prepare and present a report on Biophysical techniques and group discussion.
2 • Report /Quiz with a Subject expert from Industry/Research
Text & References :
SN. Type Title/Name Description ISBN/ URL

• Essentials of Biophysics, P Narayanan
1 Book (2005), New Age International Publication,
New Delhi.
• Handbook of Molecular Biophysics
2 Book (Methods & Application), 2009, HG Bohr,
Wiley
• Elementary Biophysics: An Introduction,
3 Book by P. K. Srivastava Physics For the
Biological Sciences, b
• Biophysical Chemistry, The Behaviour of
4 Book biological macromolecules, Vol I,II, III,
Cantor and Schim
• Molecular and Cellular Biophysics, Meyer
5 Book
B Jackson (2006), Cambridge)

Course Curriculum

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Course Curriculum

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Course Curriculam

SN. Course Code Course Name

Course Contents / Syllabus :

SN. Module Descriptors / Topics Weightage

Course Learning Outcomes :

SN. Course Learning Outcomes

SN. Pedagogy Methods

SN. Type Component Name Marks

SN. Type Component Name Marks

Lab/ Practical details, if applicable :

SN. Lab / Practical Details

List of Professional skill development activities :

Text & References :

SN. Type Title/Name Description ISBN/ URL

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