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    2 Lymph Node and Spleen

    Uploaded by

    Hussein algrish

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    © All Rights Reserved
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    2 Lymph Node and Spleen

    Uploaded by

    Hussein algrish
    4 views18 pages

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    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    4 views18 pages

    2 Lymph Node and Spleen

    Uploaded by

    Hussein algrish

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 18

    Lymphatic system

    By
    Dr. Shereen Hamed
    Lecturer of Histology & Cell Biology Faculty of Medicine.
    Mansoura University
    Lymphatic system

    2ry lymphatic
    1ry lymphatic organs
    organs

    -lymph node
    -bone marrow
    -Spleen
    - thymus
    -MALT
    Lymphoid nodule (follicle)

    • It is the structural
    and functional unit of
    the lymphoid tissue
    Lymphoid nodule (follicle)

    • Rounded basophilic
    mass formed of small
    lymphocytes (mainly B
    lymphocytes & few T
    lymphocytes)
    Types of lymph follicle

    1ry follicles 2ry follicles

    without germinal -germinal center (a pale central


    center area (formed due to activation
    of small lymphocytes to
    medium sized lymphocyte by
    exposure to an antigen).
    Lymph Node.

    Stroma Parenchyma. Lymph sinuses.

    Capsule Cortex
    1) Sub capsular lymph
    Trabeculae Medulla sinus
    Reticular fibers Thymus dependant zone 2) Cortical & subcortical
    sinuses.
    3) Medullary sinuses
    Stroma
    capsule Trabeculae Reticular fibers

    dense C.T.,
    penetrated
    by divide cortex
    lymphatic into cortical
    vessels compartments.
    Parenchyma
    thymus dependent
    Cortex Medulla
    zone

    irregular
    lymphatic Deeper part
    +++ T medullary
    follicles of cortex
    lymphocytes cords
    Migrate from
    thymus to LN
    Def: Spaces surrounding Lymph sinuses
    lymphatic follicles & medullary
    cords that contain lymph
    Cortical &
    Subcapsular S. Medullary S.
    subcortical S.
    Function: Filtration of lymph by
    macrophages present in it.
    Under
    Around follicles
    Capsule Around the
    medullary cords
    Spleen

    Stroma Parenchyma

    -Capsule (CT & smooth ms.) -White pulp


    -Trabeculae -Red pulp
    -Reticular fibers -Thymus dependant
    zone
    Parenchyma
    thymus dependent
    White pulp Red pulp
    zone

    Splenic
    Surround central a. Blood
    lymphatic (Billroth)
    follicles +++ T lymphocytes sinusoids
    cords
    contain
    central artery
    Scattered
    allover spleen
    Irregular bl. Irregular
    Channels masses of
    Non diffuse
    continuous lymphatic
    B.M. tissue blood
    cells
    Macrophage macrophages
    (littoral cells)
    between blood
    sinusoids
    Lymph Node Spleen
    Number Numerous, widely distributed in the Single organ, in the abdomen.
    body

    Capsule Dense C.T. Dense C.T. with smooth muscles

    Parenchyma Cortex → lymph follicles (no central White pulp →lymph follicles (with central
    artery). artery)
    Medulla → medullary cords Red Pulp →blood & diffuse lymph tissue

    Sinuses Lymph sinuses (contain lymph) Blood sinusoids (contain blood)

    Function Filtration of lymph Filtration & storage of blood


    - Production of small lymphocyte → - Destruction of old RBCs
    humoral & cell mediated immunity

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