Physico-Chemical Evaluation of Rasakarpura
Physico-Chemical Evaluation of Rasakarpura
Physico-Chemical Evaluation of Rasakarpura
Materials.
Three steps:
Preparation of Parada Churna.
Mixing of Paradachurna ahd Saindhava Lavana.
Sublimation of final product.
Parada churna- 1part parada+1.5 part Ghandhakamla.
Paradachurna and Saindhava lavana were triturated for
30min.
Subjected for heat 12hrs in EMF
Finally Rasakarpura is collected.
Samples analysed were
Samples I: Parada Churna
Samples II: Rasakarpura
Samples III: Residue obtained from Kupi
Analysis of Sample I Parada churna:
Estimation of mercury
Analysis of Sample II Rasakarpura
A. Evaluation on classical method:
Colour, Odour,Texture.
B. Evaluation on modern parameters:
a) Qualitative analysis for Hgcl2:
Contd….
To an aqueous solution of the sample ammonia solution
was added drop wise and any change was noted and
compared.
It was carried out
By adding Diluted HCl.
By adding H2S solution.
By adding KI solution.
By adding NaOH solution.
By addingNH4OH solution
Contd….
Quantitative Analysis:
i)Loss on drying.
ii) Ash value
iii)Determination of water soluble matter.
iv)Estimation of Mercury.
v) Estimation of chlorine.
vi) Inductively coupled plasma Analysis
Parameters Rasakarpura
1.Shabda N.S
2.Sparsha Corrosive
3.Rupa White crystals
4.Gandha N.S
Table-1 contd…..
Sodium 71.6520
Magnesium 08.1363
Calcium 15.7630
Discussion
It reveals that the major constitute of rasakarpura is
mercury. 71.65mg/kg of sodium,08.13mg/kg
magnesium and 15.76mg/kg calcium were also
evaluated in trace form. This analysis indicates that
Rasakarpura is not the pure form of mercuric chloride,
but sodium, magnesium and calcium are also found
into the trace amount in it. The quantitative estimation
of percentage of mercury is supported by the result of
ICP.
Qualitative test for mercury was found to be negative in
residue.
Conclusion
Rasakarpura should be considered as cocktail of
mercuric chloride as major constituent and Sodium,
Magnesium and Calcium as trace elements.
PHARMACEUTICAL STANDARDIZATION
OF RASAKARPURA
Neky J. Mehta **B. Ravishankar ***P. K. Prajapati